-
1
-
-
0042023711
-
Alzheimer disease in the US population: Prevalence estimates using the 2000 census
-
[1] Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003; 60(8): 1119-22.
-
(2003)
Arch Neurol
, vol.60
, Issue.8
, pp. 1119-1122
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
-
2
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
[2] Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging 2000; 21(3): 383-421.
-
(2000)
Neurobiol Aging
, vol.21
, Issue.3
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
-
3
-
-
33847613885
-
Inflammatory processes in Alzheimer's disease
-
[3] Heneka MT, O'Banion MK. Inflammatory processes in Alzheimer's disease. J Neuroimmunol 2007; 184(1-2): 69-91.
-
(2007)
J Neuroimmunol
, vol.184
, Issue.1-2
, pp. 69-91
-
-
Heneka, M.T.1
O'banion, M.K.2
-
4
-
-
84865529158
-
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
-
[4] Bateman RJ, Xiong C, Benzinger TL, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 2012; 367(9): 795-804.
-
(2012)
N Engl J Med
, vol.367
, Issue.9
, pp. 795-804
-
-
Bateman, R.J.1
Xiong, C.2
Benzinger, T.L.3
-
5
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
[5] Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7(3): 280-92.
-
(2011)
Alzheimers Dement
, vol.7
, Issue.3
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
-
6
-
-
79955464911
-
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
-
[6] Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011; 43(5): 436-41.
-
(2011)
Nat Genet
, vol.43
, Issue.5
, pp. 436-441
-
-
Naj, A.C.1
Jun, G.2
Beecham, G.W.3
-
7
-
-
55049142500
-
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
-
[7] Bertram L, Lange C, Mullin K, et al. Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet 2008; 83(5): 623-32.
-
(2008)
Am J Hum Genet
, vol.83
, Issue.5
, pp. 623-632
-
-
Bertram, L.1
Lange, C.2
Mullin, K.3
-
8
-
-
79955484414
-
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
-
[8] Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011; 43(5): 429-35.
-
(2011)
Nat Genet
, vol.43
, Issue.5
, pp. 429-435
-
-
Hollingworth, P.1
Harold, D.2
Sims, R.3
-
9
-
-
84872057940
-
TREM2 variants in Alzheimer's disease
-
[9] Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in Alzheimer's disease. N Engl J Med 2013; 368(2): 117-27.
-
(2013)
N Engl J Med
, vol.368
, Issue.2
, pp. 117-127
-
-
Guerreiro, R.1
Wojtas, A.2
Bras, J.3
-
10
-
-
84872088087
-
Variant of TREM2 associated with the risk of Alzheimer's disease
-
[10] Jonsson T, Stefansson H, Steinberg S, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013; 368(2): 107-16.
-
(2013)
N Engl J Med
, vol.368
, Issue.2
, pp. 107-116
-
-
Jonsson, T.1
Stefansson, H.2
Steinberg, S.3
-
11
-
-
84878433339
-
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
[11] Griciuc A, Serrano-Pozo A, Parrado AR, et al. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013; 78(4): 631-43.
-
(2013)
Neuron
, vol.78
, Issue.4
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozo, A.2
Parrado, A.R.3
-
12
-
-
84881503738
-
CD33 Alzheimer's riskaltering polymorphism, CD33 expression, and exon 2 splicing
-
[12] Malik M, Simpson JF, Parikh I, et al. CD33 Alzheimer's riskaltering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci 2013; 33(33): 13320-5.
-
(2013)
J Neurosci
, vol.33
, Issue.33
, pp. 13320-13325
-
-
Malik, M.1
Simpson, J.F.2
Parikh, I.3
-
13
-
-
84904479732
-
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
-
243ra86
-
[13] Kleinberger G, Yamanishi Y, Suarez-Calvet M, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med 2014; 6(243): 243ra86.
-
(2014)
Sci Transl Med
, vol.6
, Issue.243
-
-
Kleinberger, G.1
Yamanishi, Y.2
Suarez-Calvet, M.3
-
14
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
[14] Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013; 45(12): 1452-8.
-
(2013)
Nat Genet
, vol.45
, Issue.12
, pp. 1452-1458
-
-
Lambert, J.C.1
Ibrahim-Verbaas, C.A.2
Harold, D.3
-
15
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
-
[15] Lambert JC, Heath S, Even G, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 2009; 41(10): 1094-9.
