Exercise improves cardiac autonomic function in obesity and diabetes

Metabolism: Clinical and Experimental

Volumn 62, Issue 5, 2013, Pages 609-621

  Voulgari, Christina ^a   Pagoni, Stamatina ^a   Vinik, Aaron ^b   Poirier, Paul ^c  

^a G GENNIMATAS GENERAL HOSPITAL   (Greece)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Cardiac autonomic neuropathy; Diabetes; Obesity; Physical exercise

Indexed keywords

AEROBIC EXERCISE; AUTONOMIC NERVOUS SYSTEM FUNCTION; DIABETES MELLITUS; EXERCISE; HEART FUNCTION; HEART RATE VARIABILITY; HUMAN; MUSCLE SYMPATHETIC NERVE ACTIVITY; OBESITY; PHYSICAL ACTIVITY; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; REVIEW;

ANIMALS; AUTONOMIC NERVOUS SYSTEM; DIABETES MELLITUS, TYPE 2; EXERCISE; HEART; HEART RATE; HUMANS; MODELS, BIOLOGICAL; OBESITY;

EID: 84876679841     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.09.005     Document Type: Review

References (102)

1. M.J. LaMonte, S.N. Blair, and T.S. Church Physical activity and diabetes prevention J Appl Physiol 99 2005 1205 1213 (Pubitemid 41214541)
2. E.A. Nyenwe, T.W. Jerkins, G.E. Umpierrez, and A.E. Kitabchi Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes Metabolism 60 1 2011 1 23
3. S.N. Blair, H.W. Kohl III, C.E. Barlow, R.S. Paffenbarger Jr., L.W. Gibbons, and C.A. Macera Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men JAMA 273 1995 1093 1098
4. K.E. Powell, and S.N. Blair The public health burdens of sedentary living habits: Theoretical but realistic estimates Med Sci Sports Exerc 26 7 1994 851 856 (Pubitemid 24200623)
5. J. Myers, M. Prakash, V. Froelicher, D. Do, S. Partington, and J.E. Atwood Exercise capacity and mortality among men referred for exercise testing N Engl J Med 346 2002 793 801 (Pubitemid 34987553)
6. P.D. Thompson, D. Buchner, and I.L. Pina American Heart Association Council on Clinical Cardiology Subcommittee on Exercise, Rehabilitation, and Prevention; American Heart Association Council on Nutrition, Physical Activity, and Metabolism Subcommittee on Physical Activity. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: A statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity) Circulation 107 2003 3109 3116
7. C.I. Ardern, P.T. Katzmarzyk, I. Janssen, T.S. Church, and S.N. Blair Revised Adult Treatment Panel III guidelines and cardiovascular disease mortality in men attending a preventive medical clinic Circulation 112 10 2005 1478 1485 (Pubitemid 41291773)
8. S. Tesfaye, A.J. Boulton, P.J. Dyck Toronto Diabetic Neuropathy Expert Group Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments Diabetes Care 33 2010 2285 2293
9. A.J. Boulton, P. Valensi, and S. Tesfaye The diabetic neuropathies: reports from the Diabetic Neuropathy Expert Panel Meeting on Neuropathy, Toronto, October 2009: Introduction Diabetes Metab Res Rev 2011 10.1002/dmrr.1228
10. V. Spallone, D. Ziegler, R. Freeman, L. Bernardi, S. Frontoni, and R. Pop-Busui Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management Diabetes Metab Res Rev 2011 10.1002/dmrr.1239
11. A.I. Vinik, and D. Ziegler Diabetic cardiovascular autonomic neuropathy Circulation 115 3 2007 387 397 (Pubitemid 46148513)
12. J.D. Lefrandt, A.J. Smit, C.J. Zeebregts, R.O. Gans, and K.H. Hoogenberg Autonomic dysfunction in diabetes: A consequence of cardiovascular damage Curr Diabetes Rev 6 6 2010 348 358
13. P. Poirier, P. Bogaty, F. Philippon, C. Garneau, C. Fortin, and J.G. Dumesnil Preclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetes Metabolism 52 2003 1056 1061 (Pubitemid 37098377)
14. C. Voulgari, I. Moyssakis, D. Perrea, D. Kyriaki, N. Katsilambros, and N. Tentolouris The association between the spatial QRS-T angle with cardiac autonomic neuropathy in subjects with type 2 diabetes mellitus Diabet Med 27 2010 1420 1429
