메뉴 건너뛰기




Volumn 4 FEB, Issue , 2014, Pages

Heterotypic cellular interactions in the ovarian tumor microenvironment: Biological significance and therapeutic implications

Author keywords

Adipocytes; Endothelial cells; Fibroblasts; Macrophages; Mesenchymal stem cells; Mesothelium; Ovarian cancer; Tumor microenvironment

Indexed keywords

A83 01; AFLIBERCEPT; ANTINEOPLASTIC AGENT; AVF 2949G; BEVACIZUMAB; CA125 PROTEIN; CD157 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; FATTY ACID BINDING PROTEIN 4; FIBROBLAST GROWTH FACTOR 2; GOG 170D; GONADORELIN RECEPTOR; HERMES ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; P CADHERIN; PEPTIDES AND PROTEINS; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; TALIN I; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 84898005205     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00018     Document Type: Short Survey
Times cited : (13)

References (79)
  • 1
    • 84872967522 scopus 로고    scopus 로고
    • Cancer statistics 2013
    • doi:10.3322/caac.21166
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin (2013) 63:11-30. doi:10.3322/caac.21166
    • (2013) CA Cancer J Clin , vol.63 , pp. 11-30
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 2
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: strategies for overcoming resistance to chemotherapy
    • doi:10.1038/nrc1123
    • Agarwal R, Kaye SB. Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer (2003) 3:502-16. doi:10.1038/nrc1123
    • (2003) Nat Rev Cancer , vol.3 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 3
    • 18344380440 scopus 로고    scopus 로고
    • Ovarian cancer metastasis: integrating insights from disparate model organisms
    • doi:10.1038/nrc1611
    • Naora H, Montell DJ. Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat Rev Cancer (2005) 5:355-66. doi:10.1038/nrc1611
    • (2005) Nat Rev Cancer , vol.5 , pp. 355-366
    • Naora, H.1    Montell, D.J.2
  • 4
    • 77956495728 scopus 로고    scopus 로고
    • Ovarian cancer development and metastasis
    • doi:10.2353/ajpath.2010.100105
    • Lengyel E. Ovarian cancer development and metastasis. Am J Pathol (2010) 177:1053-64. doi:10.2353/ajpath.2010.100105
    • (2010) Am J Pathol , vol.177 , pp. 1053-1064
    • Lengyel, E.1
  • 5
    • 84862313384 scopus 로고    scopus 로고
    • Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis
    • doi:10.1007/s10555-012-9351-2
    • Sodek KL, Murphy KJ, Brown TJ, Ringuette MJ. Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. Cancer Metastasis Rev (2012) 31:397-414. doi:10.1007/s10555-012-9351-2
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 397-414
    • Sodek, K.L.1    Murphy, K.J.2    Brown, T.J.3    Ringuette, M.J.4
  • 6
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • doi:10.1146/annurev.pathol.1.110304.100224
    • Tlsty TD, Coussens LM. Tumor stroma and regulation of cancer development. Annu Rev Pathol (2006) 1:119-50. doi:10.1146/annurev.pathol.1.110304.100224
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 7
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • doi:10.1038/nrc1877
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer (2006) 6:392-401. doi:10.1038/nrc1877
    • (2006) Nat Rev Cancer , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 8
    • 0036738565 scopus 로고    scopus 로고
    • Mesothelial cells: their structure, function and role in serosal repair
    • doi:10.1046/j.1440-1843.2002.00404.x
    • Mutsaers SE. Mesothelial cells: their structure, function and role in serosal repair. Respirology (2002) 7:171-91. doi:10.1046/j.1440-1843.2002.00404.x
    • (2002) Respirology , vol.7 , pp. 171-191
    • Mutsaers, S.E.1
  • 9
    • 63649151399 scopus 로고    scopus 로고
    • A binding domain on mesothelin for CA125/MUC16
    • doi:10.1074/jbc.M806776200
    • Kaneko O, Gong L, Zhang J, Hansen JK, Hassan R, Lee B, et al. A binding domain on mesothelin for CA125/MUC16. J Biol Chem (2009) 284:3739-49. doi:10.1074/jbc.M806776200
    • (2009) J Biol Chem , vol.284 , pp. 3739-3749
    • Kaneko, O.1    Gong, L.2    Zhang, J.3    Hansen, J.K.4    Hassan, R.5    Lee, B.6