-
(2009)
Nat Genet
, vol.41
, Issue.10
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
-
16
-
-
78149360132
-
Fate mapping analysis reveals that adult microglia derive from primitive macrophages
-
[16] Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010; 330(6005): 841-5.
-
(2010)
Science
, vol.330
, Issue.6005
, pp. 841-845
-
-
Ginhoux, F.1
Greter, M.2
Leboeuf, M.3
-
17
-
-
78149435065
-
The myeloid cells of the central nervous system parenchyma
-
[17] Ransohoff RM and Cardona AE. The myeloid cells of the central nervous system parenchyma. Nature 2010; 468(7321): 253-62.
-
(2010)
Nature
, vol.468
, Issue.7321
, pp. 253-262
-
-
Ransohoff, R.M.1
Cardona, A.E.2
-
18
-
-
84893745524
-
Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
-
[18] Butovsky O, Jedrychowski MP, Moore CS, et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat Neurosci 2014; 17(1): 131-43.
-
(2014)
Nat Neurosci
, vol.17
, Issue.1
, pp. 131-143
-
-
Butovsky, O.1
Jedrychowski, M.P.2
Moore, C.S.3
-
19
-
-
84888324248
-
The microglial sensome revealed by direct RNA sequencing
-
[19] Hickman SE, Kingery ND, Ohsumi TK, et al. The microglial sensome revealed by direct RNA sequencing. Nat Neurosci 2013; 16(12): 1896-905.
-
(2013)
Nat Neurosci
, vol.16
, Issue.12
, pp. 1896-1905
-
-
Hickman, S.E.1
Kingery, N.D.2
Ohsumi, T.K.3
-
20
-
-
84867740805
-
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
-
[20] Gautier EL, Shay T, Miller J, et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol 2012; 13(11): 1118-28.
-
(2012)
Nat Immunol
, vol.13
, Issue.11
, pp. 1118-1128
-
-
Gautier, E.L.1
Shay, T.2
Miller, J.3
-
21
-
-
80052633284
-
Synaptic pruning by microglia is necessary for normal brain development
-
[21] Paolicelli RC, Bolasco G, Pagani F, et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011; 333(6048): 1456-8.
-
(2011)
Science
, vol.333
, Issue.6048
, pp. 1456-1458
-
-
Paolicelli, R.C.1
Bolasco, G.2
Pagani, F.3
-
22
-
-
84896692474
-
Deficient neuronmicroglia signaling results in impaired functional brain connectivity and social behavior
-
[22] Zhan Y, Paolicelli RC, Sforazzini F, et al. Deficient neuronmicroglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci 2014; 17(3): 400-6.
-
(2014)
Nat Neurosci
, vol.17
, Issue.3
, pp. 400-406
-
-
Zhan, Y.1
Paolicelli, R.C.2
Sforazzini, F.3
-
23
-
-
84861427387
-
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
-
[23] Schafer DP, Lehrman EK, Kautzman AG, et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 2012; 74(4): 691-705.
-
(2012)
Neuron
, vol.74
, Issue.4
, pp. 691-705
-
-
Schafer, D.P.1
Lehrman, E.K.2
Kautzman, A.G.3
-
24
-
-
36849076770
-
The classical complement cascade mediates CNS synapse elimination
-
[24] Stevens B, Allen NJ, Vazquez LE, et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007; 131(6): 1164-78.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1164-1178
-
-
Stevens, B.1
Allen, N.J.2
Vazquez, L.E.3
-
25
-
-
84872176512
-
Microglia: New roles for the synaptic stripper
-
[25] Kettenmann H, Kirchhoff F, Verkhratsky A. Microglia: new roles for the synaptic stripper. Neuron 2013; 77(1): 10-8.
-
(2013)
Neuron
, vol.77
, Issue.1
, pp. 10-18
-
-
Kettenmann, H.1
Kirchhoff, F.2
Verkhratsky, A.3
-
26
-
-
3242803587
-
Nonsteroidal antiinflammatory drugs for the prevention of Alzheimer's disease: A systematic review
-
[26] Szekely CA, Thorne JE, Zandi PP, et al. Nonsteroidal antiinflammatory drugs for the prevention of Alzheimer's disease: a systematic review. Neuroepidemiology 2004; 23(4): 159-69.
