Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population

Gene

Volumn 493, Issue 1, 2012, Pages 142-147

  Al Daghri, Nasser M ^a   Al Attas, Omar S ^a   Alokail, Majed S ^a   Alkharfy, Khalid M ^a,b   Hussain, Tajamul ^a   Yakout, Sobhy ^a   Vinodson, Benjamin ^a   Sabico, Shaun ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Adiponectin; Adiponectin gene polymorphisms; Diabetes mellitus; Saudi

Indexed keywords

ADIPONECTIN;

ADULT; ANTHROPOMETRY; ARAB; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DYSLIPIDEMIA; FEMALE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPONECTIN; ADULT; ARABS; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC DISEASES; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84655163842     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.11.045     Document Type: Article

References (50)

1. Al-Daghri N.M. High prevalence of metabolic syndrome manifestations among Arab youth: a call for early intervention. Eur. J. Clin. Invest. 2010, 40:1063-1066.
2. Al-Daghri N.M., Al-Attas O.S., Alokail M.S., Alkharfy K.M., Sabico S., Chrousos G.P. Decreasing prevalence of the full metabolic syndrome but a persistently high prevalence of dyslipidemia among adult urban Saudis. PLoS One 2010, 5(8):e12159.
3. Al-Daghri N.M., Al-Attas O.S., Alokail M.S., Alkharfy K.M., Yousef M., Sabico S.L., Chrousos G.P. Diabetes mellitus type 2 and other chronic non-communicable diseases in the central region, Saudi Arabia (Riyadh Cohort 2): a decade of an epidemic. BMC Med. 2011, 9:76.
4. Al-Daghri N.M., Al-Attas O.S., Alokail M.S., Alkharfy K.M., Hussain T. Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes. Mol. Biol. Rep. 2011, 38:3703-3708.
5. Al-Daghri N.M., Al-Attas O.S., Alokail M.S., Alkharfy K.M., Yakout S.M., Sabico S., Gibson G., Chrousos G.P., Kumar S. Parent-Offspring transmission of adipocytokine levels and their associations with metabolic traits. PLoS One 2011, 6(4):e18182.
6. Bouatia-Naji N., Meyre D., Lobbens S., Séron K., Fumeron F., Balkau B., Heude B., Jouret B., Scherer P.E., Dina C., Weill J., Froguel P. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006, 55:545-550.
7. Bruun J.M., Lihn A.S., Verdich C., Pedersen S.B., Toubro S., Astrup A., Richelsen B. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am. J. Physiol. Endocrinol. Metab. 2003, 285:E527-E533.
8. Comuzzie A.G., Funahashi T., Sonnenberg G., Martin L.J., Jacob H.J., Black A.E., Maas D., Takahashi M., Kihara S., Tanaka S., Matsuzawa Y., Blangero J., Cohen D., Kissebah A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab. 2001, 86:4321-4325.
9. Conne B., Stutz A., Vassalli J.D. The 3' untranslated region of messenger RNA: a molecular 'hotspot' for pathology?. Nat. Med. 2000, 6:637-641.
10. Daimon T., Oizumi T., Saitoh T., Kameda W., Hirata A., Yamaguchi H., Ohnuma H., Igarashi M., Tominaga M., Kato T., Funagata study Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population, the Funagata study. Diabetes Care 2003, 26:2015-2020.
11. Filippi E., Sentinelli F., Trischitta V., Romeo S., Arca M., Leonetti F., Di Mario U., Baroni M.G. Association of the human adiponectin gene and insulin resistance. Eur. J. Hum. Genet. 2004, 12:199-205.
12. Gilmore R.C., Baker J., Dempsey S., Marchan R., Corprew R.N., Byrd G., Maeda N., Smithies O., Bukoski R.D., Harewood K.R., Chatterjee P.K. Using PAC nested deletions o order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus. Gene 2001, 275:65-72.
13. González-Sánchez J.L., Martínez-Calatrava M.J., Martínez-Larrad M.T., Zabena C., Fernández-Pérez C., Laakso M., Serrano-Ríos M. Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. Clin. Chem. 2006, 52:97-103.
