Variations in adipokine genes AdipoQ, Lep, and LepR are associated with risk for obesity-related metabolic disease: The modulatory role of gene-nutrient interactions

Journal of Obesity

Volumn 2011, Issue , 2011, Pages

  Enns, Jennifer Emily ^a   Taylor, Carla G ^a   Zahradka, Peter ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84857134272     PISSN: 20900708     EISSN: 20900716     Source Type: Journal    
DOI: 10.1155/2011/168659     Document Type: Review

References (129)

1. Schelbert K. B., Comorbidities of Obesity. Primary Care 2009 36 2 271 285 2-s2.0-66149160249 10.1016/j.pop.2009.01.009
2. Calle E. E., Rodriguez C., Walker-Thurmond K., Thun M. J., Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults. New England Journal of Medicine 2003 348 17 1625 1638 2-s2.0-0037464510 10.1056/NEJMoa021423
3. Samanic C., Chow W. H., Gridley G., Jarvholm B., Fraumeni J. F. Jr., Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes and Control 2006 17 7 901 909 2-s2.0-33746089143 10.1007/s10552-006-0023-9
4. Ukkola O., Bouchard C., Clustering of metabolic abnormalities in obese individuals: the role of genetic factors. Annals of Medicine 2001 33 2 79 90 2-s2.0-0035051032
5. Flegal K. M., kmf2@cdc.gov Carroll M. D., Ogden C. L., Curtin L. R., Prevalence and trends in obesity among US adults, 1999-2008. Journal of the American Medical Association 2010 303 3 235 241 10.1001/jama.2009.2014
6. Kopelman P. G., Obesity as a medical problem. Nature 2000 404 6778 635 643 2-s2.0-0034611791
7. Trayhurn P., Wood I. S., Adipokines: inflammation and the pleiotropic role of white adipose tissue. British Journal of Nutrition 2004 92 3 347 355 2-s2.0-6944237757 10.1079/BJN20041213
8. Li F. Y., Cheng K. K., Lam K. S., Vanhoutte P. M., Xu A., Cross-talk between adipose tissue and vasculature: role of adiponectin. Acta Physiologica. In press
9. Hauner H., Secretory factors from human adipose tissue and their functional role. Proceedings of the Nutrition Society 2005 64 2 163 169 2-s2.0-20444471451 10.1079/PNS2005428
10. Bluher M., Adipose tissue dysfunction in obesity. Experimental and Clinical Endocrinology and Diabetes 2009 117 6 241 250 2-s2.0-68849132248 10.1055/s-0029-1192044
11. Bays H. E., González-Campoy J. M., Bray G. A., Kitabchi A. E., Bergman D. A., Schorr A. B., Rodbard H. W., Henry R. R., Pathogenic potential of adipose tissue and metabolic consequences of adipocyte hypertrophy and increased visceral adiposity. Expert Review of Cardiovascular Therapy 2008 6 3 343 368 2-s2.0-41449114649 10.1586/14779072.6.3.343
12. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Tsuboyama-Kasaoka N., Ezaki O., Akanuma Y., Gavrilova O., Vinson C., Reitman M. L., Kagechika H., Shudo K., Yoda M., Nakano Y., Tobe K., Nagai R., Kimura S., Tomita M., Froguel P., Kadowaki T., The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001 7 8 941 946 2-s2.0-17944365228 10.1038/90984
13. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., Yamashita S., Noda M., Kita S., Ueki K., Eto K., Akanuma Y., Froguel P., Foufelle F., Ferre P., Carling D., Kimura S., Nagai R., Kahn B. B., Kadowaki T., Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002 8 11 1288 1295 2-s2.0-0036851817 10.1038/nm788
14. Kadowaki T., kadowaki-3im@h.u-tokyo.ac.jp Yamauchi T., Adiponectin and adiponectin receptors. Endocrine Reviews 2005 26 3 439 451 10.1210/er.2005-0005
15. Díez J. J., mibarsd@infomed.es Iglesias P., The role of the novel adipocyte-derived hormone adiponectin in human disease. European Journal of Endocrinology 2003 148 3 293 300 10.1530/eje.0.1480293
16. Hotta K., Funahashi T., Arita Y., Takahashi M., Matsuda M., Okamoto Y., Iwahashi H., Kuriyama H., Ouchi N., Maeda K., Nishida M., Kihara S., Sakai N., Nakajima T., Hasegawa K., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Hanafusa T., Matsuzawa Y., Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 6 1595 1599 2-s2.0-0034096988
17. Trayhurn P., Wood I. S., Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochemical Society Transactions 2005 33 5 1078 1081 2-s2.0-27844545767 10.1042/BST20051078
18. Hajer G. R., Van Haeften T. W., Visseren F. L. J., f.l.j. visseren@umcutrecht.nl Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. European Heart Journal 2008 29 24 2959 2971 10.1093/eurheartj/ehn387
