Obesity-linked diabetes in the arab world: A review;Diabète lié à l'obésité dans le monde arabe: Analyse

Eastern Mediterranean Health Journal

Volumn 21, Issue 6, 2015, Pages 420-439

  Abuyassin, B ^a   Laher, I ^a  

^a Department of Pharmacology and Therapeutics ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BIOLOGICAL FACTOR; FATTY ACID; GLUCOSE; INTERLEUKIN 6; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RESISTIN; RETINOL BINDING PROTEIN 4; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASPIN;

ADIPOSE TISSUE; ALLELE; ARAB; BODY FAT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIET; ETHNICITY; FAMILY HISTORY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEREDITY; HUMAN; INCIDENCE; INSULIN RESISTANCE; LIFESTYLE; LIPOTOXICITY; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PREVALENCE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW (TOPIC); WAIST CIRCUMFERENCE; COMPLICATION; CULTURAL ANTHROPOLOGY; DIABETES MELLITUS, TYPE 2; GENETICS; PATHOPHYSIOLOGY;

ARAB WORLD; DIABETES MELLITUS, TYPE 2; HUMANS; OBESITY; PREVALENCE;

EID: 84941082295     PISSN: 10203397     EISSN: None     Source Type: Journal    
DOI: 10.26719/2015.21.420     Document Type: Review

References (145)

1. IDF diabetes atlas. 4th ed. Brussels: International Diabetes Federation; 2008 (http://www.idf.org/sites/default/files/IDF-Diabetes-Atlas-4th-edition.pdf, accessed 10 June 2015).
2. American Diabetes Association. Economic costs of diabetes in the U.S. in 2007. Diabetes Care. 2008 Mar;31(3):596–615. PMID:18308683
3. World health statistics 2008. Geneva: World Health Organization; 2008 (http://www.who.int/whosis/whostat/2008/en/, accessed 10 June 2015).
4. Assaad-Khalil SH, Al Arouj M, Almaatouq M, Amod A, Assaad SN, Azar ST, et al. Barriers to the delivery of diabetes care in the Middle East and South Africa: a survey of 1,082 practising physicians in five countries. Int J Clin Pract. 2013 Nov;67(11):1144-50. PMID:24165428
5. Al-Maskari F, El-Sadig M, Nagelkerke N. Assessment of the direct medical costs of diabetes mellitus and its complications in the United Arab Emirates. BMC Public Health. 2010;10:679. PMID:21059202
6. Bonora E, Targher G, Formentini G, Calcaterra F, Lombardi S, Marini F, et al. The metabolic syndrome is an independent predictor of cardiovascular disease in Type 2 diabetic subjects. Prospective data from the Verona Diabetes Complications Study. Diabet Med. 2004 Jan;21(1):52–8. PMID:14706054
7. Masuo K, Rakugi H, Ogihara T, Esler MD, Lambert GW. Cardio-vascular and renal complications of type 2 diabetes in obesity: role of sympathetic nerve activity and insulin resistance. Curr Diabetes Rev. 2010 Mar;6(2):58–67. PMID:20034369
8. Raz I. Complex impact of obesity on type 2 diabetes. Isr Med Assoc J. 2005;7:402–3
9. Montague CT, O’Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes. 2000 Jun;49(6):883–8. PMID:10866038
10. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA. 1999 Oct 27;282(16):1523–9. PMID:10546691
11. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesityrelated health risk factors, 2001. JAMA. 2003 Jan 1;289(1):76–9. PMID:12503980
12. Khan S. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006 Dec 14;444(7121):840-6. PMID:17167471
13. Day C, Bailey C. Obesity in the pathogenesis of type 2 diabetes. Br J Diabetes Vasc Dis. 2011;11:55–61
14. Karpe F, Dickmann JR, Frayn KN. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes. 2011;60(10):2441–9. PMID:21948998
15. Santomauro AT, Boden G, Silva ME, Rocha DM, Santos RF, Ursich MJ, Strassmann PG, Wajchenberg BL. Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999 Sep;48(9):1836–41. PMID:10480616
16. Thévenod F. Masur K, Thévenod F, Zänker KS, eds. Diabetes and cancer. Epidemiological evidence and molecular links. Front diabetes. Volume 19. Basel: Karger; 2008 pp 1–18 (https://www.karger.com/ProdukteDB/Katalogteile/isbn3_8055/_86/_40/fdiab19_02.pdf, accessed 10 June 2015).
