Cholinergic anti-inflammatory pathway: A possible approach to protect against myocardial ischemia reperfusion injury

Chinese Medical Journal

Volumn 123, Issue 19, 2010, Pages 2720-2726

  Xiong, Jun ^a   Xue, Fu Shan ^a   Yuan, Yu Jing ^a   Wang, Qiang ^a   Liao, Xu ^a   Wang, Wei Li ^a  

^a PLASTIC SURGERY HOSPITAL   (China)

Author keywords

Cytokines; Inflammation; Myocardial ischemia reperfusion injury; Nicotine acetylcholine receptor; Vagal nerve stimulation

Indexed keywords

ACETYLCHOLINE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; NICOTINIC RECEPTOR;

ACETYLCHOLINE RELEASE; ACUTE HEART INFARCTION; CHOLINERGIC SYSTEM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; ISCHEMIC PRECONDITIONING; MEDLINE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PERCUTANEOUS CORONARY INTERVENTION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; VAGUS NERVE STIMULATION;

ANIMALS; CYTOKINES; HUMANS; INFLAMMATION; MODELS, BIOLOGICAL; MYOCARDIAL REPERFUSION INJURY; VAGUS NERVE STIMULATION;

EID: 78149272143     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.19.019     Document Type: Review

References (50)

1. Matsukawa A. STAT proteins in innate immunity during sepsis: lessons from gene knockout mice. Acta Med Okayama 2007; 61: 239-245.
2. Xiong J, Xue FS, Xu YC, Yang QY, Liao X, Wang WL. Cholinergic agonists may produce preservation of myocardial ischaemia/reperfusion injury. Med Hypotheses 2009; 73: 312-314.
3. Gallowitsch-Puerta M, Pavlov VA. Neuro-immune interactions via the cholinergic anti-inflammatory pathway. Life Sci 2007; 80: 2325-2329.
4. Pavlov VA, Parrish WR, Rosas-Ballina M, Ochani M, Puerta M, Ochani K, et al. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav Immun 2009; 23: 41-45.
5. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458-462.
6. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003; 421: 384-388.
7. Moccia F, Frost C, Berra-Romani R, Tanzi F, Adams DJ. Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells. Am J Physiol Heart Circ Physiol 2004; 286: H486-H491.
8. Yeboah MM, Xue X, Javdan M, Susin M, Metz CN. Nicotinic acetylcholine receptor expression and regulation in the rat kidney after ischemia-reperfusion injury. Am J Physiol Renal Physiol 2008; 295: F654-F661.
9. Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 2003; 9: 125-134.
10. Huston JM, Gallowitsch-Puerta M, Ochani M, Ochani K, Yuan R, Rosas-Ballina M, et al. Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med 2007; 35: 2762-2768.
11. Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331-342.
12. Yang H, Wang H, Czura CJ, Tracey KJ. The cytokine activity of HMGB1. J Leukoc Biol 2005; 78: 1-8.
13. Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004; 10: 1216-1221.
14. Rosas-Ballina M, Tracey KJ. Cholinergic control of inflammation. J Intern Med 2009; 265: 663-679.
15. Song XM, Li JG, Wang YL, Hu ZF, Zhou Q, Du Zh, et al. The protective effect of the cholinergic anti-inflammatory pathway against septic shock in rats. Shock 2008; 30: 468-472.
16. van Westerloo DJ, Giebelen IA, Meijers JC, Daalhuisen J, de Vos AF, Levi M, et al. Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats. J Thromb Haemost 2006; 4: 1997-2002.
17. Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, Huston J, et al. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 2005; 201: 1113-1123.
18. Wittebole X, Hahm S, Coyle SM, Kumar A, Calvano SE, Lowry SF. Nicotine exposure alters in vivo human responses to endotoxin. Clin Exp Immunol 2007; 147: 28-34.
19. Li H, Yang TD. Vagus nerve stimulation may be used in the therapy of myocarditis. Med Hypotheses 2009; 73: 725-727.
20. Hausenloy DJ, Yellon DM. Myocardial protection: is primary PCI enough? Nat Clin Pract Cardiovasc Med 2009; 6: 12-13.
21. Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, et al. Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. J Thorac Cardiovasc Surg 2009; 138: 977-984.
22. Litt MR, Jeremy RW, Weisman HF, Winkelstein JA, Becker LC. Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury. Circulation 1989; 80: 1816-1827.
23. Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 2004; 61: 481-497.
24. Pavlov VA. Cholinergic modulation of inflammation. Int J Clin Exp Med 2008; 1: 203-212.