-
(2004)
Neuroepidemiology
, vol.23
, Issue.4
, pp. 159-169
-
-
Szekely, C.A.1
Thorne, J.E.2
Zandi, P.P.3
-
28
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
[28] Veld BA, Ruitenberg A, Hofman A, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001; 345(21): 1515-21.
-
(2001)
N Engl J Med
, vol.345
, Issue.21
, pp. 1515-1521
-
-
Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
-
29
-
-
0029811901
-
Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
-
[29] McGeer PL, Schulzer M, and McGeer EG. Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 1996; 47(2): 425-32.
-
(1996)
Neurology
, vol.47
, Issue.2
, pp. 425-432
-
-
McGeer, P.L.1
Schulzer, M.2
McGeer, E.G.3
-
30
-
-
43149102747
-
Protective effects of NSAIDs on the development of Alzheimer disease
-
[30] Vlad SC, Miller DR, Kowall NW, et al. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 2008; 70(19): 1672-7.
-
(2008)
Neurology
, vol.70
, Issue.19
, pp. 1672-1677
-
-
Vlad, S.C.1
Miller, D.R.2
Kowall, N.W.3
-
31
-
-
79960769591
-
Extended results of the Alzheimer's disease anti-inflammatory prevention trial
-
[31] Breitner JC, Baker LD, Montine TJ, et al. Extended results of the Alzheimer's disease anti-inflammatory prevention trial. Alzheimers Dement 2011; 7(4): 402-11.
-
(2011)
Alzheimers Dement
, vol.7
, Issue.4
, pp. 402-411
-
-
Breitner, J.C.1
Baker, L.D.2
Montine, T.J.3
-
32
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial
-
[32] Aisen PS, Schafer KA, Grundman M, et al. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. Jama 2003; 289(21): 2819-26.
-
(2003)
Jama
, vol.289
, Issue.21
, pp. 2819-2826
-
-
Aisen, P.S.1
Schafer, K.A.2
Grundman, M.3
-
33
-
-
33845803191
-
Long-term efficacy and safety of celecoxib in Alzheimer's disease
-
[33] Soininen H, West C, Robbins J, et al. Long-term efficacy and safety of celecoxib in Alzheimer's disease. Dement Geriatr Cogn Disord 2007; 23(1): 8-21.
-
(2007)
Dement Geriatr Cogn Disord
, vol.23
, Issue.1
, pp. 8-21
-
-
Soininen, H.1
West, C.2
Robbins, J.3
-
34
-
-
21144447586
-
A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment
-
[34] Thal LJ, Ferris SH, Kirby L, et al. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 2005; 30(6): 1204-15.
-
(2005)
Neuropsychopharmacology
, vol.30
, Issue.6
, pp. 1204-1215
-
-
Thal, L.J.1
Ferris, S.H.2
Kirby, L.3
-
35
-
-
34249058674
-
Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
-
[35] Lyketsos CG, Breitner JC, Green RC, et al. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology 2007; 68(21): 1800-8.
-
(2007)
Neurology
, vol.68
, Issue.21
, pp. 1800-1808
-
-
Lyketsos, C.G.1
Breitner, J.C.2
Green, R.C.3
-
36
-
-
47549107705
-
Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
-
[36] Martin BK, Szekely C, Brandt J, et al. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 2008; 65(7): 896-905.
-
(2008)
Arch Neurol
, vol.65
, Issue.7
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
Brandt, J.3
-
37
-
-
77949540912
-
Emerging roles of PGE2 receptors in models of neurological disease
-
[37] Andreasson K. Emerging roles of PGE2 receptors in models of neurological disease. Prostaglandins Other Lipid Mediat 2010; 91(3-4): 104-12.
-
(2010)
Prostaglandins Other Lipid Mediat
, vol.91
, Issue.3-4
, pp. 104-112
-
-
Reasson, K.1
-
38
-
-
10344267004
-
COX-2-derived prostacyclin confers atheroprotection on female mice
-
[38] Egan KM, Lawson JA, Fries S, et al. COX-2-derived prostacyclin confers atheroprotection on female mice. Science 2004; 306(5703): 1954-7.
-
(2004)
Science
, vol.306
, Issue.5703
, pp. 1954-1957
-
-
Egan, K.M.1
Lawson, J.A.2
Fries, S.3
-
39
-
-
36348932768
-
COX-2 inhibitors and cardiovascular risk
-
[39] Funk CD, FitzGerald GA. COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol 2007; 50(5): 470-9.