17. Havel PJ. Update on adipocyte hormones: regulation of energy balance and carbohydratelipid metabolism. Diabetes. 2004 Feb;53 Suppl 1:S143–51.PMID:14749280
18. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008 Dec;29(24):2959–71. PMID:18775919
19. Kusminski CM, McTernan PG, Kumar S. Role of resistin in obesity, insulin resistance and Type II diabetes. Clin Sci (Lond). 2005 Sep;109(3):243–56. PMID:16104844
20. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995 Nov 10;270(45):26746–9. PMID:7592907
21. Ryu S, Park S, Kim S. The relation of serum adiponectin and resistin concentrations with metabolic risk factors. J Korean Soc Endocrinol. 2005;20(5):444–51
22. Yamamoto Y, Hirose H, Saito I, Tomita M, Taniyama M, Matsubara K, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond). 2002 Aug;103(2):137–42. PMID:12149104
23. Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factoralpha expression. Diabetes. 2003 Jul;52(7):1779–85. Diabetes. PMID:12829646
24. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev. 2005 Feb;6(1):13–21. PMID:15655035
25. Alfadda AA. Circulating adipokines in healthy versus unhealthy overweight and obese subjects. Int J Endocrinol. 2014;2014:170434. PMID:24550983
26. Abdullah AR, Hasan HA, Raigangar VL. Analysis of the relationship of leptin, high-sensitivity C-reactive protein, adiponectin, insulin, and uric acid to metabolic syndrome in lean, overweight, and obese young females. Metab Syndr Relat Disord. 2009 Feb;7(1):17–22. PMID:19025443
27. Rizk N, Awni R, Osman M. M Zirie. Hypoadiponectinemia in obese and diabetic subjects in the State of Qatar. Int J Diabetes Metab. 2008;16:123–9
28. Abaza D, El Arab A, Mohamed E, El Arab H. The relation between asthma, body fat distribution and serum adiponectin in obese Egyptian children. Egypt J Hosp Med. 2011;45:585–94
29. Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1247–59. PMID:19724019
30. Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences. Circ Res. 2007 Sep 14;101(6):545–59. PMID:17872473
31. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003 Oct;149(4):331–5. PMID:14514348
32. Adams-Huet B, Devaraj S, Siegel D, Jialal I. Increased adipose tissue insulin resistance in metabolic syndrome: relationship to circulating adipokines. Metab Syndr Relat Disord. 2014 Dec;12(10):503–7. PMID:25162912
33. Finucane FM, Luan J, Wareham NJ, Sharp SJ, O'Rahilly S, Balkau B, et al. Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia. 2009 Nov;52(11):2345–9
34. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001 Jan 18;409(6818):307–12. PMID:11201732
35. Ukkola O. Resistin—a mediator of obesity-associated insulin resistance or an innocent bystander? Eur J Endocrinol. 2002 Nov;147(5):571–4. PMID:12444887
36. Gharibeh MY, Al Tawallbeh GM, Abboud MM, Radaideh A, Alhader AA, Khabour OF. Correlation of plasma resistin with obesity and insulin resistance in type 2 diabetic patients. Diabetes Metab. 2010 Dec;36(6 Pt 1):443–9. PMID:20739208
37. Degawa-Yamauchi M, Bovenkerk JE, Juliar BE, Watson W, Kerr K, Jones R, et al. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab. 2003 Nov;88(11):5452–5. PMID:14602788
38. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, et al. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab. 2003 Oct;88(10):4848–56. PMID:14557464
39. Iqbal N, Seshadri P, Stern L, Loh J, Kundu S, Jafar T, et al. Serum resistin is not associated with obesity or insulin resistance in humans. Eur Rev Med Pharmacol Sci. 2005 May;9(3):161–5. PMID:16080635
40. Chang YH, Chang DM, Lin KC, Shin SJ, Lee YJ. Visfatin in overweightobesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a metaanalysis and systemic review. Diabetes Metab Res Rev. 2011 Sep;27(6):515–27. PMID:21484978