19. Maury E., Brichard S. M., Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and Cellular Endocrinology 2010 314 1 1 16 2-s2.0-70350188297 10.1016/j.mce.2009.07.031
20. Matsuzawa Y., matsuzawa-yuji@sumitomo-hp.or.jp Adiponectin: a key player in obesity related disorders. Current Pharmaceutical Design 2010 16 17 1896 1901 10.2174/138161210791208893
21. Vionnet N., Hani E. H., Dupont S., Gallina S., Francke S., Dotte S., De Matos F., Durand E., Lepretre F., Lecoeur C., Gallina P., Zekiri L., Dina C., Froguel P., Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosiome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. American Journal of Human Genetics 2000 67 6 1470 1480 2-s2.0-0033652271 10.1086/316887
22. Francke S., Manraj M., Lacquemant C., Lecoeur C., Leprêtre F., Passa P., Hebe A., Corset L., Yan S. L. K., Lahmidi S., Jankee S., Gunness T. K., Ramjuttun U. S., Balgobin V., Dina C., Froguel P., A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Human Molecular Genetics 2001 10 24 2751 2765 2-s2.0-18244398717
23. Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., Boutin P., Vaxillaire M., Leprêtre F., Dupont S., Hara K., Clément K., Bihain B., Kadowaki T., Froguel P., Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Human Molecular Genetics 2002 11 21 2607 2614 2-s2.0-18644369745
24. De Courten B. V., Hanson R. L., Funahashi T., Lindsay R. S., Matsuzawa Y., Tanaka S., Thameem F., Gruber J. D., Froguel P., Wolford J. K., jwolford@tgen.org Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians. Diabetes 2005 54 1 284 289 10.2337/diabetes.54.1.284
25. Chuang L. M., Chiu Y. F., Sheu W. H. H., Hung YI. J., Ho L. T., Grove J., Rodriguez B., Quertermous T., Chen Y. D. I., Hsiung C. A., Tai T. Y., Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of chinese and Japanese origin. Journal of Clinical Endocrinology and Metabolism 2004 89 11 5772 5778 2-s2.0-8744292054 10.1210/jc.2004-0640
26. Comuzzie A. G., Funahashi T., Sonnenberg G., Martin L. J., Jacob H. J., Kwitek Black A. E., Maas D., Takahashi M., Kihara S., Tanaka S., Matsuzawa Y., Blangero J., Cohen D., Kissebah A., The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2001 86 9 4321 4325 2-s2.0-17944362243 10.1210/jc.86.9.4321
27. Guo X., Saad M. F., Langefeld C. D., Williams A. H., Cui J., Taylor K. D., Norris J. M., Jinagouda S., Darwin C. H., Mitchell B. D., Bergman R. N., Sutton B., Chen Y. D. I., Wagenknecht L. E., Bowden D. W., Rotter J. I., Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS Family Study. Diabetes 2006 55 6 1723 1730 2-s2.0-33748295594 10.2337/db05-0428
28. Lindsay R. S., Funahashi T., Krakoff J., Matsuzawa Y., Tanaka S., Kobes S., Bennett P. H., Tataranni P. A., Knowler W. C., Hanson R. L., Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 2003 52 9 2419 2425 2-s2.0-0041819992 10.2337/diabetes.52.9.2419
29. Menzaghi C., Trischitta V., Doria A., Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 2007 56 5 1198 1209 2-s2.0-34248187069 10.2337/db06-0506
30. Gu H. F., Biomarkers of adiponectin: plasma protein variation and genomic DNA polymorphisms. Biomarker Insights 2009 4 123 133
31. Bouatia-Naji N., Meyre D., Lobbens S., Séron K., Fumeron F., Balkau B., Heude B., Jouret B., Scherer P. E., Dina C., Weill J., Froguel P., p.froguel@imperial.ac.uk ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes 2006 55 2 545 550 10.2337/diabetes.55.02.06.db05-0971
32. Menzaghi C., Ercolino T., Salvemini L., Coco A., Kim S. H., Fini G., Doria A., Trischitta V., Multigenic control of serum adiponectin levels: evidence for a role of the APM1 gene and a locus on 14q13. Physiological Genomics 2005 19 170 174 2-s2.0-11144250219 10.1152/physiolgenomics.00122.2004
33. Morandi A., Maffeis C., Lobbens S., Bouatia-Naji N., Heude B., Pinelli L., Meyre D., Froguel P., Early detrimental metabolic outcomes of rs17300539-A Allele of ADIPOQ gene despite higher adiponectinemia. Obesity 2010 18 7 1469 1473 2-s2.0-77954142863 10.1038/oby.2009.403
