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Volumn 21, Issue 9, 2015, Pages 560-570

Cell-penetrating peptides: Strategies for anticancer treatment

Author keywords

Anticancer; Cell penetrating peptide; Elastin like polypeptide; Tumor targeting

Indexed keywords

ANTINEOPLASTIC AGENT; CELL PENETRATING PEPTIDE;

EID: 84940526100     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.06.005     Document Type: Review
Times cited : (192)

References (106)
  • 1
    • 84873252557 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: from concept to clinical applications
    • Allen T.M., Cullis P.R. Liposomal drug delivery systems: from concept to clinical applications. Adv. Drug Deliv. Rev. 2013, 65:36-48.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 36-48
    • Allen, T.M.1    Cullis, P.R.2
  • 2
    • 0035795022 scopus 로고    scopus 로고
    • PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats
    • Li Y-P., et al. PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats. J. Control. Release 2001, 71:203-211.
    • (2001) J. Control. Release , vol.71 , pp. 203-211
    • Li, Y.-P.1
  • 3
    • 84901339386 scopus 로고    scopus 로고
    • Penetrating the cell membrane, thermal targeting and novel anticancer drugs: the development of thermally targeted, elastin-like polypeptide cancer therapeutics
    • Ryu J.S., et al. Penetrating the cell membrane, thermal targeting and novel anticancer drugs: the development of thermally targeted, elastin-like polypeptide cancer therapeutics. Ther. Deliv. 2014, 5:429-445.
    • (2014) Ther. Deliv. , vol.5 , pp. 429-445
    • Ryu, J.S.1
  • 4
    • 84898542045 scopus 로고    scopus 로고
    • Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies
    • Figueiredo I.R., et al. Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies. IUBMB Life 2014, 66:182-194.
    • (2014) IUBMB Life , vol.66 , pp. 182-194
    • Figueiredo, I.R.1
  • 5
    • 77952231544 scopus 로고    scopus 로고
    • Cell-penetrating peptides and their therapeutic applications
    • Sebbage V. Cell-penetrating peptides and their therapeutic applications. Biosci. Horizons 2009, 2:64-72.
    • (2009) Biosci. Horizons , vol.2 , pp. 64-72
    • Sebbage, V.1
  • 6
    • 84878628958 scopus 로고    scopus 로고
    • Cell-penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy
    • Fales A.M., et al. Cell-penetrating peptide enhanced intracellular Raman imaging and photodynamic therapy. Mol. Pharm. 2013, 10:2291-2298.
    • (2013) Mol. Pharm. , vol.10 , pp. 2291-2298
    • Fales, A.M.1
  • 7
    • 70349759756 scopus 로고    scopus 로고
    • Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis
    • Aroui S., et al. Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis. Apoptosis 2009, 14:1352-1365.
    • (2009) Apoptosis , vol.14 , pp. 1352-1365
    • Aroui, S.1
  • 8
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • Frankel A.D., Pabo C.O. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 1988, 55:1189-1193.
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 9
    • 65549133368 scopus 로고    scopus 로고
    • Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment
    • El-Sayed A., et al. Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment. AAPS J. 2009, 11:13-22.
    • (2009) AAPS J. , vol.11 , pp. 13-22
    • El-Sayed, A.1
  • 10
    • 84866535298 scopus 로고    scopus 로고
    • Applications of cell-penetrating peptides for tumor targeting and future cancer therapies
    • Regberg J., et al. Applications of cell-penetrating peptides for tumor targeting and future cancer therapies. Pharmaceuticals (Basel) 2012, 5:991-1007.
    • (2012) Pharmaceuticals (Basel) , vol.5 , pp. 991-1007
    • Regberg, J.1
  • 11
    • 0031423050 scopus 로고    scopus 로고
    • Cellular delivery of oligonucleotides by synthetic import peptide carrier
    • Dokka S., et al. Cellular delivery of oligonucleotides by synthetic import peptide carrier. Pharm. Res. 1997, 14:1759-1764.
    • (1997) Pharm. Res. , vol.14 , pp. 1759-1764
    • Dokka, S.1
  • 12
    • 79960425133 scopus 로고    scopus 로고
    • Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12
    • Nakayama F., et al. Fibroblast growth factor-12 (FGF12) translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain: involvement of internalization in the in vivo role of exogenous FGF12. J. Biol. Chem. 2011, 286:25823-25834.
