Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: Role of Nrf2/ARE pathway

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 7, 2015, Pages 10420-10428

  Cheng, Liang ^a   Jin, Zhenxiao ^a   Zhao, Rong ^a   Ren, Kai ^a   Deng, Chao ^a   Yu, Shiqiang ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HO 1; MDA; Myocardial ischemia reperfusion injury; Nrf 2; Resveratrol; SOD

Indexed keywords

BETA ACTIN; CREATINE KINASE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; MALONALDEHYDE; MYELOPEROXIDASE; RESVERATROL; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONTROLLED STUDY; HEART FUNCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE PRESSURE; INFLAMMATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84940676188     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Basgut B, Kayki G, Bartosova L, Ozakca I, Seymen A, Kandilci HB, Ugur M, Turan B and Ozcelikay AT. Cardioprotective effects of 44Bu, a newly synthesized compound, in rat heart subjected to ischemia/reperfusion injury. Eur J Pharmacol 2010; 640: 117-123.
2. Ramzy D, Rao V and Weisel RD. Clinical applicability of preconditioning and postconditioning: the cardiothoracic surgeons's view. Cardiovasc Res 2006; 70: 174-180.
3. Heusch G, Musiolik J, Gedik N and Skyschally A. Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion. Circ Res 2011; 109: 1302-1308.
4. Xiong J, Xue FS, Yuan YJ, Wang Q, Liao X and Wang WL. Cholinergic anti-inflammatory pathway: a possible approach to protect against myocardial ischemia reperfusion injury. Chin Med J (Engl) 2010; 123: 2720-2726.
5. Naidu BV, Farivar AS, Woolley SM, Grainger D, Verrier ED and Mulligan MS. Novel broad-spectrum chemokine inhibitor protects against lung ischemia-reperfusion injury. J Heart Lung Transplant 2004; 23: 128-134.
6. Cabigas EB, Somasuntharam I, Brown ME, Che PL, Pendergrass KD, Chiang B, Taylor WR and Davis ME. Over-expression of catalase in myeloid cells confers acute protection following myocardial infarction. Int J Mol Sci 2014; 15: 9036-9050.
7. Sekhar KR, Yan XX and Freeman ML. Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2. Oncogene 2002; 21: 6829-6834.
8. Radjendirane V, Joseph P, Lee YH, Kimura S, Klein-Szanto AJ, Gonzalez FJ and Jaiswal AK. Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity. J Biol Chem 1998; 273: 7382-7389.
9. Ku BM, Joo Y, Mun J, Roh GS, Kang SS, Cho GJ, Choi WS and Kim HJ. Heme oxygenase protects hippocampal neurons from ethanol-induced neurotoxicity. Neurosci Lett 2006; 405: 168-171.
10. Zhu H, Itoh K, Yamamoto M, Zweier JL and Li Y. Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: protection against reactive oxygen and nitrogen species-induced cell injury. FEBS Lett 2005; 579: 3029-3036.
11. Purdom-Dickinson SE, Lin Y, Dedek M, Morrissy S, Johnson J and Chen QM. Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor. J Mol Cell Cardiol 2007; 42: 159-176.
12. Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY and Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 2002; 26: 175-182.
13. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM and Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004; 114: 1248-1259.
14. Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S and Sugawara I. Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol 2008; 128: 366-373.
15. Renaud S and de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339: 1523-1526.
16. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR and Kim AL. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 2007; 224: 274-283.
17. Aluyen JK, Ton QN, Tran T, Yang AE, Gottlieb HB and Bellanger RA. Resveratrol: potential as anticancer agent. J Diet Suppl 2012; 9: 45-56.
18. Piotrowska H, Myszkowski K, Ziolkowska A, Kulcenty K, Wierzchowski M, Kaczmarek M, Murias M, Kwiatkowska-Borowczyk E and Jodynis-Liebert J. Resveratrol analogue 3,-4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells. Toxicol Appl Pharmacol 2012; 263: 53-60.
19. Xu Y, Nie L, Yin YG, Tang JL, Zhou JY, Li DD and Zhou SW. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells. Toxicol Appl Pharmacol 2012; 259: 395-401.
20. Li J, Feng L, Xing Y, Wang Y, Du L, Xu C, Cao J, Wang Q, Fan S, Liu Q and Fan F. Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1. Int J Mol Sci 2014; 15: 5928-5939.
21. Li F, Gong Q, Dong H and Shi J. Resveratrol, a neuroprotective supplement for Alzheimer's disease. Curr Pharm Des 2012; 18: 27-33.
22. Taguchi K, Motohashi H and Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011; 16: 123-140.
23. Tkachev VO, Menshchikova EB and Zenkov NK. Mechanism of the Nrf2/Keap1/ARE signaling system. Biochemistry (Mosc) 2011; 76: 407-422.
24. Black SC and Rodger IW. Methods for studying experimental myocardial ischemic and reperfusion injury. J Pharmacol Toxicol Methods 1996; 35: 179-190.
25. Speyer CL and Ward PA. Role of endothelial chemokines and their receptors during inflammation. J Invest Surg 2011; 24: 18-27.
26. Lefer AM, Ma XL, Weyrich A and Lefer DJ. Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury. Agents Actions Suppl 1993; 41: 127-135.
27. Loh KP, Huang SH, De Silva R, Tan BK and Zhu YZ. Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res 2006; 3: 327-337.
28. Manzanero S, Santro T and Arumugam TV. Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury. Neurochem Int 2013; 62: 712-718.
29. Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martinez G and Leon OS. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res 2001; 41: 233-241.
30. Niizuma K, Yoshioka H, Chen H, Kim GS, Jung JE, Katsu M, Okami N and Chan PH. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 2010; 1802: 92-99.
31. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21: 2-14.
32. Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S and Dore S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neu-roscience 2007; 147: 53-59.
33. Kaspar JW, Niture SK and Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 2009; 47: 1304-1309.
34. Niture SK and Jaiswal AK. INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis. Cell Death Differ 2011; 18: 439-451.
35. Hseu YC, Chou CW, Senthil Kumar KJ, Fu KT, Wang HM, Hsu LS, Kuo YH, Wu CR, Chen SC and Yang HL. Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food Chem Toxicol 2012; 50: 1245-1255.
36. Srisook K, Kim C and Cha YN. Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch. Antioxid Redox Signal 2005; 7: 1674-1687.
37. Surh YJ, Kundu JK, Li MH, Na HK and Cha YN. Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Arch Pharm Res 2009; 32: 1163-1176.
38. Kim YM, Pae HO, Park JE, Lee YC, Woo JM, Kim NH, Choi YK, Lee BS, Kim SR and Chung HT. Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2011; 14: 137-167.