Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 11, 2014, Pages 2486-2494

  Yaoita, Nobuhiro ^a   Shirakawa, Ryutaro ^b   Fukumoto, Yoshihiro ^a   Sugimura, Koichiro ^a   Miyata, Satoshi ^a   Miura, Yutaka ^a   Nochioka, Kotaro ^a   Miura, Masanobu ^a   Tatebe, Shunsuke ^a   Aoki, Tatsuo ^a   Yamamoto, Saori ^a   Satoh, Kimio ^a   Kimura, Tomohiro ^b   Shimokawa, Hiroaki ^a   Horiuchi, Hisanori ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Blood platelets; Chronic thromboembolic pulmonary hypertension; GTP binding proteins; Pulmonary hypertension

Indexed keywords

BIOLOGICAL MARKER; D DIMER; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN RECEPTOR; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; PADGEM PROTEIN; RAC1 PROTEIN; RAL PROTEIN; RAP1 PROTEIN; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THROMBIN; VASCULAR CELL ADHESION MOLECULE 1; FIBRIN;

ADULT; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; PROTEIN BINDING; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; THROMBOCYTE ACTIVATION; AGED; CASE CONTROL STUDY; CHRONIC DISEASE; DRUG EFFECTS; HEMODYNAMICS; LUNG EMBOLISM; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS; THROMBOCYTE;

ADULT; AGED; BLOOD PLATELETS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; FIBRIN; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; P-SELECTIN; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PULMONARY EMBOLISM; RAL GTP-BINDING PROTEINS; REGRESSION ANALYSIS; RHOA GTP-BINDING PROTEIN; THROMBIN;

EID: 84911918024     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304404     Document Type: Article

References (30)

