-
1
-
-
43449132987
-
Head and neck cancer
-
Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet 2008, 371:1695-1709. 10.1016/S0140-6736(08)60728-X, 18486742.
-
(2008)
Lancet
, vol.371
, pp. 1695-1709
-
-
Argiris, A.1
Karamouzis, M.V.2
Raben, D.3
Ferris, R.L.4
-
2
-
-
81155126038
-
Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer
-
21975930
-
Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Singh B, Weigert R, Molinolo AA, Gutkind JS. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res 2011, 71:7103-7112. 10.1158/0008-5472.CAN-10-3192, 21975930.
-
(2011)
Cancer Res
, vol.71
, pp. 7103-7112
-
-
Patel, V.1
Marsh, C.A.2
Dorsam, R.T.3
Mikelis, C.M.4
Masedunskas, A.5
Amornphimoltham, P.6
Nathan, C.A.7
Singh, B.8
Weigert, R.9
Molinolo, A.A.10
Gutkind, J.S.11
-
3
-
-
38549152194
-
Principles of bioactive lipid signalling: lessons from sphingolipids
-
18216770
-
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008, 9:139-150. 10.1038/nrm2329, 18216770.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
4
-
-
3543114272
-
Biologically active sphingolipids in cancer pathogenesis and treatment
-
15286740
-
Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004, 4:604-616. 10.1038/nrc1411, 15286740.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 604-616
-
-
Ogretmen, B.1
Hannun, Y.A.2
-
6
-
-
79955799347
-
A role of sphingosine kinase 1 in head and neck carcinogenesis
-
Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila) 2011, 4:454-462. 10.1158/1940-6207.CAPR-10-0299.
-
(2011)
Cancer Prev Res (Phila)
, vol.4
, pp. 454-462
-
-
Shirai, K.1
Kaneshiro, T.2
Wada, M.3
Furuya, H.4
Bielawski, J.5
Hannun, Y.A.6
Obeid, L.M.7
Ogretmen, B.8
Kawamori, T.9
-
7
-
-
78751544538
-
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition
-
20848438
-
Sinha UK, Schorn VJ, Hochstim C, Chinn SB, Zhu S, Masood R. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck 2011, 33:178-188. 10.1002/hed.21418, 20848438.
-
(2011)
Head Neck
, vol.33
, pp. 178-188
-
-
Sinha, U.K.1
Schorn, V.J.2
Hochstim, C.3
Chinn, S.B.4
Zhu, S.5
Masood, R.6
-
8
-
-
80053173129
-
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma
-
21936950
-
Pan J, Tao YF, Zhou Z, Cao BR, Wu SY, Zhang YL, Hu SY, Zhao WL, Wang J, Lou GL, Li Z, Feng X, Ni J. An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma. J Transl Med 2011, 9:157. 10.1186/1479-5876-9-157, 21936950.
-
(2011)
J Transl Med
, vol.9
, pp. 157
-
-
Pan, J.1
Tao, Y.F.2
Zhou, Z.3
Cao, B.R.4
Wu, S.Y.5
Zhang, Y.L.6
Hu, S.Y.7
Zhao, W.L.8
Wang, J.9
Lou, G.L.10
Li, Z.11
Feng, X.12
Ni, J.13
-
9
-
-
77958025091
-
The expression of sphingosine kinase-1 in head and neck carcinoma
-
20606403
-
Facchinetti MM, Gandini NA, Fermento ME, Sterin-Speziale NB, Ji Y, Patel V, Gutkind JS, Rivadulla MG, Curino AC. The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs 2010, 192:314-324. 10.1159/000318173, 20606403.
-
(2010)
Cells Tissues Organs
, vol.192
, pp. 314-324
-
-
Facchinetti, M.M.1
Gandini, N.A.2
Fermento, M.E.3
Sterin-Speziale, N.B.4
Ji, Y.5
Patel, V.6
Gutkind, J.S.7
Rivadulla, M.G.8
Curino, A.C.9
-
10
-
-
70350743117
-
Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma
-
19825947
-
Egloff AM, Rothstein ME, Seethala R, Siegfried JM, Grandis JR, Stabile LP. Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma. Clin Cancer Res 2009, 15:6529-6540. 10.1158/1078-0432.CCR-09-0862, 19825947.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6529-6540
-
-
Egloff, A.M.1
Rothstein, M.E.2
Seethala, R.3
Siegfried, J.M.4
Grandis, J.R.5
Stabile, L.P.6
-
11
-
-
77956941983
-
Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
-
20622897
-
Wheeler SE, Suzuki S, Thomas SM, Sen M, Leeman-Neill RJ, Chiosea SI, Kuan CT, Bigner DD, Gooding WE, Lai SY, Grandis JR. Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. Oncogene 2010, 29:5135-5145. 10.1038/onc.2009.279, 20622897.