  • 10
    • 84871923792 scopus 로고    scopus 로고
    • Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion
    • doi:10.1038/mt.2012.187
    • Cheung LW, Yung S, Chan TM, Leung PC, Wong AS. Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion. Mol Ther (2013) 21:78-90. doi:10.1038/mt.2012.187
    • (2013) Mol Ther , vol.21 , pp. 78-90
    • Cheung, L.W.1    Yung, S.2    Chan, T.M.3    Leung, P.C.4    Wong, A.S.5
  • 11
    • 0029051006 scopus 로고
    • Expression and function of beta 1 and alpha v beta 3 integrins in ovarian cancer
    • doi:10.1006/gyno.1995.1214
    • Cannistra SA, Ottensmeier C, Niloff J, Orta B, DiCarlo J. Expression and function of beta 1 and alpha v beta 3 integrins in ovarian cancer. Gynecol Oncol (1995) 58:216-25. doi:10.1006/gyno.1995.1214
    • (1995) Gynecol Oncol , vol.58 , pp. 216-225
    • Cannistra, S.A.1    Ottensmeier, C.2    Niloff, J.3    Orta, B.4    DiCarlo, J.5
  • 12
    • 0032588952 scopus 로고    scopus 로고
    • CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells
    • doi:10. 1016/S0002-9440(10)65406-5
    • Lessan K, Aguiar DJ, Oegema T, Siebenson L, Skubitz AP. CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. Am J Pathol (1999) 154:1525-37. doi:10.1016/S0002-9440(10)65406-5
    • (1999) Am J Pathol , vol.154 , pp. 1525-1537
    • Lessan, K.1    Aguiar, D.J.2    Oegema, T.3    Siebenson, L.4    Skubitz, A.P.5
  • 13
    • 51049098978 scopus 로고    scopus 로고
    • Vitronectin and its receptors partly mediate adhesion of ovarian cancer cells to peritoneal mesothelium in vitro
    • doi:10.1159/000152941
    • Heyman L, Kellouche S, Fernandes J, Dutoit S, Poulain L, Carreiras F. Vitronectin and its receptors partly mediate adhesion of ovarian cancer cells to peritoneal mesothelium in vitro. Tumour Biol (2008) 29:231-44. doi:10.1159/000152941
    • (2008) Tumour Biol , vol.29 , pp. 231-244
    • Heyman, L.1    Kellouche, S.2    Fernandes, J.3    Dutoit, S.4    Poulain, L.5    Carreiras, F.6
  • 14
    • 60549088136 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis
    • doi:10.1158/0008-5472.CAN-08-2678
    • Slack-Davis JK, Atkins KA, Harrer C, Hershey ED, Conaway M. Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. Cancer Res (2009) 69:1469-76. doi:10.1158/0008-5472.CAN-08-2678
    • (2009) Cancer Res , vol.69 , pp. 1469-1476
    • Slack-Davis, J.K.1    Atkins, K.A.2    Harrer, C.3    Hershey, E.D.4    Conaway, M.5
  • 15
    • 74749087064 scopus 로고    scopus 로고
    • The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions
    • doi:10.1016/j.mce.2009.12.025
    • Ko SY, Lengyel E, Naora H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol Cell Endocrinol (2010) 317:112-9. doi:10.1016/j.mce.2009.12.025
    • (2010) Mol Cell Endocrinol , vol.317 , pp. 112-119
    • Ko, S.Y.1    Lengyel, E.2    Naora, H.3
  • 16
    • 80053169555 scopus 로고    scopus 로고
    • Ovarian cancer spheroids use myosin-generated force to clear the mesothelium
    • doi:10.1158/2159-8274.CD-11-0010
    • Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, et al. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov (2011) 1:144-57. doi:10.1158/2159-8274.CD-11-0010
    • (2011) Cancer Discov , vol.1 , pp. 144-157
    • Iwanicki, M.P.1    Davidowitz, R.A.2    Ng, M.R.3    Besser, A.4    Muranen, T.5    Merritt, M.6
  • 17
    • 77955452824 scopus 로고    scopus 로고
    • Functional role and prognostic significance of CD157 in ovarian carcinoma
    • doi:10.1093/jnci/djq256
    • Ortolan E, Arisio R, Morone S, Bovino P, Lo-Buono N, Nacci G, et al. Functional role and prognostic significance of CD157 in ovarian carcinoma. J Natl Cancer Inst (2010) 102:1160-77. doi:10.1093/jnci/djq256
    • (2010) J Natl Cancer Inst , vol.102 , pp. 1160-1177
    • Ortolan, E.1    Arisio, R.2    Morone, S.3    Bovino, P.4    Lo-Buono, N.5    Nacci, G.6
  • 18
    • 0027176482 scopus 로고
    • Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H
    • Cannistra SA, Kansas GS, Niloff J, DeFranzo B, Kim Y, Ottensmeier C. Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H. Cancer Res (1993) 53:3830-8.