41. Izadi M, Goodarzi M, Khalaj H, Khorshidi D, Doali H. Serum adiponectin levels are inversely correlated with insulin resistance in obese men with type 2 diabetes. Int J Endocrinol Metab. 2011;9(1):253–7
42. Ehtisham S, Barrett TG, Shaw NJ. Type 2 diabetes mellitus in UK children—an emerging problem. Diabet Med. 2000 Dec;17(12):867–71. PMID:11168330
43. Punnose J, Agarwal MM, Bin-Uthman S. Type 2 diabetes mellitus among children and adolescents in Al-Ain: a case series. East Mediterr Health J. 2005 Jul;11(4):788–97. PMID:16700395
44. Osman H, Elsadek N, Abdullah M. Type 2 diabetes in Sudanese children and adolescents. Sudan J Paediatr. 2013;13(2):17–23
45. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9945):766–81. PMID:24880830
46. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world–a growing challenge. N Engl J Med. 2007 Jan 18;356(3):213–5. PMID:17229948
47. Boutayeb A, Lamlili MEN, Boutayeb W, Maamri A, Ziyyat A, Ramdani N. The rise of diabetes prevalence in the Arab region. Open Journal of Epidemiology. 2012;2:55–60. doi: 10.4236/ojepi.2012.22009
48. Al-Nozha MM, Al-Mazrou YY, Al-Maatouq MA, Arafah MR, Khalil MZ, Khan NB, et al. Obesity in Saudi Arabia. Saudi Med J. 2005 May;26(5):824–9. PMID:15951877
49. el-Hazmi MA, Warsy AS. Prevalence of overweight and obesity in diabetic and non-diabetic Saudis. East Mediterr Health J. 2000 Mar-May;6(2-3):276–82. PMID:11556013
50. Al-Shahrani A, Al-Khaldi Y. Obesity among diabetic and hypertensive patients in Aseer region, Saudi Arabia. Saudi J Obes. 2013;1(1):14–7
51. IDF diabetes atlas, 6th ed. Brussels: International Diabetes Federation; 2013 http://www.idf.orgdiabetesatlas, accessed 10 June 2015).
52. Alarouj M, Bennakhi A, Alnesef Y, Sharifi M, Elkum N. Diabetes and associated cardiovascular risk factors in the State of Kuwait: the first national survey. Int J Clin Pract. 2013 Jan;67(1):89–96. PMID:23241053
53. Malik M, Bakir A, Saab BA, King H. Glucose intolerance and associated factors in the multi-ethnic population of the United Arab Emirates: results of a national survey. Diabetes Res Clin Pract. 2005 Aug;69(2):188–95. PMID:16005369
54. Arafat M, Salam A, Arafat O. The association of type 2 diabetes with obesity and other factors: in multinational community. Int J Pharm Pharm Sci. 2014;6(9):257–60
55. Alhyas L, McKay A, Balasanthiran A, Majeed A. Prevalences of overweight, obesity, hyperglycaemia, hypertension and dyslipidaemia in the Gulf: systematic review. JRSM Short Rep. 2011 Jul; 2(7):55
56. Bos M, Agyemang C. Prevalence and complications of diabetes mellitus in Northern Africa, a systematic review. BMC Public Health. 2013;13:387. PMID:23617762
57. Jaber LA, Brown MB, Hammad A, Nowak SN, Zhu Q, Ghafoor A, et al. Epidemiology of diabetes among Arab Americans. Diabetes Care. 2003 Feb;26(2):308–13. PMID:12547854
58. Musaiger A, Shahbeek N. The relationship between obesity and prevalence of chronic diseases in the Arab women. J Hum Ecol. Special Issue. 2005;13:97–100
59. Rissel C, Lesjak M, Ward J. Cardiovascular risk factors among Arabic-speaking patients attending Arabic-speaking general practitioners in Sydney, Australia: opportunities for intervention. Ethn Health. 1998 Aug;3(3):213–22. PMID:9798119
60. Thow AM, Waters AM. AIHW 2005. Diabetes in culturally and linguistically diverse Australians. Cat. no. CVD 30. Canberra: Australian Institute of Health and Welfare; 2005
61. Musaiger AO, Al-Mannai M, Tayyem R, Al-Lalla O, Ali EY, Kalam F, et al. Prevalence of overweight and obesity among adolescents in seven arab countries: a cross-cultural study. J Obes. 2012;2012:981390. PMID:23029605
62. Musaiger AO, Al-Mannai M, Al-Lalla O, Saghir S, Halahleh I, Benhamed MM, et al. Obesity among adolescents in five Arab countries; relative to gender and age. Nutr Hosp. 2013 Nov-Dec;28(6):1922–5. PMID:24506370
