Size-dependent specific targeting and efficient gene silencing in peritoneal macrophages using a pH-sensitive cationic liposomal siRNA carrier

International Journal of Pharmaceutics

Volumn 495, Issue 1, 2015, Pages 171-178

  Matsui, Hideki ^a   Sato, Yusuke ^a   Hatakeyama, Hiroto ^a   Akita, Hidetaka ^a   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Administration route; Multifunctional envelope type nano device Size; Peritoneal macrophages; pH Sensitive cationic lipid; Short interference RNA

Indexed keywords

DRUG CARRIER; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YSK05 MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; CATION; LIPID; MACROGOL DERIVATIVE; NANOPARTICLE; PIPERIDINE DERIVATIVE; YSK05;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; GENE; GENE EXPRESSION; GENE SILENCING; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PARTICLE SIZE; PERITONEUM MACROPHAGE; PH; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; HUMAN; RNA INTERFERENCE;

ANIMALS; CATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG CARRIERS; GENE EXPRESSION; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; MACROPHAGES, PERITONEAL; MICE; NANOPARTICLES; PIPERIDINES; POLYETHYLENE GLYCOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84941006321     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.044     Document Type: Article

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