14. Gu H.F., Abulaiti A., Ostenson C.G., Humphreys K., Wahlestedt C., Brookes A.J., Efendic S. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes 2004, 53:S31-S35.
15. Hajer G.R., van Haeften T.W., Visseren F.L. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur. Heart J. 2008, 29:2959-2971.
16. Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., Yamauchi T., Otabe S., Okada T., Eto K., Kadowaki H., Hagura R., Akanuma Y., Yazaki Y., Nagai R., Taniyama M., Matsubara K., Yoda M., Nakano Y., Tomita M., Kimura S., Ito C., Froguel P., Kadowaki T. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002, 51:536-540.
17. Hivert M.F., Manning A.K., McAteer J.B., Florez J.C., Dupuis J., Fox C.S., O'Donnell C.J., Cupples L.A., Meigs J.B. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes 2008, 57:3353-3359.
18. Hu P.F., Bao J.P., Wu L.D. The emerging role of adipokines in osteoarthritis: a narrative review. Mol. Biol. Rep. 2011, 38:873-878.
19. Hwang J.Y., Park J.E., Choi Y.J., Huh K.B., Kim W.Y. SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with type II diabetes mellitus in Korea. Eur. J. Clin. Nutr. 2010, 64:105-107.
20. Jang Y., Chae J.S., Koh S.J., Hyun Y.J., Kim J.Y., Jeong Y.J., Park S., Ahn C.M., Lee J.H. The influence of the adiponectin gene on adiponectin concentrations and parameters of metabolic syndrome in non-diabetic Korean women. Clin. Chim. Acta 2008, 391:85-90.
21. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 2006, 116:1784-1792.
22. Kissebah A.H., Sonnenberg G.E., Myklebust J., Goldstein M., Broman K., James R.G., Marks J.A., Krakower G.R., Jacob H.J., Weber J., Martin L., Blangero J., Comuzzie A.G. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:14478-14483.
23. Labrecque B., Beaudry D., Mayhue M., Halle C., Bordignon V., Murphy B.D., Palin M.F. Molecular characterization and expression analysis of the porcine paraoxonase 3 (PON3) gene. Gene 2009, 443:110-120.
24. Lee Y.Y., Lee N.S., Cho Y.M., Moon M.K., Jung H.S., Park Y.J., Park H.J., Youn B.S., Lee H.K., Park K.S., Shin H.D. Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabet. Med. 2005, 22:569-575.
25. Li Y., Li X., Shi L., Yang M., Yang Y., Tao W., Shi L., Xiong Y., Zhang Y., Yao Y. Association of adiponectin SNP+45 and SNP+276 with ype 2 diabetes in Han Chinese populations: a meta-analysis of 26 case-control studies. PLoS One 2011, 6(5):e19686.
26. Lindsay R.S., Funahashi T., Krakoff J., Matsuzawa Y., Tanaka S., Kobes S., Bennett P.H., Tataranni P.A., Knowler W.C., Hanson R.L. Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 2003, 52:2419-2425.
27. Liu F., He Z., Deng S., Zhang H., Li N., Xu J. Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population. Mol. Biol. Rep. 2011, 38:1983-1988.
28. Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. 1996, 221:286-289.
29. Maeda N., Takahashi M., Funahashi T., Kihara S., Nishizawa H., Kishida K., Nagaretani H., Matsuda M., Komuro R., Ouchi N., Kuriyama H., Hotta K., Nakamura T., Shimomura I., Matsuzawa Y. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001, 50:2094-2099.
30. Matsuda M., Shimomura I., Sata M., Arita Y., Nishida M., Maeda N., Kumada M., Okamoto Y., Nagaretani H., Nishizawa H., Kishida K., Komuro R., Ouchi N., Kihara S., Nagai R., Funahashi T., Matsuzawa Y. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J. Biol. Chem. 2002, 277:37487-37491.
31. Matsuzawa Y., Funahashi T., Kihara S., Shimomura I. Arterioscler. Thromb. Vasc. Biol. 2004, 24:29-33.