15. J.W. Sacre, B. Franjic, C.L. Jellis, C. Jenkins, J.S. Coombes, and T.H. Marwick Association of cardiac autonomic neuropathy with subclinical myocardial dysfunction in type 2 diabetes J Am Coll Cardiol Img. 3 2010 1207 1215
16. P. Poirier, M.A. Cornier, and T. Mazzone on behalf of the American Heart Association Obesity Committee of the Council on Nutrition; Physical Activity, and Metabolism. Bariatric Surgery and Cardiovascular Risk Factors: A scientific statement from the American Heart Association Circulation 123 2011 1683 1701
17. C. Voulgari, N. Tentolouris, P. Dilaveris, D. Tousoulis, N. Katsilambros, and C. Stefanadis Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals J Am Coll Cardiol 58 13 2011 1343 1350
18. N. Tentolouris, S. Liatis, and N. Katsilambros Sympathetic system activity in obesity and metabolic syndrome Ann N Y Acad Sci 1083 2006 129 152 (Pubitemid 44955470)
19. N. Angelopoulos, A. Goula, and G. Tolis Current knowledge in the neurophysiologic modulation of obesity Metabolism 54 9 2005 1202 1217 (Pubitemid 41206881)
20. Cardiometabolic Risk Working Group: Executive Committee L.A. Leiter, D.H. Fitchett, and R.E. Gilbert Cardiometabolic risk in Canada: A detailed analysis and position paper by the cardiometabolic risk working group Can J Cardiol 27 2 2011 e1 e33
21. S. Mora, N. Cook, J.E. Buring, P.M. Ridker, and I.M. Lee Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms Circulation 116 2007 2110 2118 (Pubitemid 350060348)
22. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Circulation 93 1996 1043 1065
23. M. Baumert, G.W. Lambert, and T. Dawood Short-term heart rate variability and cardiac norepinephrine spillover in patients with depression and panic disorder Am J Physiol Heart Circ Physiol 297 2 2009 H674 H679
24. H. Tsuji, M.G. Larson, and F.J. Venditti Jr. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94 1996 2850 2855 (Pubitemid 26411751)
25. R.E. Maser, B.D. Mitchell, A.I. Vinik, and R. Freeman The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: A meta-analysis Diabetes Care 26 2003 1895 1901 (Pubitemid 36929140)
26. F. Iellamo, J.M. Legramante, M. Massaro, G. Raimondi, and A. Galante Effects of residential exercise training on baroreflex sensitivity and heart rate variability in patients with coronary artery disease: A randomized, controlled study Circulation 102 2000 2588 2592
27. L.H. Opie, and D.J. Paterson Blood pressure and peripheral circulation L.H. Opie, Heart physiology 1st ed. 2004 Lippincott Williams & Wilkins Philadelphia, PA 433 434
28. I. Skrapari, N. Tentolouris, and N. Katsilambros Baroreflex function: determinants in healthy subjects and disturbances in diabetes, obesity and metabolic syndrome Curr Diabetes Rev 2 3 2006 329 338 (Pubitemid 44194435)
29. Y.H. Lee, F. Magkos, C.S. Mantzoros, and E.S. Kang Effects of leptin and adiponectin on pancreatic β-cell function Metabolism 60 12 2011 1664 1672
30. C.N. Moran, N.D. Barwell, D. Malkova, S.J. Cleland, I. McPhee, and C.J. Packard Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors Metabolism 60 2 2011 206 214
31. E. Lambert, T. Dawood, M. Schlaich, N. Straznicky, M. Esler, and G. Lambert Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk Clin Exp Pharmacol Physiol 35 4 2008 503 507 (Pubitemid 351326788)
32. M. Rosenbaum, and R.L. Leibel Adaptive thermogenesis in humans Int J Obes (Lond) 34 Suppl 1 2010 S47 S55
33. P. Poirier Obesity, adiposity indices, and blood pressure; ethnicity does matter Am J Hypertens 21 2008 244 (Pubitemid 351323285)
34. J. Galgani, and E. Ravussin Energy metabolism, fuel selection and body weight regulation Int J Obes (Lond) 32 Suppl 7 2008 S109 S119
35. M.A. Van Baak Meal-induced activation of the sympathetic nervous system and its cardiovascular and thermogenic effects in man Physiol Behav 94 2008 178 186
