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Volumn 11, Issue , 2011, Pages

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

Author keywords

Cyp450; Hepatocyte like cell; Immortalization; Msc

Indexed keywords

BASAL EXPRESSION; CELL LINES; CYP450; CYTOCHROME P450; HEPATOCYTE-LIKE CELL; HEPATOCYTES; HEPATOTOXICITY; HUMAN HEPATOCYTES; HUMAN MESENCHYMAL STEM CELLS; IMMORTALIZATION; MESENCHYMAL STEM CELL; MSC; PRIMARY HEPATOCYTES; UP-REGULATION;

EID: 80053378608     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-89     Document Type: Article
Times cited : (38)

References (61)
  • 1
    • 54949144309 scopus 로고    scopus 로고
    • Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
    • 10.1007/s00216-008-2291-6, 18695978
    • Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem 2008, 392(6):1093-1108. 10.1007/s00216-008-2291-6, 18695978.
    • (2008) Anal Bioanal Chem , vol.392 , Issue.6 , pp. 1093-1108
    • Zanger, U.M.1    Turpeinen, M.2    Klein, K.3    Schwab, M.4
  • 2
    • 33644842869 scopus 로고    scopus 로고
    • Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites
    • 10.1016/j.ejps.2005.12.007, 16472997
    • Zamek-Gliszczynski MJ, Hoffmaster KA, Nezasa K, Tallman MN, Brouwer KL. Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci 2006, 27(5):447-486. 10.1016/j.ejps.2005.12.007, 16472997.
    • (2006) Eur J Pharm Sci , vol.27 , Issue.5 , pp. 447-486
    • Zamek-Gliszczynski, M.J.1    Hoffmaster, K.A.2    Nezasa, K.3    Tallman, M.N.4    Brouwer, K.L.5
  • 3
    • 67349231225 scopus 로고    scopus 로고
    • CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines
    • 10.1016/j.taap.2009.03.001, 2752030, 19285097
    • Uno S, Endo K, Ishida Y, Tateno C, Makishima M, Yoshizato K, Nebert DW. CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines. Toxicol Appl Pharmacol 2009, 237(1):119-126. 10.1016/j.taap.2009.03.001, 2752030, 19285097.
    • (2009) Toxicol Appl Pharmacol , vol.237 , Issue.1 , pp. 119-126
    • Uno, S.1    Endo, K.2    Ishida, Y.3    Tateno, C.4    Makishima, M.5    Yoshizato, K.6    Nebert, D.W.7
  • 4
    • 33748905486 scopus 로고    scopus 로고
    • Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    • 10.1124/dmd.106.010132, 16837568
    • Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM. Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos 2006, 34(10):1742-1748. 10.1124/dmd.106.010132, 16837568.
    • (2006) Drug Metab Dispos , vol.34 , Issue.10 , pp. 1742-1748
    • Ripp, S.L.1    Mills, J.B.2    Fahmi, O.A.3    Trevena, K.A.4    Liras, J.L.5    Maurer, T.S.6    de Morais, S.M.7
  • 5
    • 70350176493 scopus 로고    scopus 로고
    • Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice
    • 10.1002/jcb.22306, 19693776
    • Tao XR, Li WL, Su J, Jin CX, Wang XM, Li JX, Hu JK, Xiang ZH, Lau JT, Hu YP. Clonal mesenchymal stem cells derived from human bone marrow can differentiate into hepatocyte-like cells in injured livers of SCID mice. J Cell Biochem 2009, 108(3):693-704. 10.1002/jcb.22306, 19693776.
    • (2009) J Cell Biochem , vol.108 , Issue.3 , pp. 693-704
    • Tao, X.R.1    Li, W.L.2    Su, J.3    Jin, C.X.4    Wang, X.M.5    Li, J.X.6    Hu, J.K.7    Xiang, Z.H.8    Lau, J.T.9    Hu, Y.P.10
  • 6
    • 16244365866 scopus 로고    scopus 로고
    • Hepatocytic gene expression in cultured rat mesenchymal stem cells
    • 10.1016/j.transproceed.2004.11.087, 15808618
    • Lange C, Bassler P, Lioznov MV, Bruns H, Kluth D, Zander AR, Fiegel HC. Hepatocytic gene expression in cultured rat mesenchymal stem cells. Transplant Proc 2005, 37(1):276-279. 10.1016/j.transproceed.2004.11.087, 15808618.
