-
1
-
-
84888865755
-
Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and sirna for potential triple-negative breast cancer treatment
-
Deng, Z. J. et al. Layer-by-layer nanoparticles for systemic codelivery of an anticancer drug and sirna for potential triple-negative breast cancer treatment. ACS Nano 7, 9571-9584 (2013
-
(2013)
ACS Nano
, vol.7
, pp. 9571-9584
-
-
Deng, Z.J.1
-
2
-
-
33746491709
-
Drug penetration in solid tumours
-
DOI 10.1038/nrc1893, PII NRC1893
-
Minchinton, A. I. & Tannock, I. F. Drug penetration in solid tumours. Nat. Rev. Cancer 6, 583-592 (2006 (Pubitemid 44140857)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.8
, pp. 583-592
-
-
Minchinton, A.I.1
Tannock, I.F.2
-
3
-
-
0347761362
-
Supramolecular Drug-Delivery Systems Based on Polymeric Core-Shell Architectures
-
DOI 10.1002/anie.200301694
-
Haag, R. Supramolecular drug-delivery systems based on polymeric core-shell architectures. Angew. Chem. Int. Ed. 43, 278-282 (2004 (Pubitemid 38090059)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.3
, pp. 278-282
-
-
Haag, R.1
-
4
-
-
84874838480
-
Polymer nanocompartments in broad-spectrum medical applications
-
Najer, A., Wu, D., Vasquez, D., Palivan, C. G. & Meier, W. Polymer nanocompartments in broad-spectrum medical applications. Nanomedicine (Lond) 8, 425-447 (2013
-
(2013)
Nanomedicine (Lond)
, vol.8
, pp. 425-447
-
-
Najer, A.1
Wu, D.2
Vasquez, D.3
Palivan, C.G.4
Meier, W.5
-
5
-
-
84887150782
-
Progress in microRNA delivery
-
Zhang, Y., Wang, Z. & Gemeinhart, R. A. Progress in microRNA delivery. J. Control. Release 172, 962-974 (2013
-
(2013)
J. Control. Release
, vol.172
, pp. 962-974
-
-
Zhang, Y.1
Wang, Z.2
Gemeinhart, R.A.3
-
6
-
-
84885483584
-
Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting
-
Perche, F. & Torchilin, V. P. Recent trends in multifunctional liposomal nanocarriers for enhanced tumor targeting. J. Drug Deliv. 2013, 705265 (2013
-
(2013)
J. Drug Deliv.
, vol.2013
, pp. 705265
-
-
Perche, F.1
Torchilin, V.P.2
-
7
-
-
84863099046
-
Cell-penetrating peptides: Breaking through to the other side
-
Koren, E. & Torchilin, V. P. Cell-penetrating peptides: breaking through to the other side. Trends Mol. Med. 18, 385-393 (2012
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 385-393
-
-
Koren, E.1
Torchilin, V.P.2
-
8
-
-
80054714982
-
Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals
-
Qin, Y. et al. Liposome formulated with TAT-modified cholesterol for improving brain delivery and therapeutic efficacy on brain glioma in animals. Int. J. Pharm. 420, 304-312 (2011
-
(2011)
Int. J. Pharm.
, vol.420
, pp. 304-312
-
-
Qin, Y.1
-
9
-
-
56049093057
-
Cell-penetrating and cell-targeting peptides in drug delivery
-
Vives, E., Schmidt, J. & Pelegrin, A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim. Biophys. Acta. 1786, 126-138 (2008
-
(2008)
Biochim. Biophys. Acta.
, vol.1786
, pp. 126-138
-
-
Vives, E.1
Schmidt, J.2
Pelegrin, A.3
-
10
-
-
84864666657
-
Size-controlled dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy
-
Takara, K. et al. Size-controlled dual-ligand modified liposomes that target the tumor vasculature show promise for use in drug-resistant cancer therapy. J. Control. Release 162, 225-232 (2012
-
(2012)
J. Control. Release
, vol.162
, pp. 225-232
-
-
Takara, K.1
-
11
-
-
79957482249
-
A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system
-
Kibria, G., Hatakeyama, H. & Harashima, H. A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system. Int. J. Pharm. 412, 106-114 (2011
-
(2011)
Int. J. Pharm.
