p53 attenuates AKT signaling by modulating membrane phospholipid composition

Oncotarget

Volumn 6, Issue 25, 2015, Pages 21240-21254

  Rueda Rincon, Natalia ^a   Bloch, Katarzyna ^a   Derua, Rita ^b   Vyas, Rajesh ^c   Harms, Amy ^d,e   Hankemeier, Thomas ^d,e   Khan, Niamat Ali ^a   Dehairs, Jonas ^a   Bagadi, Muralidhararao ^a   Binda, Maria Mercedes ^f   Waelkens, Etienne ^b   Marine, Jean Christophe ^c   Swinnen, Johannes V ^a  

^a KU Leuven and University Hospitals Leuven and Leuven Cancer Institute   (Belgium)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d LEIDEN UNIVERSITY   (Netherlands)

^e Netherlands Metabolomics Centre   (Netherlands)

^f Louvain Centre for Toxicology and Applied Pharmacology LTAP   (Belgium)

Author keywords

Cancer; p53; Phospholipids; SCD; SREBP

Indexed keywords

ACYL COENZYME A DESATURASE 1; MEMBRANE PHOSPHOLIPID; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; ACYL COENZYME A DESATURASE; AKT1 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; IMIDAZOLE DERIVATIVE; LIPID; MDM2 PROTEIN, HUMAN; NUTLIN 3; PHOSPHOLIPID; PIPERAZINE DERIVATIVE; PROTEIN MDM2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TP53 PROTEIN, HUMAN; UNSATURATED FATTY ACID;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FATTY ACID DESATURATION; GENE REPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHOSPHOLIPID METABOLISM; ANIMAL; C57BL MOUSE; CHEMISTRY; DISEASE COURSE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; METABOLISM; NEOPLASM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE PROGRESSION; FATTY ACIDS, UNSATURATED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS; PHOSPHOLIPIDS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84940773140     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4067     Document Type: Article

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