Morphological and functional characterization and assessment of iPSC-derived hepatocytes for in vitro toxicity testing

Toxicological Sciences

Volumn 147, Issue 1, 2015, Pages 39-54

  Lu, Jingtao ^a   Einhorn, Shannon ^b   Venkatarangan, Lata ^c   Miller, Manda ^a   Mann, David A ^b   Watkins, Paul B ^a,d   LeCluyse, Edward ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b Cellular Dynamics International Inc   (United States)

^c QPS DMPK Hepatic Biosciences   (United States)

^d IL   (United States)

Author keywords

Hepatocytes; In vitro models; Induced pluripotent stem cells; Toxicity testing

Indexed keywords

ALBUMIN; ALPHA 1 ANTITRYPSIN; ASIALOGLYCOPROTEIN RECEPTOR; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DRUG METABOLIZING ENZYME; GLYCOGEN; NEFAZODONE; PARACETAMOL; THEOPHYLLINE; TROGLITAZONE; TROVAFLOXACIN; TUMOR NECROSIS FACTOR ALPHA; NAPHTHYRIDINE DERIVATIVE; QUINOLONE DERIVATIVE;

ADULT; ARTICLE; CARBOHYDRATE SYNTHESIS; CELL FUNCTION; CELL MEMBRANE; CELL METABOLISM; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; FETUS; FUNCTIONAL ASSESSMENT; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPIDOSIS; LIPOGENESIS; LIVER CELL; MORPHOLOGICAL TRAIT; NEWBORN; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TOXIC HEPATITIS; TOXICITY TESTING; BILE; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; INDUCED PLURIPOTENT STEM CELL; LIPID METABOLISM; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; PREGNANCY; PROCEDURES; REPRODUCIBILITY; ULTRASTRUCTURE;

ACETAMINOPHEN; ADULT; BILE; CELLS, CULTURED; DRUG-INDUCED LIVER INJURY; FEMALE; FLUOROQUINOLONES; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HEPATOCYTES; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INFANT, NEWBORN; LIPID METABOLISM; LIPIDOSES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NAPHTHYRIDINES; PREGNANCY; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS; TRANSCRIPTION, GENETIC;

EID: 84940647648     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv117     Document Type: Article

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