UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: Implications for human lens aging and cataract formation

Journal of Biological Chemistry

Volumn 289, Issue 24, 2014, Pages 17111-17123

  Linetsky, Mikhail ^a,b   Raghavan, Cibin T ^b   Johar, Kaid ^c   Fan, Xingjun ^b   Monnier, Vincent M ^b   Vasavada, Abhay R ^c   Nagaraj, Ram H ^b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ILADEVI CATARACT AND IOL RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PROTEINS;

ADVANCED GLYCATION END PRODUCTS; CATARACT FORMATION; INDOLEAMINE 2 ,3-DIOXYGENASE; KYNURENINE PATHWAYS; OXIDATION PRODUCTS; SENILE CATARACT; TRYPTOPHAN OXIDATION; UVA IRRADIATIONS;

OXIDATION;

ADVANCED GLYCATION END PRODUCT; ASCORBIC ACID; GLUTATHIONE; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; LENS PROTEIN; SODIUM ASCORBIC ACID COTRANSPORTER;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CATARACTOGENESIS; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LENS; LIGHT EXPOSURE; LIGHT INTENSITY; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATION; PHOTOOXIDATION; PRIORITY JOURNAL; RADIATION EXPOSURE; SENILE CATARACT; ULTRAVIOLET A RADIATION;

AGING; ASCORBIC ACID; CATARACT; GLYCATION; LENS; TRYPTOPHAN;

ANIMALS; ASCORBIC ACID; CATARACT; CRYSTALLINS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KYNURENINE; LENS, CRYSTALLINE; MICE; OXIDATION-REDUCTION; ULTRAVIOLET RAYS;

EID: 84902455489     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.554410     Document Type: Article

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