36. Vinik AI, Maser RE, Ziegler D. Autonomic imbalance: prophet of doom or scope for hope? Diabet Med. 201;28(6):643-51.
37. C. Voulgari, M. Psallas, A. Kokkinos, V. Argiana, N. Katsilambros, and N. Tentolouris The association between cardiac autonomic neuropathy with metabolic and other factors in subjects with type 1 and type 2 diabetes J Diabetes Complications 25 2011 159 167
38. K. Kitsios, A. Tsapas, and P. Karagianni Glycemia and cardiovascular risk: challenging evidence based medicine Hippokratia 15 3 2011 199 204
39. N. Papanas, A.I. Vinik, and D. Ziegler Neuropathy in prediabetes: does the clock start ticking early? Nat Rev Endocrinol 7 11 2011 682 690
40. C. Voulgari, D. Papadogiannis, and N. Tentolouris Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies Vasc Health Risk Manag 6 2010 883 903
41. S.R. Colberg, R.J. Sigal, and B. Fernhall American College of Sports Medicine; American Diabetes Association. Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement Diabetes Care 33 2010 e147 e167
42. R.L. Verrier, and C. Antzelevitch Autonomic aspects of arrhythmogenesis: The enduring and the new Curr Opin Cardiol 19 2004 2 11 (Pubitemid 39107132)
43. A.J. Hautala, A.M. Kiviniemi, and M.P. Tulppo Individual responses to aerobic exercise: The role of the autonomic nervous system Neurosci Biobehav Rev 33 2009 107 115
44. M.N. Hawkins, Q. Barnes, S. Purkayastha, W. Eubank, S. Ogoh, and P.B. Raven The effects of aerobic fitness and beta1-adrenergic receptor blockade on cardiac work during dynamic exercise J Appl Physiol 106 2009 486 493
45. G.E. Billman, and M. Kukielka Effect of endurance exercise training on heart rate onset and heart rate recovery responses to submaximal exercise in animals susceptible to ventricular fibrillation J Appl Physiol 102 2007 231 240 (Pubitemid 46089771)
46. V.A. Cornelissen, and R.H. Fagard Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors Hypertension 46 2005 667 675 (Pubitemid 43186737)
47. T.H. Niemelä, A.M. Kiviniemi, A.J. Hautala, J.A. Salmi, V. Linnamo, and M.P. Tulppo Recovery pattern of baroreflex sensitivity after exercise Med Sci Sports Exerc 40 2008 864 870
48. M. Buchheit, and C. Gindre Cardiac parasympathetic regulation: respective associations with cardiorespiratory fitness and training load Am J Physiol Heart Circ Physiol 291 2006 H451 H458
49. A.J. Hautala, A.M. Kiviniemi, and T.H. Mäkikallio Muscle sympathetic nerve activity at rest compared to exercise tolerance Eur J Appl Physiol 102 2008 533 538
50. I.M. Lee Physical activity and cardiac protection Curr Sports Med Rep 9 2010 214 219
51. D.H. Thijssen, A.J. Maiorana, G. O'Driscoll, N.T. Cable, M.T. Hopman, and D.J. Green Impact of inactivity and exercise on the vasculature in humans Eur J Appl Physiol 108 2010 845 875
52. H. Ito, A. Ohshima, and M. Tsuzuki Effects of increased physical activity and mild calorie restriction on heart rate variability in obese women Jpn Heart J 42 2001 459 469 (Pubitemid 33040836)
53. A. Figueroa, T. Baynard, B. Fernhall, R. Carhart, and J.A. Kanaley Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes Eur J Appl Physiol 100 2007 437 444 (Pubitemid 46773993)
54. I.C. Trombetta, L.T. Batalha, and M.U. Rondon Weight loss improves neurovascular and muscle metaboreflex control in obesity Am J Physiol Heart Circ Physiol 285 2003 H974 H982