32. Melistas L., Mantzoros C.S., Kontogianni M., Antonopoulou S., Ordovas J.M., Yiannakouris N. Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women. Eur. J. Endocrinol. 2009, 161:845-852.
33. Menzaghi C., Ercolino T., Di Paola R., Berg A.H., Warram J.H., Scherer P.E., Trischitta V., Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002, 51:2306-2312.
34. Menzaghi C., Trischitta V., Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 2007, 56:1198-1209.
35. Pérez-Martínez P., López-Miranda J., Cruz-Teno C., Delgado-Lista J., Jiménez-Gómez Y., Fernández J.M., Gómez M.J., Marín C., Pérez-Jiménez F., Ordovás J.M. J. Nutr. 2008, 138:1609-1614.
36. Populaire C., Mori Y., Dina C., Vasseur F., Vaxillaire M., Kadowaki T., Froguel P. Does the -11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?. Diabetologia 2003, 46:443-445.
37. Rabe K., Lehrke M., Parhofer K.G., Broedl U.C. Adipokines and insulin resistance. Mol. Med. 2008, 14:741-751.
38. Rasmussen-Torvik L.J., Pankow J.S., Jacobs D.R., Steinberger J., Moran A., Sinaiko A.R. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum. Genet. 2009, 125:21-28.
39. Schwarz P.E., Govindarajalu S., Towers W., Schwanebeck U., Fischer S., Vasseur F., Bornstein S.R., Schulze J. Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population. Horm. Metab. Res. 2006, 38:447-451.
40. Stumvoll M., Tschritter O., Fritsche A., Staiger H., Renn W., Weisser M., Machicao F., Häring H. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 2002, 51:37-41.
41. Szopa M., Malczewska-Malec M., Kiec-Wilk B., Skupien J., Wolkow P., Malecki M.T., Sieradzki J. Variants of the adiponectin gene and type 2 diabetes in a Polish population. Acta Diabetol. 2009, 46:317-322.
42. Takahashi M., Arita Y., Yamagata K., Matsukawa Y., Okutomi K., Horie M., Shimomura I., Hotta K., Kuriyama H., Kihara S., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y. Genomic structure and mutations in adipose-specific gene, adiponectin. Int. J. Obes. Relat. Metab. Disord. 2000, 24:861-868.
43. Tso A.W., Sham P.C., Wat N.M., Xu A., Cheung B.M., Rong R., Fong C.H., Xu J.Y., Cheng K.K., Janus E.D., Lam K.S. Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: a 5-year follow-up study. Diabetologia 2006, 49:1806-1815.
44. Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., Boutin P., Vaxillaire M., Leprêtre F., Dupont S., Hara K., Clément K., Bihain B., Kadowaki T., Froguel P. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum. Mol. Genet. 2002, 11:2607-2614.
45. Vionnet N., Hani E.H., Dupont S., Gallina S., Francke S., Dotte S., De Matos F., Durand E., Leprêtre F., Lecoeur C., Gallina P., Zekiri L., Dina C., Froguel P. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am. J. Hum. Genet. 2000, 67:1470-1480.
46. Vozarova de Courten B., Hanson R.L., Funahashi T., Lindsay R.S., Matsuzawa Y., Tanaka S., Thameem F., Gruber J.D., Froguel P., Wolford J.K. Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. Diabetes 2005, 54:284-289.
47. Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R.E., Tataranni P.A. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab. 2001, 86:1930-1935.
48. Wolford J.K., Bogardus C., Ossowski V., Prochazka M. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. Gene 2000, 241:143-148.
49. Yang W.S., Lee W.J., Funahashi T., Tanaka S., Matsuzawa Y., Chao C.L., Chen C.L., Tai T.Y., Chuang L.M. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J. Clin. Endocrinol. Metab. 2001, 86:3815-3819.
50. Yang W.S., Yang Y.C., Chen C.L., Wu I.L., Lu J.Y., Lu F.H., Tai T.Y., Chang C.J. Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am. J. Clin. Nutr. 2007, 86:509-513.