34. Fumeron F., fumeron@bichat.inserm.fr Aubert R., Siddiq A., Betoulle D., Péan F., Hadjadj S., Tichet J., Wilpart E., Chesnier M. -C., Balkau B., Froguel P., Marre M., Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 2004 53 4 1150 1157 10.2337/diabetes.53.4.1150
35. Yang M., Qui C. C., Chen W., Xu L. L., Yu M., Xiang H. D., Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality. Biomedical and Environmental Sciences 2008 21 6 454 459 2-s2.0-59849086658 10.1016/S0895-3988(09)60002-7
36. Gu H. F., harvest.gu@molmed.ki.se Abulaiti A., Östenson C.-G., Humphreys K., Wahlestedt C., Brookes A. J., Efendic S., Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes 2004 53 supplement 1 S31 S35
37. Gibson F., Froguel P., Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians. Diabetes 2004 53 11 2977 2983 2-s2.0-7044239427 10.2337/diabetes.53.11.2977
38. Henneman P., Aulchenko Y. S., Frants R. R., Zorkoltseva I. V., Zillikens M. C., Frolich M., Oostra B. A., Van Dijk K. W., Van Duijn C. M., Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits. Diabetes Care 2010 33 4 908 913 2-s2.0-77953065694 10.2337/dc09-1385
39. Kyriakou T., Collins L. J., Spencer-Jones N. J., Malcolm C., Wang X., Snieder H., Swaminathan R., Burling K. A., Hart D. J., Spector T. D., O'Dell S. D., Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. Journal of Human Genetics 2008 53 8 718 727 2-s2.0-48549102383 10.1007/s10038-008-0303-1
40. Woo J. G., Dolan L. M., Deka R., Kaushal R. D., Shen Y., Pal P., Daniels S. R., Martin L. J., Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 2006 55 2 523 529 2-s2.0-33644745284 10.2337/diabetes.55.02.06.db05-0446
41. Hivert M. F., Manning A. K., McAteer J. B., Florez J. C., Dupuis J., Fox C. S., O'Donnell C. J., Cupples L. A., Meigs J. B., Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the framingham offspring study. Diabetes 2008 57 12 3353 3359 2-s2.0-58149333293 10.2337/db08-0700
42. Vasseur F., Helbecque N., Lobbens S., Vasseur-Delannoy V., Dina C., Clément K., Boutin P., Kadowaki T., Scherer P. E., Froguel P., Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 2005 48 5 892 899 2-s2.0-20044384547 10.1007/s00125-005-1729-z
43. Ong K. L., Li M., Tso A. W. K., Xu A., Cherny S. S., Sham P. C., Tse H. F., Lam T. H., Cheung B. M. Y., mycheung@hku.hk Lam K. S. L., ksllam@hku.hk Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. European Journal of Endocrinology 2010 163 2 251 257 10.1530/EJE-10-0251
44. Prior S. L., Gable D. R., Cooper J. A., Bain S. C., Hurel S. J., Humphries S. E., Stephens J. W., Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus. European Heart Journal 2009 30 10 1263 1269 2-s2.0-66249126304 10.1093/eurheartj/ehp090
45. Hoefle G., Muendlein A., Saely C. H., Risch L., Rein P., Koch L., Schmid F., Aczel S., Marte T., Langer P., Drexel H., The -11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men. Thrombosis and Haemostasis 2007 97 3 451 457 2-s2.0-33947301943 10.1160/TH06-11-0646
46. Pechlivanis S., Bermejo J. L., Pardini B., Naccarati A., Vodickova L., Novotny J., Hemminki K., Vodicka P., Försti A., Genetic variation in adipokine genes and risk of colorectal cancer. European Journal of Endocrinology 2009 160 6 933 940 2-s2.0-66149128387 10.1530/EJE-09-0039
47. Carvajal-Carmona L. G., Spain S., Kerr D., Houlston R., Cazier J. B., Tomlinson I., Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK. Human Molecular Genetics 2009 18 10 1889 1892 2-s2.0-65449148996 10.1093/hmg/ddp109
48. Kaklamani V. G., Wisinski K. B., Sadim M., Gulden C., Do A., Offit K., Baron J. A., Ahsan H., Mantzoros C., Pasche B., Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. Journal of the American Medical Association 2008 300 13 1523 1531 2-s2.0-54849159000 10.1001/jama.300.13.1523
49. Qi LU., Doria A., Manson J. E., Meigs J. B., Hunter D., Mantzoros C. S., Hu F. B., Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes 2006 55 5 1512 1516 2-s2.0-33745312587 10.2337/db05-1520
50. Wassel C. L., Pankow J. S., Jacobs D. R. Jr., Steffes M. W., Li NA., Schreiner P. J., Variants in the Adiponectin Gene and Serum Adiponectin: The Coronary Artery Development in Young Adults (CARDIA) Study. Obesity 2010 18 12 2333 2338 2-s2.0-77950644379 10.1038/oby.2010.85