    • (2011) J. Biol. Chem. , vol.286 , pp. 25823-25834
    • Nakayama, F.1
  • 13
    • 38949184554 scopus 로고    scopus 로고
    • Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy
    • Deshayes S., et al. Delivery of proteins and nucleic acids using a non-covalent peptide-based strategy. Adv. Drug Deliv. Rev. 2008, 60:537-547.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 537-547
    • Deshayes, S.1
  • 14
    • 1942435239 scopus 로고    scopus 로고
    • Amphipathic peptides and drug delivery
    • Fernandez-Carneado J., et al. Amphipathic peptides and drug delivery. Biopolymers 2004, 76:196-203.
    • (2004) Biopolymers , vol.76 , pp. 196-203
    • Fernandez-Carneado, J.1
  • 15
    • 80053326172 scopus 로고    scopus 로고
    • RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers
    • Tian H., et al. RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers. J. Control. Release 2011, 155:47-53.
    • (2011) J. Control. Release , vol.155 , pp. 47-53
    • Tian, H.1
  • 16
    • 0032922213 scopus 로고    scopus 로고
    • Intercellular trafficking of VP22-GFP fusion proteins
    • Elliott G., O'Hare P. Intercellular trafficking of VP22-GFP fusion proteins. Gene Ther. 1999, 6:149-151.
    • (1999) Gene Ther. , vol.6 , pp. 149-151
    • Elliott, G.1    O'Hare, P.2
  • 17
    • 84888270870 scopus 로고    scopus 로고
    • Peptides as drugs: from screening to application
    • Dietrich U., et al. Peptides as drugs: from screening to application. Curr. Pharm. Biotechnol. 2013, 14:501-512.
    • (2013) Curr. Pharm. Biotechnol. , vol.14 , pp. 501-512
    • Dietrich, U.1
  • 18
    • 42049095153 scopus 로고    scopus 로고
    • Cell-penetrating peptides: from molecular mechanisms to therapeutics
    • Morris M.C., et al. Cell-penetrating peptides: from molecular mechanisms to therapeutics. Biol. Cell 2008, 100:201-217.
    • (2008) Biol. Cell , vol.100 , pp. 201-217
    • Morris, M.C.1
  • 19
    • 70349456654 scopus 로고    scopus 로고
    • Recent advances in the use of cell-penetrating peptides for medical and biological applications
    • Fonseca S.B., et al. Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv. Drug Deliv. Rev. 2009, 61:953-964.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 953-964
    • Fonseca, S.B.1
  • 20
    • 0346460957 scopus 로고    scopus 로고
    • Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake
    • Richard J.P., et al. Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem. 2003, 278:585-590.
    • (2003) J. Biol. Chem. , vol.278 , pp. 585-590
    • Richard, J.P.1
  • 21
    • 34548183102 scopus 로고    scopus 로고
    • Arginine-rich peptides and their internalization mechanisms
    • Futaki S., et al. Arginine-rich peptides and their internalization mechanisms. Biochem. Soc. Trans. 2007, 35:784-787.
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 784-787
    • Futaki, S.1
  • 22
    • 34547114456 scopus 로고    scopus 로고
    • Pathways of clathrin-independent endocytosis
    • Mayor S., Pagano R.E. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol. 2007, 8:603-612.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 603-612
    • Mayor, S.1    Pagano, R.E.2
  • 23
    • 35048856889 scopus 로고    scopus 로고
    • Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study
    • El-Andaloussi S., et al. Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study. Biochem. J. 2007, 407:285-292.
    • (2007) Biochem. J. , vol.407 , pp. 285-292
    • El-Andaloussi, S.1
  • 24
    • 84881022447 scopus 로고    scopus 로고
    • Solution NMR studies of cell-penetrating peptides in model membrane systems
    • Maler L. Solution NMR studies of cell-penetrating peptides in model membrane systems. Adv. Drug Deliv. Rev. 2013, 65:1002-1011.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1002-1011
    • Maler, L.1
  • 25
    • 79952201089 scopus 로고    scopus 로고
    • Homeoprotein intercellular transfer, the hidden face of cell-penetrating peptides
    • Prochiantz A. Homeoprotein intercellular transfer, the hidden face of cell-penetrating peptides. Methods Mol. Biol. 2011, 683:249-257.
    • (2011) Methods Mol. Biol. , vol.683 , pp. 249-257
    • Prochiantz, A.1
  • 26
    • 0025787585 scopus 로고
    • Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin
    • Mor A., et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry 1991, 30:8824-8830.