-
(2010)
Oncogene
, vol.29
, pp. 5135-5145
-
-
Wheeler, S.E.1
Suzuki, S.2
Thomas, S.M.3
Sen, M.4
Leeman-Neill, R.J.5
Chiosea, S.I.6
Kuan, C.T.7
Bigner, D.D.8
Gooding, W.E.9
Lai, S.Y.10
Grandis, J.R.11
-
12
-
-
2442699980
-
Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy
-
15158755
-
Taha TA, Argraves KM, Obeid LM. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta 2004, 1682:48-55. 10.1016/j.bbalip.2004.01.006, 15158755.
-
(2004)
Biochim Biophys Acta
, vol.1682
, pp. 48-55
-
-
Taha, T.A.1
Argraves, K.M.2
Obeid, L.M.3
-
13
-
-
60849110803
-
S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor
-
19131156
-
Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett 2009, 276:171-179. 10.1016/j.canlet.2008.11.025, 19131156.
-
(2009)
Cancer Lett
, vol.276
, pp. 171-179
-
-
Li, M.H.1
Sanchez, T.2
Yamase, H.3
Hla, T.4
Oo, M.L.5
Pappalardo, A.6
Lynch, K.R.7
Lin, C.Y.8
Ferrer, F.9
-
14
-
-
78649982367
-
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
-
21102457
-
Lee H, Deng J, Kujawski M, Yang C, Liu Y, Herrmann A, Kortylewski M, Horne D, Somlo G, Forman S, Jove R, Yu H. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med 2010, 16:1421-1428. 10.1038/nm.2250, 21102457.
-
(2010)
Nat Med
, vol.16
, pp. 1421-1428
-
-
Lee, H.1
Deng, J.2
Kujawski, M.3
Yang, C.4
Liu, Y.5
Herrmann, A.6
Kortylewski, M.7
Horne, D.8
Somlo, G.9
Forman, S.10
Jove, R.11
Yu, H.12
-
15
-
-
34250174504
-
The role of epithelial-mesenchymal transition in cancer pathology
-
17558857
-
Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007, 39:305-318. 10.1080/00313020701329914, 17558857.
-
(2007)
Pathology
, vol.39
, pp. 305-318
-
-
Guarino, M.1
Rubino, B.2
Ballabio, G.3
-
16
-
-
0026322974
-
E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis
-
1933895
-
Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 1991, 51:6328-6337. 1933895.
-
(1991)
Cancer Res
, vol.51
, pp. 6328-6337
-
-
Schipper, J.H.1
Frixen, U.H.2
Behrens, J.3
Unger, A.4
Jahnke, K.5
Birchmeier, W.6
-
17
-
-
84860389234
-
Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin
-
21557297
-
Zuo JH, Zhu W, Li MY, Li XH, Yi H, Zeng GQ, Wan XX, He QY, Li JH, Qu JQ, Chen Y, Xiao ZQ. Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin. J Cell Biochem 2011, 112:2508-2517. 10.1002/jcb.23175, 21557297.
-
(2011)
J Cell Biochem
, vol.112
, pp. 2508-2517
-
-
Zuo, J.H.1
Zhu, W.2
Li, M.Y.3
Li, X.H.4
Yi, H.5
Zeng, G.Q.6
Wan, X.X.7
He, Q.Y.8
Li, J.H.9
Qu, J.Q.10
Chen, Y.11
Xiao, Z.Q.12
-
18
-
-
79960301614
-
Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Galphaq coupling
-
21652634
-
Kim ES, Kim JS, Kim SG, Hwang S, Lee CH, Moon A. Sphingosine 1-phosphate regulates matrix metalloproteinase-9 expression and breast cell invasion through S1P3-Galphaq coupling. J Cell Sci 2011, 124:2220-2230. 10.1242/jcs.076794, 21652634.