    • (1993) Cancer Res , vol.53 , pp. 3830-3838
    • Cannistra, S.A.1    Kansas, G.S.2    Niloff, J.3    DeFranzo, B.4    Kim, Y.5    Ottensmeier, C.6
  • 19
    • 0030895244 scopus 로고    scopus 로고
    • In vivo inhibition of CD44 limits intra-abdominal spread of a human ovarian cancer xenograft in nude mice: a novel role for CD44 in the process of peritoneal implantation
    • Strobel T, Swanson L, Cannistra SA. In vivo inhibition of CD44 limits intra-abdominal spread of a human ovarian cancer xenograft in nude mice: a novel role for CD44 in the process of peritoneal implantation. Cancer Res (1997) 57:1228-32.
    • (1997) Cancer Res , vol.57 , pp. 1228-1232
    • Strobel, T.1    Swanson, L.2    Cannistra, S.A.3
  • 22
    • 0142009696 scopus 로고    scopus 로고
    • The influence of microvessel density on ovarian carcinogenesis
    • doi:10. 1016/S0090-8258(03)00367-6
    • Stone PJ, Goodheart MJ, Rose SL, Smith BJ, DeYoung BR, Buller RE. The influence of microvessel density on ovarian carcinogenesis. Gynecol Oncol (2003) 90:566-71. doi:10.1016/S0090-8258(03)00367-6
    • (2003) Gynecol Oncol , vol.90 , pp. 566-571
    • Stone, P.J.1    Goodheart, M.J.2    Rose, S.L.3    Smith, B.J.4    DeYoung, B.R.5    Buller, R.E.6
  • 23
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • doi:10.1038/nrc909
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer (2002) 2:795-803. doi:10.1038/nrc909
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 24
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • doi:10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol (2005) 23:1011-27. doi:10.1200/JCO.2005.06.081
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 25
    • 34447499062 scopus 로고    scopus 로고
    • Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition
    • doi:10.1200/JCO.2007.11.1088
    • Martin L, Schilder R. Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition. J Clin Oncol (2007) 25:2894-901. doi:10.1200/JCO.2007.11.1088
    • (2007) J Clin Oncol , vol.25 , pp. 2894-2901
    • Martin, L.1    Schilder, R.2
  • 26
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res (2003) 9:5721-8.
    • (2003) Clin Cancer Res , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6
  • 27
    • 69849111795 scopus 로고    scopus 로고
    • Aflibercept in epithelial ovarian carcinoma
    • doi:10.2217/fon.09.35
    • Moroney JW, Sood AK, Coleman RL. Aflibercept in epithelial ovarian carcinoma. Future Oncol (2009) 5:591-600. doi:10.2217/fon.09.35
    • (2009) Future Oncol , vol.5 , pp. 591-600
    • Moroney, J.W.1    Sood, A.K.2    Coleman, R.L.3
  • 28
    • 84892928754 scopus 로고    scopus 로고
    • Intravenous aflibercept in patients with platinum-resistant, advanced ovarian cancer: results of a randomized, double-blind, Phase 2, parallel-arm study
    • doi:10.1002/cncr.28406
    • Tew WP, Colombo N, Ray-Coquard I, Del Campo JM, Oza A, Pereira D, et al. Intravenous aflibercept in patients with platinum-resistant, advanced ovarian cancer: results of a randomized, double-blind, Phase 2, parallel-arm study. Cancer (2014) 120:335-43. doi:10.1002/cncr.28406
    • (2014) Cancer , vol.120 , pp. 335-343
    • Tew, W.P.1    Colombo, N.2    Ray-Coquard, I.3    Del Campo, J.M.4    Oza, A.5    Pereira, D.6
  • 29
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study
    • doi:10.1200/JCO.2007.11.5345
    • Burger RA, Sill MW, Monk BJ, Greer BE, Sorosky JI. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol (2007) 25:5165-71. doi:10.1200/JCO.2007.11.5345
    • (2007) J Clin Oncol , vol.25 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 30
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • doi:10.1200/JCO.2007.12.0782
    • Cannistra SA, Matulonis UA, Penson RT, Hambleton J, Dupont J, Mackey H, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol (2007) 25:5180-6. doi:10.1200/JCO.2007.12.0782
    • (2007) J Clin Oncol , vol.25
    • Cannistra, S.A.1    Matulonis, U.A.2    Penson, R.T.3    Hambleton, J.4    Dupont, J.5    Mackey, H.6
