A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 969, Issue , 2014, Pages 235-240

  Nag, Subhasree ^a   Qin, Jiang Jiang ^a   Patil, Shivaputra ^b   Deokar, Hemantkumar ^b   Buolamwini, John K ^b   Wang, Wei ^a   Zhang, Ruiwen ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

LC MS MS; Mouse plasma; Pharmacokinetics; Pyrido b indole; SP 141

Indexed keywords

CHROMATOGRAPHY; DICHLOROMETHANE; EXTRACTION; FORMIC ACID; HEXANE; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; POLYCYCLIC AROMATIC HYDROCARBONS;

INTRAVENOUS ADMINISTRATION; LC-MS/MS; LOWER LIMIT OF QUANTIFICATIONS; MOUSE PLASMA; MULTIPLE-REACTION MONITORING MODES; PYRIDO[B]INDOLE; SP-141; TRIPLE-QUADRUPOLE MASS SPECTROMETRY;

MAMMALS;

ANTINEOPLASTIC AGENT; SP 141; UNCLASSIFIED DRUG; 6-METHOXY-1-(NAPHTHALEN-1-YL)-9H-PYRIDO(3,4-B)INDOLE; INDOLE DERIVATIVE; PYRIDINE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; FREEZE THAWING; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; ANIMAL; BLOOD; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INDOLES; LINEAR MODELS; MICE; PYRIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84929136393     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.08.030     Document Type: Article

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