    • (1991) Biochemistry , vol.30 , pp. 8824-8830
    • Mor, A.1
  • 27
    • 67649130542 scopus 로고    scopus 로고
    • Antimicrobial peptides: to membranes and beyond
    • Marcos J.F., Gandia M. Antimicrobial peptides: to membranes and beyond. Expert Opin. Drug Discov. 2009, 4:659-671.
    • (2009) Expert Opin. Drug Discov. , vol.4 , pp. 659-671
    • Marcos, J.F.1    Gandia, M.2
  • 28
    • 0036948138 scopus 로고    scopus 로고
    • Mode of action of membrane active antimicrobial peptides
    • Shai Y. Mode of action of membrane active antimicrobial peptides. Biopolymers 2002, 66:236-248.
    • (2002) Biopolymers , vol.66 , pp. 236-248
    • Shai, Y.1
  • 29
    • 0033811166 scopus 로고    scopus 로고
    • Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain
    • Bolton S.J., et al. Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain. Eur. J. Neurosci. 2000, 12:2847-2855.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 2847-2855
    • Bolton, S.J.1
  • 30
    • 84878947567 scopus 로고    scopus 로고
    • A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells
    • Lim K.J., et al. A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. PLoS ONE 2013, 8:e66084.
    • (2013) PLoS ONE , vol.8 , pp. e66084
    • Lim, K.J.1
  • 31
    • 84859439673 scopus 로고    scopus 로고
    • Peptides for cell-selective drug delivery
    • Svensen N., et al. Peptides for cell-selective drug delivery. Trends Pharmacol. Sci. 2012, 33:186-192.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 186-192
    • Svensen, N.1
  • 32
    • 77949762340 scopus 로고    scopus 로고
    • Targeting of drugs and nanoparticles to tumors
    • Ruoslahti E., et al. Targeting of drugs and nanoparticles to tumors. J. Cell Biol. 2010, 188:759-768.
    • (2010) J. Cell Biol. , vol.188 , pp. 759-768
    • Ruoslahti, E.1
  • 33
    • 33645751057 scopus 로고    scopus 로고
    • Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide
    • Tan M., et al. Selective inhibition of ErbB2-overexpressing breast cancer in vivo by a novel TAT-based ErbB2-targeting signal transducers and activators of transcription 3-blocking peptide. Cancer Res. 2006, 66:3764-3772.
    • (2006) Cancer Res. , vol.66 , pp. 3764-3772
    • Tan, M.1
  • 34
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: what does it promise in tissue-targeted therapeutics?
    • Salazar M.D.A., Ratnam M. The folate receptor: what does it promise in tissue-targeted therapeutics?. Cancer Metastasis Rev. 2007, 26:141-152.
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 141-152
    • Salazar, M.D.A.1    Ratnam, M.2
  • 35
    • 0141715047 scopus 로고    scopus 로고
    • Integrin targeting using RGD-PEI conjugates for in vitro gene transfer
    • Kunath K., et al. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J. Gene Med. 2003, 5:588-599.
    • (2003) J. Gene Med. , vol.5 , pp. 588-599
    • Kunath, K.1
  • 36
    • 84860380857 scopus 로고    scopus 로고
    • CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma
    • Wang L., et al. CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma. Biomaterials 2012, 33:5107-5114.
    • (2012) Biomaterials , vol.33 , pp. 5107-5114
    • Wang, L.1
  • 37
    • 0036416110 scopus 로고    scopus 로고
    • Therapeutic cancer targeting peptides
    • Aina O.H., et al. Therapeutic cancer targeting peptides. Peptide Sci. 2002, 66:184-199.
    • (2002) Peptide Sci. , vol.66 , pp. 184-199
    • Aina, O.H.1
  • 38
    • 67349230238 scopus 로고    scopus 로고
    • Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape
    • Endoh T., Ohtsuki T. Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape. Adv. Drug Deliv. Rev. 2009, 61:704-709.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 704-709
    • Endoh, T.1    Ohtsuki, T.2
  • 39
    • 84856544910 scopus 로고    scopus 로고
    • A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis
    • Moktan S., et al. A thermally responsive biopolymer conjugated to an acid-sensitive derivative of paclitaxel stabilizes microtubules, arrests cell cycle, and induces apoptosis. Invest. New Drugs 2012, 30:236-248.