  • 31
    • 84866493383 scopus 로고    scopus 로고
    • AURELIA: a randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC)
    • abstr LBA5002
    • Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, et al. AURELIA: a randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC). J Clin Oncol (2012) 30(Suppl):abstr LBA5002.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3    Reuss, A.4    Poveda, A.5    Kristensen, G.6
  • 32
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • doi:10.1200/JCO.2012.42.0505
    • Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol (2012) 30:2039-45. doi:10.1200/JCO.2012.42.0505
    • (2012) J Clin Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3    Judson, P.L.4    Teneriello, M.G.5    Husain, A.6
  • 33
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • doi:10.1158/0008-5472.CAN-04-1443
    • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res (2004) 64:7099-109. doi:10.1158/0008-5472.CAN-04-1443
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 34
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial
    • doi:10 1200/JCO. 2009. 26. 7856
    • Matei D, Sill MW, Lankes HA, DeGeest K, Bristow RE, Mutch D, et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial. J Clin Oncol (2011) 29:69-75. doi:10.1200/JCO.2009.26.7856
    • (2011) J Clin Oncol , vol.29 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3    DeGeest, K.4    Bristow, R.E.5    Mutch, D.6
  • 35
    • 79952818552 scopus 로고    scopus 로고
    • Overview of anti-angiogenic agents in development for ovarian cancer
    • doi:10.1016/j.ygyno.2010.11.035
    • Burger RA. Overview of anti-angiogenic agents in development for ovarian cancer. Gynecol Oncol (2011) 121:230-8. doi:10.1016/j.ygyno.2010.11.035
    • (2011) Gynecol Oncol , vol.121 , pp. 230-238
    • Burger, R.A.1
  • 36
    • 81155151896 scopus 로고    scopus 로고
    • Anti-angiogenic agents in ovarian cancer: dawn of a new era?
    • doi:10.1007/s11912-011-0194-8
    • Liu J, Matulonis UA. Anti-angiogenic agents in ovarian cancer: dawn of a new era? Curr Oncol Rep (2011) 13:450-8. doi:10.1007/s11912-011-0194-8
    • (2011) Curr Oncol Rep , vol.13 , pp. 450-458
    • Liu, J.1    Matulonis, U.A.2
  • 37
    • 84869407359 scopus 로고    scopus 로고
    • Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies
    • doi:10.1200/JCO.2012.41.9242
    • Bottsford-Miller JN, Coleman RL, Sood AK. Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol (2012) 30:4026-34. doi:10.1200/JCO.2012.41.9242
    • (2012) J Clin Oncol , vol.30 , pp. 4026-4034
    • Bottsford-Miller, J.N.1    Coleman, R.L.2    Sood, A.K.3
  • 38
    • 0141892161 scopus 로고    scopus 로고
    • Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions
    • doi:10.1002/path.1430
    • Manabe Y, Toda S, Miyazaki K, Sugihara H. Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol (2003) 201:221-8. doi:10.1002/path.1430
    • (2003) J Pathol , vol.201 , pp. 221-228
    • Manabe, Y.1    Toda, S.2    Miyazaki, K.3    Sugihara, H.4
  • 39
    • 0142149063 scopus 로고    scopus 로고
    • Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase
    • doi:10.1074/jbc.M304984200
    • Onuma M, Bub JD, Rummel TL, Iwamoto Y. Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase. J Biol Chem (2003) 278:42660-7. doi:10.1074/jbc.M304984200
    • (2003) J Biol Chem , vol.278 , pp. 42660-42667
    • Onuma, M.1    Bub, J.D.2    Rummel, T.L.3    Iwamoto, Y.4
  • 41
    • 84873692225 scopus 로고    scopus 로고
    • Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways
    • doi:10.3892/ijo.2013.1789
    • Chen C, Chang YC, Lan MS, Breslin M. Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways. Int J Oncol (2013) 42:1113-9. doi:10.3892/ijo.2013.1789
    • (2013) Int J Oncol , vol.42 , pp. 1113-1119
    • Chen, C.1    Chang, Y.C.2    Lan, M.S.3    Breslin, M.4
  • 42
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • doi:10.1038/nm.2492
    • Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 17:1498-503. doi:10.1038/nm.2492