63. bin Zaal AA, Musaiger AO, D’Souza R; BinZaal AA. Dietary habits associated with obesity among adolescents in Dubai, United Arab Emirates. Nutr Hosp. 2009 Jul-Aug;24(4):437–44. PMID:19721923
64. Musaiger AO. Overweight and obesity in Eastern Mediterranean Region: prevalence and possible causes. J Obes. 2011;2011:407237. doi: 10.11552011407237
65. Musaiger AO, Lloyd OL, Al-Neyadi SM, Bener AB. Lifestyle factors associated with obesity among male university students in the United Arab Emirates. J Nutr Food Sci. 2003;33(4):145–7
66. Jaber LA, Brown MB, Hammad A, Zhu Q, Herman WH. Lack of acculturation is a risk factor for diabetes in Arab immigrants in the US. Diabetes Care. 2003 Jul;26(7):2010–4. PMID:12832304
67. Mackevics V, Heid IM, Wagner SA, Cip P, Doppelmayr H, Lejnieks A, et al. The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians. Eur J Hum Genet. 2006 Mar;14(3):349–56. PMID:16418740
68. Jungtrakoon P, Plengvidhya N, Tangjittipokin W, Chimnaronk S, Salaemae W, Chongjaroen N, et al. Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects. PLoS One. 2011;6(10):e26792. PMID:22046359
69. Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Eriksson JG, Venojärvi M, et al. Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet. 2011;12:5. PMID:21219602
70. Kottyan L, Woo JG, Keddache M, Banach W, Crimmins NA, Dolan LM, et al. Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes. Springerplus. 2012 Dec;1(1):66. PMID:23396303
71. Ramya K, Ayyappa KA, Ghosh S, Mohan V, Radha V. Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population. Gene. 2013 Dec 15;532(2):253–62. PMID:24055485
72. Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM. The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab. 2005 Jul;90(7):4255–9. PMID:15870125
73. Mtiraoui N, Ezzidi I, Turki A, Chaieb A, Mahjoub T, Almawi WY. Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs. Diabetes Res Clin Pract. 2012 Aug;97(2):290–7. PMID:22497971
74. Chiodini BD, Specchia C, Gori F, Barlera S, D’Orazio A, Pietri S, et al.; GISSI Prevenzione Investigators; SiBioC-GISSI Prevenzione Group. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis. 2010 Aug;4(4):223–30. PMID:20576642
75. Beebe-Dimmer JL, Zuhlke KA, Ray AM, Lange EM, Cooney KA. Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis. 2010 Dec;13(4):362–8. PMID:20697428
76. Enns JE, Taylor CG, Zahradka P. Variations in adipokine genes AdipoQ, Lep, and LepR are associated with risk for obesity-related metabolic disease: the modulatory role of gene-nutrient interactions. J Obes. 2011;2011:168659. PMID:21773001
77. Zadjali F, Al-Yahyaee S, Hassan MO, Albarwani S, Bayoumi RA. Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: family-based study. Gene. 2013 Sep 25;527(2):663–9. PMID:23845780
78. Alkhateeb A, Al-Azzam S, Zyadine R, Abuarqoub D. Genetic association of adiponectin with type 2 diabetes in Jordanian Arab population. Gene. 2013;512(1):61–3. PMID:23041553
79. Soriguer F, Morcillo S, Cardona F, Rojo-Martínez G, de la Cruz Almaráz M, Ruiz de Adana ML, et al. Pro12Ala polymord-phism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid. J Nutr. 2006 Sep;136(9):2325–30. PMID:16920849
80. Tönjes A, Stumvoll M. The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk. Curr Opin Clin Nutr Metab Care. 2007 Jul;10(4):410–4. PMID:17563457
81. Wakil SM, Al-Rubeaan K, Alsmadi O, Imtiaz F, Carroll P, Rajab M, et al. The peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and type 2 diabetes in an Arab population. Diabetes Care. 2006 Jan;29(1):171–2. PMID:16373923
82. Meyer BF, Alsmadi O, Wakil S, Al-Rubeaan K. Genetics of type 2 diabetes in Arabs: what we know to date. Int J Diabetes Mellit. 2009;1(1):32–4
