Urothelial cancer associated 1: a long noncoding RNA with a crucial role in cancer

Journal of Cancer Research and Clinical Oncology

Volumn 142, Issue 7, 2016, Pages 1407-1419

  Xue, Mei ^a   Chen, Wei ^a   Li, Xu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cancer; Chemoresistance; Long noncoding RNA; Metastasis; UCA1

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; LONG UNTRANSLATED RNA; MICRORNA; RNA ISOFORM; UNCLASSIFIED DRUG; UROTHELIAL CANCER ASSOCIATED 1; TUMOR MARKER; UCA1 RNA, HUMAN;

APOPTOSIS; BLADDER CANCER; BREAST CANCER; CANCER DIAGNOSIS; CANCER THERAPY; CELL PROLIFERATION; COLORECTAL CANCER; DRUG RESISTANCE; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION; GENETIC REGULATION; HUMAN; LIVER CELL CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; METABOLISM; METASTASIS; OVARY CANCER; PRIORITY JOURNAL; REVIEW; RNA ANALYSIS; RNA STRUCTURE; STOMACH CANCER; TONGUE CARCINOMA; TUMOR INVASION; DISEASE COURSE; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; NEOPLASM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

BIOMARKERS, TUMOR; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; RNA, LONG NONCODING; TRANSCRIPTION, GENETIC;

EID: 84940827207     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-2042-y     Document Type: Review

References (77)

1. Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL (2013) Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep 5(6):1611–1624. doi:10.1016/j.celrep.2013.11.021
2. Broxterman HJ, Gotink KJ, Verheul HM (2009) Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Updat 12(4–5):114–126. doi:10.1016/j.drup.2009.07.001
3. Cao WJ, Wu HL, He BS, Zhang YS, Zhang ZY (2013) Analysis of long non-coding RNA expression profiles in gastric cancer. World J Gastroenterol 19(23):3658–3664. doi:10.3748/wjg.v19.i23.3658
4. Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364–378. doi:10.1016/j.ejphar.2014.07.025
5. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, Lagarde J, Veeravalli L, Ruan X, Ruan Y, Lassmann T, Carninci P, Brown JB, Lipovich L, Gonzalez JM, Thomas M, Davis CA, Shiekhattar R, Gingeras TR, Hubbard TJ, Notredame C, Harrow J, Guigo R (2012) The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22(9):1775–1789. doi:10.1101/gr.132159.111
6. Ellis BC, Graham LD, Molloy PL (2014) CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta 1843(2):372–386. doi:10.1016/j.bbamcr.2013.10.016
7. Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F, Liu Y (2014) Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J 281(7):1750–1758. doi:10.1111/febs.12737
8. Fang R, Xiao T, Fang Z, Sun Y, Li F, Gao Y, Feng Y, Li L, Wang Y, Liu X, Chen H, Liu XY, Ji H (2012) MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem 287(27):23227–23235. doi:10.1074/jbc.M112.373084
9. Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H (2014) Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol 117(1):89–95. doi:10.1016/j.oooo.2013.09.007
10. Ganapathy-Kanniappan S, Geschwind JF (2013) Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer 12:152. doi:10.1186/1476-4598-12-152
11. Gilkes DM, Semenza GL, Wirtz D (2014) Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat Rev Cancer 14(6):430–439. doi:10.1038/nrc3726
12. Giza DE, Vasilescu C, Calin GA (2014) MicroRNAs and ceRNAs: therapeutic implications of RNA networks. Expert Opin Biol Ther 14(9):1285–1293. doi:10.1517/14712598.2014.920812
13. Gutschner T, Baas M, Diederichs S (2011) Noncoding RNA gene silencing through genomic integration of RNA destabilizing elements using zinc finger nucleases. Genome Res 21(11):1944–1954. doi:10.1101/gr.122358.111
14. Gutschner T, Diederichs S (2012) The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol 9(6):703–719. doi:10.4161/rna.20481
15. Gutschner T, Hammerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zornig M, MacLeod AR, Spector DL, Diederichs S (2013) The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73(3):1180–1189. doi:10.1158/0008-5472.CAN-12-2850
16. Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, Bernstein BE, Kellis M, Regev A, Rinn JL, Lander ES (2009) Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458(7235):223–227. doi:10.1038/nature07672
17. Han Y, Liu Y, Zhang H, Wang T, Diao R, Jiang Z, Gui Y, Cai Z (2013) Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1. FEBS Lett. doi:10.1016/j.febslet.2013.10.023
18. Han Y, Yang YN, Yuan HH, Zhang TT, Sui H, Wei XL, Liu L, Huang P, Zhang WJ, Bai YX (2014) UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology 46(5):396–401. doi:10.1097/PAT.0000000000000125
19. Hanna N, Ohana P, Konikoff FM, Leichtmann G, Hubert A, Appelbaum L, Kopelman Y, Czerniak A, Hochberg A (2012) Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer. Cancer Gene Ther 19(6):374–381. doi:10.1038/cgt.2012.10
20. Hessels D, Klein GJ, van Oort I, Karthaus HF, van Leenders GJ, van Balken B, Kiemeney LA, Witjes JA, Schalken JA (2003) DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer. Eur Urol 44(1):8–15
21. Hiemer SE, Szymaniak AD, Varelas X (2014) The transcriptional regulators TAZ and YAP direct transforming growth factor beta-induced tumorigenic phenotypes in breast cancer cells. J Biol Chem 289(19):13461–13474. doi:10.1074/jbc.M113.529115
22. Ho TT, Zhou N, Huang J, Koirala P, Xu M, Fung R, Wu F, Mo YY (2014) Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines. Nucleic Acids Res 43(3):e17. doi:10.1093/nar/gku1198
23. Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu M, Mo YY (2014) Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis 5:e1008. doi:10.1038/cddis.2013.541
24. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142(3):409–419. doi:10.1016/j.cell.2010.06.040
25. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA (2013) Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell 152(3):570–583. doi:10.1016/j.cell.2013.01.003
