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Volumn 20, Issue 7, 2012, Pages 2338-2352
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Design, synthesis, and biological evaluation of 4-arylmethyl-1- phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
a
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Author keywords
4 Arylmethyl 1 phenylpyrazole derivatives; 4 Aryloxy 1 phenylpyrazole derivatives; Androgen receptor antagonists; Castration resistant prostate cancer
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Indexed keywords
1 ARYLMETHYL 4 (4CYANOPHENYL)PYRROLE DERIVATIVE;
2 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
2 CHLORO 4 [4 (4 FLUOROBENZYL) 3,5 DIMETHYL 1H PYRAZOL 1 YL]BENZONITRILE;
2 CHLORO 4 [4 (4 FLUOROPHENOXY) 3,5 DIMETHYL 1H PYRAZOL 1 YL]BENZONITRILE;
3 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
3 CHLORO 4 [4 (4 FLUOROBENZYL) 3,5 DIMETHYL 1H PYRAZOL 1 YL]BENZONITRILE;
4 (4 FLUOROBENZYL) 3,5 DIMETHYL 1H PYRAZOLE;
4 (4 FLUOROPHENOXY) 3,5 DIMETHYL 1H PYRAZOLE;
4 [4 (4 FLUOROBENZYL) 3,5 DIMETHYL 1H PYRAZOL 1 YL] 2 (TRIFLUOROMETHYL)BENZONITRILE;
4 [4 (4 FLUOROBENZYL) 3,5 DIMETHYL 1H PYRAZOL 1 YL]BENZONITRILE;
4 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL] N (2 HYDROXY 2 METHYLPROPYL)BENZAMIDE;
4 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
4 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]OXY]BENZOIC ACID;
4 ARYLMETHYL 1 PHENYLPYRAZOLE DERIVATIVE;
4 ARYLOXY 1 PHENYLPYRAZOLE DERIVATIVE;
4 BENZYL 1 PHENYLPYRAZOLE DERIVATIVE;
ANDROGEN RECEPTOR;
ANDROGEN RECEPTOR ANTAGONIST;
BICALUTAMIDE;
METHYL 2 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)METHYL]BENZOIC ACID;
METHYL 2 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
METHYL 3 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)METHYL]BENZOIC ACID;
METHYL 3 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
METHYL 4 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)METHYL]BENZOIC ACID;
METHYL 4 [(3,5 DIMETHYL 1H PYRAZOL 4 YL)OXY]BENZOIC ACID;
METHYL 4 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZOIC ACID;
N [5 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]OXY]PYRIDIN 2 YL]ACETAMIDE;
N TERT BUTYL 4 [[1 (3 CHLORO 4 CYANOPHENYL) 3,5 DIMETHYL 1H PYRAZOL 4 YL]METHYL]BENZAMIDE;
PROSTATE SPECIFIC ANTIGEN;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ACYLATION;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTINEOPLASTIC ACTIVITY;
AREA UNDER THE CURVE;
ARTICLE;
BINDING AFFINITY;
CANCER INHIBITION;
CASTRATION RESISTANT PROSTATE CANCER;
CHEMICAL MODIFICATION;
CHEMICAL REACTION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
CROSS COUPLING REACTION;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG DESIGN;
DRUG EFFICACY;
DRUG SCREENING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
IN VIVO STUDY;
MALE;
MOUSE;
MUTANT;
NONHUMAN;
POLYMERIZATION;
PROTEIN BLOOD LEVEL;
PROTEIN SECRETION;
RECEPTOR BLOCKING;
SOLVOLYSIS;
STRUCTURE ACTIVITY RELATION;
SUBSTITUTION REACTION;
SUZUKI REACTION;
TREATMENT DURATION;
TUMOR VOLUME;
TUMOR XENOGRAFT;
WILD TYPE;
ADMINISTRATION, ORAL;
ANDROGEN RECEPTOR ANTAGONISTS;
ANIMALS;
CELL LINE, TUMOR;
CELL PROLIFERATION;
DRUG DESIGN;
HUMANS;
MALE;
MICE;
MICE, NUDE;
PROSTATE-SPECIFIC ANTIGEN;
PROSTATIC NEOPLASMS;
PYRAZOLES;
PYRIDINES;
RECEPTORS, ANDROGEN;
TRANSPLANTATION, HETEROLOGOUS;
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EID: 84863416983
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.02.005 Document Type: Article |
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Times cited : (29)
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References (42)
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