    • (2012) Invest. New Drugs , vol.30 , pp. 236-248
    • Moktan, S.1
  • 40
    • 0141955920 scopus 로고    scopus 로고
    • Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy
    • Dreher M.R., et al. Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy. J. Control. Release 2003, 91:31-43.
    • (2003) J. Control. Release , vol.91 , pp. 31-43
    • Dreher, M.R.1
  • 41
    • 84855772787 scopus 로고    scopus 로고
    • Cleavable linkers in chemical biology
    • Leriche G., et al. Cleavable linkers in chemical biology. Bioorg. Med. Chem. 2012, 20:571-582.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 571-582
    • Leriche, G.1
  • 42
    • 84900758830 scopus 로고    scopus 로고
    • A proapoptotic peptide conjugated to penetratin selectively inhibits tumor cell growth
    • Alves I.D., et al. A proapoptotic peptide conjugated to penetratin selectively inhibits tumor cell growth. Biochim. Biophys. Acta Biomembranes 2014, 1838:2087-2098.
    • (2014) Biochim. Biophys. Acta Biomembranes , vol.1838 , pp. 2087-2098
    • Alves, I.D.1
  • 43
    • 84864572139 scopus 로고    scopus 로고
    • Protease-activated drug development
    • Choi K.Y., et al. Protease-activated drug development. Theranostics 2012, 2:156.
    • (2012) Theranostics , vol.2 , pp. 156
    • Choi, K.Y.1
  • 44
    • 84927127531 scopus 로고    scopus 로고
    • Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis
    • Orzechowska E.J., et al. Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis. BMC Cancer 2014, 14:771.
    • (2014) BMC Cancer , vol.14 , pp. 771
    • Orzechowska, E.J.1
  • 45
    • 84902551145 scopus 로고    scopus 로고
    • Matrix metalloproteinase 2-responsive micelle for siRNA delivery
    • Wang H-X., et al. Matrix metalloproteinase 2-responsive micelle for siRNA delivery. Biomaterials 2014, 35:7622-7634.
    • (2014) Biomaterials , vol.35 , pp. 7622-7634
    • Wang, H.-X.1
  • 46
    • 84878451456 scopus 로고    scopus 로고
    • Octa-arginine-modified pegylated liposomal doxorubicin: an effective treatment strategy for non-small cell lung cancer
    • Biswas S., et al. Octa-arginine-modified pegylated liposomal doxorubicin: an effective treatment strategy for non-small cell lung cancer. Cancer Lett. 2013, 335:191-200.
    • (2013) Cancer Lett. , vol.335 , pp. 191-200
    • Biswas, S.1
  • 47
    • 84920396574 scopus 로고    scopus 로고
    • Enhanced intracellular translocation and biodistribution of gold nanoparticles functionalized with a cell-penetrating peptide (VG-21) from vesicular stomatitis virus
    • Tiwari P.M., et al. Enhanced intracellular translocation and biodistribution of gold nanoparticles functionalized with a cell-penetrating peptide (VG-21) from vesicular stomatitis virus. Biomaterials 2014, 35:9484-9494.
    • (2014) Biomaterials , vol.35 , pp. 9484-9494
    • Tiwari, P.M.1
  • 48
    • 27744525788 scopus 로고    scopus 로고
    • Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery
    • Massodi I., et al. Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery. J. Control. Release 2005, 108:396-408.
    • (2005) J. Control. Release , vol.108 , pp. 396-408
    • Massodi, I.1
  • 49
    • 0037452668 scopus 로고    scopus 로고
    • Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes
    • Torchilin V.P., et al. Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:1972-1977.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 1972-1977
    • Torchilin, V.P.1
  • 50
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986, 46:6387-6392.
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 51
    • 60749108001 scopus 로고    scopus 로고
    • Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    • Maeda H., et al. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. Eur. J. Pharm. Biopharm. 2009, 71:409-419.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 409-419
    • Maeda, H.1
  • 52
    • 84893653202 scopus 로고    scopus 로고
    • Dendrimer as nanocarrier for drug delivery
    • Kesharwani P., et al. Dendrimer as nanocarrier for drug delivery. Prog. Polymer Sci. 2014, 39:268-307.
    • (2014) Prog. Polymer Sci. , vol.39 , pp. 268-307
    • Kesharwani, P.1
  • 53
    • 84915767964 scopus 로고    scopus 로고
    • Theranostic nanoparticles
    • Chen F., et al. Theranostic nanoparticles. J. Nucl. Med. 2014, 55:1919-1922.