55. M. Facchini, G. Malfatto, and L. Sala Changes of autonomic cardiac profile after a 3-week integrated body weight reduction program in severely obese patients J Endocrinol Invest 26 2003 138 142 (Pubitemid 36503061)
56. D.M. Prado, A.G. Silva, and I.C. Trombetta Exercise training associated with diet improves heart rate recovery and cardiac autonomic nervous system activity in obese children Int J Sports Med 31 2010 860 865
57. M.K. Kim, K. Tanaka, M.J. Kim, T. Matsuo, and R. Ajisaka Exercise training-induced changes in heart rate recovery in obese men with metabolic syndrome Metab Syndr Relat Disord 7 2009 469 476
58. N.E. Straznicky, E.A. Lambert, and P.J. Nestel Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects Diabetes 59 2010 71 79
59. N.E. Straznicky, M.T. Grima, and N. Eikelis The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components J Clin Endocrinol Metab 96 3 2011 E503 E508
60. N.E. Straznicky, M.T. Grima, and E.A. Lambert Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals J Hypertens 29 3 2011 553 564
61. D. Felber Dietrich, U. Ackermann-Liebrich, and C. Schindler Sapaldia team. Effect of physical activity on heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study Eur J Appl Physiol 104 2008 557 565
62. C.P. Earnest, P. Poirier, M.R. Carnethon, S.N. Blair, and T.S. Church Autonomic function and change in insulin for exercising postmenopausal women Maturitas 65 2010 284 291
63. S. Goulopoulou, T. Baynard, and R.M. Franklin Exercise training improves cardiovascular autonomic modulation in response to glucose ingestion in obese adults with and without type 2 diabetes mellitus Metabolism 59 2010 901 910
64. J.A. Blumenthal, M.A. Babyak, and A. Hinderliter Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: The ENCORE study Arch Intern Med 170 2010 126 135
65. L. De Jonge, E.A. Moreira, C.K. Martin, E. Ravussin, and Pennington CALERIE Team Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals Obesity 18 2010 414 416 (Silver Spring)
66. V. Castello, R.P. Simões, D. Bassi, A.M. Catai, R. Arena, and A. Borghi-Silva Impact of aerobic exercise training on heart rate variability and functional capacity in obese women after gastric bypass surgery Obes Surg 21 11 2011 1739 1749
67. K. Masuo, H. Rakugi, T. Ogihara, and G.W. Lambert Different mechanisms in weight loss-induced blood pressure reduction between a calorie-restricted diet and exercise Hypertens Res 35 1 2012 41 47
68. P. Poirier, S. Mawhinney, and L. Grondin Prior meal enhances the plasma glucose lowering effect of exercise in type 2 diabetes Med Sci Sports Exerc 33 2001 1259 1264 (Pubitemid 32729839)
69. P. Brassard, A. Ferland, K. Marquis, F. Maltais, J. Jobin, and P. Poirier Impact of diabetes, chronic heart failure, congenital heart disease and chronic obstructive pulmonary disease on acute and chronic exercise responses Can J Cardiol 23 Suppl B 2007 89B 96B (Pubitemid 47629148)
70. P. Brassard, A. Ferland, P. Bogaty, M. Desmeules, J. Jobin, and P. Poirier Influence of glycemic control on pulmonary function and heart rate in response to exercise in subjects with type 2 diabetes mellitus Metabolism 55 11 2006 1532 1537 (Pubitemid 44537351)