83. el-Hazmi MA, al-Swailem AR, Warsy AS, al-Swailem AM, Sulaimani R, al-Meshari AA. Consanguinity among the Saudi Arabian population. J Med Genet. 1995 Aug;32(8):623–6. PMID:7473654
84. Cauchi S, Froguel P. Identification of genetic factors associated with Type 2 Diabetes in Saudis: The lessons from European studies. Int J Diabetes Mellit. 2010;2:133–6
85. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007 Jun;39(6):770–5. PMID:17460697
86. Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, et al.; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes. 2007 Dec;56(12):3101–4. PMID:17804762
87. Hertel JK, Johansson S, Raeder H, Midthjell K, Lyssenko V, Groop L, et al. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia. 2008 Jun;51(6):971–7. PMID:18437351
88. Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, et al. Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One. 2008;3(5):e2031. PMID:18461161
89. Nemr R, Almawi AW, Echtay A, Sater MS, Daher HS, Almawi WY. Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population. Diabetes Res Clin Pract. 2012 Feb;95(2):e37-40. PMID:22119613
90. Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes. 2008 Aug;57(8):2226–33. PMID:18469204
91. Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, et al. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes. 2007 Dec;56(12):3105–11. PMID:17827400
92. Nemr R, Echtay A, Dashti EA, Almawi AW, Al-Busaidi AS, Keleshian SH, et al. Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.Diabetes Res Clin Pract. 2012 May;96(2):225–9. PMID:22245690
93. Almawi WY, Nemr R, Keleshian SH, Echtay A, Saldanha FL, Al-Doseri FA, et al. A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population. Diabetes Res Clin Pract. 2013 Nov;102(2):117–22. PMID:24145053
94. Non-communicable diseases [Internet]. Cairo: World Health Organization Regional Office for the Eastern Mediterranean (http://www.emro.who.int/entity/noncommunicable-diseases/ index.html, accessed 11 June 2015).
95. Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, et al.; Look AHEAD Research Group. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011 Jul;34(7):1481–6. PMID:21593294
96. Bosello O, Armellini F, Zamboni M, Fitchet M. The benefits of modest weight loss in type II diabetes. Int J Obes Relat Metab Disord. 1997 Mar;21 Suppl 1:S10–3. PMID:9130035
97. Lau DC, Teoh H. Benefits of modest weight loss on the management of type 2 diabetes mellitus. Can J Diabetes. 2013 Apr;37(2):128–34. PMID:24070804
98. Musaiger AO, Al Hazzaa HM, Al-Qahtani A, Elati J, Ramadan J, Aboulella NA, et al. Strategy to combat obesity and to promote physical activity in Arab countries. Diabetes Metab Syndr Obes. 2011;4:89–97. PMID:21660292
99. The work of WHO in the Eastern Mediterranean Region: annual report of the Regional Director. Alexandria: World Health Organization Regional Office for the Eastern Mediterranean; 2003
100. Al-Shehri F, Moqbel M, Al-Shahrani A, Al-Khaldi Y, Abu-Melha W. Management of obesity: Saudi clinical guideline. Saudi. J Obes. 2013;1(1):18–30
101. Tillin T, Sattar N, Godsland IF, Hughes AD, Chaturvedi N, Forouhi NG. –Ethnicity-specific obesity cut-points in the development of type 2 diabetes—a prospective study including three ethnic groups in the United Kingdom. Diabet Med. 2015 Feb;32(2):226-34. PMID:25186015
102. Klimentidis YC, Chen Z, Arora A, Hsu CH. Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk. Diabetologia. 2014 Dec;57(12):2530–4. PMID:25273344
103. Chowdhury R, Narayan KM, Zabetian A, Raj S, Tabassum R. Genetic studies of type 2 diabetes in South Asians: a systematic overview. Curr Diabetes Rev. 2014;10(4):258–74. PMID:25001234
104. AlSaleh A, O’Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, et al.; RISCK Study Group. Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. Am J Clin Nutr. 2011 Jul;94(1):262–9. PMID:21562092
105. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Hussain T, Yakout S, et al. Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population. Gene. 2012 Feb 1;493(1):142–7. PMID:22155316
106. Anokute CC. Suspected synergism between consanguinity and familial aggregation in type 2 diabetes mellitus in Saudi Arabia. J R Soc Health. 1992 Aug;112(4):167–9. PMID:1433147
107. Farouq I. Al Zurba and Ahmad Al Garf -Prevalence of diabetes mellitus among Bahrainis attending primary health care centres. East Mediterr Health J. 1996;2(2):274–82
108. Abolfotouh MA, Soliman LA, Mansour E, Farghaly M, El-Dawaiaty AA. Central obesity among adults in Egypt: prevalence and associated morbidity. East Mediterr Health J. 2008 Jan-Feb;14(1):57–68. PMID:18557452
109. Herman WH, Ali MA, Aubert RE, Engelgau MM, Kenny SJ, Gunter EW, et al. Diabetes mellitus in Egypt: risk factors and prevalence. Diabet Med. 1995 Dec;12(12):1126–31. PMID:8750225
110. Ali BA, Abdallah ST, Abdallah AM, Hussein MM. The Frequency of Type 2 Diabetes Mellitus among Diabetic Children in El Minia Governorate, Egypt. Sultan Qaboos Univ Med J. 2013 Aug;13(3):399–403. PMID:23984025
111. Saadi H, Carruthers SG, Nagelkerke N, Al-Maskari F, Afandi B, Reed R, et al. Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Res Clin Pract. 2007 Dec;78(3):369–77. PMID:17532085
112. Mansour AA, Al-Maliky AA, Kasem B, Jabar A, Mosbeh KA. Prevalence of diagnosed and undiagnosed diabetes mellitus in adults aged 19 years and older in Basrah, Iraq. Diabetes Metab Syndr Obes. 2014;7:139–44. PMID:24833912
113. Mansour AA, Al-Jazairi MI. Predictors of incident diabetes mellitus in Basrah, Iraq. Ann Nutr Metab. 2007;51(3):277–80. PMID:17622787
114. Ajlouni K, Khader YS, Batieha A, Ajlouni H, El-Khateeb M. An increase in prevalence of diabetes mellitus in Jordan over 10 years. J Diabetes Complications. 2008 Sep-Oct;22(5):317–24. PMID:18413210
115. Al Khalaf MM, Eid MM, Najjar HA, Alhajry KM, Doi SA, Thalib L. Screening for diabetes in Kuwait and evaluation of risk scores. East Mediterr Health J. 2010 Jul;16(7):725–31. PMID:20799528
116. Abdella N, Khogali M, al-Ali S, Gumaa K, Bajaj J. Known type 2 diabetes mellitus among the Kuwaiti population. A prevalence study. Acta Diabetol. 1996 Jul;33(2):145–9. PMID:8870817
117. Moussa MA, Alsaeid M, Abdella N, Refai TM, Al-Sheikh N, Gomez JE. Prevalence of type 2 diabetes mellitus among Kuwaiti children and adolescents. Med Princ Pract. 2008;17(4):270–5. PMID:18523392
118. Naja F, Hwalla N, Itani L, Salem M, Azar ST, Zeidan MN, et al. Dietary patterns and odds of Type 2 diabetes in Beirut, Lebanon: a case–control study. Nutr Metab (Lond). 2012;9(1):111. PMID:23270372
119. Ghassibe-Sabbagh M, Deeb M, Salloum AK, Mouzaya F, Haber M, Al-Sarraj Y, et al. Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. Diabetol Metab Syndr. 2014;6(1):89. PMID:25191526
120. Kadiki OA, Roaeid RB. Prevalence of diabetes mellitus and impaired glucose tolerance in Benghazi Libya. Diabetes Metab. 2001 Dec;27(6):647–54. PMID:11852372
121. Rguibi M, Belahsen R. Prevalence and associated risk factors of undiagnosed diabetes among adult Moroccan Sahraoui women. Public Health Nutr. 2006 Sep;9(6):722–7. PMID:16925877
122. Al-Moosa S, Allin S, Jemiai N, Al-Lawati J, Mossialos E. Diabetes and urbanization in the Omani population: an analysis of national survey data. Popul Health Metr. 2006;4:5. PMID:16635266
123. Abdul-Rahim HF, Husseini A, Giacaman R, Jervell J, Bjertness E. Diabetes mellitus in an urban Palestinian population: prevalence and associated factors. East Mediterr Health J. 2001 Jan-Mar;7(1-2):67–78. PMID:12596954
124. Yassin MM, Altibi HI, Elshanti AF. Clinical and biochemical features of type 2 diabetic patients in Gaza Governorate, Gaza Strip. West Afr J Med. 2011 Jan-Feb;30(1):51–6. PMID:21863590