    • (2014) J. Nucl. Med. , vol.55 , pp. 1919-1922
    • Chen, F.1
  • 54
    • 34447258534 scopus 로고    scopus 로고
    • Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging
    • Rhyner M.N., et al. Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomedicine 2006, 1:209-217.
    • (2006) Nanomedicine , vol.1 , pp. 209-217
    • Rhyner, M.N.1
  • 55
    • 84873179175 scopus 로고    scopus 로고
    • Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing
    • Li K., et al. Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing. Sci. Rep. 2013, 3:1150.
    • (2013) Sci. Rep. , vol.3 , pp. 1150
    • Li, K.1
  • 56
    • 84907200459 scopus 로고    scopus 로고
    • Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy
    • Shin M.C., et al. Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy. J. Control. Release 2014, 194:197-210.
    • (2014) J. Control. Release , vol.194 , pp. 197-210
    • Shin, M.C.1
  • 57
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker N., et al. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal. Biochem. 2005, 338:284-293.
    • (2005) Anal. Biochem. , vol.338 , pp. 284-293
    • Parker, N.1
  • 58
    • 0027406702 scopus 로고
    • Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein
    • Garin-Chesa P., et al. Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein. Am. J. Pathol. 1993, 142:557.
    • (1993) Am. J. Pathol. , vol.142 , pp. 557
    • Garin-Chesa, P.1
  • 59
    • 84875152889 scopus 로고    scopus 로고
    • Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation
    • Kang M.J., et al. Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation. Int. J. Nanomedicine 2013, 8:1155.
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 1155
    • Kang, M.J.1
  • 60
    • 72449180818 scopus 로고    scopus 로고
    • Integrins
    • Barczyk M., et al. Integrins. Cell Tissue Res. 2010, 339:269-280.
    • (2010) Cell Tissue Res. , vol.339 , pp. 269-280
    • Barczyk, M.1
  • 61
    • 84896493907 scopus 로고    scopus 로고
    • Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting
    • Liu Y., et al. Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 2014, 35:4835-4847.
    • (2014) Biomaterials , vol.35 , pp. 4835-4847
    • Liu, Y.1
  • 62
    • 84940564466 scopus 로고    scopus 로고
    • Elastin-like polypeptide for improved drug delivery for anticancer therapy: preclinical studies and future applications
    • Ryu J.S., Raucher D. Elastin-like polypeptide for improved drug delivery for anticancer therapy: preclinical studies and future applications. Expert Opin. Drug Deliv. 2014, 1-15.
    • (2014) Expert Opin. Drug Deliv. , pp. 1-15
    • Ryu, J.S.1    Raucher, D.2
  • 63
    • 23144442466 scopus 로고    scopus 로고
    • Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy
    • Bidwell G.L., Raucher D. Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy. Mol. Cancer Ther. 2005, 4:1076-1085.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1076-1085
    • Bidwell, G.L.1    Raucher, D.2
  • 64
    • 84908370947 scopus 로고    scopus 로고
    • Elastin-like polypeptides: the influence of its molecular weight on local hyperthermia-induced tumor accumulation
    • Ryu J.S., Raucher D. Elastin-like polypeptides: the influence of its molecular weight on local hyperthermia-induced tumor accumulation. Eur. J. Pharm. Biopharm. 2014, 88:382-389.
    • (2014) Eur. J. Pharm. Biopharm. , vol.88 , pp. 382-389
    • Ryu, J.S.1    Raucher, D.2
  • 65
    • 84900508774 scopus 로고    scopus 로고
    • Anti-tumor efficacy of a therapeutic peptide based on thermo-responsive elastin-like polypeptide in combination with gemcitabine
    • Ryu J.S., Raucher D. Anti-tumor efficacy of a therapeutic peptide based on thermo-responsive elastin-like polypeptide in combination with gemcitabine. Cancer Lett. 2014, 348:177-184.
    • (2014) Cancer Lett. , vol.348 , pp. 177-184
    • Ryu, J.S.1    Raucher, D.2
  • 66
    • 84859505371 scopus 로고    scopus 로고
    • A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth
    • Bidwell G.L., et al. A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth. Cancer Lett. 2012, 319:136-143.
    • (2012) Cancer Lett. , vol.319 , pp. 136-143
    • Bidwell, G.L.1
  • 67
    • 73549108720 scopus 로고    scopus 로고
    • Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier
    • Massodi I., et al. Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier. Int. J. Cancer 2010, 126:533-544.