    • (2005) Transplant Proc , vol.37 , Issue.1 , pp. 276-279
    • Lange, C.1    Bassler, P.2    Lioznov, M.V.3    Bruns, H.4    Kluth, D.5    Zander, A.R.6    Fiegel, H.C.7
  • 7
    • 56049102132 scopus 로고    scopus 로고
    • Fetal liver-conditioned medium induces hepatic specification from mouse bone marrow mesenchymal stromal cells: a novel strategy for hepatic transdifferentiation
    • 10.1080/14653240802360704, 18985473
    • Pan RL, Chen Y, Xiang LX, Shao JZ, Dong XJ, Zhang GR. Fetal liver-conditioned medium induces hepatic specification from mouse bone marrow mesenchymal stromal cells: a novel strategy for hepatic transdifferentiation. Cytotherapy 2008, 10(7):668-675. 10.1080/14653240802360704, 18985473.
    • (2008) Cytotherapy , vol.10 , Issue.7 , pp. 668-675
    • Pan, R.L.1    Chen, Y.2    Xiang, L.X.3    Shao, J.Z.4    Dong, X.J.5    Zhang, G.R.6
  • 8
    • 35648943163 scopus 로고    scopus 로고
    • Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression
    • 10.1111/j.1872-034X.2007.00162.x, 17627621
    • Shimomura T, Yoshida Y, Sakabe T, Ishii K, Gonda K, Murai R, Takubo K, Tsuchiya H, Hoshikawa Y, Kurimasa A, et al. Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatol Res 2007, 37(12):1068-1079. 10.1111/j.1872-034X.2007.00162.x, 17627621.
    • (2007) Hepatol Res , vol.37 , Issue.12 , pp. 1068-1079
    • Shimomura, T.1    Yoshida, Y.2    Sakabe, T.3    Ishii, K.4    Gonda, K.5    Murai, R.6    Takubo, K.7    Tsuchiya, H.8    Hoshikawa, Y.9    Kurimasa, A.10
  • 9
    • 34547461813 scopus 로고    scopus 로고
    • Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes
    • 10.1002/hep.21704, 17596885
    • Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, Okochi H, Ochiya T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology 2007, 46(1):219-228. 10.1002/hep.21704, 17596885.
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 219-228
    • Banas, A.1    Teratani, T.2    Yamamoto, Y.3    Tokuhara, M.4    Takeshita, F.5    Quinn, G.6    Okochi, H.7    Ochiya, T.8
  • 10
    • 70449721168 scopus 로고    scopus 로고
    • Expression of liver-specific markers in naive adipose-derived mesenchymal stem cells
    • 10.1111/j.1478-3231.2009.02054.x, 19515222
    • Zemel R, Bachmetov L, Ad-El D, Abraham A, Tur-Kaspa R. Expression of liver-specific markers in naive adipose-derived mesenchymal stem cells. Liver Int 2009, 29(9):1326-1337. 10.1111/j.1478-3231.2009.02054.x, 19515222.
    • (2009) Liver Int , vol.29 , Issue.9 , pp. 1326-1337
    • Zemel, R.1    Bachmetov, L.2    Ad-El, D.3    Abraham, A.4    Tur-Kaspa, R.5
  • 11
    • 40349085915 scopus 로고    scopus 로고
    • A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells
    • 10.1111/j.1742-4658.2008.06287.x, 18318837
    • Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T. A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J 2008, 275(6):1260-1273. 10.1111/j.1742-4658.2008.06287.x, 18318837.
    • (2008) FEBS J , vol.275 , Issue.6 , pp. 1260-1273
    • Yamamoto, Y.1    Banas, A.2    Murata, S.3    Ishikawa, M.4    Lim, C.R.5    Teratani, T.6    Hatada, I.7    Matsubara, K.8    Kato, T.9    Ochiya, T.10
  • 13
    • 39749171878 scopus 로고    scopus 로고
    • Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    • 10.1053/j.gastro.2007.12.024, 18243183
    • Campard D, Lysy PA, Najimi M, Sokal EM. Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology 2008, 134(3):833-848. 10.1053/j.gastro.2007.12.024, 18243183.
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 833-848
    • Campard, D.1    Lysy, P.A.2    Najimi, M.3    Sokal, E.M.4
  • 14
    • 68049132606 scopus 로고    scopus 로고
    • Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells
    • 10.1080/14653240902849754, 19513901
    • Zhao Q, Ren H, Li X, Chen Z, Zhang X, Gong W, Liu Y, Pang T, Han ZC. Differentiation of human umbilical cord mesenchymal stromal cells into low immunogenic hepatocyte-like cells. Cytotherapy 2009, 11(4):414-426. 10.1080/14653240902849754, 19513901.