-
(2007)
J Cardiovasc Pharmacol
, vol.50
, Issue.5
, pp. 470-479
-
-
Funk, C.D.1
Fitzgerald, G.A.2
-
40
-
-
80555136833
-
Neuronal and vascular protection by the prostaglandin E2 EP4 receptor in a mouse model of cerebral ischemia
-
[40] Liang X, Lin L, Wang Q, et al. Neuronal and vascular protection by the prostaglandin E2 EP4 receptor in a mouse model of cerebral ischemia. J Clin Invest 2011; 121(11): 4362-71.
-
(2011)
J Clin Invest
, vol.121
, Issue.11
, pp. 4362-4371
-
-
Liang, X.1
Lin, L.2
Wang, Q.3
-
41
-
-
77953638394
-
The prostaglandin E2 Eprostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity
-
[41] Shi J, Johansson J, Woodling NS, et al. The prostaglandin E2 Eprostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J Immunol 2010; 184(12): 7207-18.
-
(2010)
J Immunol
, vol.184
, Issue.12
, pp. 7207-7218
-
-
Shi, J.1
Johansson, J.2
Woodling, N.S.3
-
42
-
-
84899490472
-
Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling
-
[42] Woodling NS, Wang Q, Priyam PG, et al. Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling. J Neurosci 2014; 34(17): 5882-94.
-
(2014)
J Neurosci
, vol.34
, Issue.17
, pp. 5882-5894
-
-
Woodling, N.S.1
Wang, Q.2
Priyam, P.G.3
-
43
-
-
80052254013
-
Effects of nonsteroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: Findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial
-
[43] Leoutsakos JM, Muthen BO, Breitner JC, et al. Effects of nonsteroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial. Int J Geriatr Psychiatry 2011.
-
(2011)
Int J Geriatr Psychiatry
-
-
Leoutsakos, J.M.1
Muthen, B.O.2
Breitner, J.C.3
-
45
-
-
0032740467
-
Elevated CSF prostaglandin E2 levels in patients with probable AD
-
[45] Montine TJ, Sidell KR, Crews BC, et al. Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 1999; 53(7): 1495-8.
-
(1999)
Neurology
, vol.53
, Issue.7
, pp. 1495-1498
-
-
Montine, T.J.1
Sidell, K.R.2
Crews, B.C.3
-
46
-
-
29644438245
-
Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease
-
[46] Combrinck M, Williams J, De Berardinis MA, et al. Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006; 77(1): 85-8.
-
(2006)
J Neurol Neurosurg Psychiatry
, vol.77
, Issue.1
, pp. 85-88
-
-
Combrinck, M.1
Williams, J.2
De Berardinis, M.A.3
-
47
-
-
84884929175
-
Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia
-
[47] Johansson JU, Pradhan, S, Lokteva LA, et al. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. J Neurosci 2013; 33: 16012-32.
-
(2013)
J Neurosci
, vol.33
, pp. 16012-16032
-
-
Johansson, J.U.1
Pradhan, S.2
Lokteva, L.A.3
-
48
-
-
4444274138
-
Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum
-
[48] Slawik H, Volk B, Fiebich B, et al. Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochem Int 2004; 45(5): 653-60.
-
(2004)
Neurochem Int
, vol.45
, Issue.5
, pp. 653-660
-
-
Slawik, H.1
Volk, B.2
Fiebich, B.3
-
49
-
-
84880759156
-
Neurotoxicity of Amyloid beta-Protein: Synaptic and Network Dysfunction
-
[49] Mucke L, Selkoe DJ. Neurotoxicity of Amyloid beta-Protein: Synaptic and Network Dysfunction. Cold Spring Harb Perspect Med 2012; 2(7): a006338.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.7
-
-
Mucke, L.1
Selkoe, D.J.2
-
50
-
-
72649097241
-
Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice
-
[50] Hein AM, Stasko MR, Matousek SB, et al. Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun 2010; 24(2): 243-53.
-
(2010)
Brain Behav Immun
, vol.24
, Issue.2
, pp. 243-253
-
-
Hein, A.M.1
Stasko, M.R.2
Matousek, S.B.3
-
51
-
-
34249027009
-
Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: Relevance for the behavioral and synaptic deficits induced by amyloid beta protein
-
[51] Medeiros R, Prediger RD, Passos GF, et al. Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein. J Neurosci 2007; 27(20): 5394-404.