    • (2011) Nat Med , vol.17 , pp. 1498-1503
    • Nieman, K.M.1    Kenny, H.A.2    Penicka, C.V.3    Ladanyi, A.4    Buell-Gutbrod, R.5    Zillhardt, M.R.6
  • 43
    • 84877065511 scopus 로고    scopus 로고
    • Fibroblasts as architects of cancer pathogenesis
    • doi:10.1016/j.bbadis.2012.10.013
    • Marsh T, Pietras K, McAllister SS. Fibroblasts as architects of cancer pathogenesis. Biochim Biophys Acta (2013) 1832:1070-8. doi:10.1016/j.bbadis.2012.10.013
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1070-1078
    • Marsh, T.1    Pietras, K.2    McAllister, S.S.3
  • 44
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • doi:10.1158/0008-5472.CAN-07-3127
    • Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res (2007) 67:10123-8. doi:10.1158/0008-5472.CAN-07-3127
    • (2007) Cancer Res , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 45
    • 0037331707 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
    • doi:10. 1016/S0002-9440(10)63834-5
    • Petersen OW, Nielsen HL, Gudjonsson T, Villadsen R, Rank F, Niebuhr E, et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol (2003) 162:391-402. doi:10.1016/S0002-9440(10)63834-5
    • (2003) Am J Pathol , vol.162 , pp. 391-402
    • Petersen, O.W.1    Nielsen, H.L.2    Gudjonsson, T.3    Villadsen, R.4    Rank, F.5    Niebuhr, E.6
  • 46
    • 84867163385 scopus 로고    scopus 로고
    • HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts
    • doi:10.1172/JCI62229
    • Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, et al. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest (2012) 122:3603-17. doi:10.1172/JCI62229
    • (2012) J Clin Invest , vol.122 , pp. 3603-3617
    • Ko, S.Y.1    Barengo, N.2    Ladanyi, A.3    Lee, J.S.4    Marini, F.5    Lengyel, E.6
  • 47
    • 78650563018 scopus 로고    scopus 로고
    • Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    • doi:10.1073/pnas.1013805107
    • Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA (2010) 107:20009-14. doi:10.1073/pnas.1013805107
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 20009-20014
    • Kojima, Y.1    Acar, A.2    Eaton, E.N.3    Mellody, K.T.4    Scheel, C.5    Ben-Porath, I.6
  • 48
    • 84871528926 scopus 로고    scopus 로고
    • MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
    • doi:10.1158/2159-8290.CD-12-0206
    • Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov (2012) 2:1100-8. doi:10.1158/2159-8290.CD-12-0206
    • (2012) Cancer Discov , vol.2 , pp. 1100-1108
    • Mitra, A.K.1    Zillhardt, M.2    Hua, Y.3    Tiwari, P.4    Murmann, A.E.5    Peter, M.E.6
  • 49
    • 9244236047 scopus 로고    scopus 로고
    • Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
    • doi:10.1158/0008-5472.CAN-04-1708
    • Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, et al. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res (2004) 64:8492-5. doi:10.1158/0008-5472.CAN-04-1708
    • (2004) Cancer Res , vol.64 , pp. 8492-8495
    • Direkze, N.C.1    Hodivala-Dilke, K.2    Jeffery, R.3    Hunt, T.4    Poulsom, R.5    Oukrif, D.6
  • 50
    • 64549145804 scopus 로고    scopus 로고
    • Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression
    • doi:10.1371/journal.pone.0004992
    • Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, et al. Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One (2009) 4:e4992. doi:10.1371/journal.pone.0004992
    • (2009) PLoS One , vol.4
    • Spaeth, E.L.1    Dembinski, J.L.2    Sasser, A.K.3    Watson, K.4    Klopp, A.5    Hall, B.6
  • 51
    • 79751501829 scopus 로고    scopus 로고
    • Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth
    • doi:10.1016/j.ccr.2011.01.020
    • Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell (2011) 19:257-72. doi:10.1016/j.ccr.2011.01.020
    • (2011) Cancer Cell , vol.19 , pp. 257-272
    • Quante, M.1    Tu, S.P.2    Tomita, H.3    Gonda, T.4    Wang, S.S.5    Takashi, S.6
  • 52
    • 18744373595 scopus 로고    scopus 로고
    • Human adipose tissue is a source of multipotent stem cells