, vol.412
, pp. 106-114
-
-
Kibria, G.1
Hatakeyama, H.2
Harashima, H.3
-
12
-
-
78649755603
-
Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration
-
Tagalakis, A. D. et al. Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration. Biomaterials 32, 1370-1376 (2011
-
(2011)
Biomaterials
, vol.32
, pp. 1370-1376
-
-
Tagalakis, A.D.1
-
13
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
84875359149
-
The tumor microenvironment: A target for combination therapy of breast cancer
-
Reisfeld, R. A. The tumor microenvironment: a target for combination therapy of breast cancer. Crit. Rev. Oncog. 18, 115-133 (2013
-
(2013)
Crit. Rev. Oncog.
, vol.18
, pp. 115-133
-
-
Reisfeld, R.A.1
-
15
-
-
84887481716
-
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
-
Pyonteck, S. M. et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat. Med. 19, 1264-1272 (2013
-
(2013)
Nat. Med.
, vol.19
, pp. 1264-1272
-
-
Pyonteck, S.M.1
-
16
-
-
84883448249
-
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis
-
Lin, Y. et al. Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis. Cancer Sci. 104, 1217-1225 (2013
-
(2013)
Cancer Sci.
, vol.104
, pp. 1217-1225
-
-
Lin, Y.1
-
17
-
-
33746718151
-
Targeting tumor-associated macrophages as a novel strategy against breast cancer
-
DOI 10.1172/JCI27648
-
Luo, Y. et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. J. Clin. Invest. 116, 2132-2141 (2006 (Pubitemid 44162322)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.8
, pp. 2132-2141
-
-
Luo, Y.1
Zhou, H.2
Krueger, J.3
Kaplan, C.4
Lee, S.-H.5
Dolman, C.6
Markowitz, D.7
Wu, W.8
Liu, C.9
Reisfeld, R.A.10
Xiang, R.11
-
18
-
-
38649088939
-
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis
-
DOI 10.1007/s00262-007-0389-x
-
Lewen, S. et al. A legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis. Cancer Immunol. Immunother. 57, 507-515 (2008 (Pubitemid 351170534)
-
(2008)
Cancer Immunology, Immunotherapy
, vol.57
, Issue.4
, pp. 507-515
-
-
Lewen, S.1
Zhou, H.2
Hu, H.-D.3
Cheng, T.4
Markowitz, D.5
Reisfeld, R.A.6
Xiang, R.7
Luo, Y.8
-
19
-
-
41149088925
-
Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis
-
DOI 10.1111/j.1600-065X.2008.00613.x
-
Xiang, R., Luo, Y., Niethammer, A. G. & Reisfeld, R. A. Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis. Immunol. Rev. 222, 117-128 (2008 (Pubitemid 351430375)
-
(2008)
Immunological Reviews
, vol.222
, Issue.1
, pp. 117-128
-
-
Xiang, R.1
Luo, Y.2
Niethammer, A.G.3
Reisfeld, R.A.4
-
20
-
-
84879731123
-
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
-
Dall, E. & Brandstetter, H. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc. Natl Acad. Sci. USA 110, 10940-10945 (2013
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 10940-10945
-
-
Dall, E.1
Brandstetter, H.2
-
21
-
-
79955673020
-
Asparagine endopeptidase is required for normal kidney physiology and homeostasis
-
Miller, G., Matthews, S. P., Reinheckel, T., Fleming, S. & Watts, C. Asparagine endopeptidase is required for normal kidney physiology and homeostasis. FASEB J. 25, 1606-1617 (2011
-
(2011)
FASEB J.
