A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

Journal of Controlled Release

Volumn 163, Issue 3, 2012, Pages 267-276

  Sato, Yusuke ^a   Hatakeyama, Hiroto ^a,b   Sakurai, Yu ^a   Hyodo, Mamoru ^a   Akita, Hidetaka ^a,b   Harashima, Hideyoshi ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Endosomal escape; Intracellular trafficking; Multifunctional envelope type nano device (MEND); pH sensitive cationic lipid; siRNA delivery

Indexed keywords

CATIONIC LIPIDS; ENDOSOMAL ESCAPE; INTRACELLULAR TRAFFICKING; NANO DEVICE; SIRNA DELIVERY;

LIPIDS; POLYETHYLENE GLYCOLS; RNA; TUMORS;

GENETIC ENGINEERING;

LIPID; LIPOSOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YSK 05;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENDOSOME; GENE SILENCING; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; MALE; MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; NANODEVICE; NONHUMAN; PH; PRIORITY JOURNAL;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; ENDOCYTOSIS; ERYTHROCYTES; GENE SILENCING; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; NANOSTRUCTURES; NEOPLASMS; PEPTIDES; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING;

EID: 84867394662     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.09.009     Document Type: Article

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