25. Li CL, Jiang J, Fan YQ, Fu GS, Wang JA, Fan WM. Knockout of the tumor necrosis factor α receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia- reperfusion injury in mice. Chin Med J 2009; 122: 566-570.
26. Shimaoka M, Park EJ. Advances in understanding sepsis. Eur J Anaesthesiol Suppl 2008; 42: 146-153.
27. Schulz R. TNFalpha in myocardial ischemia/reperfusion: damage vs. protection. J Mol Cell Cardiol 2008; 45: 712-714.
28. Xiao H, Chen Z, Liao Y, Cheng X, Liu K, Wang Y, et al. Positive correlation of tumor necrosis factor-alpha early expression in myocardium and ventricular arrhythmias in rats with acute myocardial infarction. Arch Med Res 2008; 39: 285-291.
29. Shu J, Ren N, Du JB, Zhang M, Cong HL, Huang TG. Increased levels of interleukin-6 and matrix metalloproteinase-9 are of cardiac origin in acute coronary syndrome. Scand Cardiovasc J 2007; 41: 149-154.
30. Kaminski KA, Kozuch M, Bonda TA, Stepaniuk MM, Waszkiewicz E, Chyczewski L, et al. Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart. Pharmacol Rep 2009; 61: 504-513.
31. Kaminski KA, Kozuch M, Bonda T, Wojtkowska I, Kozieradzka A, Dobrzycki S, et al. Coronary sinus concentrations of interleukin 6 and its soluble receptors are affected by reperfusion and may portend complications in patients with myocardial infarction. Atherosclerosis 2009; 206: 581-587.
32. Kanda T, Takahashi T. Interleukin-6 and cardiovascular diseases. Jpn Heart J 2004; 45: 183-193.
33. Oozawa S, Mori S, Kanke T, Takahashi H, Liu K, Tomono Y, et al. Effects of HMGB1 on ischemia-reperfusion injury in the rat heart. Circ J 2008; 72: 1178-1184.
34. Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008; 117: 3216-3226.
35. Steffens S, Montecucco F, Mach F. The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury. Thromb Haemost 2009; 102: 240-247.
36. Gourdin MJ, Bree B, De Kock M. The impact of ischaemia-reperfusion on the blood vessel. Eur J Anaesthesiol 2009; 26: 537-547.
37. Bernik TR, Friedman SG, Ochani M, Diraimo R, Susarla S, Czura CJ, et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg 2002; 36: 1231-1236.
38. Mioni C, Bazzani C, Giuliani D, Altavilla D, Leone S, Ferrari A, et al. Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/ reperfusion injury in rats. Crit Care Med 2005; 33: 2621-2628.
39. Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, et al. Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. J Thorac Cardiovasc Surg 2009; 137: 223-231.
40. Hausenloy DJ, Yellon DM. Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. Heart Fail Rev 2007; 12: 217-234.
41. Lecour S. Activation of the protective survivor activating factor enhancement (SAFE) pathway against reperfusion injury: does it go beyond the RISK pathway? J Mol Cell Cardiol 2009; 47: 32-40.
42. Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, et al. Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha. FEBS Lett 2005; 579: 2111-2118.
43. Marrero MB, Bencherif M. Convergence of α7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-κB. Brain Res 2009; 1256: 1-7.
44. Zuanetti G, De Ferrari GM, Priori SG, Schwartz PJ. Protective effect of vagal stimulation on reperfusion arrhythmias in cats. Circ Res 1987; 61: 429-435.
45. Kawada T, Yamazaki T, Akiyama T, Li M, Ariumi H, Mori H, et al. Vagal stimulation suppresses ischemia-induced myocardial interstitial norepinephrine release. Life Sci 2006; 78: 882-887.
46. Johnston GR, Webster NR. Cytokines and the immuno- modulatory function of the vagus nerve. Br J Anaesth 2009; 102: 453-462.
47. Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C, et al. Long term vagal stimulation in patients with advanced heart failure: first experience in man. Eur J Heart Fail 2008; 10: 884-891.
48. Sun HY, Xue FS, Xu YC, Li CW, Yang QY, Liao X, et al. Propofol improves cardiac functional recovery after ischemia-reperfusion by upregulating nitric oxide synthase activity in the isolated rat hearts. Chin Med J 2009; 122: 3048-3054.
49. Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, et al. Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia- reperfusion injury in rabbit. Am J Physiol Heart Circ Physiol 2007; 293: H2254-H2261.
50. Zamotrinsky AV, Kondratiev B, de Jong JW. Vagal neurostimulation in patients with coronary artery disease. Auton Neurosci 2001; 88: 109-116.