    • doi:10.1091/mbc.E02-02-0105
    • Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell (2002) 13:4279-95. doi:10.1091/mbc.E02-02-0105
    • (2002) Mol Biol Cell , vol.13 , pp. 4279-4295
    • Zuk, P.A.1    Zhu, M.2    Ashjian, P.3    De Ugarte, D.A.4    Huang, J.I.5    Mizuno, H.6
  • 53
    • 43049148411 scopus 로고    scopus 로고
    • Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells
    • doi:10.1634/stemcells.2007-0742
    • Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, Cho M, et al. Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells. Stem Cells (2008) 26:789-97. doi:10.1634/stemcells.2007-0742
    • (2008) Stem Cells , vol.26 , pp. 789-797
    • Jeon, E.S.1    Moon, H.J.2    Lee, M.J.3    Song, H.Y.4    Kim, Y.M.5    Cho, M.6
  • 54
    • 79951852902 scopus 로고    scopus 로고
    • Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion
    • doi:10.1016/j.canlet.2011.01.011
    • Zhang Y, Tang H, Cai J, Zhang T, Guo J, Feng D, et al. Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion. Cancer Lett (2011) 303:47-55. doi:10.1016/j.canlet.2011.01.011
    • (2011) Cancer Lett , vol.303 , pp. 47-55
    • Zhang, Y.1    Tang, H.2    Cai, J.3    Zhang, T.4    Guo, J.5    Feng, D.6
  • 55
    • 79961006281 scopus 로고    scopus 로고
    • Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production
    • doi:10.1172/JCI45273
    • McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, et al. Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest (2011) 121:3206-19. doi:10.1172/JCI45273
    • (2011) J Clin Invest , vol.121 , pp. 3206-3219
    • McLean, K.1    Gong, Y.2    Choi, Y.3    Deng, N.4    Yang, K.5    Bai, S.6
  • 56
    • 71449100603 scopus 로고    scopus 로고
    • Strategies for TGF-beta modulation: a review of recent patents
    • doi:10.1517/13543770903397400
    • Bonafoux D, Lee WC. Strategies for TGF-beta modulation: a review of recent patents. Expert Opin Ther Pat (2009) 19:1759-69. doi:10.1517/13543770903397400
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1759-1769
    • Bonafoux, D.1    Lee, W.C.2
  • 57
    • 84866029510 scopus 로고    scopus 로고
    • Complexities of TGF-β targeted cancer therapy
    • doi:10.7150/ijbs.4564
    • Connolly EC, Freimuth J, Akhurst RJ. Complexities of TGF-β targeted cancer therapy. Int J Biol Sci (2012) 8:964-78. doi:10.7150/ijbs.4564
    • (2012) Int J Biol Sci , vol.8 , pp. 964-978
    • Connolly, E.C.1    Freimuth, J.2    Akhurst, R.J.3
  • 58
    • 84855393328 scopus 로고    scopus 로고
    • Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness
    • doi:10.1093/carcin/bgr230
    • Cai J, Tang H, Xu L, Wang X, Yang C, Ruan S, et al. Fibroblasts in omentum activated by tumor cells promote ovarian cancer growth, adhesion and invasiveness. Carcinogenesis (2012) 33:20-9. doi:10.1093/carcin/bgr230
    • (2012) Carcinogenesis , vol.33 , pp. 20-29
    • Cai, J.1    Tang, H.2    Xu, L.3    Wang, X.4    Yang, C.5    Ruan, S.6
  • 59
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • doi:10.1172/JCI38988
    • Santos AM, Jung J, Aziz N, Kissil JL, Puré E. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest (2009) 119:3613-25. doi:10.1172/JCI38988
    • (2009) J Clin Invest , vol.119 , pp. 3613-3625
    • Santos, A.M.1    Jung, J.2    Aziz, N.3    Kissil, J.L.4    Puré, E.5
  • 60
    • 0037219532 scopus 로고    scopus 로고
    • Stromal antigen targeting by a humanized monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer
    • doi:10.1159/000069863
    • Hofheinz RD, al-Batran SE, Hartmann F, Hartung G, Jäger D, Renner C, et al. Stromal antigen targeting by a humanized monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Onkologie (2003) 26:44-8. doi:10.1159/000069863
    • (2003) Onkologie , vol.26 , pp. 44-48
    • Hofheinz, R.D.1    al-Batran, S.E.2    Hartmann, F.3    Hartung, G.4    Jäger, D.5    Renner, C.6
  • 61
    • 84866096019 scopus 로고    scopus 로고
    • Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug
    • doi:10.1093/jnci/djs336