    • (2009) Cytotherapy , vol.11 , Issue.4 , pp. 414-426
    • Zhao, Q.1    Ren, H.2    Li, X.3    Chen, Z.4    Zhang, X.5    Gong, W.6    Liu, Y.7    Pang, T.8    Han, Z.C.9
  • 15
    • 77950603767 scopus 로고    scopus 로고
    • New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity
    • 10.1089/scd.2009.0299, 19958166
    • Anzalone R, Iacono ML, Corrao S, Magno F, Loria T, Cappello F, Zummo G, Farina F, La Rocca G. New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity. Stem Cells Dev 2010, 19(4):423-438. 10.1089/scd.2009.0299, 19958166.
    • (2010) Stem Cells Dev , vol.19 , Issue.4 , pp. 423-438
    • Anzalone, R.1    Iacono, M.L.2    Corrao, S.3    Magno, F.4    Loria, T.5    Cappello, F.6    Zummo, G.7    Farina, F.8    La Rocca, G.9
  • 16
    • 77949457175 scopus 로고    scopus 로고
    • The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver
    • 10.1038/nprot.2010.7, 20224562
    • Stock P, Bruckner S, Ebensing S, Hempel M, Dollinger MM, Christ B. The generation of hepatocytes from mesenchymal stem cells and engraftment into murine liver. Nat Protoc 2010, 5(4):617-627. 10.1038/nprot.2010.7, 20224562.
    • (2010) Nat Protoc , vol.5 , Issue.4 , pp. 617-627
    • Stock, P.1    Bruckner, S.2    Ebensing, S.3    Hempel, M.4    Dollinger, M.M.5    Christ, B.6
  • 17
    • 40449118677 scopus 로고    scopus 로고
    • Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure
    • Cho CH, Parashurama N, Park EY, Suganuma K, Nahmias Y, Park J, Tilles AW, Berthiaume F, Yarmush ML. Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB J 2008, 22(3):898-909.
    • (2008) FASEB J , vol.22 , Issue.3 , pp. 898-909
    • Cho, C.H.1    Parashurama, N.2    Park, E.Y.3    Suganuma, K.4    Nahmias, Y.5    Park, J.6    Tilles, A.W.7    Berthiaume, F.8    Yarmush, M.L.9
  • 18
    • 78751643138 scopus 로고    scopus 로고
    • Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Hepatocyte-like Cells on Nanofibers and Their Transplantation into a Carbon Tetrachloride-Induced Liver Fibrosis Model
    • 10.1007/s12015-010-9126-5, 20182823
    • Piryaei A, Valojerdi MR, Shahsavani M, Baharvand H. Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Hepatocyte-like Cells on Nanofibers and Their Transplantation into a Carbon Tetrachloride-Induced Liver Fibrosis Model. Stem Cell Rev 2011, 7(1):103-18. 10.1007/s12015-010-9126-5, 20182823.
    • (2011) Stem Cell Rev , vol.7 , Issue.1 , pp. 103-118
    • Piryaei, A.1    Valojerdi, M.R.2    Shahsavani, M.3    Baharvand, H.4
  • 20
    • 59849123877 scopus 로고    scopus 로고
    • Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo
    • 10.1111/j.1478-3231.2008.01855.x, 19141029
    • Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, Zhou H, Mao F. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int 2009, 29(3):356-365. 10.1111/j.1478-3231.2008.01855.x, 19141029.
    • (2009) Liver Int , vol.29 , Issue.3 , pp. 356-365
    • Yan, Y.1    Xu, W.2    Qian, H.3    Si, Y.4    Zhu, W.5    Cao, H.6    Zhou, H.7    Mao, F.8
  • 21
    • 77950553914 scopus 로고    scopus 로고
    • No contribution of umbilical cord mesenchymal stromal cells to capillarization and venularization of hepatic sinusoids accompanied by hepatic differentiation in carbon tetrachloride-induced mouse liver fibrosis
    • 10.3109/14653241003596661, 20184502
    • Ren H, Zhao Q, Cheng T, Lu S, Chen Z, Meng L, Zhu X, Yang S, Xing W, Xiao Y, et al. No contribution of umbilical cord mesenchymal stromal cells to capillarization and venularization of hepatic sinusoids accompanied by hepatic differentiation in carbon tetrachloride-induced mouse liver fibrosis. Cytotherapy 2010, 12(3):371-383. 10.3109/14653241003596661, 20184502.
