A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma

FASEB Journal

Volumn 29, Issue 7, 2015, Pages 2803-2813

  Salama, Mohamed F ^a,b   Carroll, Brittany ^a   Adada, Mohamad ^a   Pulkoski Gross, Michael ^a   Hannun, Yusuf A ^a   Obeid, Lina M ^a,c  

^a STONY BROOK UNIVERSITY   (United States)

^b Mansoura University   (Egypt)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Focal adhesion kinase; HIF 2; S1P receptor; Sphingosine 1 phosphate

Indexed keywords

2 AMINO 2 (3 OCTYLPHENYLCARBAMOYL)ETHYL PHOSPHATE; 4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; FOCAL ADHESION KINASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; SPHINGOSINE KINASE 1; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; FOCAL ADHESION KINASE 1; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; PTK2 PROTEIN, HUMAN; S1PR2 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE; VHL PROTEIN, HUMAN;

ANGIOGENESIS; ARTICLE; AUTOCRINE EFFECT; CANCER SURVIVAL; CELL INVASION; CELL PROLIFERATION; CHORIOALLANTOIS; CONTROLLED STUDY; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SURVIVAL RATE; TUMOR INVASION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CARCINOMA, RENAL CELL; DOWN REGULATION; GENETICS; KIDNEY NEOPLASMS; METABOLISM; MUTATION; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; UPREGULATION;

PHOS;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; DOWN-REGULATION; FOCAL ADHESION KINASE 1; GENE KNOCKDOWN TECHNIQUES; HUMANS; KIDNEY NEOPLASMS; LYSOPHOSPHOLIPIDS; MUTATION; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; UP-REGULATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84940393356     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-270413     Document Type: Article

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