Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects

Archiv der Pharmazie

Volumn 348, Issue 9, 2015, Pages 650-665

  Mekheimer, Ramadan A ^a,b   Sayed, Ahmed A Radwan ^a,b   Ahmed, Eltaib A ^c   Sadek, Kamal U ^b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b El Minia University ^*  (Egypt)

^c Faculty of Education   (Sudan)

Author keywords

1,2,4 Triazolo 1,5 a pyridines; Anti inflammatory; Antioxidant; Caenorhabiditis elegans; Synthesis

Indexed keywords

2 ETHYLTHIO 6 FORMYL 5 OXO 1 PHENYL 7 (2 PHENYL HYDRAZINYL) 1,5 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 2 ETHYLTHIO 6 FORMYL 5 OXO 1 PHENYL 7 (PIPERIDIN 1 YL) 1,5 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 2 ETHYLTHIO 6 FORMYL 7 (4 METHOXYPHENYLAMINO) 5 OXO 1 PHENYL 1,5 DIHYDRO 1,2,4 TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 2 ETHYLTHIO 8 METHOXY 5 OXO 1 PHENYL 1,5 DIHYDROBENZO[B][1,2,4]TRIAZOLO[1,5 G][1,6]NAPHTHYRIDINE 12 CARBONITRILE; 7 BENZYLAMINO 2 ETHYLTHIO 6 FORMYL 5 OXO 1 PHENYL 1,5 DIHYDRO [1,2,4]TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; 7 ETHYLTHIO 4 OXO 8 PHENYL 4,8 DIHYDRO 1H PYRAZOLO[3,4 D][1,2,4]TRIAZOLO[1,5 A] PYRIDINE 9 CARBONITRILE; 7 ISOBUTYLAMINO 2 ETHYLTHIO 6 FORMYL 5 OXO 1 PHENYL 1,5 DIHYDRO [1,2,4]TRIAZOLO[1,5 A]PYRIDINE 8 CARBONITRILE; ADVANCED GLYCATION END PRODUCT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; INDOMETACIN; OLIVE OIL; PROANTHOCYANIDIN; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; 1,1-DIPHENYL-2-PICRYLHYDRAZYL; 1,2,4-TRIAZOLE; BIPHENYL DERIVATIVE; CARRAGEENAN; DEXTRAN; PICRIC ACID; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; HEAT STRESS; HEAT TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; LIFE EXTENSION; LIFESPAN; MALE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; EDEMA; GLYCOSYLATION; HEAT SHOCK RESPONSE; LONGEVITY; METABOLISM; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME FACTOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIPHENYL COMPOUNDS; CAENORHABDITIS ELEGANS; CARRAGEENAN; DEXTRANS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EDEMA; GLYCOSYLATION; GLYCOSYLATION END PRODUCTS, ADVANCED; HEAT-SHOCK RESPONSE; LONGEVITY; MALE; MOLECULAR STRUCTURE; OXIDATIVE STRESS; PICRATES; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRIAZOLES;

EID: 84940725421     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201500069     Document Type: Article

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