26. Kornfeld JW, Bruning JC (2014) Regulation of metabolism by long, non-coding RNAs. Front Genet 5:57. doi:10.3389/fgene.2014.00057
27. Kumar PP, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM (2014) Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. doi:10.7554/eLife.02805
28. Lee GL, Dobi A, Srivastava S (2011) Prostate cancer: diagnostic performance of the PCA3 urine test. Nat Rev Urol 8(3):123–124. doi:10.1038/nrurol.2011.10
29. Li JY, Ma X, Zhang CB (2014a) Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol 7(11):7938–7944
30. Li L, Feng T, Lian Y, Zhang G, Garen A, Song X (2009) Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA 106(31):12956–12961. doi:10.1073/pnas.0906005106
31. Li Z, Li X, Wu S, Xue M, Chen W (2014b) Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci 105(8):951–955. doi:10.1111/cas.12461
32. Liu Q, Huang J, Zhou N, Zhang Z, Zhang A, Lu Z, Wu F, Mo YY (2013a) LncRNA loc285194 is a p53-regulated tumor suppressor. Nucleic Acids Res 41(9):4976–4987. doi:10.1093/nar/gkt182
33. Liu SP, Yang JX, Cao DY, Shen K (2013b) Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials. Cancer Biol Med 10(3):138–141. doi:10.7497/j.issn.2095-3941.2013.03.003
34. Luo M, Li Z, Wang W, Zeng Y, Liu Z, Qiu J (2013) Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett 333(2):213–221. doi:10.1016/j.canlet.2013.01.033
35. Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, Eshraghi M, Manda KD, Wiechec E, Los M (2007) Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat 10(1–2):13–29. doi:10.1016/j.drup.2007.01.003
36. Matouk I, Raveh E, Ohana P, Lail RA, Gershtain E, Gilon M, De Groot N, Czerniak A, Hochberg A (2013) The increasing complexity of the oncofetal h19 gene locus: functional dissection and therapeutic intervention. Int J Mol Sci 14(2):4298–4316. doi:10.3390/ijms14024298
37. Matouk IJ, Mezan S, Mizrahi A, Ohana P, Abu-Lail R, Fellig Y, Degroot N, Galun E, Hochberg A (2010) The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim Biophys Acta 1803(4):443–451. doi:10.1016/j.bbamcr.2010.01.010
38. Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: insights into functions. Nat Rev Genet 10(3):155–159. doi:10.1038/nrg2521
39. Mercer TR, Mattick JS (2013) Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol 20(3):300–307. doi:10.1038/nsmb.2480
40. Michalik KM, You X, Manavski Y, Doddaballapur A, Zornig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RA, Dimmeler S (2014) Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res 114(9):1389–1397. doi:10.1161/CIRCRESAHA.114.303265
41. Mizrahi A, Czerniak A, Ohana P, Amiur S, Gallula J, Matouk I, Abu-Lail R, Birman T, Hochberg A, Levy T (2010) Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report. J Med Case Rep 4:228. doi:10.1186/1752-1947-4-228
42. Nana-Sinkam SP, Croce CM (2011) Non-coding RNAs in cancer initiation and progression and as novel biomarkers. Mol Oncol 5(6):483–491. doi:10.1016/j.molonc.2011.10.003
43. Qi P, Du X (2013) The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Mod Pathol 26(2):155–165. doi:10.1038/modpathol.2012.160
44. Rorive S, Sandras F, Biskri L, Fossion C, Catteau X, Roumeguere T, Bossche Vanden, Mijatovic T, Salmon I (2009) RT-PCR-based UCA1 expression detection in urine samples as non-invasive reliable method for urothelial cancer diagnosis. EJC Suppl 7(4):28–29. doi:10.1016/S1359-6349(09)72204-9
45. Ruan K, Song G, Ouyang G (2009) Role of hypoxia in the hallmarks of human cancer. J Cell Biochem 107(6):1053–1062. doi:10.1002/jcb.22214
46. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP (2011) A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146(3):353–358. doi:10.1016/j.cell.2011.07.014
47. Shen X, Qi P, Du X (2015) Long non-coding RNAs in cancer invasion and metastasis. Mod Pathol 28(1):4–13. doi:10.1038/modpathol.2014.75
48. Smaldone MC, Davies BJ (2010) BC-819, a plasmid comprising the H19 gene regulatory sequences and diphtheria toxin A, for the potential targeted therapy of cancers. Curr Opin Mol Ther 12(5):607–616
49. Srivastava AK, Singh PK, Rath SK, Dalela D, Goel MM, Bhatt ML (2014) Appraisal of diagnostic ability of UCA1 as a biomarker of carcinoma of the urinary bladder. Tumour Biol 35(11):11435–11442. doi:10.1007/s13277-014-2474-z
50. Stephan C, Ralla B, Jung K (2014) Prostate-specific antigen and other serum and urine markers in prostate cancer. Biochim Biophys Acta 1846(1):99–112. doi:10.1016/j.bbcan.2014.04.001
51. Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505(7483):344–352. doi:10.1038/nature12986
52. Tian Y, Zhang X, Hao Y, Fang Z, He Y (2014) Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma. Melanoma Res 24(4):335–341. doi:10.1097/CMR.0000000000000080
53. Tsai MC, Spitale RC, Chang HY (2011) Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res 71(1):3–7. doi:10.1158/0008-5472.CAN-10-2483
54. Tsang WP, Ng EK, Ng SS, Jin H, Yu J, Sung JJ, Kwok TT (2010) Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer. Carcinogenesis 31(3):350–358. doi:10.1093/carcin/bgp181
55. Tsang WP, Wong TW, Cheung AH, Co CN, Kwok TT (2007) Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA 13(6):890–898. doi:10.1261/rna.359007
56. Vander HM, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324(5930):1029–1033. doi:10.1126/science.1160809
57. Wang F, Li X, Xie X, Zhao L, Chen W (2008) UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett 582(13):1919–1927. doi:10.1016/j.febslet.2008.05.012
58. Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL, Chen J, Liu X, Wang SK (2015a) Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget 6(10):7899–7917
59. Wang F, Zhou J, Xie X, Hu J, Chen L, Hu Q, Guo H, Yu C (2015b) Involvement of SRPK1 in cisplatin resistance related to long non-coding RNA UCA1 in human ovarian cancer cells. Neoplasma 62(3):432–438. doi:10.4149/neo_2015_051
60. Wang J, Liu X, Wu H, Ni P, Gu Z, Qiao Y, Chen N, Sun F, Fan Q (2010) CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 38(16):5366–5383. doi:10.1093/nar/gkq285
61. Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43(6):904–914. doi:10.1016/j.molcel.2011.08.018
62. Wang T, Yuan J, Feng N, Li Y, Lin Z, Jiang Z, Gui Y (2014a) Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer. Tumour Biol 35(10):10075–10084. doi:10.1007/s13277-014-2321-2
63. Wang X, Gong Y, Jin B, Wu C, Yang J, Wang L, Zhang Z, Mao Z (2014b) Long non-coding RNA urothelial carcinoma associated 1 induces cell replication by inhibiting BRG1 in 5637 cells. Oncol Rep 32(3):1281–1290. doi:10.3892/or.2014.3309
64. Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ, Chen YC, Qian XP, Lu TJ, Yu LZ, Zhang Y, Xin DQ, Na YQ, Chen WF (2006) Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res 12(16):4851–4858. doi:10.1158/1078-0432.CCR-06-0134
65. Wang Y, Chen W, Yang C, Wu W, Wu S, Qin X, Li X (2012) Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol 41(1):276–284. doi:10.3892/ijo.2012.1443
66. Warburg O (1956) On the origin of cancer cells. Science 123(3191):309–314
67. Wu W, Zhang S, Li X, Xue M, Cao S, Chen W (2013) Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PLoS One 8(9):e73920. doi:10.1371/journal.pone.0073920
68. Xue M, Li X, Li Z, Chen W (2014a) Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion. Tumour Biol 35(7):6901–6912. doi:10.1007/s13277-014-1925-x
69. Xue M, Li X, Wu W, Zhang S, Wu S, Li Z, Chen W (2014b) Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein alpha contributes to bladder cancer cell growth and reduced apoptosis. Oncol Rep 31(5):1993–2000. doi:10.3892/or.2014.3092
70. Yang C, Li X, Wang Y, Zhao L, Chen W (2012) Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene 496(1):8–16. doi:10.1016/j.gene.2012.01.012
71. Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, Sun SH (2013a) Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell 49(6):1083–1096. doi:10.1016/j.molcel.2013.01.010
72. Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G (2013b) Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma. J Cancer Res Clin Oncol 139(3):437–445. doi:10.1007/s00432-012-1324-x
73. Yang F, Zhang H, Mei Y, Wu M (2014) Reciprocal regulation of HIF-1alpha and lincRNA-p21 modulates the Warburg effect. Mol Cell 53(1):88–100. doi:10.1016/j.molcel.2013.11.004
74. Zhang Q, Su M, Lu G, Wang J (2013a) The complexity of bladder cancer: long noncoding RNAs are on the stage. Mol Cancer 12(1):101. doi:10.1186/1476-4598-12-101
75. Zhang Z, Zhu Z, Watabe K, Zhang X, Bai C, Xu M, Wu F, Mo YY (2013b) Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ 20(11):1558–1568. doi:10.1038/cdd.2013.110
76. Zheng Q, Wu F, Dai WY, Zheng DC, Zheng C, Ye H, Zhou B, Chen JJ, Chen P (2015) Aberrant expression of UCA1 in gastric cancer and its clinical significance. Clin Transl Oncol. doi:10.1007/s12094-015-1290-2
77. Zhou Y, Zhang X, Klibanski A (2012) MEG3 noncoding RNA: a tumor suppressor. J Mol Endocrinol 48(3):R45–R53. doi:10.1530/JME-12-0008