Melatonin-loaded lecithin/chitosan nanoparticles: Physicochemical characterisation and permeability through Caco-2 cell monolayers

International Journal of Pharmaceutics

Volumn 381, Issue 2, 2009, Pages 205-213

  Hafner, Anita ^a   Lovrić, Jasmina ^a   Voinovich, Dario ^b   Filipović Grčić, Jelena ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Chitosan; Lecithin; Melatonin; Nanoparticles; Transmucosal permeability

Indexed keywords

CHITOSAN; MELATONIN; PHOSPHATIDYLCHOLINE;

ARTICLE; CELL STRAIN CACO 2; CELL VIABILITY; CONCENTRATION PROCESS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE PERMEABILITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ZETA POTENTIAL;

ALGORITHMS; BIOCOMPATIBLE MATERIALS; CACO-2 CELLS; CELL SURVIVAL; CHITOSAN; COLLOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG STABILITY; ELECTRIC IMPEDANCE; ELECTROCHEMICAL TECHNIQUES; HUMANS; INTESTINAL MUCOSA; LECITHINS; MELATONIN; MUCINS; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; SOLUBILITY; SUSPENSIONS;

EID: 70349287549     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.07.001     Document Type: Article

References (36)

1. Amidi M., Romeijn S.G., Borchard G., Junginger H.E., Hennink W.E., and Jiskoot W. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J. Control. Release 111 (2006) 107-116
2. Bechgaard E., Lindhardt K., and Martinsen L. Intranasal absorption of melatonin in vivo bioavailability study. Int. J. Pharm. 182 (1999) 1-5
3. Bénès L., Claustrat B., Horrière F., Geoffriau M., Konsil J., Parrott K.A., de Grande G., McQuinn R.L., and Ayres J.W. Transmucosal, oral, controlled-release, and transdermal drug administration in human subjects: a crossover study with melatonin. J. Pharm. Sci. 86 (1997) 1115-1119
4. Ceraulo L., Fanara S., Turco Liveri V., Ruggirello A., Panzeri W., and Mele A. Orientation and molecular contacts of melatonin confined into AOT and lecithin reversed micellar systems. Colloids Surf. A: Physicochem. Eng. Aspects 316 (2008) 307-312
5. Chen F., Zhang Z.R., Yuan F., Qin X., Wang M., and Huang Y. In vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein delivery. Int. J. Pharm. 349 (2008) 226-233
6. Conner S.D., and Schmid S.L. Regulated portals of entry into the cell. Nature 422 (2003) 37-44
7. Costantino H.R., Illum L., Brandt G., Johnson P.H., and Quay S.C. Intranasal delivery: physicochemical and therapeutic aspects. Int. J. Pharm. 337 (2007) 1-24
8. Ekelund K., Östh K., Påhlstorp C., Björk E., Ulvenlund S., and Johansson F. Correlation between epithelial toxicity and surfactant structure as derived from the effects of polyethyleneoxide surfactants on Caco-2 cell monolayers and pig nasal mucosa. J. Pharm. Sci. 94 (2005) 730-744
9. England R.J.A., Homer J.J., Knight L.C., and Ell S.R. Nasal pH measurement: a reliable and repeatable parameter. Clin. Otolaryngol. 24 (1999) 67-68
10. Filipović-Grčić J., Škalko-Basnet N., and Jalšenjak I. Mucoadhesive chitosan-coated liposomes: characteristics and stability. J. Microencapsulation 18 (2001) 3-12
11. Florea B.I., Thanou M., Junginger H.E., and Borchard G. Enhancement of bronchial octreotide absorption by chitosan and N-trimethyl chitosan shows linear in vitro/in vivo correlation. J. Control. Release 10 (2006) 353-361
12. Fočo A., Gašperlin M., and Kristl J. Investigation of liposomes as carriers of sodium ascorbyl phosphate for cutaneous photoprotection. Int. J. Pharm. 291 (2005) 21-29
13. Furubayashi T., Kamaguchi A., Kawaharada K., Masaoka Y., Kataoka M., Yamashita S., Higashi Y., and Sakane T. Kinetic model to predict the absorption of nasally applied drugs from in vitro transcellular permeability of drugs. Biol. Pharm. Bull. 30 (2007) 1007-1010
14. Gerelli Y., Barbieri S., Di Bari M.T., Deriu A., Cantù L., Brocca P., Sonvico F., Colombo P., May R., and Motta S. Structure of self-organized multilayer nanoparticles for drug delivery. Langmuir 24 (2008) 11378-11384