-
(2007)
J Neurosci
, vol.27
, Issue.20
, pp. 5394-5404
-
-
Medeiros, R.1
Prediger, R.D.2
Passos, G.F.3
-
52
-
-
77953675879
-
Probing the biology of Alzheimer's disease in mice
-
[52] Ashe KH, Zahs KR. Probing the biology of Alzheimer's disease in mice. Neuron 2010; 66(5): 631-45.
-
(2010)
Neuron
, vol.66
, Issue.5
, pp. 631-645
-
-
Ashe, K.H.1
Zahs, K.R.2
-
53
-
-
0041921071
-
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease
-
[53] Yan Q, Zhang J, Liu H, et al. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci 2003; 23(20): 7504-9.
-
(2003)
J Neurosci
, vol.23
, Issue.20
, pp. 7504-7509
-
-
Yan, Q.1
Zhang, J.2
Liu, H.3
-
54
-
-
0035691115
-
Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice
-
[54] Lim GP, Yang F, Chu T, et al. Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice. Neurobiol Aging 2001; 22(6): 983-91.
-
(2001)
Neurobiol Aging
, vol.22
, Issue.6
, pp. 983-991
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
-
55
-
-
0034254924
-
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease
-
[55] Lim GP, Yang F, Chu T, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci 2000; 20(15): 5709-14.
-
(2000)
J Neurosci
, vol.20
, Issue.15
, pp. 5709-5714
-
-
Lim, G.P.1
Yang, F.2
Chu, T.3
-
56
-
-
39749188810
-
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
-
[56] Kotilinek LA, Westerman MA, Wang Q, et al. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain 2008; 131(Pt 3): 651-64.
-
(2008)
Brain
, vol.131
, pp. 651-664
-
-
Kotilinek, L.A.1
Westerman, M.A.2
Wang, Q.3
-
57
-
-
0036798125
-
Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent
-
[57] Montine TJ, Milatovic D, Gupta RC, et al. Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. J Neurochem 2002; 83(2): 463-70.
-
(2002)
J Neurochem
, vol.83
, Issue.2
, pp. 463-470
-
-
Montine, T.J.1
Milatovic, D.2
Gupta, R.C.3
-
58
-
-
27444436866
-
Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity
-
[58] Shie FS, Montine KS, Breyer RM, et al. Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity. Glia 2005; 52(1): 70-7.
-
(2005)
Glia
, vol.52
, Issue.1
, pp. 70-77
-
-
Shie, F.S.1
Montine, K.S.2
Breyer, R.M.3
-
59
-
-
84940911821
-
The PGE2 PE2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
-
[59] Liang X, Wang Q, Lokteva L, et al. The PGE2 PE2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Soc. Neuroscience 2007; 2007(160.16).
-
(2007)
Soc. Neuroscience
, vol.2007
, Issue.160-16
-
-
Liang, X.1
Wang, Q.2
Lokteva, L.3
-
60
-
-
54849418885
-
The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
-
[60] Liang X, Wang Q, Shi J, et al. The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann Neurol 2008; 64(3): 304-14.
-
(2008)
Ann Neurol
, vol.64
, Issue.3
, pp. 304-314
-
-
Liang, X.1
Wang, Q.2
Shi, J.3
-
61
-
-
77956955758
-
The role of microglia in amyloid clearance from the AD brain
-
[61] Lee CY, Landreth GE. The role of microglia in amyloid clearance from the AD brain. J Neural Transm 2010; 117(8): 949-60.
-
(2010)
J Neural Transm
, vol.117
, Issue.8
, pp. 949-960
-
-
Lee, C.Y.1
Landreth, G.E.2
-
62
-
-
51149120624
-
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
-
[62] Hickman SE, Allison EK, and El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 2008; 28(33): 8354-60.
-
(2008)
J Neurosci
, vol.28
, Issue.33
, pp. 8354-8360
-
-
Hickman, S.E.1
Allison, E.K.2
El Khoury, J.3
-
64
-
-
17144380506
-
Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity
-
[64] Shie FS, Breyer RM, Montine TJ. Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity. Am J Pathol 2005; 166(4): 1163-72.
-
(2005)
Am J Pathol
, vol.166
, Issue.4
, pp. 1163-1172
-
-
Shie, F.S.1
Breyer, R.M.2
Montine, T.J.3
Microglia Lacking, E.4
-
65
-
-
27744462871
-
Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
-
[65] Liang X, Wang Q, Hand T, et al. Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 2005; 25(44): 10180-7.
