메뉴 건너뛰기




Volumn 9, Issue 11, 2008, Pages 813-825

Silent synapses and the emergence of a postsynaptic mechanism for LTP

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 54249097847     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn2501     Document Type: Review
Times cited : (512)

References (129)
  • 1
    • 0024443793 scopus 로고
    • The impact of postsynaptic calcium on synaptic transmission - its role in long-term potentiation
    • Malenka, R. C., Kauer, J. A., Perkel, D. J. & Nicoll, R. A. The impact of postsynaptic calcium on synaptic transmission - its role in long-term potentiation. Trends Neurosci. 12, 444-450 (1989).
    • (1989) Trends Neurosci , vol.12 , pp. 444-450
    • Malenka, R.C.1    Kauer, J.A.2    Perkel, D.J.3    Nicoll, R.A.4
  • 2
    • 0029018512 scopus 로고    scopus 로고
    • Liao, D., Hessler, N. A. & Malinow, R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375, 400-404 (1995). This paper and reference 3, which was published two months later, first established the presence of hippocampal CA1 silent synapses. Both groups used a minimal-stimulation technique to isolate synapses exhibiting the (now classic) physiological signature of a silent synapse - the presence of N-EPSCs but not A-EPSCs - and both groups went on to show that LTP triggered the rapid recruitment of an AMPAR-mediated response.
    • Liao, D., Hessler, N. A. & Malinow, R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375, 400-404 (1995). This paper and reference 3, which was published two months later, first established the presence of hippocampal CA1 silent synapses. Both groups used a minimal-stimulation technique to isolate synapses exhibiting the (now classic) physiological signature of a silent synapse - the presence of N-EPSCs but not A-EPSCs - and both groups went on to show that LTP triggered the rapid recruitment of an AMPAR-mediated response.
  • 3
    • 0029162513 scopus 로고
    • Evidence for silent synapses: Implications for the expression of LTP
    • Isaac, J. T., Nicoll, R. A. & Malenka, R. C. Evidence for silent synapses: implications for the expression of LTP. Neuron 15, 427-434 (1995).
    • (1995) Neuron , vol.15 , pp. 427-434
    • Isaac, J.T.1    Nicoll, R.A.2    Malenka, R.C.3
  • 4
    • 0015423876 scopus 로고
    • Factors forming the edge of a receptive field: The presence of relatively ineffective afferent terminals
    • Merrill, E. G. & Wall, P. D. Factors forming the edge of a receptive field: the presence of relatively ineffective afferent terminals. J. Physiol. 226, 825-846 (1972).
    • (1972) J. Physiol , vol.226 , pp. 825-846
    • Merrill, E.G.1    Wall, P.D.2
  • 5
    • 0017783502 scopus 로고
    • The presence of ineffective synapses and the circumstances which unmask them
    • Wall, P. D. The presence of ineffective synapses and the circumstances which unmask them. Philos. Trans. R. Soc. Lond. B Biol. Sci. 278, 361-372 (1977).
    • (1977) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.278 , pp. 361-372
    • Wall, P.D.1
  • 6
    • 0030884946 scopus 로고    scopus 로고
    • Silent synapses speak up
    • Malenka, R. C. & Nicoll, R. A. Silent synapses speak up. Neuron 19, 473-476 (1997).
    • (1997) Neuron , vol.19 , pp. 473-476
    • Malenka, R.C.1    Nicoll, R.A.2
  • 7
    • 0025020998 scopus 로고
    • Quantal analysis of synaptic potentials in neurons of the central nervous system
    • Redman, S. Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiol. Rev. 70, 165-198 (1990).
    • (1990) Physiol. Rev , vol.70 , pp. 165-198
    • Redman, S.1
  • 8
    • 0032723918 scopus 로고    scopus 로고
    • Speaking out of turn: A role for silent synapses in pain
    • Kerchner, G. A., Li, P. & Zhuo, M. Speaking out of turn: a role for silent synapses in pain. IUBMB Life 48, 251-256 (1999).
    • (1999) IUBMB Life , vol.48 , pp. 251-256
    • Kerchner, G.A.1    Li, P.2    Zhuo, M.3
  • 9
    • 0026410387 scopus 로고
    • Silent synaptic connections and their modifiability
    • Faber, D. S., Lin, J. W. & Korn, H. Silent synaptic connections and their modifiability. Ann. NY Acad. Sci. 627, 151-164 (1991).