    • Brennen WN, Rosen DM, Wang H, Isaacs JT, Denmeade SR. Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug. J Natl Cancer Inst (2012) 104:1320-34. doi:10.1093/jnci/djs336
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1320-1334
    • Brennen, W.N.1    Rosen, D.M.2    Wang, H.3    Isaacs, J.T.4    Denmeade, S.R.5
  • 62
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • doi:10. 1016/S1471-4906(02)02302-5
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 23:549-55. doi:10.1016/S1471-4906(02)02302-5
    • (2002) Trends Immunol , vol.23 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 63
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • doi:10.1189/jlb.0609385
    • Solinas G, Germano G, Mantovani A, Allavena P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol (2009) 86:1065-73. doi:10.1189/jlb.0609385
    • (2009) J Leukoc Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 64
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumor progression and metastasis
    • doi:10.1038/nrc1256
    • Pollard JW. Tumour-educated macrophages promote tumor progression and metastasis. Nat Rev Cancer (2004) 4:71-8. doi:10.1038/nrc1256
    • (2004) Nat Rev Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 65
    • 0028960487 scopus 로고
    • The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer
    • doi:10.1172/JCI117933
    • Negus RP, Stamp GW, Relf MG, Burke F, Malik ST, Bernasconi S, et al. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J Clin Invest (1995) 95:2391-6. doi:10.1172/JCI117933
    • (1995) J Clin Invest , vol.95 , pp. 2391-2396
    • Negus, R.P.1    Stamp, G.W.2    Relf, M.G.3    Burke, F.4    Malik, S.T.5    Bernasconi, S.6
  • 66
    • 0030953238 scopus 로고    scopus 로고
    • Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1
    • Chambers SK, Kacinski BM, Ivins CM, Carcangiu ML. Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: a poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1. Clin Cancer Res (1997) 3:999-1007.
    • (1997) Clin Cancer Res , vol.3 , pp. 999-1007
    • Chambers, S.K.1    Kacinski, B.M.2    Ivins, C.M.3    Carcangiu, M.L.4
  • 67
    • 39649120597 scopus 로고    scopus 로고
    • Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
    • doi:10.1182/blood-2007-02-072587
    • Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood (2007) 110:4319-30. doi:10.1182/blood-2007-02-072587
    • (2007) Blood , vol.110 , pp. 4319-4330
    • Duluc, D.1    Delneste, Y.2    Tan, F.3    Moles, M.P.4    Grimaud, L.5    Lenoir, J.6
  • 68
    • 77957028841 scopus 로고    scopus 로고
    • Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation
    • doi:10.1111/j.1349-7006.2010.01652.x
    • Takaishi K, Komohara Y, Tashiro H, Ohtake H, Nakagawa T, Katabuchi H, et al. Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation. Cancer Sci (2010) 101:2128-36. doi:10.1111/j.1349-7006.2010.01652.x
    • (2010) Cancer Sci , vol.101 , pp. 2128-2136
    • Takaishi, K.1    Komohara, Y.2    Tashiro, H.3    Ohtake, H.4    Nakagawa, T.5    Katabuchi, H.6
  • 69
    • 84890357888 scopus 로고    scopus 로고
    • Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype
    • doi:10.1016/j.ajpath.2013.09.017
    • Ko SY, Ladanyi A, Lengyel E, Naora H. Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype. Am J Pathol (2014) 184:271-81. doi:10.1016/j.ajpath.2013.09.017
    • (2014) Am J Pathol , vol.184 , pp. 271-281
    • Ko, S.Y.1    Ladanyi, A.2    Lengyel, E.3    Naora, H.4
  • 70
    • 0027246256 scopus 로고
    • Secretion of epidermal growth factor by macrophages associated with breast carcinoma
    • doi:10. 1016/0140-6736(93)91348-P
    • O'Sullivan C, Lewis CE, Harris AL, McGee JO. Secretion of epidermal growth factor by macrophages associated with breast carcinoma. Lancet (1993) 342:148-9. doi:10.1016/0140-6736(93)91348-P
    • (1993) Lancet , vol.342 , pp. 148-149
    • O'Sullivan, C.1    Lewis, C.E.2    Harris, A.L.3    McGee, J.O.4
  • 71
    • 0005339099 scopus 로고    scopus 로고