51. Ruchat S.-M., Loos R. J. F., Rankinen T., Vohl M.-C., Weisnagel S. J., Després J.-P., Bouchard C., Pérusse L., louis.perusse@kin.msp. ulaval.ca Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. Diabetic Medicine 2008 25 4 400 406 10.1111/j.1464-5491.2008.02396.x
52. Mohammadzadeh G., Zarghami N., Associations between single-nucleotide polymorphisms of the adiponectin gene, serum adiponectin levels and increased risk of type 2 diabetes mellitus in Iranian obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation 2009 69 7 764 771 2-s2.0-74549129481 10.3109/00365510903137237
53. Low C. F., Mohd Tohit E. R., Chong P. P., Idris F., Adiponectin SNP45TG is associated with gestational diabetes mellitus. Archives of Gynecology and Obstetrics. In press 2-s2.0-77953329939 10.1007/s00404-010-1548-4
54. Melistas L., Mantzoros C. S., Kontogianni M., Antonopoulou S., Ordovas J. M., Yiannakouris N., Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women. European Journal of Endocrinology 2009 161 6 845 852 2-s2.0-72949108241 10.1530/EJE-09-0492
55. Wang Z. L., Xia B., Shrestha U., Jiang L., Ma C. W., Chen Q., Chen H., Hu Z. G., Correlation between adiponectin polymorphisms and non-alcoholic fatty liver disease with or without metabolic syndrome in Chinese population. Journal of Endocrinological Investigation 2008 31 12 1086 1091 2-s2.0-63049122519
56. Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., Yamauchi T., Otabe S., Okada T., Eto K., Kadowaki H., Hagura R., Akanuma Y., Yazaki Y., Nagai R., Taniyama M., Matsubara K., Yoda M., Nakano Y., Kimura S., Tomita M., Kimura S., Ito C., Froguel P., Kadowaki T., Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 51 2 536 540 2-s2.0-0036061598
57. Li L. L., Kang X. L., Ran X. J., Wang YE., Wang C. H., Huang L., Ren J., Luo X., Mao X. M., Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clinical and Experimental Pharmacology and Physiology 2007 34 12 1287 1290 2-s2.0-35549004470 10.1111/j.1440-1681.2007.04713.x
58. Sutton B. S., Weinert S., Langefeld C. D., Williams A. H., Campbell J. K., Saad M. F., Haffner S. M., Norris J. M., Bowden D. W., Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study. Human Genetics 2005 117 2-3 107 118 2-s2.0-26944500225 10.1007/s00439-005-1260-9
59. Lee Y. Y., Lee N. S., Cho Y. M., Moon M. K., Jung H. S., Park Y. J., Park H. J., Youn B. S., Lee H. K., Park K. S., Shin H. D., Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabetic Medicine 2005 22 5 569 575 2-s2.0-20944450034 10.1111/j.1464-5491.2005.01460.x
60. Mackevics V., Heid I. M., Wagner S. A., Cip P., Doppelmayr H., Lejnieks A., Gohlke H., Ladurner G., Illig T., Iglseder B., Kronenberg F., Paulweber B., The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians. European Journal of Human Genetics 2006 14 3 349 356 2-s2.0-33645146268 10.1038/sj.ejhg.5201552
61. González-Sánchez J. L., Zabena C. A., Martínez- Larrad M. T., Fernandez-Pérez C., Pérez-Barba M., Laakso M., Serrano-Ríos M., An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obesity Research 2005 13 5 807 812 2-s2.0-24144482709
62. Zacharova J., Chiasson J. -L., Laakso M., markku.laakso@kuh.fi The common polymorphisms (Single Nucleotide Polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Diabetes 2005 54 3 893 899 10.2337/diabetes.54.3.893
63. Nakatani K., Noma K., Nishioka J., Kasai Y., Morioka K., Katsuki A., Hori Y., Yano Y., Sumida Y., Wada H., Nobori T., Adiponectin gene variation associates with the increasing risk of type 2 diabetes in non-diabetic Japanese subjects. International Journal of Molecular Medicine 2005 15 1 173 177 2-s2.0-21644447527
64. Ukkola O., Ravussin E., Jacobson P., Sjöström L., Bouchard C., Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort. Metabolism: Clinical and Experimental 2003 52 7 881 884 2-s2.0-0042090545 10.1016/S0026-0495(03)00074-X
65. Bacci S., Menzaghi C., Ercolino T., Ma X., Rauseo A., Salvemini L., Vigna C., Fanelli R., Di Mario U., Doria A., Trischitta V., The +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with coronary artery disease in type 2 diabetic patients. Diabetes Care 2004 27 8 2015 2020 2-s2.0-3342971026 10.2337/diacare.27.8.2015
66. Lacquemant C., Froguel P., Lobbens S., Izzo P., Dina C., Ruiz J., The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabetic Medicine 2004 21 7 776 781 2-s2.0-3142770007 10.1111/j.1464-5491.2004.01224.x