, vol.25
, pp. 1606-1617
-
-
Miller, G.1
Matthews, S.P.2
Reinheckel, T.3
Fleming, S.4
Watts, C.5
-
22
-
-
0038243036
-
Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy
-
Liu, C., Sun, C., Huang, H., Janda, K. & Edgington, T. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 63, 2957-2964 (2003 (Pubitemid 36667169)
-
(2003)
Cancer Research
, vol.63
, Issue.11
, pp. 2957-2964
-
-
Liu, C.1
Sun, C.2
Huang, H.3
Janda, K.4
Edgington, T.5
-
23
-
-
84887017138
-
Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection
-
Chen, Y. J. et al. Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection. Biomaterials 35, 304-315 (2013
-
(2013)
Biomaterials
, vol.35
, pp. 304-315
-
-
Chen, Y.J.1
-
24
-
-
84878419479
-
Effects of legumain as a potential prognostic factor on gastric cancers
-
Li, N. et al. Effects of legumain as a potential prognostic factor on gastric cancers. Med. Oncol. 30, 621 (2013
-
(2013)
Med. Oncol.
, vol.30
, pp. 621
-
-
Li, N.1
-
25
-
-
82255191976
-
Synthetic enzyme inhibitor: A novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity
-
Liao, D. et al. Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine 7, 665-673 (2011
-
(2011)
Nanomedicine
, vol.7
, pp. 665-673
-
-
Liao, D.1
-
26
-
-
84872113307
-
Functional imaging of legumain in cancer using a new quenched activity-based probe
-
Edgington, L. E. et al. Functional imaging of legumain in cancer using a new quenched activity-based probe. J. Am. Chem. Soc. 135, 174-182 (2013
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 174-182
-
-
Edgington, L.E.1
-
27
-
-
84855427940
-
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain proteaseactivated auristatin prodrug
-
Liu, Y., Bajjuri, K. M., Liu, C. & Sinha, S. C. Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain proteaseactivated auristatin prodrug. Mol. Pharm. 9, 168-175 (2012
-
(2012)
Mol. Pharm.
, vol.9
, pp. 168-175
-
-
Liu, Y.1
Bajjuri, K.M.2
Liu, C.3
Sinha, S.C.4
-
28
-
-
78650532605
-
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity
-
Bajjuri, K. M., Liu, Y., Liu, C. & Sinha, S. C. The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity. ChemMedChem 6, 54-59 (2011
-
(2011)
ChemMedChem
, vol.6
, pp. 54-59
-
-
Bajjuri, K.M.1
Liu, Y.2
Liu, C.3
Sinha, S.C.4
-
29
-
-
31544445218
-
Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms
-
DOI 10.1158/0008-5472.CAN-05-2591
-
Wu, W. et al. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug-resistant neoplasms. Cancer Res. 66, 970-980 (2006 (Pubitemid 43165965)
-
(2006)
Cancer Research
, vol.66
, Issue.2
, pp. 970-980
-
-
Wu, W.1
Luo, Y.2
Sun, C.3
Liu, Y.4
Kuo, P.5
Varga, J.6
Xiang, R.7
Reisfeld, R.8
Janda, K.D.9
Edgington, T.S.10
Liu, C.11
-
30
-
-
63749126402
-
A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain
-
Stern, L. et al. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug. Chem. 20, 500-510 (2009
-
(2009)
Bioconjug. Chem.
, vol.20
, pp. 500-510
-
-
Stern, L.1
-
31
-
-
84893204137
-
Current trends in the use of liposomes for tumor targeting
-
Deshpande, P. P., Biswas, S. & Torchilin, V. P. Current trends in the use of liposomes for tumor targeting. Nanomedicine (Lond) 8, 1323-1342 (2013
-
(2013)
Nanomedicine (Lond)
, vol.8
, pp. 1323-1342
-
-
Deshpande, P.P.1
Biswas, S.2
Torchilin, V.P.3
-
32
-
-
80053295245
-
Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications
-
Sawant, R. R. & Torchilin, V. P. Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications. Methods Mol. Biol. 751, 357-378 (2011
-
(2011)
Methods Mol. Biol.