    • (2010) Int. J. Cancer , vol.126 , pp. 533-544
    • Massodi, I.1
  • 68
    • 84883333001 scopus 로고    scopus 로고
    • Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells
    • Cantini L., et al. Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells. PLoS ONE 2013, 8:e73348.
    • (2013) PLoS ONE , vol.8 , pp. e73348
    • Cantini, L.1
  • 69
    • 84896759012 scopus 로고    scopus 로고
    • PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide-doxorubicin conjugate for tumor-specific therapy
    • Yang Y., et al. PEGylated liposomes with NGR ligand and heat-activable cell-penetrating peptide-doxorubicin conjugate for tumor-specific therapy. Biomaterials 2014, 35:4368-4381.
    • (2014) Biomaterials , vol.35 , pp. 4368-4381
    • Yang, Y.1
  • 70
    • 84872560827 scopus 로고    scopus 로고
    • Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides
    • Savariar E.N., et al. Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res. 2013, 73:855-864.
    • (2013) Cancer Res. , vol.73 , pp. 855-864
    • Savariar, E.N.1
  • 71
    • 84902655584 scopus 로고    scopus 로고
    • Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery
    • Crisp J.L., et al. Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery. Mol. Cancer Ther. 2014, 13:1514-1525.
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 1514-1525
    • Crisp, J.L.1
  • 72
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • Tannock I.F., Rotin D. Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res. 1989, 49:4373-4384.
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 74
    • 33746674416 scopus 로고    scopus 로고
    • 'SMART' drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers
    • Sawant R., et al. 'SMART' drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug. Chem. 2006, 17:943-949.
    • (2006) Bioconjug. Chem. , vol.17 , pp. 943-949
    • Sawant, R.1
  • 75
    • 79960226262 scopus 로고    scopus 로고
    • Physiology and pathophysiology of matrix metalloproteases
    • Klein T., Bischoff R. Physiology and pathophysiology of matrix metalloproteases. Amino Acids 2011, 41:271-290.
    • (2011) Amino Acids , vol.41 , pp. 271-290
    • Klein, T.1    Bischoff, R.2
  • 76
    • 70449732503 scopus 로고    scopus 로고
    • Matrix metalloproteinases as novel biomarker s and potential therapeutic targets in human cancer
    • Roy R., et al. Matrix metalloproteinases as novel biomarker s and potential therapeutic targets in human cancer. J. Clin. Oncol. 2009, 27:5287-5297.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5287-5297
    • Roy, R.1
  • 77
    • 33645571901 scopus 로고    scopus 로고
    • Matrix metalloproteinases in bone marrow: roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies
    • Yu X., Han Z. Matrix metalloproteinases in bone marrow: roles of gelatinases in physiological hematopoiesis and hematopoietic malignancies. Histol. Histopathol. 2006, 21:519-531.
    • (2006) Histol. Histopathol. , vol.21 , pp. 519-531
    • Yu, X.1    Han, Z.2
  • 78
    • 84903625230 scopus 로고    scopus 로고
    • Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment
    • Liu Z., et al. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat. Commun. 2014, 5:4280.
    • (2014) Nat. Commun. , vol.5 , pp. 4280
    • Liu, Z.1
  • 79
    • 84878782419 scopus 로고    scopus 로고
    • Cell-penetrating peptides: 20 years later, where do we stand?
    • Bechara C., Sagan S. Cell-penetrating peptides: 20 years later, where do we stand?. FEBS Lett. 2013, 587:1693-1702.
    • (2013) FEBS Lett. , vol.587 , pp. 1693-1702
    • Bechara, C.1    Sagan, S.2
  • 80
    • 38949206876 scopus 로고    scopus 로고
    • Cell penetrating peptide conjugates of steric block oligonucleotides
    • Lebleu B., et al. Cell penetrating peptide conjugates of steric block oligonucleotides. Adv. Drug Deliv. Rev. 2008, 60:517-529.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 517-529
    • Lebleu, B.1
  • 81
    • 78650155418 scopus 로고    scopus 로고
    • Efficacy and safety evaluation of a novel botulinum toxin topical gel for the treatment of moderate to severe lateral canthal lines
    • Brandt F., et al. Efficacy and safety evaluation of a novel botulinum toxin topical gel for the treatment of moderate to severe lateral canthal lines. Dermatol. Surg. 2010, 36(Suppl. 4):2111-2118.
