Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action

Oncotarget

Volumn 6, Issue 25, 2015, Pages 21379-21394

  Voruganti, Sukesh ^a   Qin, Jiang Jiang ^a   Sarkar, Sushanta ^a   Nag, Subhasree ^a   Walbi, Ismail A ^a   Wang, Shu ^b   Zhao, Yuqing ^c   Wang, Wei ^a   Zhang, Ruiwen ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b TEXAS TECH UNIVERSITY   (United States)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Ginsenoside; MDM2; Molecular targeting efficiency; Oral delivery; PEG PLGA nanoparticles

Indexed keywords

GINSENOSIDE; NANOPARTICLE; ANTINEOPLASTIC AGENT; DRUG CARRIER; GINSENOSIDE 25-OCH3-PPD; MACROGOL DERIVATIVE; MDM2 PROTEIN, HUMAN; POLYESTER; POLYETHYLENE GLYCOL-POLY(LACTIDE-CO-GLYCOLIDE); PROTEIN MDM2; PROTEIN P53; TP53 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SAFETY; DRUG SYNTHESIS; ENCAPSULATION; GENE TARGETING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MDM2 GENE; MOUSE; NONHUMAN; ONCOGENE; PH; PHYSICAL CHEMISTRY; PROSTATE CANCER; SUSTAINED DRUG RELEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; CACO-2 CELL LINE; CANCER TRANSPLANTATION; CHEMISTRY; MALE; METABOLISM; NANOMEDICINE; ORAL DRUG ADMINISTRATION; PROSTATIC NEOPLASMS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GINSENOSIDES; HUMANS; MALE; MICE; NANOMEDICINE; NANOPARTICLES; NEOPLASM TRANSPLANTATION; POLYESTERS; POLYETHYLENE GLYCOLS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MDM2; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84940755759     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4091     Document Type: Article

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