Protective effect of vitamin e against ethanol-induced hyperhomocysteinemia, DNA damage, and atrophy in the developing male rat brain

Alcoholism: Clinical and Experimental Research

Volumn 33, Issue 7, 2009, Pages 1181-1186

  Shirpoor, Alireza ^a,b   Salami, Siamak ^b   Khadem Ansari, Mohammad Hassan ^b   Minassian, Syranush ^a   Yegiazarian, Marine ^a  

^a YEREVAN STATE UNIVERSITY   (Armenia)

^b URMIA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Developing Brain; DNA Damage; Fetal Alcohol Spectrum Disorders; Homocysteine; Vitamin E

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; HOMOCYSTEINE;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ATROPHY; BRAIN DEVELOPMENT; BRAIN WEIGHT; CEREBELLUM; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; FEMALE; HIPPOCAMPUS; HYPERHOMOCYSTEINEMIA; LACTATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PREGNANCY; PRIORITY JOURNAL; PROGENY; RAT; WEIGHT CHANGE; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; ATROPHY; BRAIN; DNA DAMAGE; ETHANOL; FEMALE; HYPERHOMOCYSTEINEMIA; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; VITAMIN E;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 67650658872     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.00941.x     Document Type: Article

References (46)

1. Abel EL, Hannigan JH (1995) Maternal risk factors in fetal alcohol syndrome: provocative and permissive influences. Neurotoxicol Teratol 17 : 445 462.
2. Aragon AS, Kalberg WO, Buckley D, Barela-Scott LM, Tabachnick BG, May PA (2008) Neuropsychological study of FASD in a sample of American Indian children: processing simple versus complex information. Alcohol Clin Exp Res 32 : 2136 2148.
3. Autti-Ramo I, Fagerlund A, Ervalahti N, Loimu L, Korkman M, Hoyme HE (2006) Fetal alcohol spectrum disorders in Finland: clinical delineation of 77 older children and adolescents. Am J Med Genet A 140 : 137 143. (Pubitemid 43054015)
4. Badger TM, Ronis MJ, Lumpkin CK, Valentine CR, Shahare M, Irby D, Huang J, Mercado C, Thomas P, Ingelman-Sundberg M, et al. (1993) Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J Pharmacol Exp Ther 264 : 438 447. (Pubitemid 23309234)
5. Barron S, Mulholland PJ, Littleton JM, Prendergast MA (2008) Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcohol Clin Exp Res 32 : 929 936. (Pubitemid 351733072)
6. Bleich S, Bandelow B, Javaheripour K, Muller A, Degner D, Wilhelm J, Havemann-Reinecke U, Sperling W, Ruther E, Kornhuber J (2003) Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett 335 : 179 182. (Pubitemid 36071629)
7. Burke MW, Palmour RM, Ervin FR, Ptito M (2009) Neuronal reduction in frontal cortex of primates after prenatal alcohol exposure. Neuroreport 20 : 13 17.
8. Ceccanti M, Alessandra Spagnolo P, Tarani L, Luisa Attilia M, Chessa L, Mancinelli R, Stegagno M, Francesco Sasso G, Romeo M, Jones KL, Robinson LK, Del Campo M, Phillip Gossage J, May PA, Eugene Hoyme H (2007) Clinical delineation of fetal alcohol spectrum disorders (FASD) in Italian children: comparison and contrast with other racial/ethnic groups and implications for diagnosis and prevention. Neurosci Biobehav Rev 31 : 270 277. (Pubitemid 46084940)
9. Chiodo LM, Janisse J, Delaney-Black V, Sokol RJ, Hannigan JH (2009) A metric of maternal prenatal risk drinking predicts neurobehavioral outcomes in preschool children. Alcohol Clin Exp Res [Epub ahead of print].