    • (2010) Dermatol. Surg. , vol.36 , pp. 2111-2118
    • Brandt, F.1
  • 82
    • 59949098048 scopus 로고    scopus 로고
    • Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts
    • Lopes L.B., et al. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. J. Invest. Dermatol. 2009, 129:590-598.
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 590-598
    • Lopes, L.B.1
  • 83
    • 84876183998 scopus 로고    scopus 로고
    • The safety and efficacy of KAI-1678- an inhibitor of epsilon protein kinase C (epsilonPKC)-versus lidocaine and placebo for the treatment of postherpetic neuralgia: a crossover study design
    • Cousins M.J., et al. The safety and efficacy of KAI-1678- an inhibitor of epsilon protein kinase C (epsilonPKC)-versus lidocaine and placebo for the treatment of postherpetic neuralgia: a crossover study design. Pain Med. 2013, 14:533-540.
    • (2013) Pain Med. , vol.14 , pp. 533-540
    • Cousins, M.J.1
  • 84
    • 80052801329 scopus 로고    scopus 로고
    • Distribution of KAI-9803, a novel delta-protein kinase C inhibitor, after intravenous administration to rats
    • Miyaji Y., et al. Distribution of KAI-9803, a novel delta-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab. Dispos. 2011, 39:1946-1953.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1946-1953
    • Miyaji, Y.1
  • 85
    • 84875420696 scopus 로고    scopus 로고
    • A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours
    • Warso M.A., et al. A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours. Br. J. Cancer 2013, 108:1061-1070.
    • (2013) Br. J. Cancer , vol.108 , pp. 1061-1070
    • Warso, M.A.1
  • 86
    • 80052722389 scopus 로고    scopus 로고
    • A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt
    • Mehta R.R., et al. A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt. Angiogenesis 2011, 14:355-369.
    • (2011) Angiogenesis , vol.14 , pp. 355-369
    • Mehta, R.R.1
  • 87
    • 84940555156 scopus 로고    scopus 로고
    • First-in-human phase I and pharmacokinetic study of DTS-108 in patients with advanced carcinomas
    • Coriat R., et al. First-in-human phase I and pharmacokinetic study of DTS-108 in patients with advanced carcinomas. J. Clin. Oncol. 2012, 30(Suppl.):2557.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2557
    • Coriat, R.1
  • 88
    • 84884131045 scopus 로고    scopus 로고
    • Cytoplasm-responsive nanocarriers conjugated with a functional cell-penetrating peptide for systemic siRNA delivery
    • Tanaka K., et al. Cytoplasm-responsive nanocarriers conjugated with a functional cell-penetrating peptide for systemic siRNA delivery. Int. J. Pharm. 2013, 455:40-47.
    • (2013) Int. J. Pharm. , vol.455 , pp. 40-47
    • Tanaka, K.1
  • 89
    • 84872805989 scopus 로고    scopus 로고
    • A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively
    • Fang B., et al. A novel cell-penetrating peptide TAT-A1 delivers siRNA into tumor cells selectively. Biochimie 2013, 95:251-257.
    • (2013) Biochimie , vol.95 , pp. 251-257
    • Fang, B.1
  • 90
    • 84937688292 scopus 로고    scopus 로고
    • Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide
    • Gehrmann M., et al. Tumor imaging and targeting potential of an Hsp70-derived 14-mer peptide. PLoS ONE 2014, 9:e105344.
    • (2014) PLoS ONE , vol.9 , pp. e105344
    • Gehrmann, M.1
  • 91
    • 84901424244 scopus 로고    scopus 로고
    • Simultaneous imaging and restoration of cell function using cell permeable peptide probe
    • Suh J.S., et al. Simultaneous imaging and restoration of cell function using cell permeable peptide probe. Biomaterials 2014, 35:6287-6298.
    • (2014) Biomaterials , vol.35 , pp. 6287-6298
    • Suh, J.S.1
  • 92
    • 84876078890 scopus 로고    scopus 로고
    • Cell penetration and cell-selective drug delivery using α-helix peptides conjugated with gold nanoparticles
    • Park H., et al. Cell penetration and cell-selective drug delivery using α-helix peptides conjugated with gold nanoparticles. Biomaterials 2013, 34:4872-4879.