, vol.751
, pp. 357-378
-
-
Sawant, R.R.1
Torchilin, V.P.2
-
33
-
-
50849144942
-
Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
-
Torchilin, V. P. Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery. Biopolymers 90, 604-610 (2008
-
(2008)
Biopolymers
, vol.90
, pp. 604-610
-
-
Torchilin, V.P.1
-
34
-
-
11844268027
-
Cationic TAT peptide transduction domain enters cells by macropinocytosis
-
DOI 10.1016/j.jconrel.2004.10.018, PII S0168365904004766
-
Kaplan, I. M., Wadia, J. S. & Dowdy, S. F. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J. Control. Release 102, 247-253 (2005 (Pubitemid 40093789)
-
(2005)
Journal of Controlled Release
, vol.102
, Issue.1
, pp. 247-253
-
-
Kaplan, I.M.1
Wadia, J.S.2
Dowdy, S.F.3
-
35
-
-
84896098716
-
SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells
-
Chen, S. et al. SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells. Carcinogenesis 14, 14 (2013
-
(2013)
Carcinogenesis
, vol.14
, pp. 14
-
-
Chen, S.1
-
36
-
-
84875928770
-
Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: Effect against breast cancer in mice
-
Liu, Z. et al. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS ONE 8, e60190 (2013
-
(2013)
PLoS ONE
, vol.8
-
-
Liu, Z.1
-
37
-
-
1842831877
-
Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones
-
DOI 10.1515/BC.2002.133
-
Niestroj, A. J. et al. Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones. Biol. Chem. 383, 1205-1214 (2002 (Pubitemid 35215069)
-
(2002)
Biological Chemistry
, vol.383
, Issue.7-8
, pp. 1205-1214
-
-
Niestroj, A.J.1
Feussner, K.2
Heiser, U.3
Dando, P.M.4
Barrett, A.5
Gerhartz, B.6
Demuth, H.-U.7
-
38
-
-
11144356057
-
Aza-Peptide Michael Acceptors: A New Class of Inhibitors Specific for Caspases and Other Clan CD Cysteine Proteases
-
DOI 10.1021/jm049938j
-
Ekici, O. D. et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J. Med. Chem. 47, 1889-1892 (2004 (Pubitemid 38453908)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.8
, pp. 1889-1892
-
-
Ekici, O.D.1
Gotz, M.G.2
James, K.E.3
Li, Z.Z.4
Rukamp, B.J.5
Asgian, J.L.6
Caffrey, C.R.7
Hansell, E.8
Dvorak, J.9
McKerrow, J.H.10
Potempa, J.11
Travis, J.12
Mikolajczyk, J.13
Salvesen, G.S.14
Powers, J.C.15
-
39
-
-
47949114921
-
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
-
Murphy, E. A. et al. Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis. Proc. Natl Acad. Sci. USA 105, 9343-9348 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9343-9348
-
-
Murphy, E.A.1
-
40
-
-
42949122012
-
Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens
-
DOI 10.1021/jm701311r
-
Gotz, M. G. et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J. Med. Chem. 51, 2816-2832 (2008 (Pubitemid 351620803)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.9
, pp. 2816-2832
-
-
Gotz, M.G.1
James, K.E.2
Hansell, E.3
Dvorak, J.4
Seshaadri, A.5
Sojka, D.6
Kopacek, P.7
McKerrow, J.H.8
Caffrey, C.R.9
Powers, J.C.10
-
41
-
-
33748859423
-
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10
-
DOI 10.1021/jm0601405
-
Ekici, O. D. et al. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2,-3,-6,-7,-8,- 9, and-10. J. Med. Chem. 49, 5728-5749 (2006 (Pubitemid 44423710)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.19
, pp. 5728-5749
-
-
Ekici, O.D.1
Li, Z.Z.2
Campbell, A.J.3
James, K.E.4
Asgian, J.L.5
Mikolajczyk, J.6
Salvesen, G.S.7
Ganesan, R.8
Jelakovic, S.9
Grutter, M.G.10
Powers, J.C.11
-
42
-
-
70949088531
-
Aza-peptidyl Michael acceptor and epoxide inhibitors-potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases)
-
Ovat, A. et al. Aza-peptidyl Michael acceptor and epoxide inhibitors-potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J. Med. Chem. 52, 7192-7210 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7192-7210
-
-
Ovat, A.1
|