    • (2010) Cytotherapy , vol.12 , Issue.3 , pp. 371-383
    • Ren, H.1    Zhao, Q.2    Cheng, T.3    Lu, S.4    Chen, Z.5    Meng, L.6    Zhu, X.7    Yang, S.8    Xing, W.9    Xiao, Y.10
  • 23
    • 4043121150 scopus 로고    scopus 로고
    • Immunolocalization of extracellular matrix components and integrins during mouse liver development
    • 10.1002/hep.20303, 15368439
    • Shiojiri N, Sugiyama Y. Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology 2004, 40(2):346-355. 10.1002/hep.20303, 15368439.
    • (2004) Hepatology , vol.40 , Issue.2 , pp. 346-355
    • Shiojiri, N.1    Sugiyama, Y.2
  • 24
    • 74949111272 scopus 로고    scopus 로고
    • The Fox genes in the liver: from organogenesis to functional integration
    • 10.1152/physrev.00018.2009, 20086072
    • Le Lay J, Kaestner KH. The Fox genes in the liver: from organogenesis to functional integration. Physiol Rev 2010, 90(1):1-22. 10.1152/physrev.00018.2009, 20086072.
    • (2010) Physiol Rev , vol.90 , Issue.1 , pp. 1-22
    • Le Lay, J.1    Kaestner, K.H.2
  • 25
    • 70349437359 scopus 로고    scopus 로고
    • Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells
    • 10.1093/humrep/dep232, 19556288
    • Unger C, Gao S, Cohen M, Jaconi M, Bergstrom R, Holm F, Galan A, Sanchez E, Irion O, Dubuisson JB, et al. Immortalized human skin fibroblast feeder cells support growth and maintenance of both human embryonic and induced pluripotent stem cells. Hum Reprod 2009, 24(10):2567-2581. 10.1093/humrep/dep232, 19556288.
    • (2009) Hum Reprod , vol.24 , Issue.10 , pp. 2567-2581
    • Unger, C.1    Gao, S.2    Cohen, M.3    Jaconi, M.4    Bergstrom, R.5    Holm, F.6    Galan, A.7    Sanchez, E.8    Irion, O.9    Dubuisson, J.B.10
  • 28
    • 53849093733 scopus 로고    scopus 로고
    • Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical
    • 10.1208/s12248-008-9037-4, 2751387, 18686044
    • Sinz M, Wallace G, Sahi J. Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical. AAPS J 2008, 10(2):391-400. 10.1208/s12248-008-9037-4, 2751387, 18686044.
    • (2008) AAPS J , vol.10 , Issue.2 , pp. 391-400
    • Sinz, M.1    Wallace, G.2    Sahi, J.3
  • 29
    • 49649087696 scopus 로고    scopus 로고
    • Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta
    • 10.1002/hep.22362, 18666263
    • Ishii K, Yoshida Y, Akechi Y, Sakabe T, Nishio R, Ikeda R, Terabayashi K, Matsumi Y, Gonda K, Okamoto H, et al. Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology 2008, 48(2):597-606. 10.1002/hep.22362, 18666263.
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 597-606
    • Ishii, K.1    Yoshida, Y.2    Akechi, Y.3    Sakabe, T.4    Nishio, R.5    Ikeda, R.6    Terabayashi, K.7    Matsumi, Y.8    Gonda, K.9    Okamoto, H.10
  • 30
    • 54049086054 scopus 로고    scopus 로고
    • Characterization and hepatogenic differentiation of mesenchymal stem cells from human amniotic fluid and human bone marrow: a comparative study
    • 10.1016/j.cellbi.2008.08.015, 18782626
    • Zheng YB, Gao ZL, Xie C, Zhu HP, Peng L, Chen JH, Chong YT. Characterization and hepatogenic differentiation of mesenchymal stem cells from human amniotic fluid and human bone marrow: a comparative study. Cell Biol Int 2008, 32(11):1439-1448. 10.1016/j.cellbi.2008.08.015, 18782626.
    • (2008) Cell Biol Int , vol.32 , Issue.11 , pp. 1439-1448
    • Zheng, Y.B.1    Gao, Z.L.2    Xie, C.3    Zhu, H.P.4    Peng, L.5    Chen, J.H.6    Chong, Y.T.7
  • 31
    • 4644231469 scopus 로고    scopus 로고
    • The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane × receptor (PXR) and constitutively activated receptor (CAR)
    • 10.1074/jbc.M404949200, 15252010
    • Burk O, Koch I, Raucy J, Hustert E, Eichelbaum M, Brockmoller J, Zanger UM, Wojnowski L. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane × receptor (PXR) and constitutively activated receptor (CAR). J Biol Chem 2004, 279(37):38379-38385. 10.1074/jbc.M404949200, 15252010.