-
(2005)
J Neurosci
, vol.25
, Issue.44
, pp. 10180-10187
-
-
Liang, X.1
Wang, Q.2
Hand, T.3
-
66
-
-
77954604328
-
Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wildtype or prostaglandin E2 receptor subtype 2-null bone marrow
-
[66] Keene CD, Chang RC, Lopez-Yglesias AH, et al. Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wildtype or prostaglandin E2 receptor subtype 2-null bone marrow. Am J Pathol 2010; 177(1): 346-54.
-
(2010)
Am J Pathol
, vol.177
, Issue.1
, pp. 346-354
-
-
Keene, C.D.1
Chang, R.C.2
Lopez-Yglesias, A.H.3
-
67
-
-
76149097203
-
Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis
-
[67] Chuang PC, Lin YJ, Wu MH, et al. Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 2010; 176(2): 850-60.
-
(2010)
Am J Pathol
, vol.176
, Issue.2
, pp. 850-860
-
-
Chuang, P.C.1
Lin, Y.J.2
Wu, M.H.3
-
68
-
-
77953129233
-
Prostaglandin E2 reduces amyloid beta-induced phagocytosis in cultured rat microglia
-
[68] Nagano T, Kimura SH, and Takemura M. Prostaglandin E2 reduces amyloid beta-induced phagocytosis in cultured rat microglia. Brain Res 2010; 1323: 11-7.
-
(2010)
Brain Res
, vol.1323
, pp. 11-17
-
-
Nagano, T.1
Kimura, S.H.2
Takemura, M.3
-
69
-
-
50949091424
-
Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii
-
[69] Aronoff DM, Hao Y, Chung J, et al. Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii. J Immunol 2008; 180(12): 8222-30.
-
(2008)
J Immunol
, vol.180
, Issue.12
, pp. 8222-8230
-
-
Aronoff, D.M.1
Hao, Y.2
Chung, J.3
-
70
-
-
33749526328
-
Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation
-
[70] Ballinger MN, Aronoff DM, McMillan TR, et al. Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J Immunol 2006; 177(8): 5499-508.
-
(2006)
J Immunol
, vol.177
, Issue.8
, pp. 5499-5508
-
-
Ballinger, M.N.1
Aronoff, D.M.2
McMillan, T.R.3
-
71
-
-
60549103394
-
Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling
-
[71] Medeiros AI, Serezani CH, Lee SP, et al. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med 2009; 206(1): 61-8.
-
(2009)
J Exp Med
, vol.206
, Issue.1
, pp. 61-68
-
-
Medeiros, A.I.1
Serezani, C.H.2
Lee, S.P.3
-
72
-
-
2942722569
-
Prostaglandin E2 in hibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP
-
[72] Aronoff DM, Canetti C, and Peters-Golden M. Prostaglandin E2 in hibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J Immunol 2004; 173(1): 559-65.
-
(2004)
J Immunol
, vol.173
, Issue.1
, pp. 559-565
-
-
Aronoff, D.M.1
Canetti, C.2
Peters-Golden, M.3
-
73
-
-
84920405563
-
Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models
-
[73] Johansson JU, Woodling NS, Wang Q, et al. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models. J Clin Invest 2015; 125(1): 350-64.
-
(2015)
J Clin Invest
, vol.125
, Issue.1
, pp. 350-364
-
-
Johansson, J.U.1
Woodling, N.S.2
Wang, Q.3
-
74
-
-
84858631674
-
The many faces of insulinlike peptide signalling in the brain
-
[74] Fernandez AM and Torres-Aleman I. The many faces of insulinlike peptide signalling in the brain. Nat Rev Neurosci 2012; 13(4): 225-39.
-
(2012)
Nat Rev Neurosci
, vol.13
, Issue.4
, pp. 225-239
-
-
Fernandez, A.M.1
Torres-Aleman, I.2
-
75
-
-
34548494847
-
Drug insight: Effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders
-
[75] Heneka MT, Landreth GE, Hull M. Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nat Clin Pract Neurol 2007; 3(9): 496-504.
