A replication study of 19 GWAS-validated type 2 diabetes at-risk variants in the Lebanese population

Diabetes Research and Clinical Practice

Volumn 102, Issue 2, 2013, Pages 117-122

  Almawi, Wassim Y ^a   Nemr, Rita ^b   Keleshian, Sose H ^c   Echtay, Akram ^d   Saldanha, Fabiola Lisa ^a   AlDoseri, Fatima A ^a   Racoubian, Eddie ^e  

^a ARABIAN GULF UNIVERSITY   (Bahrain)

^b RIZK HOSPITAL   (Lebanon)

^c HAIGAZIAN UNIVERSITY   (Lebanon)

^d RAFIC HARIRI UNIVERSITY HOSPITAL   (Lebanon)

^e St Marc Medical Center   (Lebanon)

Author keywords

Genome wide association scans; Polymorphisms; Type 2 diabetes

Indexed keywords

NOTCH2 RECEPTOR; POTASSIUM CHANNEL KCNQ1;

ADAM30 GENE; ADAMTS9 AS2 GENE; ADULT; ALX4 GENE; ARAB; ARTICLE; CAUCASIAN; COL8A1 GENE; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; JAZF1 GENE; KCNQ1 GENE; LEBANESE; LOC387761 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTCH2 GENE; POPULATION BASED CASE CONTROL STUDY; POPULATION GENETICS; REPLICATION STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE; THADA GENE; TMEFF2 GENE; VALIDATION STUDY; WFS1 GENE;

GENOME-WIDE ASSOCIATION SCANS; POLYMORPHISMS; TYPE 2 DIABETES;

ADULT; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LEBANON; MALE; MIDDLE AGED;

EID: 84888437513     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.09.001     Document Type: Article

References (31)

1. Ginter E., Simko V. Global prevalence and future of diabetes mellitus. Adv Exp Med Biol 2012, 771:35-41.
2. Whiting D.R., Guariguata L., Weil C., Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011, 94:311-321.
3. Cho Y.S., Lee J.Y., Park K.S., Nho C.W. Genetics of type 2 diabetes in East Asian populations. Curr Diabetes Rep 2012, 12:686-696.
4. Pattin K.A., Moore J.H. Genome-wide association studies for the identification of biomarkers in metabolic diseases. Expert Opin Med Diagn 2010, 4:39-51.
5. Sanghera D.K., Blackett P.R. Type 2 diabetes genetics: beyond GWAS. J Diabetes Metab 2012, 3(198).
6. van de Bunt M., Gloyn A.L. From genetic association to molecular mechanism. Curr Diabetes Rep 2010, 10:452-466.
7. Mtiraoui N., Turki A., Nemr R., Echtay A., Izzidi I., Al-Zaben G.S., et al. Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPAR(, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs. Diabetes Metab 2012, 38:444-449.
8. Nemr R., Almawi A.W., Echtay A., Sater M.S., Daher H.S., Almawi W.Y. Replication study of common variants in CDKAL1 and CDKN2A/2B genes associated with type 2 diabetes in Lebanese Arab population. Diabetes Res Clin Pract 2012, 95:e37-e40.
9. Nemr R., Echtay A., Dashti E.A., Almawi A.W., Al-Busaidi A.S., Keleshian S.H., et al. Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs. Diabetes Res Clin Pract 2012, 96:225-229.
10. Nemr R., Turki A., Echtay A., Al-Zaben G.S., Daher H.S., Irani-Hakime N.A., et al. Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects. Diabetes Res Clin Pract 2012, 98:e23-e27.
11. Cauchi S., Ezzidi I., El Achhab Y., Mtiraoui N., Chaieb L., Salah D., et al. European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes Metab 2012, 38:316-323.
12. Staiger H., Machicao F., Stefan N., Tschritter O., Thamer C., Kantartzis K., et al. Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS ONE 2007, 2:e832.
13. Ioannidis J.P., Patsopoulos N.A., Evangelou E. Heterogeneity in meta-analyses of genome-wide association investigations. PLoS ONE 2007, 2:e841.
14. Klimentidis Y.C., Abrams M., Wang J., Fernandez J.R., Allison D.B. Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions. Hum Genet 2011, 129:407-418.
15. Al-Daghri N.M., Alkharfy K.M., Alokail M.S., Alenad A.M., Al-Attas O.S., Abdul Khader M., et al. Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population. Clin Endocrinol (Oxf) 2013, March(1). 10.1111/cen.12187.
16. Alsmadi O., Al-Rubeaan K., Mohamed G., Alkayal F., Al-Saud H., Al-Saud N.A., et al. Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population. BMC Med Genet 2008, 9:72.
17. Nemr R., Al-Busaidi A.S., Sater M.S., Echtay A., Saldhana F.L., Keleshian S.H., et al. Lack of replication of common EXT2 gene variants with susceptibility to type 2 diabetes in Lebanese Arabs. Diabetes Metab 2013, pii: S1262-3636(13)00091-8 [in press]. 10.1016/j.diabet.2013.05.001.
18. Ereqat S., Nasereddin A., Cauchi S., Azmi K., Abdeen Z., Amin R. Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population. Acta Diabetol 2010, 47(Suppl. 1):195-198.
19. Ezzidi I., Mtiraoui N., Cauchi S., Vaillant E., Dechaume A., Chaieb M., et al. Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC Med Genet 2009, 10:33.
20. Saadi H., Nagelkerke N., Carruthers S.G., Benedict S., Abdulkhalek S., Reed R., et al. Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects. Diabetes Res Clin Pract 2008, 80:392-398.
21. Zalloua P.A., Xue Y., Khalife J., Makhoul N., Debiane L., Platt D.E., et al. Y-chromosomal diversity in Lebanon is structured by recent historical events. Am J Hum Genet 2008, 82:873-882.
22. Wray N.R., Goddard M.E., Visscher P.M. Prediction of individual genetic risk to disease from genome-wide association studies. Genome Res 2007, 17:1520-1528.
23. Grant R.W., Moore A.F., Florez J.C. Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care 2009, 32:1107-1114.
24. Gupta V., Vinay D.G., Rafiq S., Kranthikumar M.V., Janipalli C.S., Giambartolomei C., et al. Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs. Diabetologia 2012, 55:349-357.
25. Turki A., Mtiraoui N., Al-Busaidi A.S., Khirallah M., Mahjoub T., Almawi W.Y. Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs. Diabetes Res Clin Pract 2012, 98(3):452-458.
26. Tsai F.J., Yang C.F., Chen C.C., Chuang L.M., Lu C.H., Chang C.T., et al. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 2010, 6:e1000847.
27. Yasuda K., Miyake K., Horikawa Y., Hara K., Osawa H., Furuta H., et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008, 40:1092-1097.
28. Unoki H., Takahashi A., Kawaguchi T., Hara K., Horikoshi M., Andersen G., et al. SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008, 40:1098-1102.
29. Been L.F., Ralhan S., Wander G.S., Mehra N.K., Singh J.R., Mulvihill J.J., et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3310 subjects from India and the US. BMC Med Genet 2011, 12:18.
30. Waters K.M., Stram D.O., Hassanein M.T., Le Marchand L., Wilkens L.R., Maskarinec G., et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet 2010, 6:e1001078.
31. McCarthy M.I. The importance of global studies of the genetics of type 2 diabetes. Diabetes Metab J 2011, 35:91-100.