71. A. Ferland, T.L. Broderick, A. Nadeau, S. Simard, J. Martin, and P. Poirier Impact of fasting and postprandial state on plasma carnitine concentrations during aerobic exercise in type 2 diabetes Acta Diabetol 44 2007 114 120 (Pubitemid 47313093)
72. E.Y. Khoo, J. Wallis, K. Tsintzas, I.A. Macdonald, and P. Mansell Effects of exenatide on circulating glucose, insulin, glucagon, cortisol and catecholamines in healthy volunteers during exercise Diabetologia 53 2010 139 143
73. A.S. Luyckx, and P.J. Lefebvre Mechanisms involved in the exercise-induced increase in glucagon secretion in rats Diabetes 23 1974 81 93
74. L.L. Watkins, R.S. Surwit, P. Grossman, and A. Sherwood Is there a glycemic threshold for impaired autonomic control? Diabetes Care 23 2000 826 830 (Pubitemid 30414201)
75. H.M. Reims, K. Sevre, E. Fossum, A. Høieggen, H. Mellem, and S.E. Kjeldsen Relations between insulin sensitivity, fitness and autonomic cardiac regulation in healthy, young men J Hypertens 22 2004 2007 2015 (Pubitemid 39341197)
76. U. Scherrer, and C. Sartori Insulin as a vascular and sympathoexcitatory hormone: Implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity Circulation 96 1997 4104 4113
77. F. Kreier, E. Fliers, and P.J. Voshol Selective parasympathetic innervation of subcutaneous and intra-abdominal fat - functional implications J Clin Invest 110 2002 1243 1250 (Pubitemid 35285750)
78. T. Gaudet-Savard, A. Ferland, and T.L. Broderick Safety and magnitude of changes in blood glucose levels following exercise performed in the fasted and the postprandial state in men with type 2 diabetes Eur J Cardiovasc Prev Rehabil 14 2007 831 836 (Pubitemid 350197014)
79. J.A. Beckman, P. Libby, and M.A. Creager Diabetes mellitus, the metabolic syndrome, and atherosclerotic vascular disease P. Libby, R.O. Bonow, D.L. Mann, D.P. Zipes, Braunwald's heart disease: A textbook of cardiovascular medicine 8th ed 2008 Saunders Elsevier Philadelphia, Pa 1094 1105
80. S.F. Praet, and L.J. van Loon Exercise therapy in type 2 diabetes Acta Diabetol 46 2009 263 278
81. C.M. Wheatley, J.C. Baldi, N.A. Cassuto, W.T. Foxx-Lupo, and E.M. Snyder Glycemic control influences lung membrane diffusion and oxygen saturation in exercise-trained subjects with type 1 diabetes: Alveolar-capillary membrane conductance in type 1 diabetes Eur J Appl Physiol 111 2011 567 578
82. G. Zhao, E.S. Ford, C. Li, and A.H. Mokdad Compliance with physical activity recommendations in US adults with diabetes Diabet Med 25 2008 221 227 (Pubitemid 351293399)
83. M.R. Carnethon, D.R. Jacobs Jr., S. Sidney, and K. Liu CARDIA study. Influence of autonomic nervous system dysfunction on the development of type 2 diabetes: The CARDIA study Diabetes Care 26 2003 3035 3041 (Pubitemid 37339495)
84. E. Vanninen, M. Uusitupa, E. Länsimies, O. Siitonen, and J. Laitinen Effect of metabolic control on autonomic function in obese patients with newly diagnosed type 2 diabetes Diabet Med 10 1 1993 66 73 (Pubitemid 23089107)
85. A. Loimaala, H.V. Huikuri, T. Koobi, M. Rinne, A. Nenonen, and I. Vuori Exercise training improves baroreflex sensitivity in type 2 diabetes Diabetes 52 2003 1837 1842 (Pubitemid 36792476)
86. S. Bhagyalakshmi, H. Nagaraja, and B. Anupama Effect of supervised integrated exercise on heart rate variability in type 2 diabetes mellitus Kardiol Pol 65 2007 363 368 (Pubitemid 46955084)