67. Beebe-Dimmer J. L., dimmerj@karmanos.org Zuhlke K. A., Ray A. M., Lange E. M., Cooney K. A., Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer and Prostatic Diseases 2010 13 4 362 368 10.1038/pcan.2010.27
68. Huang MC, Wang TN, Lee KT, Adiponectin gene SNP276 variants and central obesity confer risks for hyperglycemia in indigenous Taiwanese. The Kaohsiung Journal of Medical Sciences 2010 26 227 236
69. Mousavinasab F., Tähtinen T., Jokelainen J., Koskela P., Vanhala M., Oikarinen J., Keinänen-Kiukaanniemi S., Laakso M., Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. Molecular Genetics and Metabolism 2006 87 2 147 151 2-s2.0-32044473085 10.1016/j.ymgme.2005.08.010
70. Verduci E., Scaglioni S., Agostoni C., Radaelli G., Biondi M., Manso A. S., Riva E., Giovannini M., The relationship of insulin resistance with SNP 276G>T at adiponectin gene and plasma long-chain polyunsaturated fatty acids in obese children. Pediatric Research 2009 66 3 346 349 2-s2.0-70350444512 10.1203/PDR.0b013e3181b1bc4a
71. Qi LU., Li T., Rimm E., Zhang C., Rifai N., Hunter D., Doria A., Hu F. B., The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes 2005 54 5 1607 1610 2-s2.0-17844362260 10.2337/diabetes.54.5.1607
72. Filippi E., Sentinelli F., Romeo S., Arca M., Berni A., Tiberti C., Verrienti A., Fanelli M., Fallarino M., Sorropago G., Baroni M. G., The adiponectin gene SNP+276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients (age ≤50 years). Journal of Molecular Medicine 2005 83 9 711 719 2-s2.0-24044479420 10.1007/s00109-005-0667-z
73. Jang Y., Lee J. H., Chae J. S., Kim O. Y., Koh S. J., Kim JI. Y., Cho H., Lee J. E., Ordovas J. M., Association of the 276G→T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. American Journal of Clinical Nutrition 2005 82 4 760 767 2-s2.0-27744570794
74. Iwashima Y., Katsuya T., Ishikawa K., Ouchi N., Ohishi M., Sugimoto K., Fu Y., Motone M., Yamamoto K., Matsuo A., Ohashi K., Kihara S., Funahashi T., Rakugi H., Matsuzawa Y., Ogihara T., Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 2004 43 6 1318 1323 2-s2.0-2542473288 10.1161/01.HYP.0000129281.03801.4b
75. Vimaleswaran K. S., Radha V., Ramya K., Babu H. N. S., Savitha N., Roopa V., Monalisa D., Deepa R., Ghosh S., Majumder P. P., Rao M. R. S., Mohan V., A novel association of a polymorphism in the first intron of adiponectin gene with type 2 diabetes, obesity and hypoadiponectinemia in Asian Indians. Human Genetics 2008 123 6 599 605 2-s2.0-45049083452 10.1007/s00439-008-0506-8
76. Specchia C., Scott K., Fortina P., Devoto M., Falkner B., Association of a polymorphic variant of the adiponectin gene with Insulin resistance in African Americans. Clinical and Translational Science 2008 1 3 194 199 2-s2.0-77953394340 10.1111/j.1752-8062.2008.00055.x
77. Ferguson J. F., Phillips C. M., Tierney A. C., Pérez- Martínez P., Defoort C., Helal O., Lairon D., Planells R., Shaw D. I., Lovegrove J. A., Gjelstad I. M. F., Drevon C. A., Blaak E. E., Saris W. H. M., Leszczyska-Gobek I., Kiec-Wilk B., Risérus U., Karlström B., Lopez-Miranda J., Roche H. M., Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. American Journal of Clinical Nutrition 2010 91 3 794 801 2-s2.0-77749254629 10.3945/ajcn.2009.28255
78. Zhang D., Ma J., Brismar K., Efendic S., Gu H. F., A single nucleotide polymorphism alters the sequence of SP1 binding site in the adiponectin promoter region and is associated with diabetic nephropathy among type 1 diabetic patients in the Genetics of Kidneys in Diabetes Study. Journal of Diabetes and its Complications 2009 23 4 265 272 2-s2.0-66949121441 10.1016/j.jdiacomp.2008. 05.004
79. Laumen H., Saningong A. D., Heid I. M., Hess J., Herder C., Claussnitzer M., Baumert J., Lamina C., Rathmann W., Sedlmeier E. M., Klopp N., Thorand B., Wichmann H. E., Illig T., Hauner H., Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 2009 58 4 984 991 2-s2.0-64649104152 10.2337/db07-1646
80. Yang W. S., Tsou P. L., Lee W. J., Tseng DA. L., Chen C. L., Peng C. C., Lee K. C., Chen M. J., Huang C. J., Tai T. Y., Chuang L. M., Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity. Journal of Molecular Medicine 2003 81 7 428 434 2-s2.0-10744230063 10.1007/s00109-002-0409-4