-
(2007)
Nat Clin Pract Neurol
, vol.3
, Issue.9
, pp. 496-504
-
-
Heneka, M.T.1
Landreth, G.E.2
Hull, M.3
-
76
-
-
84870226700
-
PPARgamma/RXRalphainduced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
-
[76] Yamanaka M, Ishikawa T, Griep A, et al. PPARgamma/RXRalphainduced and CD36-mediated microglial amyloid-beta phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J Neurosci 2012; 32(48): 17321-31.
-
(2012)
J Neurosci
, vol.32
, Issue.48
, pp. 17321-17331
-
-
Yamanaka, M.1
Ishikawa, T.2
Griep, A.3
-
78
-
-
84877950101
-
Comment on "ApoEdirected therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models"
-
[78] Fitz NF, Cronican AA, Lefterov I, et al. Comment on "ApoEdirected therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models". Science 2013; 340(6135): 924-c.
-
(2013)
Science
, vol.340
, Issue.6135
-
-
Fitz, N.F.1
Cronican, A.A.2
Lefterov, I.3
-
79
-
-
17744376173
-
A PPAR gamma-LXRABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
-
[79] Chawla A, Boisvert WA, Lee CH, et al. A PPAR gamma-LXRABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001; 7(1): 161-71.
-
(2001)
Mol Cell
, vol.7
, Issue.1
, pp. 161-171
-
-
Chawla, A.1
Boisvert, W.A.2
Lee, C.H.3
-
81
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
[81] Jiang Q, Lee CY, Mandrekar S, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron 2008; 58(5): 681-93.
-
(2008)
Neuron
, vol.58
, Issue.5
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
-
82
-
-
84864249514
-
Mechanisms underlying the rapid peroxisome proliferator-activated receptorgamma- mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
-
[82] Mandrekar-Colucci S, Karlo JC, and Landreth GE. Mechanisms underlying the rapid peroxisome proliferator-activated receptorgamma- mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci 2012; 32(30): 10117-28.
-
(2012)
J Neurosci
, vol.32
, Issue.30
, pp. 10117-10128
-
-
Mandrekar-Colucci, S.1
Karlo, J.C.2
Landreth, G.E.3
-
83
-
-
79953181649
-
Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes
-
[83] Nishitsuji K, Hosono T, Uchimura K, et al. Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes. J Biol Chem 2011; 286(8): 6393-401.
-
(2011)
J Biol Chem
, vol.286
, Issue.8
, pp. 6393-6401
-
-
Nishitsuji, K.1
Hosono, T.2
Uchimura, K.3
-
84
-
-
33748756773
-
A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology
-
[84] Blain JF, Aumont N, Theroux L, et al. A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiology. Eur J Neurosci 2006; 24(5): 1245-51.
-
(2006)
Eur J Neurosci
, vol.24
, Issue.5
, pp. 1245-1251
-
-
Blain, J.F.1
Aumont, N.2
Theroux, L.3
-
85
-
-
33645288619
-
A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling
-
[85] Takayama K, Sukhova GK, Chin MT, et al. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. Circ Res 2006; 98(4): 499-504.
-
(2006)
Circ Res
, vol.98
, Issue.4
, pp. 499-504
-
-
Takayama, K.1
Sukhova, G.K.2
Chin, M.T.3
-
86
-
-
44349180951
-
Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
-
[86] Minami M, Shimizu K, Okamoto Y, et al. Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J Biol Chem 2008; 283(15): 9692-703.
-
(2008)
J Biol Chem
, vol.283
, Issue.15
, pp. 9692-9703
-
-
Minami, M.1
Shimizu, K.2
Okamoto, Y.3
-
87
-
-
34548317001
-
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
-
[87] Lazarus M, Yoshida K, Coppari R, et al. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 2007; 10(9): 1131-3.
-
(2007)
Nat Neurosci
, vol.10
, Issue.9
, pp. 1131-1133
-
-
Lazarus, M.1
Yoshida, K.2
Coppari, R.3
-
88
-
-
0032541676
-
Impaired febrile response in mice lacking the prostaglandin
-
[88] Ushikubi F, Segi E, Sugimoto Y, et al. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 1998; 395(6699): 281-4.
-
(1998)
E Receptor Subtype EP3. Nature
, vol.395
, Issue.6699
, pp. 281-284
-
-
Ushikubi, F.1
Segi, E.2
Sugimoto, Y.3
-
89
-
-
70149117812
-
E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection
-
[89] Aronoff DM, Lewis C, Serezani CH, et al. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol 2009; 183(4): 2642-9.
