Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator

Journal of Biological Chemistry

Volumn 287, Issue 43, 2012, Pages 35953-35963

  Shulga, Yulia V ^a   Anderson, Richard A ^b   Topham, Matthew K ^c   Epand, Richard M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CHAIN; IN-VITRO; ISOFORMS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 5 KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATES; SIGNALING EVENTS;

CHEMICAL ACTIVATION; ENZYMES; PHOSPHORYLATION;

SUBSTRATES;

1 STEAROYL 2 ARACHIDONYL PHOSPHATIDYLINOSITOL 4 PHOSPHATE; 1 STEAROYL 2 OLEOYL PHOSPHATIDYLINOSITOL 4 PHOSPHATE; DIPALMITOYL PHOSPHATIDYLINOSITOL 4 PHOSPHATE; ISOENZYME; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE ALPHA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE BETA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE GAMMA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; IN VITRO STUDY; LIPID COMPOSITION; MICHAELIS CONSTANT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; STEREOCHEMISTRY;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; HUMANS; ISOENZYMES; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SUBSTRATE SPECIFICITY; U937 CELLS;

EID: 84867783383     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.370155     Document Type: Article

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