    • (2004) J Biol Chem , vol.279 , Issue.37 , pp. 38379-38385
    • Burk, O.1    Koch, I.2    Raucy, J.3    Hustert, E.4    Eichelbaum, M.5    Brockmoller, J.6    Zanger, U.M.7    Wojnowski, L.8
  • 32
    • 79952199658 scopus 로고    scopus 로고
    • HNF-4alpha determines hepatic differentiation of human mesenchymal stem cells from bone marrow
    • 10.3748/wjg.v16.i40.5092, 2965287, 20976847
    • Chen ML, Lee KD, Huang HC, Tsai YL, Wu YC, Kuo TM, Hu CP, Chang C. HNF-4alpha determines hepatic differentiation of human mesenchymal stem cells from bone marrow. World J Gastroenterol 2010, 16(40):5092-5103. 10.3748/wjg.v16.i40.5092, 2965287, 20976847.
    • (2010) World J Gastroenterol , vol.16 , Issue.40 , pp. 5092-5103
    • Chen, M.L.1    Lee, K.D.2    Huang, H.C.3    Tsai, Y.L.4    Wu, Y.C.5    Kuo, T.M.6    Hu, C.P.7    Chang, C.8
  • 33
    • 37249076884 scopus 로고    scopus 로고
    • Stem cell plasticity: learning from hepatogenic differentiation strategies
    • 10.1002/dvdy.21330, 17907200
    • Banas A, Yamamoto Y, Teratani T, Ochiya T. Stem cell plasticity: learning from hepatogenic differentiation strategies. Dev Dyn 2007, 236(12):3228-3241. 10.1002/dvdy.21330, 17907200.
    • (2007) Dev Dyn , vol.236 , Issue.12 , pp. 3228-3241
    • Banas, A.1    Yamamoto, Y.2    Teratani, T.3    Ochiya, T.4
  • 34
    • 70849088109 scopus 로고    scopus 로고
    • Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton's jelly into hepatocyte-like cells
    • 10.1080/14653240903051533, 19657806
    • Zhang YN, Lie PC, Wei X. Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton's jelly into hepatocyte-like cells. Cytotherapy 2009, 11(5):548-558. 10.1080/14653240903051533, 19657806.
    • (2009) Cytotherapy , vol.11 , Issue.5 , pp. 548-558
    • Zhang, Y.N.1    Lie, P.C.2    Wei, X.3
  • 35
    • 63849329673 scopus 로고    scopus 로고
    • Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
    • 10.1136/gut.2008.154880, 19022918
    • Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, Brulport M, Hengstler JG, Dollinger MM, Fleig WE, et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut 2009, 58(4):570-581. 10.1136/gut.2008.154880, 19022918.
    • (2009) Gut , vol.58 , Issue.4 , pp. 570-581
    • Aurich, H.1    Sgodda, M.2    Kaltwasser, P.3    Vetter, M.4    Weise, A.5    Liehr, T.6    Brulport, M.7    Hengstler, J.G.8    Dollinger, M.M.9    Fleig, W.E.10
  • 36
    • 34247368402 scopus 로고    scopus 로고
    • Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities
    • 10.1089/clo.2006.0045, 17386014
    • Hay DC, Zhao D, Ross A, Mandalam R, Lebkowski J, Cui W. Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities. Cloning Stem Cells 2007, 9(1):51-62. 10.1089/clo.2006.0045, 17386014.
    • (2007) Cloning Stem Cells , vol.9 , Issue.1 , pp. 51-62
    • Hay, D.C.1    Zhao, D.2    Ross, A.3    Mandalam, R.4    Lebkowski, J.5    Cui, W.6
  • 37
    • 66149163071 scopus 로고    scopus 로고
    • A comprehensive review on mesenchymal stem cell growth and senescence
    • 10.1089/rej.2009.0830, 19405814
    • Ksiazek K. A comprehensive review on mesenchymal stem cell growth and senescence. Rejuvenation Res 2009, 12(2):105-116. 10.1089/rej.2009.0830, 19405814.
    • (2009) Rejuvenation Res , vol.12 , Issue.2 , pp. 105-116
    • Ksiazek, K.1
  • 38
    • 75749115996 scopus 로고    scopus 로고
    • Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
    • 10.1073/pnas.0909333107, 2824310, 20080645
    • Gjerdrum C, Tiron C, Hoiby T, Stefansson I, Haugen H, Sandal T, Collett K, Li S, McCormack E, Gjertsen BT, et al. Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci USA 2010, 107(3):1124-1129. 10.1073/pnas.0909333107, 2824310, 20080645.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.3 , pp. 1124-1129
    • Gjerdrum, C.1    Tiron, C.2    Hoiby, T.3    Stefansson, I.4    Haugen, H.5    Sandal, T.6    Collett, K.7    Li, S.8    McCormack, E.9    Gjertsen, B.T.10
  • 39
    • 47249166372 scopus 로고    scopus 로고
    • Replicative senescence of mesenchymal stem cells: a continuous and organized process
    • 10.1371/journal.pone.0002213, 2374903, 18493317
    • Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, Saffrich R, Benes V, Blake J, Pfister S, Eckstein V, et al. Replicative senescence of mesenchymal stem cells: a continuous and organized process. PLoS One 2008, 3(5):e2213. 10.1371/journal.pone.0002213, 2374903, 18493317.