    • (1991) Ann. NY Acad. Sci , vol.627 , pp. 151-164
    • Faber, D.S.1    Lin, J.W.2    Korn, H.3
  • 10
    • 0028985362 scopus 로고
    • Latent inhibitory connections become functional during activity-dependent plasticity
    • Charpier, S., Behrends, J. C., Triller, A., Faber, D. S. & Korn, H. "Latent" inhibitory connections become functional during activity-dependent plasticity. Proc. Natl Acad. Sci. USA 92, 117-120 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 117-120
    • Charpier, S.1    Behrends, J.C.2    Triller, A.3    Faber, D.S.4    Korn, H.5
  • 11
    • 0024498748 scopus 로고
    • The effects of postsynaptic levels of cyclic AMP on excitatory and inhibitory responses of an identified central neuron
    • Wolszon, L. & Faber, D. The effects of postsynaptic levels of cyclic AMP on excitatory and inhibitory responses of an identified central neuron. J. Neurosci. 9, 784-797 (1989).
    • (1989) J. Neurosci , vol.9 , pp. 784-797
    • Wolszon, L.1    Faber, D.2
  • 12
    • 0023883427 scopus 로고
    • Synaptic transmission mediated by single club endings on the goldfish Mauthner cell. II. Plasticity of excitatory postsynaptic potentials
    • Lin, J. W. & Faber, D. S. Synaptic transmission mediated by single club endings on the goldfish Mauthner cell. II. Plasticity of excitatory postsynaptic potentials. J. Neurosci. 8, 1313-1325 (1988).
    • (1988) J. Neurosci , vol.8 , pp. 1313-1325
    • Lin, J.W.1    Faber, D.S.2
  • 13
    • 0023879754 scopus 로고
    • Synaptic transmission mediated by single club endings on the goldfish Mauthner cell. I. Characteristics of electrotonic and chemical postsynaptic potentials
    • Lin, J. W. & Faber, D. S. Synaptic transmission mediated by single club endings on the goldfish Mauthner cell. I. Characteristics of electrotonic and chemical postsynaptic potentials. J. Neurosci. 8, 1302-1312 (1988).
    • (1988) J. Neurosci , vol.8 , pp. 1302-1312
    • Lin, J.W.1    Faber, D.S.2
  • 14
    • 0028200201 scopus 로고
    • Activity-induced changes in synaptic release sites at the crayfish neuromuscular junction
    • Wojtowicz, J. M., Marin, l. & Atwood, H. L. Activity-induced changes in synaptic release sites at the crayfish neuromuscular junction. J. Neurosci. 14, 3688-3703 (1994).
    • (1994) J. Neurosci , vol.14 , pp. 3688-3703
    • Wojtowicz, J.M.1    Marin, L.2    Atwood, H.L.3
  • 15
    • 0026409036 scopus 로고
    • Activity-dependent recruitment of silent synapses
    • Wojtowicz, J. M., Smith, B. R. & Atwood, H. L. Activity-dependent recruitment of silent synapses. Ann. NY Acad. Sci. 627, 169-179 (1991).
    • (1991) Ann. NY Acad. Sci , vol.627 , pp. 169-179
    • Wojtowicz, J.M.1    Smith, B.R.2    Atwood, H.L.3
  • 16
    • 0027348873 scopus 로고
    • Quantal release of neurotransmitter and long-term potentiation
    • Stevens, C. F. Quantal release of neurotransmitter and long-term potentiation. Cell 72, 55-63 (1993).
    • (1993) Cell , vol.72 , pp. 55-63
    • Stevens, C.F.1
  • 17
    • 0029093566 scopus 로고
    • Contrasting properties of two forms of long-term potentiation in the hippocampus
    • Nicoll, R. A. & Malenka, R. C. Contrasting properties of two forms of long-term potentiation in the hippocampus. Nature 377, 115-118 (1995).
    • (1995) Nature , vol.377 , pp. 115-118
    • Nicoll, R.A.1    Malenka, R.C.2
  • 18
    • 0024151163 scopus 로고    scopus 로고
    • Kauer, J. A., Malenka, R. C. & Nicoll, R. A. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus. Neuron 1, 911-917 (1988).
    • Kauer, J. A., Malenka, R. C. & Nicoll, R. A. A persistent postsynaptic modification mediates long-term potentiation in the hippocampus. Neuron 1, 911-917 (1988).
  • 19
    • 0024264902 scopus 로고
    • Contributions of quisqualate and NMDA receptors to the induction and expression of LTP
    • Muller, D., Joly, M. & Lynch, G. Contributions of quisqualate and NMDA receptors to the induction and expression of LTP. Science 242, 1694-1697 (1988).