-
(2011)
J Cell Sci
, vol.124
, pp. 2220-2230
-
-
Kim, E.S.1
Kim, J.S.2
Kim, S.G.3
Hwang, S.4
Lee, C.H.5
Moon, A.6
-
19
-
-
0030666022
-
Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole
-
9815580
-
Wu Y, Palad AJ, Wasilenko WJ, Blackmore PF, Pincus WA, Schechter GL, Spoonster JR, Kohn EC, Somers KD. Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole. Clin Cancer Res 1997, 3:1915-1921. 9815580.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1915-1921
-
-
Wu, Y.1
Palad, A.J.2
Wasilenko, W.J.3
Blackmore, P.F.4
Pincus, W.A.5
Schechter, G.L.6
Spoonster, J.R.7
Kohn, E.C.8
Somers, K.D.9
-
20
-
-
33749055594
-
Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
-
16984731
-
Squarize CH, Castilho RM, Sriuranpong V, Pinto DS, Gutkind JS. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia 2006, 8:733-746. 10.1593/neo.06274, 16984731.
-
(2006)
Neoplasia
, vol.8
, pp. 733-746
-
-
Squarize, C.H.1
Castilho, R.M.2
Sriuranpong, V.3
Pinto, D.S.4
Gutkind, J.S.5
-
21
-
-
84906823715
-
-
Sphingosine-1-phosphate receptor S1P1 expression predicts cervical metastasis in oral cavity squamous cell carcinoma. In American Head & Neck Society, 8th International Conference on Head and Neck Cancer: July 22-24, 2012; Toronto, ON, Canada
-
Ledgerwood L, Tinling S, Gandour-Edwards R, Farwell D: Sphingosine-1-phosphate receptor S1P1 expression predicts cervical metastasis in oral cavity squamous cell carcinoma. In American Head & Neck Society, 8th International Conference on Head and Neck Cancer: July 22-24, 2012; Toronto, ON, Canada; 2012.
-
(2012)
-
-
Ledgerwood, L.1
Tinling, S.2
Gandour-Edwards, R.3
Farwell, D.4
-
22
-
-
84872406787
-
Sphingosine-1-phosphate links persistent stat3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
23273921
-
Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S. Sphingosine-1-phosphate links persistent stat3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 2013, 23:107-120. 10.1016/j.ccr.2012.11.013, 23273921.
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
Nagahashi, M.2
Kim, E.Y.3
Harikumar, K.B.4
Yamada, A.5
Huang, W.C.6
Hait, N.C.7
Allegood, J.C.8
Price, M.M.9
Avni, D.10
Takabe, K.11
Kordula, T.12
Milstien, S.13
Spiegel, S.14
-
23
-
-
84874441180
-
Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways
-
22684547
-
Liu SQ, Huang JA, Qin MB, Su YJ, Lai MY, Jiang HX, Tang GD. Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. Int J Colorectal Dis 2012, 27:1569-1578. 10.1007/s00384-012-1510-y, 22684547.
-
(2012)
Int J Colorectal Dis
, vol.27
, pp. 1569-1578
-
-
Liu, S.Q.1
Huang, J.A.2
Qin, M.B.3
Su, Y.J.4
Lai, M.Y.5
Jiang, H.X.6
Tang, G.D.7
-
24
-
-
33749035470
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
-
16951222
-
Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res 2006, 12:5064-5073. 10.1158/1078-0432.CCR-06-0913, 16951222.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5064-5073
-
-
Sok, J.C.1
Coppelli, F.M.2
Thomas, S.M.3
Lango, M.N.4
Xi, S.5
Hunt, J.L.6
Freilino, M.L.7
Graner, M.W.8
Wikstrand, C.J.9
Bigner, D.D.10
Gooding, W.E.11
Furnari, F.B.12
Grandis, J.R.13
-
25
-
-
0027183870
-
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
-
8339264
-
Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 1993, 53:3579-3584. 8339264.
-
(1993)
Cancer Res
, vol.53
, pp. 3579-3584
-
-
Grandis, J.R.1
Tweardy, D.J.2
-
26
-
-
21744437097
-
Expression of protein tyrosine kinases in head and neck squamous cell carcinomas
-
Ongkeko WM, Altuna X, Weisman RA, Wang-Rodriguez J. Expression of protein tyrosine kinases in head and neck squamous cell carcinomas. Am J Clin Pathology 2005, 124:71-76. 10.1309/BTLN5WTMJ3PCNRRC.