    • (2008) PLoS One , vol.3 , Issue.5
    • Wagner, W.1    Horn, P.2    Castoldi, M.3    Diehlmann, A.4    Bork, S.5    Saffrich, R.6    Benes, V.7    Blake, J.8    Pfister, S.9    Eckstein, V.10
  • 40
    • 49549114293 scopus 로고    scopus 로고
    • Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer
    • 10.1111/j.1582-4934.2008.00299.x, 18318690
    • Boker W, Yin Z, Drosse I, Haasters F, Rossmann O, Wierer M, Popov C, Locher M, Mutschler W, Docheva D, et al. Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med 2008, 12(4):1347-1359. 10.1111/j.1582-4934.2008.00299.x, 18318690.
    • (2008) J Cell Mol Med , vol.12 , Issue.4 , pp. 1347-1359
    • Boker, W.1    Yin, Z.2    Drosse, I.3    Haasters, F.4    Rossmann, O.5    Wierer, M.6    Popov, C.7    Locher, M.8    Mutschler, W.9    Docheva, D.10
  • 41
    • 67650688417 scopus 로고    scopus 로고
    • Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics
    • 10.1089/ten.tea.2008.0205, 3092731, 19125642
    • Wolbank S, Stadler G, Peterbauer A, Gillich A, Karbiener M, Streubel B, Wieser M, Katinger H, van Griensven M, Redl H, et al. Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics. Tissue Eng Part A 2009, 15(7):1843-1854. 10.1089/ten.tea.2008.0205, 3092731, 19125642.
    • (2009) Tissue Eng Part A , vol.15 , Issue.7 , pp. 1843-1854
    • Wolbank, S.1    Stadler, G.2    Peterbauer, A.3    Gillich, A.4    Karbiener, M.5    Streubel, B.6    Wieser, M.7    Katinger, H.8    van Griensven, M.9    Redl, H.10
  • 42
    • 10444258868 scopus 로고    scopus 로고
    • Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite [corrected] extensive proliferation
    • 10.1016/j.bbrc.2004.11.059, 15596132
    • Abdallah BM, Haack-Sorensen M, Burns JS, Elsnab B, Jakob F, Hokland P, Kassem M. Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite [corrected] extensive proliferation. Biochem Biophys Res Commun 2005, 326(3):527-538. 10.1016/j.bbrc.2004.11.059, 15596132.
    • (2005) Biochem Biophys Res Commun , vol.326 , Issue.3 , pp. 527-538
    • Abdallah, B.M.1    Haack-Sorensen, M.2    Burns, J.S.3    Elsnab, B.4    Jakob, F.5    Hokland, P.6    Kassem, M.7
  • 44
    • 41149117381 scopus 로고    scopus 로고
    • Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells
    • 10.1016/j.bbrc.2008.03.011, 18339310
    • Zhao YM, Li JY, Lan JP, Lai XY, Luo Y, Sun J, Yu J, Zhu YY, Zeng FF, Zhou Q, et al. Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 2008, 369(4):1114-1119. 10.1016/j.bbrc.2008.03.011, 18339310.
    • (2008) Biochem Biophys Res Commun , vol.369 , Issue.4 , pp. 1114-1119
    • Zhao, Y.M.1    Li, J.Y.2    Lan, J.P.3    Lai, X.Y.4    Luo, Y.5    Sun, J.6    Yu, J.7    Zhu, Y.Y.8    Zeng, F.F.9    Zhou, Q.10
  • 45
    • 77954376911 scopus 로고    scopus 로고
    • The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells
    • 10.1158/0008-5472.CAN-09-4229, 20530672
    • Jagani Z, Wiederschain D, Loo A, He D, Mosher R, Fordjour P, Monahan J, Morrissey M, Yao YM, Lengauer C, et al. The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells. Cancer Res 2010, 70(13):5528-5538. 10.1158/0008-5472.CAN-09-4229, 20530672.