    • (1988) Science , vol.242 , pp. 1694-1697
    • Muller, D.1    Joly, M.2    Lynch, G.3
  • 20
    • 0003457678 scopus 로고
    • Long-term potentiation differentially affects two components of synaptic responses in hippocampus
    • Muller, D. & Lynch, G. Long-term potentiation differentially affects two components of synaptic responses in hippocampus. Proc. Natl Acad. Sci. USA 85, 9346-9350 (1988).
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 9346-9350
    • Muller, D.1    Lynch, G.2
  • 21
    • 0028242805 scopus 로고    scopus 로고
    • Kullmann, D. M. Amplitude fluctuations of dualcomponent EPSCs in hippocampal pyramidal cells: implications for long-term potentiation. Neuron 12, 1111-1120 (1994). As one of the last milestones in the journey that ultimately led to the discovery of silent synapses in the hippocampus, this study elegantly illustrated that the quantal content for N-EPSCs is paradoxically different from the quantal content for A-EPSCs, and that only the latter changes during LTP. Kullmann proposed that LTP-induced uncovering of latent AMPAR clusters could explain this finding, in the absence of any change in presynaptic glutamate release.
    • Kullmann, D. M. Amplitude fluctuations of dualcomponent EPSCs in hippocampal pyramidal cells: implications for long-term potentiation. Neuron 12, 1111-1120 (1994). As one of the last milestones in the journey that ultimately led to the discovery of silent synapses in the hippocampus, this study elegantly illustrated that the quantal content for N-EPSCs is paradoxically different from the quantal content for A-EPSCs, and that only the latter changes during LTP. Kullmann proposed that LTP-induced uncovering of latent AMPAR clusters could explain this finding, in the absence of any change in presynaptic glutamate release.
  • 22
    • 0024423656 scopus 로고
    • NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus
    • Bekkers, J. M. & Stevens, C. F. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature 341, 230-233 (1989).
    • (1989) Nature , vol.341 , pp. 230-233
    • Bekkers, J.M.1    Stevens, C.F.2
  • 23
    • 0025456905 scopus 로고
    • Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors
    • Patneau, D. K. & Mayer, M. L. Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J. Neurosci. 10, 2385-2399 (1990).
    • (1990) J. Neurosci , vol.10 , pp. 2385-2399
    • Patneau, D.K.1    Mayer, M.L.2
  • 24
    • 0027359647 scopus 로고
    • Evidence for all-or-none regulation of neurotransmitter release: Implications for long-term potentiation
    • Perkel, D. J. & Nicoll, R. A. Evidence for all-or-none regulation of neurotransmitter release: implications for long-term potentiation. J. Physiol. 471, 481-500 (1993).
    • (1993) J. Physiol , vol.471 , pp. 481-500
    • Perkel, D.J.1    Nicoll, R.A.2
  • 25
    • 0028028527 scopus 로고
    • Multivesicular release from excitatory synapses of cultured hippocampal neurons
    • Tong, G. & Jahr, C. E. Multivesicular release from excitatory synapses of cultured hippocampal neurons. Neuron 12, 51-59 (1994).
    • (1994) Neuron , vol.12 , pp. 51-59
    • Tong, G.1    Jahr, C.E.2
  • 26
    • 0034068876 scopus 로고    scopus 로고
    • Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'
    • Choi, S., Klingauf, J. & tsien, R. W. Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'. Nature Neurosci. 3, 330-336 (2000).
    • (2000) Nature Neurosci , vol.3 , pp. 330-336
    • Choi, S.1    Klingauf, J.2    tsien, R.W.3
  • 27
    • 0026699874 scopus 로고
    • The relative contribution of NMDA receptor channels in the expression of long-term potentiation in the hippocampal CA1 region
    • Asztely, F., Wigstrom, H. & Gustafsson, B. The relative contribution of NMDA receptor channels in the expression of long-term potentiation in the hippocampal CA1 region. Eur. J. Neurosci. 4, 681-690 (1992).
    • (1992) Eur. J. Neurosci , vol.4 , pp. 681-690
    • Asztely, F.1    Wigstrom, H.2    Gustafsson, B.3
  • 28
    • 0023845212 scopus 로고
    • Phorbol ester-induced synaptic potentiation differs from longterm potentiation in the guinea pig hippocampus in vitro
    • Gustafsson, B., Huang, Y. Y. & Wigstrom, H. Phorbol ester-induced synaptic potentiation differs from longterm potentiation in the guinea pig hippocampus in vitro. Neurosci. Lett. 85, 77-81 (1988).