87. G. Zoppini, V. Cacciatori, and M.L. Gemma Effect of moderate aerobic exercise on sympatho-vagal balance in type 2 diabetic patients Diabet Med 24 2007 370 376 (Pubitemid 46452395)
88. B. Sridhar, N. Haleagrahara, R. Bhat, A.B. Kulur, S. Avabratha, and P. Adhikary Increase in the heart rate variability with deep breathing in diabetic patients after 12-month exercise training Tohoku J Exp Med 220 2010 107 113
89. K.M. Madden, C. Lockhart, T.F. Potter, and D. Cuff Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia Clin J Sport Med 20 4 2010 312 317
90. M.J. Simmonds, C.L. Minahan, K.R. Serre, and G.C. Gass Preliminary findings in the heart rate variability and haemorheology response to varied frequency and duration of walking in women 65-74 yr with type 2 diabetes Clin Hemorheol Microcirc 2012
91. S.R. Chen, Y.J. Lee, H.W. Chiu, and C. Jeng Impact of glycemic control, disease duration, and exercise on heart rate variability in children with type 1 diabetes mellitus J Formos Med Assoc 106 2007 935 942 (Pubitemid 350285085)
92. K. Howorka, J. Pumprla, P. Haber, J. Koller-Strametz, J. Mondrzyk, and A. Schabmann Effects of physical training on heart rate variability in diabetic patients with various degrees of cardiovascular autonomic neuropathy Cardiovasc Res 34 1997 206 214 (Pubitemid 27261931)
93. M. Pagkalos, N. Koutlianos, E. Kouidi, E. Pagkalos, K. Mandroukas, and A. Deligiannis Heart rate variability modifications following exercise training in type 2 diabetic patients with definite cardiac autonomic neuropathy Br J Sports Med 42 2008 47 54 (Pubitemid 351158210)
94. S. Tesfaye, and D. Selvarajah Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy Diabetes Metab Res Rev 28 Suppl 1 2012 8 14 10.1002/dmrr.2239
95. N. Papanas, P. Paschos, D. Papazoglou, K. Papatheodorou, K. Paletas, and E. Maltezos Accuracy of the Neuropad test for the diagnosis of distal symmetric polyneuropathy in type 2 diabetes Diabetes Care 34 2011 1378 1382
96. P.M. Kluding, M. Pasnoor, R. Singh, S. Jernigan, K. Farmer, and J. Rucker The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy J Diabetes Complications 2012 http://dx.doi.org/10.1016/j.bbr.2011.03.031
97. P. Gaede, H. Lund-Andersen, H.H. Parving, and O. Pedersen Effect of a multifactorial intervention on mortality in type 2 diabetes N Engl J Med 358 2008 580 591 (Pubitemid 351214285)
98. G.R. Dutton, F. Tan, B.C. Provost, J.L. Sorenson, B. Allen, and D. Smith Relationship between self-efficacy and physical activity among patients with type 2 diabetes J Behav Med 32 2009 270 277
99. J. Gleeson-Kreig Social support and physical activity in type 2 diabetes: A social ecologic approach Diabetes Educ 34 2008 1037 1044
100. R.E. Rhodes, D.E. Warburton, and H. Murray Characteristics of physical activity guidelines and their effect on adherence: A review of randomized trials Sports Med 39 2009 355 375
101. A.D. Deshpande, E.A. Baker, S.L. Lovegreen, and R.C. Brownson Environmental correlates of physical activity among individuals with diabetes in the rural midwest Diabetes Care 28 2005 1012 1018 (Pubitemid 40616605)
102. G.N. Healy, D.W. Dunstan, and J. Salmon Breaks in sedentary time: beneficial associations with metabolic risk Diabetes Care 31 4 2008 661 666