-
(2009)
J Immunol
, vol.183
, Issue.4
, pp. 2642-2649
-
-
Aronoff, D.M.1
Lewis, C.2
Serezani, C.H.3
-
90
-
-
60449104218
-
Screening of innate immune receptors in neurodegenerative diseases: A similar pattern
-
[90] Letiembre M, Liu Y, Walter S, et al. Screening of innate immune receptors in neurodegenerative diseases: A similar pattern. Neurobiol Aging 2007.
-
(2007)
Neurobiol Aging
-
-
Letiembre, M.1
Liu, Y.2
Walter, S.3
-
91
-
-
35848963223
-
Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease
-
[91] Walter S, Letiembre M, Liu Y, et al. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell Physiol Biochem 2007; 20(6): 947-56.
-
(2007)
Cell Physiol Biochem
, vol.20
, Issue.6
, pp. 947-956
-
-
Walter, S.1
Letiembre, M.2
Liu, Y.3
-
92
-
-
84871955193
-
Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease
-
[92] Shi J, Wang Q, Johansson JU, et al. Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Ann Neurol 2012; 72(5): 788-98.
-
(2012)
Ann Neurol
, vol.72
, Issue.5
, pp. 788-798
-
-
Shi, J.1
Wang, Q.2
Johansson, J.U.3
-
93
-
-
0036403838
-
Oxidative stress increases expression and activity of BACE in NT2 neurons
-
[93] Tamagno E, Bardini P, Obbili A, et al. Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis 2002; 10(3): 279-88.
-
(2002)
Neurobiol Dis
, vol.10
, Issue.3
, pp. 279-288
-
-
Tamagno, E.1
Bardini, P.2
Obbili, A.3
-
94
-
-
4744369310
-
Aging-related increase in oxidative stress correlates with developmental pattern of betasecretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology
-
[94] Apelt J, Bigl M, Wunderlich P, et al. Aging-related increase in oxidative stress correlates with developmental pattern of betasecretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology. Int J Dev Neurosci 2004; 22(7): 475-84.
-
(2004)
Int J Dev Neurosci
, vol.22
, Issue.7
, pp. 475-484
-
-
Apelt, J.1
Bigl, M.2
Wunderlich, P.3
-
95
-
-
27644451820
-
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: Accumulation in Purkinje cells of the cerebellum
-
[95] Candelario-Jalil E, Slawik H, Ridelis I, et al. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. J Mol Neurosci 2005; 27(3): 303-10.
-
(2005)
J Mol Neurosci
, vol.27
, Issue.3
, pp. 303-310
-
-
Candelario-Jalil, E.1
Slawik, H.2
Ridelis, I.3
-
96
-
-
32244432739
-
Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity
-
[96] Kawano T, Anrather J, Zhou P, et al. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat Med 2006; 12(2): 225-9.
-
(2006)
Nat Med
, vol.12
, Issue.2
, pp. 225-229
-
-
Kawano, T.1
Anrather, J.2
Zhou, P.3
-
97
-
-
29544440041
-
Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage
-
[97] Ahmad AS, Saleem S, Ahmad M, et al. Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol Sci 2006; 89(1): 265-70.
-
(2006)
Toxicol Sci
, vol.89
, Issue.1
, pp. 265-270
-
-
Ahmad, A.S.1
Saleem, S.2
Ahmad, M.3
-
98
-
-
84863422490
-
PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease
-
[98] Zhen G, Kim YT, Li RC, et al. PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. Neurobiol Aging 2012; 33(9): 2215-9.
-
(2012)
Neurobiol Aging
, vol.33
, Issue.9
, pp. 2215-2219
-
-
Zhen, G.1
Kim, Y.T.2
Li, R.C.3
-
99
-
-
0345189366
-
Inflammatory blockade restores adult hippocampal neurogenesis
-
[99] Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003; 302(5651): 1760-5.
-
(2003)
Science
, vol.302
, Issue.5651
, pp. 1760-1765
-
-
Monje, M.L.1
Toda, H.2
Palmer, T.D.3
-
100
-
-
67049097402
-
Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2
-
[100] Keene CD, Chang R, Stephen C, et al. Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. Am J Pathol 2009; 174(6): 2300-9.
-
(2009)
Am J Pathol
, vol.174
, Issue.6
, pp. 2300-2309
-
-
Keene, C.D.1
Chang, R.2
Stephen, C.3
|