15. He P., Davis S.S., and Illum L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int. J. Pharm. 166 (1998) 75-88
16. Hong S., Bielinska A.U., Mecke A., Keszler B., Beals J.L., Shi X., Balogh L., Orr B.G., Baker Jr. J.R., and Banaszak Holl M.M. Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjugate Chem. 15 (2004) 774-782
17. Jones A.T., Gumbleton M., and Duncan R. Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. Adv. Drug Deliv. Rev. 55 (2003) 1353-1357
18. Kelmann R.G., Kuminek G., Teixeira H.F., and Koester L.S. Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process. Int. J. Pharm. 342 (2007) 231-239
19. Kudsiova L., and Lawrence M.J. A comparison of the effect of chitosan and chitosan-coated vesicles on monolayer integrity and permeability across Caco-2 and 16HBE14o-cells. J. Pharm. Sci. 97 (2008) 3998-4010
20. López-Pinto J.M., González-Rodríguez M.L., and Rabasco A.M. Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int. J. Pharm. 298 (2005) 1-12
21. Maestrelli F., González-Rodriguez M.L., Rabasco A.M., and Mura P. Preparation and characterisation of liposomes encapsulating ketoprofen-cyclodextrin complexes for transdermal drug delivery. Int. J. Pharm. 298 (2005) 55-67
22. Mao S., Chen J., Wei Z., Liu H., and Bi D. Intranasal administration of melatonin starch microspheres. Int. J. Pharm. 272 (2004) 37-43
23. Mao S., Germershaus O., Fischer D., Linn T., Schnepf R., and Kissel T. Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells. Pharm. Res. 22 (2005) 2058-2068
24. Martinac A., Filipović-Grčić J., Voinovich D., Perissutti B., and Franceschinis E. Development and bioadhesive properties of chitosan-ethylcellulose microspheres for nasal delivery. Int. J. Pharm. 291 (2005) 69-77
25. Pavelić Z., Škalko-Basnet N., Filipović-Grčić J., Martinac A., and Jalšenjak I. Development and in vitro evaluation of a liposomal vaginal delivery system for acyclovir. J. Control. Release 106 (2005) 34-43
26. Sadeghi A.M.M., Dorkoosh F.A., Avadi M.R., Weinhold M., Bayat A., Delie F., Gurny R., Larijani B., Rafiee-Tehrani M., and Junginger H.E. Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur. J. Pharm. Biopharm. 70 (2008) 270-278
27. Schaffazick S.R., Pohlmann A.R., de Cordova C.A.S., Creczynski-Pasa T.B., and Guterres S.S. Protective properties of melatonin-loaded nanoparticles against lipid peroxidation. Int. J. Pharm. 289 (2005) 209-213
28. Schaffazick S.R., Siqueira I.R., Badejo A.S., Jornada D.S., Pohlmann A.R., Netto C.A., and Guterres S.S. Incorporation in polymeric nanocapsules improves the antioxidant effect of melatonin against lipid peroxidation in mice brain and liver. Eur. J. Pharm. Biopharm. 69 (2008) 64-71
29. Schubert M.A., Harms M., and Müller-Goymann C.C. Structural investigations on lipid nanoparticles containing high amounts of lecithin. Eur. J. Pharm. Sci. 27 (2006) 226-236
30. Singh J., Pandit S., Bramwell V.W., and Alpar H.O. Diphtheria toxoid loaded poly-(ε-caprolactone) nanoparticles as mucosal vaccine delivery systems. Methods 38 (2006) 96-105
31. Singla A.K., and Chawla M. Chitosan: some pharmaceutical and biological aspects-an update. J. Pharm. Pharmacol. 53 (2001) 1047-1067
32. Smith J., Wood E., and Dornish M. Effect of chitosan on epithelial cell tight junctions. Pharm. Res. 21 (2004) 43-49
33. Sonvico F., Cagnani A., Rossi A., Motta S., Di Bari M.T., Cavatorta F., Alonso M.J., Deriu A., and Colombo P. Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction. Int. J. Pharm. 324 (2006) 67-73
34. Unfried K., Albrecht C., Klotz L.O., Von Mikecz A., Grether-Beck S., and Schins R.P.F. Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1 (2007) 52-71
35. van den Berg M.P., Merkus P., Romeijn S.G., Verhoef J.C., and Merkus F.W. Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study. Pharm. Res. 21 (2004) 799-802
36. Zhang X., Zhang H., Wu Z., Wang Z., Niu H., and Li C. Nasal absorption enhancement of insulin using PEG-grafted chitosan nanoparticles. Eur. J. Pharm. Biopharm. 68 (2008) 526-534