Cytoplasm-responsive nanocarriers conjugated with a functional cell-penetrating peptide for systemic siRNA delivery

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 40-47

  Tanaka, Ko ^a   Kanazawa, Takanori ^a   Horiuchi, Shogo ^a   Ando, Taichi ^a   Sugawara, Ken ^a   Takashima, Yuuki ^a   Seta, Yasuo ^a   Okada, Hiroaki ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b Okada DDS Research Institute Inc   (Japan)

Author keywords

Anti tumor effect; Anti VEGF siRNA; Cell penetrating peptide; Cytoplasm responsive nanocarriers; Disulfide linkage; Systemic delivery polymer micelles

Indexed keywords

CELL PENETRATING PEPTIDE; MACROGOL DERIVATIVE; NANOCARRIER; POLYCAPROLACTONE; POLYMER; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CELL BASED GENE THERAPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; GENE SILENCING; GENETIC TRANSFECTION; MALE; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; SYSTEMIC THERAPY; TUMOR VOLUME;

ANTI-TUMOR EFFECT; ANTI-VEGF SIRNA; CELL-PENETRATING PEPTIDE; CYTOPLASM-RESPONSIVE NANOCARRIERS; DISULFIDE LINKAGE; SYSTEMIC DELIVERY POLYMER MICELLES;

ANIMALS; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; CYTOPLASM; DRUG CARRIERS; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; NEOPLASMS; POLYESTERS; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84884131045     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.069     Document Type: Article

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