2-hydroxyglutarate inhibits ATP synthase and mTOR Signaling

Cell Metabolism

Volumn 22, Issue 3, 2015, Pages 508-515

  Fu, Xudong ^a   Chin, Randall M ^b   Vergnes, Laurent ^a   Hwang, Heejun ^a   Deng, Gang ^b   Xing, Yanpeng ^b   Pai, Melody Y ^b   Li, Sichen ^a   Ta, Lisa ^a   Fazlollahi, Farbod ^c   Chen, Chuo ^d   Prins, Robert M ^a   Teitell, Michael A ^a,b   Nathanson, David A ^a   Lai, Albert ^a   Faull, Kym F ^c   Jiang, Meisheng ^a   Clarke, Steven G ^b   Cloughesy, Timothy F ^a   Graeber, Thomas G ^a,b   Braas, Daniel ^a,b   Christofk, Heather R ^a,b   Jung, Michael E ^a,b   Reue, Karen ^a,b   Huang, Jing ^a,b   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; ISOCITRATE DEHYDROGENASE 1; KETONE BODY; MAMMALIAN TARGET OF RAPAMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; ADENOSINE TRIPHOSPHATASE; ALPHA-HYDROXYGLUTARATE; GLUTARIC ACID DERIVATIVE; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; TARGET OF RAPAMYCIN KINASE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELL CYCLE ARREST; CELL GROWTH; CELL MUTANT; CELL VIABILITY; CONTROLLED STUDY; ENZYME INHIBITION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; LIFESPAN; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; TUMOR CELL; YOUNG ADULT; ANIMAL; CELL PROLIFERATION; GENETICS; LONGEVITY; METABOLISM; MUTATION; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CAENORHABDITIS ELEGANS; CELL PROLIFERATION; GLIOBLASTOMA; GLUTARATES; HUMANS; ISOCITRATE DEHYDROGENASE; LONGEVITY; MUTATION; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84940726154     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.06.009     Document Type: Article

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