    • (2013) Biomaterials , vol.34 , pp. 4872-4879
    • Park, H.1
  • 93
    • 84919621614 scopus 로고    scopus 로고
    • Enhanced cellular uptake of a TAT-conjugated peptide inhibitor targeting the polo-box domain of polo-like kinase 1
    • Kim S.M., et al. Enhanced cellular uptake of a TAT-conjugated peptide inhibitor targeting the polo-box domain of polo-like kinase 1. Amino Acids 2014, 46:2595-2603.
    • (2014) Amino Acids , vol.46 , pp. 2595-2603
    • Kim, S.M.1
  • 94
    • 84906536749 scopus 로고    scopus 로고
    • A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide
    • Barras D., et al. A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide. J. Biol. Chem. 2014, 289:23701-23711.
    • (2014) J. Biol. Chem. , vol.289 , pp. 23701-23711
    • Barras, D.1
  • 95
    • 84898727051 scopus 로고    scopus 로고
    • LXXLL peptide converts transportan 10 to a potent inducer of apoptosis in breast cancer cells
    • Tints K., et al. LXXLL peptide converts transportan 10 to a potent inducer of apoptosis in breast cancer cells. Int. J. Mol. Sci. 2014, 15:5680-5698.
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 5680-5698
    • Tints, K.1
  • 96
    • 84899509680 scopus 로고    scopus 로고
    • A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling
    • Kim D., et al. A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling. Cancer Res. 2014, 74:2144-2151.
    • (2014) Cancer Res. , vol.74 , pp. 2144-2151
    • Kim, D.1
  • 97
    • 84884994343 scopus 로고    scopus 로고
    • VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia
    • Prezma T., et al. VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia. Cell Death Dis. 2013, 4:e809.
    • (2013) Cell Death Dis. , vol.4 , pp. e809
    • Prezma, T.1
  • 98
    • 84871920565 scopus 로고    scopus 로고
    • Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells
    • Kuroda Y., et al. Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells. Eur. J. Pharmacol. 2013, 698:87-94.
    • (2013) Eur. J. Pharmacol. , vol.698 , pp. 87-94
    • Kuroda, Y.1
  • 99
    • 84871645347 scopus 로고    scopus 로고
    • TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses
    • Zhao B., et al. TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses. Vaccine 2013, 31:545-552.
    • (2013) Vaccine , vol.31 , pp. 545-552
    • Zhao, B.1
  • 100
    • 33846510441 scopus 로고    scopus 로고
    • Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin
    • Bidwell G.L., et al. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem. Pharmacol. 2007, 73:620-631.
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 620-631
    • Bidwell, G.L.1
  • 101
    • 34250620539 scopus 로고    scopus 로고
    • A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance
    • Bidwell G.L., et al. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest. New Drugs 2007, 25:313-326.
    • (2007) Invest. New Drugs , vol.25 , pp. 313-326
    • Bidwell, G.L.1
  • 102
    • 29144445979 scopus 로고    scopus 로고
    • Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc
    • Bidwell G.L., Raucher D. Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc. Biochem. Pharmacol. 2006, 71:248-256.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 248-256
    • Bidwell, G.L.1    Raucher, D.2
  • 103
    • 61449119855 scopus 로고    scopus 로고
    • Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP
    • Massodi I., et al. Inhibition of ovarian cancer cell metastasis by a fusion polypeptide Tat-ELP. Clin. Exp. Metastasis 2009, 26:251-260.
    • (2009) Clin. Exp. Metastasis , vol.26 , pp. 251-260
    • Massodi, I.1
  • 104
    • 67649834226 scopus 로고    scopus 로고
    • Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer
    • Massodi I., et al. Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer. Molecules 2009, 14:1999-2015.
    • (2009) Molecules , vol.14 , pp. 1999-2015
    • Massodi, I.1
  • 105
    • 84867334463 scopus 로고    scopus 로고
    • Anticancer activity of proapoptotic peptides is highly improved by thermal targeting using elastin-like polypeptides
    • Moktan S., Raucher D. Anticancer activity of proapoptotic peptides is highly improved by thermal targeting using elastin-like polypeptides. Int. J. Pept. Res. Ther. 2012, 18:227-237.
    • (2012) Int. J. Pept. Res. Ther. , vol.18 , pp. 227-237
    • Moktan, S.1    Raucher, D.2
  • 106
    • 77951254936 scopus 로고    scopus 로고
    • A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation
    • Bidwell G.L., et al. A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides 2010, 31:834-841.
    • (2010) Peptides , vol.31 , pp. 834-841
    • Bidwell, G.L.1


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