Protection of the Developing Brain with Anthocyanins Against Ethanol-Induced Oxidative Stress and Neurodegeneration

Molecular Neurobiology

Volumn 51, Issue 3, 2015, Pages 1278-1291

  Shah, Shahid Ali ^a   Yoon, Gwang Ho ^a   Kim, Myeong Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Apoptosis; COX 2; Hippocampus; Intracellular signaling; NF B

Indexed keywords

ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID SUBTYPE GLUTAMATE RECEPTOR, HUMAN; ANTHOCYANIN; GLUTAMATE RECEPTOR; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE;

ANIMAL; APOPTOSIS; BRAIN; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HIPPOCAMPUS; METABOLISM; NERVE CELL; NEWBORN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANIMALS, NEWBORN; ANTHOCYANINS; APOPTOSIS; BRAIN; ETHANOL; HIPPOCAMPUS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 84940281577     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8805-7     Document Type: Article

References (45)

1. Ikonomidou C et al (2000) Ethanol-induced apoptotic neurodegeneration and the fetal alcohol syndrome. Science 287:1056–1060
2. Ikonomidou C et al (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70–74
3. Jevtovic-Todorovic V et al (2003) Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 23:876–882
4. Clarren SK, Smith DW (1978) The fetal alcohol syndrome. N Engl J Med 298:1063–1067
5. Guerri C (1998) Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure. Alcohol Clin Exp Res 22:304–312
6. Barnes DE, Walker DW (1981) Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus. Brain Res 227:333–340
7. Farr KL et al (1988) Prenatal ethanol exposure decreases hippocampal 3H-glutamate binding in 45-day-old rats. Alcohol 5:125–133
8. Heaton MB et al (1995) Prenatal ethanol exposure alters neurotrophic activity in the developing rat hippocampus. Neurosci Lett 188:132–136
9. Xu J (2003) Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem 278:26929–26937
10. Zhang FX et al (1998) N-methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of N-methyl-D-aspartate and its inhibition by ethanol. J Biol Chem 273:26596–26602
11. Bhave SV et al (1999) Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action. J Neurosci 19:3277–3286
12. Crews FT, Nixon K (2009) Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol 44:115–127
13. Haorah J et al (2008) Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radic Biol Med 45:1542–1550
14. Hampton MB, Orrenius S (1998) Redox regulation of apoptotic cell death. Biofactors 8:1–5
15. Cohen-Kerem R, Koren G (2003) Antioxidants and fetal protection against ethanol teratogenicity. I. Review of the experimental data and implications to humans. Neurotoxicol Teratol 25:1–9
16. Duthie G et al (2000) Plant polyphenols in cancer and heart diseases: implication as nutritional antioxidants. Nutrition Res Rev 13:79–106
17. Chen G, Luo J (2010) Anthocyanins: are they beneficial in treating ethanol neurotoxicity? Neurotox Res 17:91–101
18. Rivero-Perez MD et al (2008) Contribution of anthocyanin fraction to the antioxidant properties of wine. Food Chem Toxicol 46:2815–2822
19. Assuncao M et al (2007) Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral study. Neuroscience 146:1581–1592
20. AB1 receptors intracellular signaling in prenatal rat hippocampal neurons. Mol Neurobiol 48:257–269
21. Olney JW et al (2002) Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Develop Brain Research 133:115–126
22. Shah SA et al (2014) Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain. Cell Death and Disease 5:e1026. doi:10.1038/cddis.2013.538
23. Koh PO (2013) Ferulic acid prevents cerebral ischemic injury-induced reduction of hippocalcin expression. Synapse 67:390–398
24. Tiwari V et al (2012) Attenuation of NF-κB mediated apoptotic signaling by tocotrienol ameliorates cognitive deficits in rats postnatally exposed to ethanol. Neurochemi Intern 61:310–320
25. Sowell ER (2002) Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure. Cereb Cortex 12:856–865
26. Sowell ER (2001) Voxel-based morphometric analyses of the brain in children and adolescents prenatally exposed to alcohol. Neuro Report 12:515–523
27. Sowell ER (2002) Mapping cortical gray matter asymmetry patterns in adolescents with heavy prenatal alcohol exposure. Neuro Image 17:1807–1819
28. Mattson SN, Riley EP (1998) A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcohol Clin Exp Res 22:279–294
29. La GL (1999) Protective effects of the flavonoid mixture, silymarin, on fetal rat brain and liver. J Ethnopharmacol 65:53–61
30. Antonio AM, Druse MJ (2008) Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 1204:16–23
31. Ghosh D, Konishi T (2007) Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function. Asia Pac J Clin Nutr 16:200–208
32. Zafra-Stone S (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51:675–683
33. Chen G et al (2009) Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 beta. Neuroto Res 15:321–331
34. Li CY (2008) Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats. Alcohol 42:683–687
35. Luo J (2009) GSK-3 beta in ethanol neurotoxicity. Mol Neurobiol 40:108–121
36. Crews F (2006) BHT blocks NF-κB activation and ethanol-induced brain damage. Alcohol Clin Ex Res 30:1938–1949
37. Izumi Y et al (2005) A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. Neuroscience 136:269–279
38. Henderson GI (1999) Ethanol, oxidative stress, reactive aldehydes, and the fetus. Front Biosci 4:541–550
39. Abel EL, Hannigan JH (1995) Maternal risk factors in fetal alcohol syndrome: provocative and permissive influences. Neurotoxicol Teratol 17:445–462
40. Shirpoor A et al (2009) Protective effect of vitamin E against ethanol-induced hyperhomocysteinemia, DNA damage, and atrophy in the developing male rat brain. Alcohol Clin Exp Res 33:1181–1186
41. Hensch TK (2005) Critical period plasticity in local cortical circuits. Nat Rev Neurosci 6:877–888
42. Crair MC, Malenka RC (1995) A critical period for long-term potentiation at thalamocortical synapses. Nature 375:325–328
43. Durand GM et al (1996) Long-term potentiation and functional synapse induction in developing hippocampus. Nature 381:71–75
44. Kerchner GA, Nicoll RA (2008) Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neu 9:813–825
45. Mameli M et al (2005) Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. J Neurosci 25:8027–8036