10. Chung YH, Hong JJ, Shin CM, Joo KM, Kim MJ, Cha CI (2003) Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation. Brain Res 967 : 226 234. (Pubitemid 36324302)
11. Davis WL, Crawford LA, Cooper OJ, Farmer GR, Thomas DL, Freeman BL (1990) Ethanol induces the generation of reactive free radicals by neural crest cells in vitro. J Craniofac Genet Dev Biol 10 : 277 293. (Pubitemid 20364367)
12. Enache M, Van Waes V, Vinner E, Lhermitte M, Maccari S, Darnaudery M (2008) Impact of an acute exposure to ethanol on the oxidative stress status in the hippocampus of prenatal restraint stress adolescent male rats. Brain Res 1191 : 55 62.
13. Fryer SL, Schweinsburg BC, Bjorkquist OA, Frank LR, Mattson SN, Spadoni AD, Riley EP (2008) Characterization of white matter microstructure in fetal alcohol spectrum disorders. Alcohol Clin Exp Res 33 : 514 521.
14. Goodlett CR, Horn KH (2001) Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res Health 25 : 175 184. (Pubitemid 33708980)
15. Green CR, Mihic AM, Nikkel SM, Stade BC, Rasmussen C, Munoz DP, Reynolds JN (2008) Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). J Child Psychol Psychiatry [Epub ahead of print].
16. Green CR, Munoz DP, Nikkel SM, Reynolds JN (2007) Deficits in eye movement control in children with fetal alcohol spectrum disorders. Alcohol Clin Exp Res 31 : 500 511. (Pubitemid 46239284)
17. Guerri C (2002) Mechanisms involved in central nervous system dysfunctions induced by prenatal ethanol exposure. Neurotox Res 4 : 327 335. (Pubitemid 35049778)
18. Guerri C, Bazinet A, Riley EP (2009) Foetal alcohol spectrum disorders and alterations in brain and behaviour. Alcohol Alcohol. 44 : 108 114.
19. Harper C (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57 : 101 110. (Pubitemid 28084272)
20. Harper C, Matsumoto I (2005) Ethanol and brain damage. Curr Opin Pharmacol 5 : 73 78. (Pubitemid 40124538)
21. Heaton MB, Paiva M, Madorsky I, Shaw G (2003) Ethanol effects on neonatal rat cortex: comparative analyses of neurotrophic factors, apoptosis-related proteins, and oxidative processes during vulnerable and resistant periods. Brain Res Dev Brain Res 145 : 249 262. (Pubitemid 37357134)
22. Hogg N (1999) The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radic Biol Med 27 : 28 33. (Pubitemid 29353080)
23. Hultberg B, Berglund M, Andersson A, Frank A (1993) Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res 17 : 687 689. (Pubitemid 23178459)
24. Jaatinen P, Rintala J (2008) Mechanisms of ethanol-induced degeneration in the developing, mature, and aging cerebellum. Cerebellum 7 : 332 347.
25. Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, Bradford BU, Forman DT, Thurman RG (2000) Gender differences in early alcohol-induced liver injury: role of CD14, NF-kappaB, and TNF-alpha. Am J Physiol Gastrointest Liver Physiol 278 : G652 G661.
26. Lebel C, Rasmussen C, Wyper K, Walker L, Andrew G, Yager J, Beaulieu C (2008) Brain diffusion abnormalities in children with fetal alcohol spectrum disorder. Alcohol Clin Exp Res 32 : 1732 1740.
27. Lewandowska E, Kujawa M, Jedrzejewska A (1994a) Ethanol-induced changes in Purkinje cells of rat cerebellum. II. The ultrastructural changes after chronic ethanol intoxication (morphometric evaluation). Folia Neuropathol 32 : 61 64.
28. Lewandowska E, Kujawa M, Jedrzejewska A (1994b) Ethanol-induced changes in Purkinje cells of the rat cerebellum. I. The ultrastructural changes following chronic ethanol intoxication (qualitative study). Folia Neuropathol 32 : 51 59.
