Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4430-4436

  Li, Xi ^a   Liu, Jia Lin ^a   Yang, Xian Hui ^a   Lu, Xiang ^a   Zhao, Ting Ting ^a   Gong, Hai Bin ^b   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

^b XUZHOU CENTRAL HOSPITAL   (China)

Author keywords

3 (1,3 Diphenyl 1H pyrazol 4 yl) N phenylacrylamide derivatives; Histone deacetlylase (HDAC); Molecular docking; Structure activity relationship

Indexed keywords

(4 CHLOROPHENYL) 3 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; (4 METHOXYPHENYL) 3 [1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]ACRYLAMIDE; 3 (1,3 DIPHENYL 1H PYRAZOL 4 YL) N PHENYLACRYLAMIDE DERIVATIVE; 3 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] N (4 CHLOROPHENYL)ACRYLAMIDE; 3 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] N (4 METHOXYPHENYL)ACRYLAMIDE; 3 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] N PHENYLACRYLAMIDE; 3 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] N PHENYLACRYLAMIDE; 3 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL] N PHENYLACRYLAMIDE; ANTINEOPLASTIC AGENT; ENTINOSTAT; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; N (4 BROMOPHENYL) 3 [1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 BROMOPHENYL) 3 [3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 BROMOPHENYL) 3 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 BROMOPHENYL) 3 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 CHLOROPHENYL) 3 [1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 CHLOROPHENYL) 3 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 METHOXYPHENYL) 3 [3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N (4 METHOXYPHENYL) 3 [3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]ACRYLAMIDE; N PHENYL 3 [1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]ACYRLAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONCENTRATION RESPONSE; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ACRYLAMIDES; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863190771     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.031     Document Type: Article

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