81. Menzaghi C., Ercolino T., Paola R. D., Berg A. H., Warram J. H., Scherer P. E., Trischitta V., Doria A., A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 2002 51 7 2306 2312 2-s2.0-0036307162
82. Abbasi F., Chu J. W., Lamendola C., McLaughlin T., Hayden J., Reaven G. M., Reaven P. D., Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 2004 53 3 585 590 2-s2.0-1442326009 10.2337/diabetes.53.3.585
83. Pérez-Martínez P., López-Miranda J., Cruz-Teno C., Delgado-Lista J., Jiménez-Gómez Y., Fernández J. M., Gómez M. J., Marín C., Pérez-Jiménez F., Ordovás J. M., Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in caucasian men. Journal of Nutrition 2008 138 9 1609 1614 2-s2.0-51049119223
84. Warodomwichit D., Shen J., Arnett D. K., Tsai M. Y., Kabagambe E. K., Peacock J. M., Hixson J. E., Straka R. J., Province M. A., An P., Lai C. Q., Parnell L. D., Borecki I. B., Ordovas J. M., ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study. Obesity 2009 17 3 511 517 2-s2.0-60849119304 10.1038/oby.2008.583
85. Chung H. K., Chae J. S., Hyun Y., Paik J. K., Kim JI. Y., Jang Y., Kwon F. H. M., Song Y. D., Lee H. C., Lee J. H., Influence of adiponectin gene polymorphisms on adiponectin level and insulin resistance index in response to dietary intervention in overweight-obese patients with impaired fasting glucose or newly diagnosed type 2 diabetes. Diabetes Care 2009 32 4 552 558 2-s2.0-65349105860 10.2337/dc08-1605
86. Tsuzaki K., Kotani K., Nagai N., Saiga K., Sano Y., Hamada T., Moritani T., Yoshimura M., Egawa K., Horikawa C., Kitagawa Y., Kiso Y., Sakane N., Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity. Journal of Endocrinological Investigation 2009 32 5 395 400 2-s2.0-70350342288
87. Skurk T., Alberti-Huber C., Herder C., Hauner H., Relationship between adipocyte size and adipokine expression and secretion. Journal of Clinical Endocrinology and Metabolism 2007 92 3 1023 1033 2-s2.0-33947502786 10.1210/jc.2006-1055
88. Fantuzzi G., Adipose tissue, adipokines, and inflammation. Journal of Allergy and Clinical Immunology 2005 115 5 911 920 2-s2.0-18144408371 10.1016/j.jaci.2005.02.023
89. Scarpace P. J., Zhang Y., Elevated leptin: consequence or cause of obesity? Frontiers in Bioscience 2007 12 3531 3544 2-s2.0-34347235476 10.2741/2332
90. Dardeno T. A., Chou S. H., Moon H. S., Chamberland J. P., Fiorenza C. G., Mantzoros C. S., Leptin in human physiology and therapeutics. Frontiers in Neuroendocrinology 2010 31 3 377 393 2-s2.0-77954259693 10.1016/j.yfrne.2010.06. 002
91. Stofkova A., Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocrine Regulations 2009 43 4 157 168 2-s2.0-77949493588
92. Thaler J. P., Schwartz M. W., mschwart@u.washington.edu Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 2010 151 9 4109 4115 10.1210/en.2010-0336
93. Coleman D. L., Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 1978 14 3 141 148 2-s2.0-0018139377
94. Ranadive S. A., Vaisse C., Lessons from extreme human obesity: monogenic disorders. Endocrinology and Metabolism Clinics of North America 2008 37 3 733 751 2-s2.0-50449099144 10.1016/j.ecl.2008.07.003
95. Friedlander Y., yechielf@ekmd.huji.ac.il Li G., Fornage M., Williams O. D., Lewis C. E., Schreiner P., Pletcher M. J., Enquobahrie D., Williams M., Siscovick D. S., Candidate molecular pathway genes related to appetite regulatory neural network, adipocyte homeostasis and obesity: results from the CARDIA Study. Annals of Human Genetics 2010 74 5 387 398 10.1111/j.1469-1809. 2010.00596.x
96. Souren N. Y., Paulussen A. D., Steyls A., Loos R. J., Stassen A. P., Gielen M., Smeets H. J., Beunen G., Fagard R., Derom C., Vlietinck R., Geraedts J. P., Zeegers M. P., Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins. International Journal of Obesity 2008 32 8 1233 1239 2-s2.0-49449085611 10.1038/ijo.2008.68
97. Meirhaeghe A., Cottel D., Amouyel P., Dallongeville J., Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. Molecular Genetics and Metabolism 2005 86 1-2 293 299 2-s2.0-26244448109 10.1016/j.ymgme.2005.05.006
98. Lucantoni R., Ponti E., Berselli M. E., Savia G., Minocci A., Calò G., De Medici C., Liuzzi A., Di Blasio A. M., The A19G polymorphism in the 5' untranslated region of the human obese gene does not affect leptin levels in severely obese patients. Journal of Clinical Endocrinology and Metabolism 2000 85 10 3589 3591 2-s2.0-0033756524
99. Hager J., Clement K., Francke S., Dina C., Raison J., Lahlou N., Rich N., Pelloux V., Basdevant A., Guy-Grand B., North M., Froguel P., A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels. International Journal of Obesity 1998 22 3 200 205
100. Hart Sailors M. L., Folsom A. R., Ballantyne C. M., Hoelscher D. M., Jackson A. S., Linda Kao W. H., Pankow J. S., Bray M. S., Genetic variation and decreased risk for obesity in the Atherosclerosis Risk in Communities Study. Diabetes, Obesity and Metabolism 2007 9 4 548 557 2-s2.0-34347393306 10.1111/j.1463-1326.2006.00637.x
101. Jiang Y., Wilk J. B., Borecki I., Williamson S., DeStefano A. L., Xu G., Liu J., Ellison R. C., Province M., Myers R. H., Common variants in the 5′ region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. American Journal of Human Genetics 2004 75 2 220 230 2-s2.0-3242725813 10.1086/422699
102. Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F., Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Annals of Human Genetics 2000 64 5 391 394 2-s2.0-0034527931 10.1017/S0003480000008277
103. Portolés O., Sorlí J. V., Francés F., Coltell O., González J. I., Sáiz C., Corella D., dolores.corella@uv.es Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. European Journal of Epidemiology 2006 21 8 605 612 10.1007/s10654-006-9045-6
104. Murugesan D., Arunachalam T., Ramamurthy V., Subramanian S., Association of polymorphisms in leptin receptor gene with obesity and type 2 diabetes in the local population of Coimbatore. Indian Journal of Human Genetics 2010 16 72 77
105. Quinton N. D., Lee A. J., Ross R. J. M., Eastell R., Blakemore A. I. F., A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Human Genetics 2001 108 3 233 236 2-s2.0-0035073893 10.1007/s004390100468
106. Mattevi V. S., Zembrzuski V. M., Hutz M. H., Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. International Journal of Obesity 2002 26 9 1179 1185 10.1038/sj.ijo.0802067
107. Yiannakouris N., Yannakoulia M., Melistas L., Chan J. L., Klimis-Zacas D., Mantzoros C. S., The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. Journal of Clinical Endocrinology and Metabolism 2001 86 9 4434 4439 2-s2.0-0034847530 10.1210/jc.86.9.4434
108. Stefan N., nstefan@mail.nih.gov Vozarova B., Del Parigi A., Ossowski V., Thompson D. B., Hanson R. L., Ravussin E., Tataranni P. A., The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. International Journal of Obesity 2002 26 12 1629 1632 10.1038/sj.ijo.0802161
109. Chiu K. C., Chu A., Chuang L. M., Saad M. F., Association of leptin receptor polymorphism with insulin resistance. European Journal of Endocrinology 2004 150 5 725 729 2-s2.0-2942718557 10.1530/eje.0.1500725
110. Van Der Vleuten G. M., Kluijtmans L. A., Hijmans A., Blom H. J., Stalenhoef A. F. H., De Graaf J., The Gln223Arg polymorphism in the leptin receptor is associated with familial combined hyperlipidemia. International Journal of Obesity 2006 30 6 892 898 2-s2.0-33744470566 10.1038/sj.ijo.0803234
111. Pimentel Duarte S. F., Francischetti E. A., Genelhu-Abreu V., Barroso S. G., Braga J. U., Cabello P. H., Gonçalves Pimentel M. M., p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. American Journal of Human Biology 2006 18 4 448 453 2-s2.0-33746126567 10.1002/ajhb.20519
112. Wauters M., Mertens I., Chagnon M., Rankinen T., Considine R. V., Chagnon Y. C., Van Gaal L. F., Bouchard C., Polymorphisms in the leptin receptor gene, body composition and fat distribution in overweight and obese women. International Journal of Obesity 2001 25 5 714 720 10.1038/sj.ijo.0801609
113. Ogawa T., Hirose H., Yamamoto Y., Nishikai K., Miyashita K., Nakamura H., Saito I., Saruta T., Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population. Metabolism 2004 53 7 879 885 10.1016/j.metabol.2004.02.009