1. Simonneau G , Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R. Updated clinical classification of pulmonary hy pertension. J Am Coll Cardiol. 2009;54(1 suppl):S43-S54.
2. Pengo V, Lensing AW, Prins MH, Marchiori A, Davidson BL, Tiozzo F, Albanese P, Biasiolo A, Pegoraro C, Iliceto S, Prandoni P; Thromboembolic Pulmonary Hypertension Study Group. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med. 2004;350:2257-2264.
3. Hoeper MM, Mayer E, Simonneau G, Rubin LJ. Chronic thromboembolic pulmonary hypertension. Circulation. 2006;113:2011-2020.
4. Nakamura M, Okada O, Sakuma M, Nakanishi N, Miyahara Y, Yamada N, Fujioka H, Kuriyama T, Kunieda T, Sugimoto T, Nakano T. Incidence and clinical characteristics of chronic pulmonary thromboembolism in Japan compared with acute pulmonary thromboembolism: results of a multicenter registry of the Japan ese Society of Pulmonary Embolism Research. Circ J. 2002;66:257-260.
5. Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002;277:25715-25721.
6. Morii N,Teru-uchi T,Tominaga T,Kumagai N,Kozaki S,Ushikubi F,Narumiya S. A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation. J Biol Chem. 1992;267:20921-20926.
7. Nishioka H, Horiuchi H, Tabuchi A, Yoshioka A, Shirakawa R, Kita T. Small GTPase Rho regulates thrombin-induced platelet aggregation. Biochem Biophys Res Commun. 2001;280:970-975.
8. Shirakawa R, Higashi T, Tabuchi A, Yoshioka A, Nishioka H, Fukuda M, Kita T, Horiuchi H. Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets. J Biol Chem. 200 4;279:10730-10737.
9. Kawato M, Shirakawa R, Kondo H, Higashi T, Ikeda T, Okawa K, Fukai S, Nureki O, Kita T, Horiuchi H. Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway. J Biol Chem. 2008;283:166-174.
10. Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, Salem HH, Jackson SP. RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem. 2002 ;277:14738-14746.
11. Suzuki Y, Yamamoto M, Wada H, Ito M, Nakano T, Sasaki Y, Narumiya S, Shiku H, Nishikawa M. Agonist-induced regulation of myosin phosphatase activity in human plat elets through activation of Rho-kinase. Blood. 1999;93:3408-3417.
12. Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood. 2011;118:3129-3136.
13. Wolf M, Boyer-Neumann C, Parent F, Eschwege V, Jaillet H, Meyer D, Simonneau G. Thrombotic risk factors in pulmonary hypertension. Eur Respir J . 2000;15:395-399.
14. Bonderman D, Skoro-Sajer N, Jakowitsch J, Adlbrecht C, Dunkler D, Taghavi S, Klepetko W, Kneussl M, Lang IM. Predictors of outcome in chronic thromboembolic pulmonary hypertension. Circulation. 2007;115:2153-2158.
15. Pepke-Zaba J, Delcroix M, Lang I, et al. Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry. Circulation. 2011;124:1973 -1981.
16. Galiè N, Hoeper MM, Humbert M, et al; Task Force for Diagnosis and Treatment of Pulmonary Hypertension of European Society of Cardiology (ESC); Euro pean Respiratory Society (ERS); International Society of Heart and Lung Transplantation (ISHLT). Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2009;34:1219-1263.
17. Adam SS, Key NS, Greenberg CS. D-dimer antigen: current concepts and future prospects. Blood. 2009;113:2878-2887.
18. Tripodi A, Mannucci PM. Markers of activated coagulation and their usefulness in the clinical laboratory. Clin Chem. 1996;42:664-669.
19. Shirakawa R, Fukai S, Kawato M, Higashi T, Kondo H, Ikeda T, Nakayama E, Okawa K, Nureki O, Kimura T, Kita T, Horiu chi H. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. J Biol Chem. 2009;284:21580-21588.
20. Saito R, Shirakawa R, Nishiyama H, et a l. Downregulation of Ral GTPaseactivating protein promotes tumor invasion and metastasis of bladder cancer. Oncogene. 2013;32:894-902.
21. Tamburrelli C, Crescente M, Izzi B, Barisciano M, Donati MB, de Gaetano G, Cerletti C. Epoprostenol inhibits human platelet-leukocyte mixed conjugate and platelet microparticle formation in whole blood. Thromb Res. 2011;128:446-451.
22. De Candia E. Mechanisms of platelet activation by thrombin: a short history. Thromb Res. 2012;129:250-256.
23. Libby P, Okamoto Y, Rocha VZ, Folco E. Inflammation in atherosclerosis: transition from theory to practice. Circ J. 2010;74:213-220.
24. Diehl P, Aleker M, Helbing T, Sossong V, Germann M, Soric hter S, Bode C, Moser M. Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension. J Thromb Thrombolysis. 2011;31:173-179.
25. Varol E, Uysal BA, Ozaydin M. Platelet indices in patients with pulmonary arterial hypertension. Clin Appl Thromb Hemost. 2011;17:E171-E174.
26. Soon E, Holmes AM, Treacy CM, Doughty NJ, Southgate L, Machado RD, Trembath RC, Jennings S, Barker L, Nicklin P, Walker C, Budd DC, Pepke-Zaba J, Morrell NW. Elevated levels of inflammatory cytokines predict survival in idiopathic and fa milial pulmonary arterial hypertension. Circulation. 2010;122:920-927.
27. Berger G,Azzam ZS,Hoffman R,Yigla M. Coagulation and anticoagulation in pulmonary arterial hypertension. Isr Med Assoc J. 2009; 11: 376-379.
28. Groth A, Vrugt B, Brock M, Speich R, Ulrich S, Huber LC. Inflammatory cytokines in pulmonary hypertension. Respir Res. 2014;15:47.
29. Wolthuis RM, Franke B, van Triest M, Bauer B, Cool RH, Camonis JH, Akkerman JW, Bos JL. Activation of the small GTPase Ral in platelets. Mol Cell Biol. 1998;18:2486-2491.
30. Kantake M, Tanabe N, Sugiura T, Shigeta A, Yanagawa N, Jujo T, Kawata N, Amano H, Matsuura Y, Nishimura R, Sekine A, Sakao S, Kasahara Y, Tatsumi K. Association of deep vein thrombosis type with clinical phenotype of chronic thromboembolic pulmonary hypertension. Int J Cardiol. 2013;165:474-477.