    • Tumor-associated macrophages in breast cancer
    • doi:10.1023/A:1020304003704
    • Leek RD, Harris AL. Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia (2002) 7:177-89. doi:10.1023/A:1020304003704
    • (2002) J Mammary Gland Biol Neoplasia , vol.7 , pp. 177-189
    • Leek, R.D.1    Harris, A.L.2
  • 72
    • 18544378009 scopus 로고    scopus 로고
    • Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma
    • doi:10.1074/jbc.M112275200
    • Schutyser E, Struyf S, Proost P, Opdenakker G, Laureys G, Verhasselt B, et al. Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. J Biol Chem (2002) 277:24584-93. doi:10.1074/jbc.M112275200
    • (2002) J Biol Chem , vol.277 , pp. 24584-24593
    • Schutyser, E.1    Struyf, S.2    Proost, P.3    Opdenakker, G.4    Laureys, G.5    Verhasselt, B.6
  • 73
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • doi:10.1038/nm1093
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 10:942-9. doi:10.1038/nm1093
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 74
    • 37649015079 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
    • doi:10.1073/pnas.0706832104
    • Tiemessen MM, Jagger AL, Evans HG, van Herwijnen MJ, John S, Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci U S A (2007) 104:19446-51. doi:10.1073/pnas.0706832104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19446-19451
    • Tiemessen, M.M.1    Jagger, A.L.2    Evans, H.G.3    van Herwijnen, M.J.4    John, S.5    Taams, L.S.6
  • 75
    • 45149134605 scopus 로고    scopus 로고
    • Re-educating tumor-associated macrophages by targeting NF-kappaB
    • doi:10.1084/jem.20080108
    • Hagemann T, Lawrence T, McNeish I, Charles KA, Kulbe H, Thompson RG, et al. "Re-educating" tumor-associated macrophages by targeting NF-kappaB. J Exp Med (2008) 205:1261-8. doi:10.1084/jem.20080108
    • (2008) J Exp Med , vol.205 , pp. 1261-1268
    • Hagemann, T.1    Lawrence, T.2    McNeish, I.3    Charles, K.A.4    Kulbe, H.5    Thompson, R.G.6
  • 76
    • 35148852659 scopus 로고    scopus 로고
    • Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo
    • doi:10.1158/0008-5472.CAN-07-1286
    • Loberg RD, Ying C, Craig M, Day LL, Sargent E, Neeley C, et al. Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res (2007) 67:9417-24. doi:10.1158/0008-5472.CAN-07-1286
    • (2007) Cancer Res , vol.67 , pp. 9417-9424
    • Loberg, R.D.1    Ying, C.2    Craig, M.3    Day, L.L.4    Sargent, E.5    Neeley, C.6
  • 77
    • 20144388299 scopus 로고    scopus 로고
    • Anti-inflammatory properties of the novel antitumor agent Yondelis (Trabectedin): inhibition of macrophage differentiation and cytokine production
    • doi:10.1158/0008-5472.CAN-04-4037
    • Allavena P, Signorelli M, Chieppa M, Erba E, Bianchi G, Marchesi F, et al. Anti-inflammatory properties of the novel antitumor agent Yondelis (Trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res (2005) 65:2964-71. doi:10.1158/0008-5472.CAN-04-4037
    • (2005) Cancer Res , vol.65 , pp. 2964-2971
    • Allavena, P.1    Signorelli, M.2    Chieppa, M.3    Erba, E.4    Bianchi, G.5    Marchesi, F.6
  • 78
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • doi:10.1016/j.ccr.2013.01.008
    • Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell (2013) 23:249-62. doi:10.1016/j.ccr.2013.01.008
    • (2013) Cancer Cell , vol.23 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3    Anselmo, A.4    Pesce, S.5    Liguori, M.6
  • 79
    • 77955491837 scopus 로고    scopus 로고
    • Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer
    • doi:10.1200/JCO.2009.25.4037
    • Monk BJ, Herzog TJ, Kaye SB, Krasner CN, Vermorken JB, Muggia FM, et al. Trabectedin plus pegylated liposomal doxorubicin in recurrent ovarian cancer. J Clin Oncol (2010) 28:3107-14. doi:10.1200/JCO.2009.25.4037
    • (2010) J Clin Oncol , vol.28 , pp. 3107-3114
    • Monk, B.J.1    Herzog, T.J.2    Kaye, S.B.3    Krasner, C.N.4    Vermorken, J.B.5    Muggia, F.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.