29. Livy DJ, Elberger AJ (2008) Alcohol exposure during the first two trimesters-equivalent alters the development of corpus callosum projection neurons in the rat. Alcohol 42 : 285 293.
30. Matsumoto I, Burke L, Inoue Y, Wilce PA (2001) Two models of ethanol withdrawal kindling. Nihon Arukoru Yakubutsu Igakkai Zasshi 36 : 53 64.
31. May PA, Gossage JP, Marais AS, Hendricks LS, Snell CL, Tabachnick BG, Stellavato C, Buckley DG, Brooke LE, Viljoen DL (2008) Maternal risk factors for fetal alcohol syndrome and partial fetal alcohol syndrome in South Africa: a third study. Alcohol Clin Exp Res 32 : 738 753. (Pubitemid 351589390)
32. Mitchell JJ, Paiva M, Heaton MB (1999) The antioxidants vitamin E and beta-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol 17 : 163 168. (Pubitemid 29096205)
33. Rajasinghe H, Jayatilleke E, Shaw S (1990) DNA cleavage during ethanol metabolism: role of superoxide radicals and catalytic iron. Life Sci 47 : 807 814. (Pubitemid 20286239)
34. Rasmussen C, Bisanz J (2008) Executive functioning in children with fetal alcohol spectrum disorders: profiles and age-related differences. Child Neuropsychol [Epub ahead of print].
35. Sayal K, Heron J, Golding J, Emond A (2007) Prenatal alcohol exposure and gender differences in childhood mental health problems: a longitudinal population-based study. Pediatrics 119 : e426 e434.
36. Shirpoor A, Minassian S, Salami S, Khadem-Ansari MH, Yeghiazaryan M (2008a) Alpha-lipoic acid decreases DNA damage and oxidative stress induced by alcohol in the developing hippocampus and cerebellum of rat. Cell Physiol Biochem 22 : 769 776.
37. Shirpoor A, Minassian S, Salami S, Khadem-Ansari MH, Yeghiazaryan M (2009) Vitamin E protects developing rat hippocampus and cerebellum against ethanol-induced oxidative stress and apoptosis. Food Chemistry 113 : 115 120.
38. Shirpoor A, Salami S, Khadem-Ansari MH, Ilkhanizadeh B, Pakdel FG, Khademvatani K (2008b) Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat. J Diabetes Complicat 000 : 000.
39. Singh NP, Lai H, Khan A (1995) Ethanol-induced single-strand DNA breaks in rat brain cells. Mutat Res 345 : 191 196. (Pubitemid 26053802)
40. Sood B, Delaney-Black V, Covington C, Nordstrom-Klee B, Ager J, Templin T, Janisse J, Martier S, Sokol RJ (2001) Prenatal alcohol exposure and childhood behavior at age 6 to 7 years. I. Dose-response effect. Pediatrics 108 : E34.
41. Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, Selhub J, Mason JB (2000) Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res 24 : 259 264. (Pubitemid 30170197)
42. Streck EL, Vieira PS, Wannmacher CM, Dutra-Filho CS, Wajner M, Wyse AT (2003) In vitro effect of homocysteine on some parameters of oxidative stress in rat hippocampus. Metab Brain Dis 18 : 147 154. (Pubitemid 36718127)
43. Upchurch GR Jr., Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr., Loscalzo J (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 272 : 17012 17017. (Pubitemid 27289806)
44. Wentzel P, Eriksson UJ (2006) Ethanol-induced fetal dysmorphogenesis in the mouse is diminished by high antioxidative capacity of the mother. Toxicol Sci 92 : 416 422. (Pubitemid 44018958)
45. Wentzel P, Rydberg U, Eriksson UJ (2006) Antioxidative treatment diminishes ethanol-induced congenital malformations in the rat. Alcohol Clin Exp Res 30 : 1752 1760. (Pubitemid 44465614)
46. Willoughby KA, Sheard ED, Nash K, Rovet J (2008) Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood. J Int Neuropsychol Soc 14 : 1022 1033.