125. Bener A, Zirie M, Janahi IM, Al-Hamaq AO, Musallam M, Wareham NJ. Prevalence of diagnosed and undiagnosed diabetes mellitus and its risk factors in a population-based study of Qatar. Diabetes Res Clin Pract. 2009 Apr;84(1):99–106. PMID:19261345
126. Bacchus RA, Bell JL, Madkour M, Kilshaw B. The prevalence of diabetes mellitus in male Saudi Arabs. Diabetologia. 1982 Oct;23(4):330–2. PMID:7141167
127. Al-Nuaim AR. Prevalence of glucose intolerance in urban and rural communities in Saudi Arabia. Diabet Med. 1997 Jul;14(7):595–602. PMID:9223399
128. Al-Nozha MM, Al-Maatouq MA, Al-Mazrou YY, Al-Harthi SS, Arafah MR, Khalil MZ, et al. Diabetes mellitus in Saudi Arabia. Saudi Med J. 2004 Nov;25(11):1603–10. PMID:15573186
129. Al-Rubeaan K, Al-Manaa HA, Khoja TA, Ahmad NA, Al-Sharqawi AH, Siddiqui K, et al. Epidemiology of abnormal glucose metabolism in a country facing its epidemic: SAUDI-DM study. J J Diabetes. 2014 Sep 30. doi: 10.1111/1753-0407.12224. PMID:25266306
130. Rahman Al-Nuaim A. Effect of overweight and obesity on glucose intolerance and dyslipidemia in Saudi Arabia, epidemiological study. Diabetes Res Clin Pract. 1997 Jun;36(3):181–91. PMID:9237785
131. Fatani HH, Mira SA, el-Zubier AG. Prevalence of diabetes mellitus in rural Saudi Arabia. Diabetes Care. 1987 Mar-Apr;10(2):180–3. PMID:3582078
132. Almajwal AM, Al-Baghli NA, Batterham MJ, Williams PG, Al-Turki KA, Al-Ghamdi AJ. Performance of body mass index in predicting diabetes and hypertension in the Eastern Province of Saudi Arabia. Ann Saudi Med. 2009 Nov-Dec;29(6):437–45. PMID:19847080
133. Al-Agha A, Ocheltree A, Shata N. Prevalence of hyperinsulinism, type 2 diabetes mellitus and metabolic syndrome among Saudi overweight and obese pediatric patients. Minerva Pediatr. 2012 Dec;64(6):623–31. PMID:23108324
134. Elbagir MN, Eltom MA, Elmahadi EM, Kadam IM, Berne C. A population-based study of the prevalence of diabetes and impaired glucose tolerance in adults in northern Sudan. Diabetes Care. 1996 Oct;19(10):1126–8. PMID:8886561
135. Albache N, Al Ali R, Rastam S, Fouad FM, Mzayek F, Maziak W. Epidemiology of Type 2 diabetes mellitus in Aleppo, Syria. J Diabetes. 2010 Jun;2(2):85–91. PMID:20923489
136. Bouguerra R, Alberti H, Salem LB, Rayana CB, Atti JE, Gaigi S, et al. The global diabetes pandemic: the Tunisian experience. Eur J Clin Nutr. 2007 Feb;61(2):160–5. PMID:16900086
137. Al-Habori M, Al-Mamari M, Al-Meeri A. Type II diabetes mellitus and impaired glucose tolerance in Yemen: prevalence, associated metabolic changes and risk factors. Diabetes Res Clin Pract. 2004 Sep;65(3):275–81. PMID:15331208
138. Gunaid AA, Assabri AM. Prevalence of type 2 diabetes and other cardiovascular risk factors in a semirural area in Yemen. East Mediterr Health J. 2008 Jan-Feb;14(1):42–56. PMID:18557451
139. Al-Sharafi BA, Gunaid AA. Prevalence of obesity in patients with type 2 diabetes mellitus in yemen. Int J Endocrinol Metab. 2014 Apr;12(2):e13633. PMID:24748890
140. Trujillo ME, Scherer PE. Adiponectin–journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med. 2005 Feb;257(2):167–75. PMID:15656875
141. Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med. 2008 Nov-Dec;14(11-12):741–51. PMID:19009016
142. Antuna-Puente B, Feve B, Fellahi S, Bastard JP. Adipokines: the missing link between insulin resistance and obesity. Diabetes Metab. 2008 Feb;34(1):2–11. PMID:18093861
143. Kahn SE. Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001 Sep;86(9):4047–58. PMID:11549624
144. Jaikanth C, Gurumurthy P, Cherian KM, Indhumathi T. Emergence of omentin as a pleiotropic adipocytokine. Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):377–83. PMID:23839538
145. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May;32(10):2010–9. PMID:22431523