    • (1988) Neurosci. Lett , vol.85 , pp. 77-81
    • Gustafsson, B.1    Huang, Y.Y.2    Wigstrom, H.3
  • 29
    • 0025353308 scopus 로고    scopus 로고
    • Malinow, R. & Tsien, R. W. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346, 177-180 (1990). This paper was groundbreaking for two reasons: first, it marked the first time that LTP was induced in a hippocampal slice by a pairing protocol during whole-cell patch-clamp recording; and second, because the signal-to-noise ratio of this technique is superior to that of intracellular sharp-electrode recordings, the authors could perform quantal analysis on EPSCs evoked by minimal stimulation and demonstrate an increase in quantal content and a decrease in synaptic failures following LTP.
    • Malinow, R. & Tsien, R. W. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346, 177-180 (1990). This paper was groundbreaking for two reasons: first, it marked the first time that LTP was induced in a hippocampal slice by a pairing protocol during whole-cell patch-clamp recording; and second, because the signal-to-noise ratio of this technique is superior to that of intracellular sharp-electrode recordings, the authors could perform quantal analysis on EPSCs evoked by minimal stimulation and demonstrate an increase in quantal content and a decrease in synaptic failures following LTP.
  • 30
    • 0025150883 scopus 로고    scopus 로고
    • Bekkers, J. M. & Stevens, C. F. Presynaptic mechanism for long-term potentiation in the hippocampus. Nature 346, 724-729 (1990). Published a month after reference 29, this paper yielded similar findings.
    • Bekkers, J. M. & Stevens, C. F. Presynaptic mechanism for long-term potentiation in the hippocampus. Nature 346, 724-729 (1990). Published a month after reference 29, this paper yielded similar findings.
  • 31
    • 0021012427 scopus 로고
    • Long-term potentiation in the hippocampus
    • Voronin, L. L. Long-term potentiation in the hippocampus. Neuroscience 10, 1051-1069 (1983).
    • (1983) Neuroscience , vol.10 , pp. 1051-1069
    • Voronin, L.L.1
  • 32
    • 0029133704 scopus 로고
    • Regulation of hippocampal transmitter release during development and long-term potentiation
    • Bolshakov, V. Y. & Siegelbaum, S. A. Regulation of hippocampal transmitter release during development and long-term potentiation. Science 269, 1730-1734 (1995).
    • (1995) Science , vol.269 , pp. 1730-1734
    • Bolshakov, V.Y.1    Siegelbaum, S.A.2
  • 33
    • 0028020340 scopus 로고
    • Changes in reliability of synaptic function as a mechanism for plasticity
    • Stevens, C. F. & Wang, Y. Changes in reliability of synaptic function as a mechanism for plasticity. Nature 371, 704-707 (1994).
    • (1994) Nature , vol.371 , pp. 704-707
    • Stevens, C.F.1    Wang, Y.2
  • 34
    • 0026505029 scopus 로고
    • Long-term potentiation is associated with increases in quantal content and quantal amplitude
    • Kullmann, D. M. & Nicoll, R. A. Long-term potentiation is associated with increases in quantal content and quantal amplitude. Nature 357, 240-244 (1992).
    • (1992) Nature , vol.357 , pp. 240-244
    • Kullmann, D.M.1    Nicoll, R.A.2
  • 35
    • 0027051487 scopus 로고
    • Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus
    • Liao, D., Jones, A. & Malinow, R. Direct measurement of quantal changes underlying long-term potentiation in CA1 hippocampus. Neuron 9, 1089-1097 (1992).
    • (1992) Neuron , vol.9 , pp. 1089-1097
    • Liao, D.1    Jones, A.2    Malinow, R.3
  • 36
    • 0026481883 scopus 로고
    • Presynaptic release probability influences the locus of long-term potentiation
    • Larkman, A., Hannay, T., Stratford, K. & Jack, J. Presynaptic release probability influences the locus of long-term potentiation. Nature 360, 70-73 (1992).
    • (1992) Nature , vol.360 , pp. 70-73
    • Larkman, A.1    Hannay, T.2    Stratford, K.3    Jack, J.4
  • 37
    • 0030042713 scopus 로고    scopus 로고
    • Changes in quantal parameters of EPSCs in rat CA1 neurones in vitro after the induction of long-term potentiation
    • Stricker, C., Field, A. C. & Redman, S. J. Changes in quantal parameters of EPSCs in rat CA1 neurones in vitro after the induction of long-term potentiation. J. Physiol. 490, 443-454 (1996).
    • (1996) J. Physiol , vol.490 , pp. 443-454
    • Stricker, C.1    Field, A.C.2    Redman, S.J.3
  • 38
    • 0025087071 scopus 로고
    • Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: A patch-clamp study
    • Edwards, F. A., Konnerth, A. & Sakmann, B. Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch-clamp study. J. Physiol. 430, 213-249 (1990).
    • (1990) J. Physiol , vol.430 , pp. 213-249
    • Edwards, F.A.1    Konnerth, A.2    Sakmann, B.3
  • 39
    • 0026433034 scopus 로고
    • LTP is a long term problem
    • Edwards, F. LTP is a long term problem. Nature 350, 271-272 (1991).
    • (1991) Nature , vol.350 , pp. 271-272
    • Edwards, F.1
  • 40
    • 0025906456 scopus 로고
    • Quantal analysis of excitatory synaptic action and depression in hippocampal slices
    • Larkman, A., Stratford, K. & Jack, J. Quantal analysis of excitatory synaptic action and depression in hippocampal slices. Nature 350, 344-347 (1991).
    • (1991) Nature , vol.350 , pp. 344-347
    • Larkman, A.1    Stratford, K.2    Jack, J.3
  • 41
    • 0025787726 scopus 로고
    • Applicability of the coefficient of variation method for analyzing synaptic plasticity
    • Faber, D. S. & Korn, H. Applicability of the coefficient of variation method for analyzing synaptic plasticity. Biophys. J. 60, 1288-1294 (1991).
    • (1991) Biophys. J , vol.60 , pp. 1288-1294
    • Faber, D.S.1    Korn, H.2
  • 42
    • 0033083208 scopus 로고    scopus 로고
    • Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices
    • Liu, G., Choi, S. & Tsien, R. W. Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron 22, 395-409 (1999).
    • (1999) Neuron , vol.22 , pp. 395-409
    • Liu, G.1    Choi, S.2    Tsien, R.W.3
  • 43
    • 0033551327 scopus 로고    scopus 로고
    • Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated
    • Mainen, Z. F., Malinow, R. & Svoboda, K. Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 399, 151-155 (1999).
    • (1999) Nature , vol.399 , pp. 151-155
    • Mainen, Z.F.1    Malinow, R.2    Svoboda, K.3
  • 44
    • 0242385305 scopus 로고    scopus 로고
    • Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: Implication of glutamate spillover and receptor saturation
    • Pankratov, Y. V. & Krishtal, O. A. Distinct quantal features of AMPA and NMDA synaptic currents in hippocampal neurons: implication of glutamate spillover and receptor saturation. Biophys. J. 85, 3375-3387 (2003).
    • (2003) Biophys. J , vol.85 , pp. 3375-3387
    • Pankratov, Y.V.1    Krishtal, O.A.2
  • 45
    • 0025765806 scopus 로고
    • Transmission between pairs of hippocampal slice neurons: Quantal levels, oscillations, and LTP
    • Malinow, R. Transmission between pairs of hippocampal slice neurons: quantal levels, oscillations, and LTP. Science 252, 722-724 (1991).
    • (1991) Science , vol.252 , pp. 722-724
    • Malinow, R.1
  • 46
    • 0027368451 scopus 로고
    • Modulation of synaptic transmission and long-term potentiation: Effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus
    • Manabe, T., Wyllie, D. J., Perkel, D. J. & Nicoll, R. A. Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. J. Neurophysiol. 70, 1451-1459 (1993).
    • (1993) J. Neurophysiol , vol.70 , pp. 1451-1459
    • Manabe, T.1    Wyllie, D.J.2    Perkel, D.J.3    Nicoll, R.A.4
  • 47
    • 0030248099 scopus 로고    scopus 로고
    • LTP of AMPA and NMDA receptor-mediated signals: Evidence for presynaptic expression and extrasynaptic glutamate spill-over
    • Kullmann, D. M., Erdemli, G. & Asztély, F. LTP of AMPA and NMDA receptor-mediated signals: evidence for presynaptic expression and extrasynaptic glutamate spill-over. Neuron 17, 461-474 (1996).
    • (1996) Neuron , vol.17 , pp. 461-474
    • Kullmann, D.M.1    Erdemli, G.2    Asztély, F.3
  • 48
    • 0027988316 scopus 로고
    • Long-term potentiation. A question of reliability
    • Collingridge, G. L. Long-term potentiation. A question of reliability. