메뉴 건너뛰기




Volumn 17, Issue 5, 2015, Pages 521-539

May BDNF Be Implicated in the Exercise-Mediated Regulation of Inflammation? Critical Review and Synthesis of Evidence

Author keywords

brain derived neurotrophic factor; cholinergic anti inflammatory pathway; critical illness; early progressive mobility; exercise; immunity; inflammation; parasympathetic nervous system; physical activity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

EID: 84941054681     PISSN: 10998004     EISSN: 15524175     Source Type: Journal    
DOI: 10.1177/1099800414555411     Document Type: Article
Times cited : (36)

References (110)
  • 2
    • 0025168085 scopus 로고
    • Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
    • R.F.AldersonA.L.AltermanY.A.BardeR.M.Lindsay (1990). Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron, 5, 297–306.
    • (1990) Neuron , vol.5 , pp. 297-306
    • Alderson, R.F.1    Alterman, A.L.2    Barde, Y.A.3    Lindsay, R.M.4
  • 3
    • 46149100739 scopus 로고    scopus 로고
    • Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons
    • J.J.AnK.GharamiG.Y.LiaoN.H.WooA.G.LauF.VanevskiB.Xu (2008). Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell, 134, 175–187.
    • (2008) Cell , vol.134 , pp. 175-187
    • An, J.J.1    Gharami, K.2    Liao, G.Y.3    Woo, N.H.4    Lau, A.G.5    Vanevski, F.6    Xu, B.7
  • 4
    • 79960197684 scopus 로고    scopus 로고
    • BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration
    • F.AngelucciF.GelfoP.De BartoloC.CaltagironeL.Petrosini (2011). BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Neurochemistry International, 59, 1–4.
    • (2011) Neurochemistry International , vol.59 , pp. 1-4
    • Angelucci, F.1    Gelfo, F.2    De Bartolo, P.3    Caltagirone, C.4    Petrosini, L.5
  • 5
    • 84857363735 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor: A novel neurotrophin involved in psychiatric and neurological disorders
    • S.BalaratnasingamA.Janca (2012). Brain derived neurotrophic factor: A novel neurotrophin involved in psychiatric and neurological disorders. Pharmacology & Therapeutics, 134, 116–124.
    • (2012) Pharmacology & Therapeutics , vol.134 , pp. 116-124
    • Balaratnasingam, S.1    Janca, A.2
  • 6
    • 0035205620 scopus 로고    scopus 로고
    • Macrophages express neurotrophins and neurotrophin receptors. Regulation of nitric oxide production by NT-3
    • R.BarouchE.AppelG.KazimirskyC.Brodie (2001). Macrophages express neurotrophins and neurotrophin receptors. Regulation of nitric oxide production by NT-3. Journal of Neuroimmunology, 112, 72–77.
    • (2001) Journal of Neuroimmunology , vol.112 , pp. 72-77
    • Barouch, R.1    Appel, E.2    Kazimirsky, G.3    Brodie, C.4
  • 7
    • 0037413615 scopus 로고    scopus 로고
    • Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells
    • A.BayasN.KruseN.F.MoriabadiF.WeberV.HummelG.WohlebenP.Rieckmann (2003). Modulation of cytokine mRNA expression by brain-derived neurotrophic factor and nerve growth factor in human immune cells. Neuroscience Letters, 335, 155–158.
    • (2003) Neuroscience Letters , vol.335 , pp. 155-158
    • Bayas, A.1    Kruse, N.2    Moriabadi, N.F.3    Weber, F.4    Hummel, V.5    Wohleben, G.6    Rieckmann, P.7
  • 8
    • 80455150287 scopus 로고    scopus 로고
    • Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis
    • C.BellangerL.DubanetM.C.LiseA.L.FauchaisD.BordessouleM.O.JauberteauD.Troutaud (2011). Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis. PLoS ONE, 6, e27213.
    • (2011) PLoS ONE , vol.6 , pp. 27213
    • Bellanger, C.1    Dubanet, L.2    Lise, M.C.3    Fauchais, A.L.4    Bordessoule, D.5    Jauberteau, M.O.6    Troutaud, D.7
  • 11
  • 13
    • 0036020555 scopus 로고    scopus 로고
    • Mortality, cardiac vagal control and physical training—What's the link?
    • A.N.BuchJ.H.CooteJ.N.Townend (2002). Mortality, cardiac vagal control and physical training—What's the link?Experimental Physiology, 87, 423–435.
    • (2002) Experimental Physiology , vol.87 , pp. 423-435
    • Buch, A.N.1    Coote, J.H.2    Townend, J.N.3
  • 14
    • 84876095076 scopus 로고    scopus 로고
    • Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor
    • D.L.CarboneR.J.Handa (2012). Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor. Neuroscience, 239, 295–303.
    • (2012) Neuroscience , vol.239 , pp. 295-303
    • Carbone, D.L.1    Handa, R.J.2
  • 15
    • 33645373042 scopus 로고    scopus 로고
    • The role of neurotrophins in muscle under physiological and pathological conditions
    • G.ChevrelR.HohlfeldM.Sendtner (2006). The role of neurotrophins in muscle under physiological and pathological conditions. Muscle & Nerve, 33, 462–476.
    • (2006) Muscle & Nerve , vol.33 , pp. 462-476
    • Chevrel, G.1    Hohlfeld, R.2    Sendtner, M.3
  • 16
    • 84861228812 scopus 로고    scopus 로고
    • Plasma concentrations but not serum concentrations of brain-derived neurotrophic factor are related to pro-inflammatory cytokines in patients undergoing major abdominal surgery
    • G.ChimientiA.MezzapesaM.T.RotelliL.LupoG.Pepe (2012). Plasma concentrations but not serum concentrations of brain-derived neurotrophic factor are related to pro-inflammatory cytokines in patients undergoing major abdominal surgery. Clinical Biochemistry, 45, 631–636.
    • (2012) Clinical Biochemistry , vol.45 , pp. 631-636
    • Chimienti, G.1    Mezzapesa, A.2    Rotelli, M.T.3    Lupo, L.4    Pepe, G.5
  • 18
    • 0031055679 scopus 로고    scopus 로고
    • Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation
    • H.J.ChoS.Y.KimM.J.ParkD.S.KimJ.K.KimM.Y.Chu (1997). Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation. Brain Research, 749, 358–362.
    • (1997) Brain Research , vol.749 , pp. 358-362
    • Cho, H.J.1    Kim, S.Y.2    Park, M.J.3    Kim, D.S.4    Kim, J.K.5    Chu, M.Y.6
  • 19
    • 1242306277 scopus 로고    scopus 로고
    • Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
    • S.ChourbajiR.HellwegD.BrandisB.ZörnerC.ZacherU.E.LangP.Gass (2004). Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Molecular Brain Research, 121, 28–36.
    • (2004) Molecular Brain Research , vol.121 , pp. 28-36
    • Chourbaji, S.1    Hellweg, R.2    Brandis, D.3    Zörner, B.4    Zacher, C.5    Lang, U.E.6    Gass, P.7
  • 20
    • 77954185813 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates satellite cell differentiation and skeletal muscle regeneration
    • C.ClowB.J.Jasmin (2010). Brain-derived neurotrophic factor regulates satellite cell differentiation and skeletal muscle regeneration. Molecular Biology of the Cell, 21, 2182–2190.
    • (2010) Molecular Biology of the Cell , vol.21 , pp. 2182-2190
    • Clow, C.1    Jasmin, B.J.2
  • 22
    • 78951494281 scopus 로고    scopus 로고
    • Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels
    • P.R.CorreiaA.PansaniF.MachadoM.AndradeA.C.SilvaF.A.ScorzaR.M.Arida (2010). Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels. Clinics, 65, 1123–1126.
    • (2010) Clinics , vol.65 , pp. 1123-1126
    • Correia, P.R.1    Pansani, A.2    Machado, F.3    Andrade, M.4    Silva, A.C.5    Scorza, F.A.6    Arida, R.M.7
  • 23
  • 25
    • 84869998324 scopus 로고    scopus 로고
    • Impact of physical activity on inflammation: Effects on cardiovascular disease risk and other inflammatory conditions
    • S.ErtekA.Cicero (2012). Impact of physical activity on inflammation: Effects on cardiovascular disease risk and other inflammatory conditions. Archives of Medical Science, 8, 794–804.
    • (2012) Archives of Medical Science , vol.8 , pp. 794-804
    • Ertek, S.1    Cicero, A.2
  • 27
    • 84858332188 scopus 로고    scopus 로고
    • Truncated TrkB: Beyond a dominant negative receptor
    • B.M.Fenner (2012). Truncated TrkB: Beyond a dominant negative receptor. Cytokine & Growth Factor Reviews, 23, 15–24.
    • (2012) Cytokine & Growth Factor Reviews , vol.23 , pp. 15-24
    • Fenner, B.M.1
  • 28
    • 34147095845 scopus 로고    scopus 로고
    • The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function
    • L.T.FerrisJ.S.WilliamsC.L.Shen (2007). The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Medicine and Science in Sports and Exercise, 39, 728–734.
    • (2007) Medicine and Science in Sports and Exercise , vol.39 , pp. 728-734
    • Ferris, L.T.1    Williams, J.S.2    Shen, C.L.3
  • 29
    • 35448949501 scopus 로고    scopus 로고
    • Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain
    • P.FollesaF.BiggioG.GoriniS.CariaG.TalaniL.DazziG.Biggio (2007). Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain. Brain Research, 1179, 28–34.
    • (2007) Brain Research , vol.1179 , pp. 28-34
    • Follesa, P.1    Biggio, F.2    Gorini, G.3    Caria, S.4    Talani, G.5    Dazzi, L.6    Biggio, G.7
  • 30
    • 84860441405 scopus 로고    scopus 로고
    • Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain
    • H.FurmagaF.R.CarrenoA.Frazer (2012). Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain. PLoS ONE, 7, e34844.
    • (2012) PLoS ONE , vol.7 , pp. 34844
    • Furmaga, H.1    Carreno, F.R.2    Frazer, A.3
  • 31
    • 79955580737 scopus 로고    scopus 로고
    • Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation
    • F.J.Gil-BeaM.SolasL.MateosB.WinbladM.J.RamírezA.Cedazo-Mínguez (2011). Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus, 21, 999–1009.
    • (2011) Hippocampus , vol.21 , pp. 999-1009
    • Gil-Bea, F.J.1    Solas, M.2    Mateos, L.3    Winblad, B.4    Ramírez, M.J.5    Cedazo-Mínguez, A.6
  • 33
    • 84873021276 scopus 로고    scopus 로고
    • Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
    • C.GomesR.FerreiraJ.GeorgeR.SanchesD.I.RodriguesN.GonçalvesR.A.Cunha (2013). Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia. Journal of Neuroinflammation, 10, 16.
    • (2013) Journal of Neuroinflammation , vol.10 , pp. 16
    • Gomes, C.1    Ferreira, R.2    George, J.3    Sanches, R.4    Rodrigues, D.I.5    Gonçalves, N.6    Cunha, R.A.7
  • 34
    • 30644477580 scopus 로고    scopus 로고
    • Supraspinal brain-derived neurotrophic factor signaling: A novel mechanism for descending pain facilitation
    • W.GuoM.T.RobbinsF.WeiS.ZouR.DubnerK.Ren (2006). Supraspinal brain-derived neurotrophic factor signaling: A novel mechanism for descending pain facilitation. Journal of Neuroscience, 26, 126–137.
    • (2006) Journal of Neuroscience , vol.26 , pp. 126-137
    • Guo, W.1    Robbins, M.T.2    Wei, F.3    Zou, S.4    Dubner, R.5    Ren, K.6
  • 36
    • 0034661765 scopus 로고    scopus 로고
    • Neuroprotection by encephalomyelitis: Rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells
    • H.HammarbergO.LidmanC.LundbergS.Y.EltayebA.W.GielenS.MuhallabF.Piehl (2000). Neuroprotection by encephalomyelitis: Rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. Journal of Neuroscience, 20, 5283–5291.
    • (2000) Journal of Neuroscience , vol.20 , pp. 5283-5291
    • Hammarberg, H.1    Lidman, O.2    Lundberg, C.3    Eltayeb, S.Y.4    Gielen, A.W.5    Muhallab, S.6    Piehl, F.7
  • 41
    • 78650748359 scopus 로고    scopus 로고
    • Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats
    • Y.JiangN.WeiT.LuJ.ZhuG.XuX.Liu (2011). Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience, 172, 398–405.
    • (2011) Neuroscience , vol.172 , pp. 398-405
    • Jiang, Y.1    Wei, N.2    Lu, T.3    Zhu, J.4    Xu, G.5    Liu, X.6
  • 42
    • 79955013441 scopus 로고    scopus 로고
    • Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat
    • Y.JiangN.WeiJ.ZhuT.LuZ.ChenG.XuX.Liu (2010). Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat. Mediators of Inflammation, 2010, 372423. doi:10.1155/2010/372423
    • (2010) Mediators of Inflammation , vol.2010
    • Jiang, Y.1    Wei, N.2    Zhu, J.3    Lu, T.4    Chen, Z.5    Xu, G.6    Liu, X.7
  • 43
    • 67549148614 scopus 로고    scopus 로고
    • Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture
    • J.JohanssonE.FormaggioG.FumagalliC.Chiamulera (2009). Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture. Neuroreport, 20, 828–832.
    • (2009) Neuroreport , vol.20 , pp. 828-832
    • Johansson, J.1    Formaggio, E.2    Fumagalli, G.3    Chiamulera, C.4
  • 44
    • 2442695092 scopus 로고    scopus 로고
    • Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects
    • E.A.JoostenD.A.Houweling (2004). Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects. Neuroreport, 15, 1163–1166.
    • (2004) Neuroreport , vol.15 , pp. 1163-1166
    • Joosten, E.A.1    Houweling, D.A.2
  • 45
    • 18144416532 scopus 로고    scopus 로고
    • Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    • F.KaregeG.BondolfiN.GervasoniM.SchwaldJ.AubryG.Bertschy (2005). Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biological Psychiatry, 57, 1068–1072.
    • (2005) Biological Psychiatry , vol.57 , pp. 1068-1072
    • Karege, F.1    Bondolfi, G.2    Gervasoni, N.3    Schwald, M.4    Aubry, J.5    Bertschy, G.6
  • 46
    • 0030271247 scopus 로고    scopus 로고
    • Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain
    • Y.KawamotoS.NakamuraS.NakanoN.OkaI.AkiguchiJ.Kimura (1996). Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain. Neuroscience, 74, 1209–1226.
    • (1996) Neuroscience , vol.74 , pp. 1209-1226
    • Kawamoto, Y.1    Nakamura, S.2    Nakano, S.3    Oka, N.4    Akiguchi, I.5    Kimura, J.6
  • 47
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    • M.KerschensteinerE.GallmeierL.BehrensV.V.LealT.MisgeldW.E.KlinkertR.Hohlfeld (1999). Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?Journal of Experimental Medicine, 189, 865–870.
    • (1999) Journal of Experimental Medicine , vol.189 , pp. 865-870
    • Kerschensteiner, M.1    Gallmeier, E.2    Behrens, L.3    Leal, V.V.4    Misgeld, T.5    Klinkert, W.E.6    Hohlfeld, R.7
  • 48
    • 84873604016 scopus 로고    scopus 로고
    • The brain derived neurotrophic factor and influences of stress in depression
    • J.Kimpton (2012). The brain derived neurotrophic factor and influences of stress in depression. Psychiatria Danubina, 24, S169–S171.
    • (2012) Psychiatria Danubina , vol.24 , pp. 169-171
    • Kimpton, J.1
  • 49
    • 0032918107 scopus 로고    scopus 로고
    • Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain
    • R.L.KleinD.MuirM.A.KingA.L.PeelS.ZolotukhinJ.C.MöllerE.M.Meyer (1999). Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain. Neuroscience, 90, 815–821.
    • (1999) Neuroscience , vol.90 , pp. 815-821
    • Klein, R.L.1    Muir, D.2    King, M.A.3    Peel, A.L.4    Zolotukhin, S.5    Möller, J.C.6    Meyer, E.M.7
  • 50
    • 77955948750 scopus 로고    scopus 로고
    • Neuroplasticity—Exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects
    • K.KnaepenM.GoekintE.M.HeymanR.Meeusen (2010). Neuroplasticity—Exercise-induced response of peripheral brain-derived neurotrophic factor: A systematic review of experimental studies in human subjects. Sports Medicine, 40, 765–801.
    • (2010) Sports Medicine , vol.40 , pp. 765-801
    • Knaepen, K.1    Goekint, M.2    Heyman, E.M.3    Meeusen, R.4
  • 52
    • 78651075999 scopus 로고    scopus 로고
    • Mortality trends in the general population: The importance of cardiorespiratory fitness
    • D.LeeE.G.ArteroX.SuiS.N.Blair (2010). Mortality trends in the general population: The importance of cardiorespiratory fitness. Journal of Psychopharmacology, 24, 27–35.
    • (2010) Journal of Psychopharmacology , vol.24 , pp. 27-35
    • Lee, D.1    Artero, E.G.2    Sui, X.3    Blair, S.N.4
  • 53
    • 80053371511 scopus 로고    scopus 로고
    • Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: An in vivo and in vitro study
    • Y.T.LinL.S.RoH.L.WangJ.C.Chen (2011). Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: An in vivo and in vitro study. Journal of Neuroinflammation, 8, 126. doi:10.1186/1742-2094-8-126
    • (2011) Journal of Neuroinflammation , vol.8 , pp. 126
    • Lin, Y.T.1    Ro, L.S.2    Wang, H.L.3    Chen, J.C.4
  • 54
    • 31144467231 scopus 로고    scopus 로고
    • Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
    • Q.R.LiuL.LuX.G.ZhuJ.P.GongY.ShahamG.R.Uhl (2006). Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Research, 1067, 1–12.
    • (2006) Brain Research , vol.1067 , pp. 1-12
    • Liu, Q.R.1    Lu, L.2    Zhu, X.G.3    Gong, J.P.4    Shaham, Y.5    Uhl, G.R.6
  • 57
    • 12344328770 scopus 로고    scopus 로고
    • Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E
    • H.LouS.K.KimE.ZaitsevC.R.SnellB.LuY.P.Loh (2005). Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase E. Neuron, 45, 245–255.
    • (2005) Neuron , vol.45 , pp. 245-255
    • Lou, H.1    Kim, S.K.2    Zaitsev, E.3    Snell, C.R.4    Lu, B.5    Loh, Y.P.6
  • 58
    • 48849116813 scopus 로고    scopus 로고
    • Cell biology of BDNF and its relevance to schizophrenia
    • B.LuK.Martinowich (2008). Cell biology of BDNF and its relevance to schizophrenia. Novartis Foundation Symposium, 289, 119–195.
    • (2008) Novartis Foundation Symposium , vol.289 , pp. 119-195
    • Lu, B.1    Martinowich, K.2
  • 59
    • 54849426071 scopus 로고    scopus 로고
    • Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    • F.D.LubinT.L.RothJ.D.Sweatt (2008). Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. Journal of Neuroscience, 28, 10576–1086.
    • (2008) Journal of Neuroscience , vol.28 , pp. 10576-11086
    • Lubin, F.D.1    Roth, T.L.2    Sweatt, J.D.3
  • 60
    • 84879461875 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neuroimmunology: Lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models
    • F.LuhderR.GoldA.FlugelR.A.Linker (2013). Brain-derived neurotrophic factor in neuroimmunology: Lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models. Archivum Immunologiae et Therapiae Experimentalis, 61, 95–105.
    • (2013) Archivum Immunologiae et Therapiae Experimentalis , vol.61 , pp. 95-105
    • Luhder, F.1    Gold, R.2    Flugel, A.3    Linker, R.A.4
  • 61
    • 84875590954 scopus 로고    scopus 로고
    • Physical activity, by enhancing parasympathetic tone and activating the cholinergic anti-inflammatory pathway, is a therapeutic strategy to restrain chronic inflammation and prevent many chronic diseases
    • H.L.LujanS.E.Dicarlo (2013). Physical activity, by enhancing parasympathetic tone and activating the cholinergic anti-inflammatory pathway, is a therapeutic strategy to restrain chronic inflammation and prevent many chronic diseases. Medical Hypotheses, 80, 548–552.
    • (2013) Medical Hypotheses , vol.80 , pp. 548-552
    • Lujan, H.L.1    Dicarlo, S.E.2
  • 62
    • 84872424920 scopus 로고    scopus 로고
    • Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism
    • J.A.LutherJ.EnesS.J.Birren (2013). Neurotrophins regulate cholinergic synaptic transmission in cultured rat sympathetic neurons through a p75-dependent mechanism. Journal of Neurophysiology, 109, 485–496.
    • (2013) Journal of Neurophysiology , vol.109 , pp. 485-496
    • Luther, J.A.1    Enes, J.2    Birren, S.J.3
  • 63
    • 63849182851 scopus 로고    scopus 로고
    • Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period
    • L.MaG.F.LopezR.F.Krimm (2009). Epithelial-derived brain-derived neurotrophic factor is required for gustatory neuron targeting during a critical developmental period. Journal of Neuroscience, 29, 3354–3364.
    • (2009) Journal of Neuroscience , vol.29 , pp. 3354-3364
    • Ma, L.1    Lopez, G.F.2    Krimm, R.F.3
  • 64
    • 44649199252 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis
    • T.K.MakarD.TrislerK.T.SuraS.SultanaN.PatelC.T.Bever (2008). Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. Journal of the Neurological Sciences, 270, 70–76.
    • (2008) Journal of the Neurological Sciences , vol.270 , pp. 70-76
    • Makar, T.K.1    Trisler, D.2    Sura, K.T.3    Sultana, S.4    Patel, N.5    Bever, C.T.6
  • 65
    • 84890757112 scopus 로고    scopus 로고
    • Activity, activity restriction, and sedentarism in nursing research
    • J.A.MaloniB.A.Smith (2014). Activity, activity restriction, and sedentarism in nursing research. Biological Research for Nursing, 16, 5–6.
    • (2014) Biological Research for Nursing , vol.16 , pp. 5-6
    • Maloni, J.A.1    Smith, B.A.2
  • 67
    • 0030267783 scopus 로고    scopus 로고
    • Expression of trKB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival
    • M.MaroderD.BellaviaD.MecoM.NapolitanoA.StiglianoE.AlesseI.Screpanti (1996). Expression of trKB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival. Journal of Immunology, 157, 2864–2872.
    • (1996) Journal of Immunology , vol.157 , pp. 2864-2872
    • Maroder, M.1    Bellavia, D.2    Meco, D.3    Napolitano, M.4    Stigliano, A.5    Alesse, E.6    Screpanti, I.7
  • 68
    • 84898858078 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: A critical review
    • D.MartelliM.J.McKinleyR.M.McAllen (2013). The cholinergic anti-inflammatory pathway: A critical review. Autonomic Neuroscience, 182, 65–69. doi:10.1016/j.autneu.2013.12.007
    • (2013) Autonomic Neuroscience , vol.182 , pp. 65-69
    • Martelli, D.1    McKinley, M.J.2    McAllen, R.M.3
  • 69
    • 67349109400 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase
    • V.B.MatthewsM.B.AströmM.H.ChanC.R.BruceK.S.KrabbeO.PrelovsekM.A.Febbraio (2009). Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia, 52, 1409–1418.
    • (2009) Diabetologia , vol.52 , pp. 1409-1418
    • Matthews, V.B.1    Aström, M.B.2    Chan, M.H.3    Bruce, C.R.4    Krabbe, K.S.5    Prelovsek, O.6    Febbraio, M.A.7
  • 70
    • 58149182926 scopus 로고    scopus 로고
    • Neurotrophic factors in autonomic nervous system plasticity and dysfunction
    • M.P.MattsonR.Wan (2008). Neurotrophic factors in autonomic nervous system plasticity and dysfunction. NeuroMolecular Medicine, 10, 157–168.
    • (2008) NeuroMolecular Medicine , vol.10 , pp. 157-168
    • Mattson, M.P.1    Wan, R.2
  • 71
    • 84155163076 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206
    • P.MiuraA.AmiroucheC.ClowG.BélangerB.J.Jasmin (2012). Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206. Journal of Neurochemistry, 120, 230–238.
    • (2012) Journal of Neurochemistry , vol.120 , pp. 230-238
    • Miura, P.1    Amirouche, A.2    Clow, C.3    Bélanger, G.4    Jasmin, B.J.5
  • 72
    • 33745009522 scopus 로고    scopus 로고
    • BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
    • K.MousaviB.J.Jasmin (2006). BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. Journal of Neuroscience, 26, 5739–5749.
    • (2006) Journal of Neuroscience , vol.26 , pp. 5739-5749
    • Mousavi, K.1    Jasmin, B.J.2
  • 73
    • 77954602712 scopus 로고    scopus 로고
    • Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervations
    • M.C.MurphyE.A.Fox (2010). Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervations. Journal of Comparative Neurology, 518, 2934–2951.
    • (2010) Journal of Comparative Neurology , vol.518 , pp. 2934-2951
    • Murphy, M.C.1    Fox, E.A.2
  • 75
    • 0033953960 scopus 로고    scopus 로고
    • Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons
    • D.NonnerE.F.BarrettJ.N.Barrett (2000). Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons. Journal of Neurochemistry, 74, 988–999.
    • (2000) Journal of Neurochemistry , vol.74 , pp. 988-999
    • Nonner, D.1    Barrett, E.F.2    Barrett, J.N.3
  • 76
    • 77649106224 scopus 로고    scopus 로고
    • Effects of exercise and muscle type on BDNF, NT-4/5, and TrKB expression in skeletal muscle
    • D.I.OgbornP.F.Gardiner (2010). Effects of exercise and muscle type on BDNF, NT-4/5, and TrKB expression in skeletal muscle. Muscle & Nerve, 41, 385–391.
    • (2010) Muscle & Nerve , vol.41 , pp. 385-391
    • Ogborn, D.I.1    Gardiner, P.F.2
  • 77
    • 0037356536 scopus 로고    scopus 로고
    • Expression of TrkB subtypes in the adult monkey cerebellar cortex
    • K.OhiraM.Hayashi (2003). Expression of TrkB subtypes in the adult monkey cerebellar cortex. Journal of Chemical Neuroanatomy, 25,175–183.
    • (2003) Journal of Chemical Neuroanatomy , vol.25 , pp. 175-183
    • Ohira, K.1    Hayashi, M.2
  • 78
    • 43349083457 scopus 로고    scopus 로고
    • From CNI-1493 to the immunological homunculus: Physiology of the inflammatory reflex
    • S.L.OkeK.J.Tracey (2008). From CNI-1493 to the immunological homunculus: Physiology of the inflammatory reflex. Journal of Leukocyte Biology, 83, 512–517.
    • (2008) Journal of Leukocyte Biology , vol.83 , pp. 512-517
    • Oke, S.L.1    Tracey, K.J.2
  • 81
    • 84882797818 scopus 로고    scopus 로고
    • Targeting translational control as a novel way to treat inflammatory disease: The emerging role of microRNAs
    • M.PlankS.MaltbyJ.MattesP.S.Foster (2013). Targeting translational control as a novel way to treat inflammatory disease: The emerging role of microRNAs. Clinical & Experimental Allergy, 43, 981–999.
    • (2013) Clinical & Experimental Allergy , vol.43 , pp. 981-999
    • Plank, M.1    Maltby, S.2    Mattes, J.3    Foster, P.S.4
  • 83
    • 34547499702 scopus 로고    scopus 로고
    • Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
    • P.PruunsildA.KazantsevaT.AidK.PalmT.Timmusk (2007). Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics, 90, 397–406.
    • (2007) Genomics , vol.90 , pp. 397-406
    • Pruunsild, P.1    Kazantseva, A.2    Aid, T.3    Palm, K.4    Timmusk, T.5
  • 84
    • 45449089260 scopus 로고    scopus 로고
    • Neurotrophin-induced upregulation of p75NTR via a protein kinase C-delta-dependent mechanism
    • S.L.RankinC.S.GuyM.RahimtulaK.M.Mearow (2008). Neurotrophin-induced upregulation of p75NTR via a protein kinase C-delta-dependent mechanism. Brain Research, 1217, 10–24.
    • (2008) Brain Research , vol.1217 , pp. 10-24
    • Rankin, S.L.1    Guy, C.S.2    Rahimtula, M.3    Mearow, K.M.4
  • 86
    • 84870990128 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury
    • C.RitterA.S.MirandaV.R.GiombelliC.D.TomasiC.M.ComimA.L.TeixeiraF.Dal-Pizzol (2012). Brain-derived neurotrophic factor plasma levels are associated with mortality in critically ill patients even in the absence of brain injury. Critical Care, 16, R234.
    • (2012) Critical Care , vol.16 , pp. 234
    • Ritter, C.1    Miranda, A.S.2    Giombelli, V.R.3    Tomasi, C.D.4    Comim, C.M.5    Teixeira, A.L.6    Dal-Pizzol, F.7
  • 89
    • 0042160201 scopus 로고    scopus 로고
    • BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanisms
    • Neuroscience
    • J.D.SlonimskyB.YangJ.M.HinternederE.B.NokesS.J.Birren (2003). BDNF and CNTF regulate cholinergic properties of sympathetic neurons through independent mechanisms. Molecular and CellularNeuroscience, 23, 648–660.
    • (2003) Molecular and Cellular , vol.23 , pp. 648-660
    • Slonimsky, J.D.1    Yang, B.2    Hinterneder, J.M.3    Nokes, E.B.4    Birren, S.J.5
  • 90
    • 77649254852 scopus 로고    scopus 로고
    • Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: Results from experimental stress and diabetes
    • F.SornelliM.FioreG.N.ChaldakovL.Aloe (2009). Adipose tissue-derived nerve growth factor and brain-derived neurotrophic factor: Results from experimental stress and diabetes. General Physiology and Biophysics, 28, 179–183.
    • (2009) General Physiology and Biophysics , vol.28 , pp. 179-183
    • Sornelli, F.1    Fiore, M.2    Chaldakov, G.N.3    Aloe, L.4
  • 92
    • 84884954393 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation
    • M.TakedaM.TakahashiJ.KitagawaT.KanazawaM.NasuS.Matsumoto (2013). Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation. Molecular Pain, 9, 49.
    • (2013) Molecular Pain , vol.9 , pp. 49
    • Takeda, M.1    Takahashi, M.2    Kitagawa, J.3    Kanazawa, T.4    Nasu, M.5    Matsumoto, S.6
  • 93
    • 84893017641 scopus 로고    scopus 로고
    • Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone
    • M.TakedaM.TakahashiS.Matsumoto (2014). Inflammation enhanced brain-derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone. Neuroscience, 261C, 223–231.
    • (2014) Neuroscience , vol.261C , pp. 223-231
    • Takeda, M.1    Takahashi, M.2    Matsumoto, S.3
  • 94
    • 38049007143 scopus 로고    scopus 로고
    • Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects
    • S.W.TangE.ChuT.HuiD.HelmesteC.Law (2008). Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neuroscience Letters, 431, 62–65.
    • (2008) Neuroscience Letters , vol.431 , pp. 62-65
    • Tang, S.W.1    Chu, E.2    Hui, T.3    Helmeste, D.4    Law, C.5
  • 95
    • 0028866230 scopus 로고
    • Neurotrophins and neuronal plasticity
    • H.Thoenen (1995). Neurotrophins and neuronal plasticity. Science, 270, 593–598.
    • (1995) Science , vol.270 , pp. 593-598
    • Thoenen, H.1
  • 96
    • 33846817498 scopus 로고    scopus 로고
    • Physiology and immunology of the cholinergic antiinflammatory pathway
    • K.J.Tracey (2007). Physiology and immunology of the cholinergic antiinflammatory pathway. Journal of Clinical Investigation, 117, 289–296.
    • (2007) Journal of Clinical Investigation , vol.117 , pp. 289-296
    • Tracey, K.J.1
  • 98
    • 0003772710 scopus 로고    scopus 로고
    • Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Retrieved from
    • U.S. Department of Health and Human Services. (1996). Physical activity and health: A report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion. Retrieved fromhttp://www.cdc.gov/nccdphp/sgr/index.htm
    • (1996) Physical activity and health: A report of the Surgeon General
  • 99
    • 84876679841 scopus 로고    scopus 로고
    • Exercise improves cardiac autonomic function in obesity and diabetes
    • C.VoulgariS.PagoniA.VinikP.Poirier (2012). Exercise improves cardiac autonomic function in obesity and diabetes. Metabolism, 62, 609–621.
    • (2012) Metabolism , vol.62 , pp. 609-621
    • Voulgari, C.1    Pagoni, S.2    Vinik, A.3    Poirier, P.4
  • 101
    • 84861446892 scopus 로고    scopus 로고
    • Regulation of the intracerebroventricular administration of brain-derived neurotrophic factor on baroreflex function and insulin sensitivity in rats
    • M.F.WangY.C.ChanH.T.LeeL.Z.Hong (2012). Regulation of the intracerebroventricular administration of brain-derived neurotrophic factor on baroreflex function and insulin sensitivity in rats. Chinese Journal of Physiology, 55, 184–191.
    • (2012) Chinese Journal of Physiology , vol.55 , pp. 184-191
    • Wang, M.F.1    Chan, Y.C.2    Lee, H.T.3    Hong, L.Z.4
  • 102
    • 0034056334 scopus 로고    scopus 로고
    • BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo
    • N.L.WardT.Hagg (2000). BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo. Experimental Neurology, 162, 297–310.
    • (2000) Experimental Neurology , vol.162 , pp. 297-310
    • Ward, N.L.1    Hagg, T.2
  • 103
    • 78649318267 scopus 로고    scopus 로고
    • Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway
    • S.Y.WuT.F.WangL.YuC.J.JenJ.I.ChuangF.S.WuY.M.Kuo (2011). Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, Behavior and Immunity, 25, 135–146.
    • (2011) Brain, Behavior and Immunity , vol.25 , pp. 135-146
    • Wu, S.Y.1    Wang, T.F.2    Yu, L.3    Jen, C.J.4    Chuang, J.I.5    Wu, F.S.6    Kuo, Y.M.7
  • 104
    • 77953473362 scopus 로고    scopus 로고
    • The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut
    • J.YangY.YuH.YuX.ZuoC.LiuL.GaoY.Li (2010). The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut. European Journal of Pain, 14, 574–579.
    • (2010) European Journal of Pain , vol.14 , pp. 574-579
    • Yang, J.1    Yu, Y.2    Yu, H.3    Zuo, X.4    Liu, C.5    Gao, L.6    Li, Y.7
  • 107
    • 2342493316 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: Relevance to regulating alpha7-containing nicotinic receptors and synaptic function
    • X.ZhouQ.NaiM.ChenJ.D.DittusM.J.HowardJ.F.Margiotta (2004). Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: Relevance to regulating alpha7-containing nicotinic receptors and synaptic function. Journal of Neuroscience, 24, 4340–4350.
    • (2004) Journal of Neuroscience , vol.24 , pp. 4340-4350
    • Zhou, X.1    Nai, Q.2    Chen, M.3    Dittus, J.D.4    Howard, M.J.5    Margiotta, J.F.6
  • 108
    • 0036845819 scopus 로고    scopus 로고
    • Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: Implications for multiple sclerosis therapy
    • T.ZiemssenT.KümpfelW.E.KlinkertO.NeuhausR.Hohlfeld (2002). Glatiramer acetate-specific T-helper 1- and 2-type cell lines produce BDNF: Implications for multiple sclerosis therapy. Brain, 125, 2381–2391.
    • (2002) Brain , vol.125 , pp. 2381-2391
    • Ziemssen, T.1    Kümpfel, T.2    Klinkert, W.E.3    Neuhaus, O.4    Hohlfeld, R.5
  • 109
    • 78649687889 scopus 로고    scopus 로고
    • The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies
    • J.A.ZoladzA.Pilc (2010). The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies. Journal of Physiology and Pharmacology, 61, 533–541.
    • (2010) Journal of Physiology and Pharmacology , vol.61 , pp. 533-541
    • Zoladz, J.A.1    Pilc, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.