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5528-5538
    • Jagani, Z.1    Wiederschain, D.2    Loo, A.3    He, D.4    Mosher, R.5    Fordjour, P.6    Monahan, J.7    Morrissey, M.8    Yao, Y.M.9    Lengauer, C.10
  • 46
    • 77955846386 scopus 로고    scopus 로고
    • Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling
    • 10.1016/j.yexcr.2010.04.013, 2924923, 20630502
    • Kim RH, Lieberman MB, Lee R, Shin KH, Mehrazarin S, Oh JE, Park NH, Kang MK. Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling. Exp Cell Res 2010, 316(16):2600-2608. 10.1016/j.yexcr.2010.04.013, 2924923, 20630502.
    • (2010) Exp Cell Res , vol.316 , Issue.16 , pp. 2600-2608
    • Kim, R.H.1    Lieberman, M.B.2    Lee, R.3    Shin, K.H.4    Mehrazarin, S.5    Oh, J.E.6    Park, N.H.7    Kang, M.K.8
  • 47
    • 78649397555 scopus 로고    scopus 로고
    • Growth factor- and cytokine-driven pathways governing liver stemness and differentiation
    • 10.3748/wjg.v16.i41.5148, 2975086, 21049549
    • Sanchez A, Fabregat I. Growth factor- and cytokine-driven pathways governing liver stemness and differentiation. World J Gastroenterol 2010, 16(41):5148-5161. 10.3748/wjg.v16.i41.5148, 2975086, 21049549.
    • (2010) World J Gastroenterol , vol.16 , Issue.41 , pp. 5148-5161
    • Sanchez, A.1    Fabregat, I.2
  • 48
    • 5444247905 scopus 로고    scopus 로고
    • Does the reservoir for self-renewal stem from the ends?
    • 10.1038/sj.onc.1207948, 15378088
    • Harrington L. Does the reservoir for self-renewal stem from the ends?. Oncogene 2004, 23(43):7283-7289. 10.1038/sj.onc.1207948, 15378088.
    • (2004) Oncogene , vol.23 , Issue.43 , pp. 7283-7289
    • Harrington, L.1
  • 50
    • 13644249950 scopus 로고    scopus 로고
    • Telomerase activity and telomere length of human mesenchymal stem cells. Changes during osteogenic differentiation
    • 10.1007/s00132-004-0739-8, 15549250
    • Schieker M, Gulkan H, Austrup B, Neth P, Mutschler W. Telomerase activity and telomere length of human mesenchymal stem cells. Changes during osteogenic differentiation. Orthopade 2004, 33(12):1373-1377. 10.1007/s00132-004-0739-8, 15549250.
    • (2004) Orthopade , vol.33 , Issue.12 , pp. 1373-1377
    • Schieker, M.1    Gulkan, H.2    Austrup, B.3    Neth, P.4    Mutschler, W.5
  • 51
    • 0035984714 scopus 로고    scopus 로고
    • Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    • 10.1038/nbt0602-592, 12042863
    • Simonsen JL, Rosada C, Serakinci N, Justesen J, Stenderup K, Rattan SI, Jensen TG, Kassem M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol 2002, 20(6):592-596. 10.1038/nbt0602-592, 12042863.
    • (2002) Nat Biotechnol , vol.20 , Issue.6 , pp. 592-596
    • Simonsen, J.L.1    Rosada, C.2    Serakinci, N.3    Justesen, J.4    Stenderup, K.5    Rattan, S.I.6    Jensen, T.G.7    Kassem, M.8
  • 52
    • 4444325936 scopus 로고    scopus 로고
    • Expression of telomerase extends longevity and enhances differentiation in human adipose tissue-derived stromal cells
    • 10.1159/000080335, 15319529
    • Jun ES, Lee TH, Cho HH, Suh SY, Jung JS. Expression of telomerase extends longevity and enhances differentiation in human adipose tissue-derived stromal cells. Cell Physiol Biochem 2004, 14(4-6):261-268. 10.1159/000080335, 15319529.
    • (2004) Cell Physiol Biochem , vol.14 , Issue.4-6 , pp. 261-268
    • Jun, E.S.1    Lee, T.H.2    Cho, H.H.3    Suh, S.Y.4    Jung, J.S.5
  • 53
    • 0034296940 scopus 로고    scopus 로고
    • Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes
    • 10.1006/mthe.2000.0141, 11020357
    • Salmon P, Oberholzer J, Occhiodoro T, Morel P, Lou J, Trono D. Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther 2000, 2(4):404-414. 10.1006/mthe.2000.0141, 11020357.