-
(2005)
Am J Clin Pathology
, vol.124
, pp. 71-76
-
-
Ongkeko, W.M.1
Altuna, X.2
Weisman, R.A.3
Wang-Rodriguez, J.4
-
27
-
-
84866517656
-
Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion
-
23028842
-
Rossa C, Sommer G, Spolidorio LC, Rosenzweig SA, Watson DK, Kirkwood KL. Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS One 2012, 7:e45197. 10.1371/journal.pone.0045197, 23028842.
-
(2012)
PLoS One
, vol.7
, pp. e45197
-
-
Rossa, C.1
Sommer, G.2
Spolidorio, L.C.3
Rosenzweig, S.A.4
Watson, D.K.5
Kirkwood, K.L.6
-
28
-
-
2442685645
-
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
-
15116091
-
Xie TX, Wei D, Liu M, Gao AC, Ali-Osman F, Sawaya R, Huang S. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene 2004, 23:3550-3560. 10.1038/sj.onc.1207383, 15116091.
-
(2004)
Oncogene
, vol.23
, pp. 3550-3560
-
-
Xie, T.X.1
Wei, D.2
Liu, M.3
Gao, A.C.4
Ali-Osman, F.5
Sawaya, R.6
Huang, S.7
-
29
-
-
0034181347
-
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion
-
10760816
-
O-Charoenrat P, Rhys-Evans P, Modjtahedi H, Court W, Box G, Eccles S. Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion. Int J Cancer 2000, 86:307-317. 10.1002/(SICI)1097-0215(20000501)86:3<307::AID-IJC2>3.0.CO;2-I, 10760816.
-
(2000)
Int J Cancer
, vol.86
, pp. 307-317
-
-
O-Charoenrat, P.1
Rhys-Evans, P.2
Modjtahedi, H.3
Court, W.4
Box, G.5
Eccles, S.6
-
30
-
-
28044434891
-
The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts
-
16149055
-
Wu L, Gonias SL. The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts. J Cell Biochem 2005, 96:1021-1033. 10.1002/jcb.20596, 16149055.
-
(2005)
J Cell Biochem
, vol.96
, pp. 1021-1033
-
-
Wu, L.1
Gonias, S.L.2
-
31
-
-
59149098234
-
Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
-
19176371
-
Song H, Li Y, Lee J, Schwartz AL, Bu G. Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res 2009, 69:879-886. 10.1158/0008-5472.CAN-08-3379, 19176371.
-
(2009)
Cancer Res
, vol.69
, pp. 879-886
-
-
Song, H.1
Li, Y.2
Lee, J.3
Schwartz, A.L.4
Bu, G.5
-
32
-
-
77955366419
-
LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways
-
20644732
-
Langlois B, Perrot G, Schneider C, Henriet P, Emonard H, Martiny L, Dedieu S. LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways. PLoS One 2010, 5:e11584. 10.1371/journal.pone.0011584, 20644732.
-
(2010)
PLoS One
, vol.5
, pp. e11584
-
-
Langlois, B.1
Perrot, G.2
Schneider, C.3
Henriet, P.4
Emonard, H.5
Martiny, L.6
Dedieu, S.7
-
33
-
-
44949233776
-
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells
-
18426913
-
Miller AV, Alvarez SE, Spiegel S, Lebman DA. Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 2008, 28:4142-4151. 10.1128/MCB.01465-07, 18426913.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4142-4151
-
-
Miller, A.V.1
Alvarez, S.E.2
Spiegel, S.3
Lebman, D.A.4
-
34
-
-
84873422851
-
Effect of sphingosine kinase 1 inhibition on blood pressure
-
23109673
-
Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM, Kawamori T. Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J 2013, 27:656-664. 10.1096/fj.12-219014, 23109673.
-
(2013)
FASEB J
, vol.27
, pp. 656-664
-
-
Furuya, H.1
Wada, M.2
Shimizu, Y.3
Yamada, P.M.4
Hannun, Y.A.5
Obeid, L.M.6
Kawamori, T.7
|