114. Fairbrother U. L., Tankó L. B., Walley A. J., Christiansen C., Froguel P., Blakemore A. I. F., Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women. Journal of Bone and Mineral Research 2007 22 4 544 550 2-s2.0-34249666244 10.1359/jbmr.070114
115. Rosmond R., Chagnon Y. C., Holm G., Chagnon M., Përusse L., Lindell K., Carlsson B., Bouchard C., Björntorp P., Hypertension in obesity and the leptin receptor gene locus. Journal of Clinical Endocrinology and Metabolism 2000 85 9 3126 3131 2-s2.0-0033694380
116. Chagnon Y. C., Chung W. K., Pérusse L., Chagnon M., Leibel R. L., Bouchard C., Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study. International Journal of Obesity 1999 23 3 278 286
117. Guízar-Mendoza J. M., Amador-Licona N., Flores-Martínez S. E., López-Cardona M. G., Ahuatzin-Trémary R., Sánchez- Corona J., Association analysis of the Gln223Arg polymorphism in the human leptin receptor gene, and traits related to obesity in Mexican adolescents. Journal of Human Hypertension 2005 19 5 341 346 2-s2.0-18644375929 10.1038/sj.jhh.1001824
118. Salopuro T., Pulkkinen L., Lindström J., Eriksson J. G., Valle T. T., Hämäläinen H., Ilanne-Parikka P., Keinänen-Kiukaanniemi S., Tuomilehto J., Laakso M., Uusitupa M., Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: the Finnish Diabetes Prevention Study. International Journal of Obesity 2005 29 10 1245 1251 2-s2.0-30544443607 10.1038/sj.ijo.0803024
119. Gallicchio L., Chang H. H., Christo D. K., Thuita L., Huang H. Y., Strickland P., Ruczinski I., Clipp S., Helzlsouer K. J., Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. BMC Medical Genetics 2009 10, article no. 103 2-s2.0-70350437856 10.1186/1471-2350-10-103
120. Mammès O., Aubert R., Betoulle D., Péan F., Herbeth B., Visvikis S., Siest G., Fumeron F., LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. European Journal of Clinical Investigation 2001 31 5 398 404 2-s2.0-0035015030 10.1046/j.1365-2362.2001. 00843.x
121. Liu Y. J., Rocha-Sanchez S. M. S., Liu P. Y., Long JI. R., Lu Y., Elze L., Recker R. R., Deng H. W., Tests of linkage and/or association of the LEPR gene polymorphisms with obesity phenotypes in Caucasian nuclear families. Physiological Genomics 2004 17 101 106 2-s2.0-3142728590 10.1152/ physiolgenomics.00213.2003
122. Wauters M., Mertens I., Rankinen T., Chagnon M., Bouchardt C., Van Gaal L., Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. Journal of Clinical Endocrinology and Metabolism 2001 86 7 3227 3232 2-s2.0-0034917636 10.1210/jc.86.7.3227
123. Park K. S., Shin H. D., Park B. L., Hyun S. C., Young M. C., Hong K. L., Lee J. Y., Lee J. K., Oh B., Kimm K., Polymorphisms in the leptin receptor (LEPR)-putative association with obesity and T2DM. Journal of Human Genetics 2006 51 2 85 91 2-s2.0-31544469841 10.1007/s10038-005-0327-8
124. Palou A., Sánchez J., Picó C., Nutrient-gene interactions in early life programming: leptin in breast milk prevents obesity later on in life. Advances in Experimental Medicine and Biology 2009 646 95 104 2-s2.0-70349234266 10.1007/978-1-4020-9173-510
125. Savino F., Liguori S. A., Update on breast milk hormones: leptin, ghrelin and adiponectin. Clinical Nutrition 2008 27 1 42 47 2-s2.0-38849192332 10.1016/j.clnu.2007.06.006
126. Bouret S. G., Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutrition Workshop Series: Pediatric Program 2010 65 25 39 10.1159/000281143
127. Phillips C. M., Goumidi L., Bertrais S., Field M. R., Ordovas J. M., Cupples L. A., Defoort C., Lovegrove J. A., Drevon C. A., Blaak E. E., Gibney M. J., Kiec-Wilk B., Karlstrom B., Lopez-Miranda J., McManus R., Hercberg S., Lairon D., Planells R., Roche H. M., Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults. Journal of Nutrition 2010 140 2 238 244 2-s2.0-74949141013 10.3945/jn.109.115329
128. De Luis D. A., Aller R., Izaola O., Gonzalez Sagrado M., Conde R., Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial. Annals of Nutrition and Metabolism 2008 52 3 209 214 2-s2.0-47249157778 10.1159/000138125
129. DeClercq V., Stringer D., Hunt R., Taylor C. G., Zahradka P., Wang M., Adipokine production by adipose tissue: a novel target for treating metabolic syndrome and its sequelae. Metabolic Syndrome: Underlying Mechanisms and Drug Therapies 2011 Hoboken, NJ, USA John Wiley & Sons 73 131