    • (2000) Mol Ther , vol.2 , Issue.4 , pp. 404-414
    • Salmon, P.1    Oberholzer, J.2    Occhiodoro, T.3    Morel, P.4    Lou, J.5    Trono, D.6
  • 54
    • 33750121487 scopus 로고    scopus 로고
    • Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
    • Talens-Visconti R, Bonora A, Jover R, Mirabet V, Carbonell F, Castell JV, Gomez-Lechon MJ. Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells. World J Gastroenterol 2006, 12(36):5834-5845.
    • (2006) World J Gastroenterol , vol.12 , Issue.36 , pp. 5834-5845
    • Talens-Visconti, R.1    Bonora, A.2    Jover, R.3    Mirabet, V.4    Carbonell, F.5    Castell, J.V.6    Gomez-Lechon, M.J.7
  • 55
    • 33845931751 scopus 로고    scopus 로고
    • Hepatic differentiation potential of commercially available human mesenchymal stem cells
    • 10.1089/ten.2006.12.3477, 17518684
    • Ong SY, Dai H, Leong KW. Hepatic differentiation potential of commercially available human mesenchymal stem cells. Tissue Eng 2006, 12(12):3477-3485. 10.1089/ten.2006.12.3477, 17518684.
    • (2006) Tissue Eng , vol.12 , Issue.12 , pp. 3477-3485
    • Ong, S.Y.1    Dai, H.2    Leong, K.W.3
  • 56
    • 52949084688 scopus 로고    scopus 로고
    • Hepatic differentiation of cord blood-derived multipotent progenitor cells (MPCs) in vitro
    • 10.1016/j.cellbi.2008.07.017, 18703150
    • Moon YJ, Lee MW, Yoon HH, Yang MS, Jang IK, Lee JE, Kim HE, Eom YW, Park JS, Kim HC, et al. Hepatic differentiation of cord blood-derived multipotent progenitor cells (MPCs) in vitro. Cell Biol Int 2008, 32(10):1293-1301. 10.1016/j.cellbi.2008.07.017, 18703150.
    • (2008) Cell Biol Int , vol.32 , Issue.10 , pp. 1293-1301
    • Moon, Y.J.1    Lee, M.W.2    Yoon, H.H.3    Yang, M.S.4    Jang, I.K.5    Lee, J.E.6    Kim, H.E.7    Eom, Y.W.8    Park, J.S.9    Kim, H.C.10
  • 57
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • 10.1002/hep.23354, 2946078, 19998274
    • Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, North PE, Dalton S, Duncan SA. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 2010, 51(1):297-305. 10.1002/hep.23354, 2946078, 19998274.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 297-305
    • Si-Tayeb, K.1    Noto, F.K.2    Nagaoka, M.3    Li, J.4    Battle, M.A.5    Duris, C.6    North, P.E.7    Dalton, S.8    Duncan, S.A.9
  • 58
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality
    • 10.1634/stemcells.20-6-530, 12456961
    • Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002, 20(6):530-541. 10.1634/stemcells.20-6-530, 12456961.
    • (2002) Stem Cells , vol.20 , Issue.6 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3    Pochampally, R.4    Cui, J.G.5    Prockop, D.J.6
  • 59
    • 0015123799 scopus 로고
    • Manual and automated methods for urea nitrogen measurement in whole serum
    • Wybenga DR, Di Giorgio J, Pileggi VJ. Manual and automated methods for urea nitrogen measurement in whole serum. Clin Chem 1971, 17(9):891-895.
    • (1971) Clin Chem , vol.17 , Issue.9 , pp. 891-895
    • Wybenga, D.R.1    Di Giorgio, J.2    Pileggi, V.J.3
  • 60
    • 33846458253 scopus 로고    scopus 로고
    • Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay
    • Youdim KA, Tyman CA, Jones BC, Hyland R. Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay. Drug Metab Dispos 2007, 35(2):275-282.
    • (2007) Drug Metab Dispos , vol.35 , Issue.2 , pp. 275-282
    • Youdim, K.A.1    Tyman, C.A.2    Jones, B.C.3    Hyland, R.4
  • 61
    • 30544442260 scopus 로고    scopus 로고
    • Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
    • 10.1016/j.ydbio.2005.11.006, 16364283
    • Bort R, Signore M, Tremblay K, Martinez Barbera JP, Zaret KS. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol 2006, 290(1):44-56. 10.1016/j.ydbio.2005.11.006, 16364283.
    • (2006) Dev Biol , vol.290 , Issue.1 , pp. 44-56
    • Bort, R.1    Signore, M.2    Tremblay, K.3    Martinez Barbera, J.P.4    Zaret, K.S.5


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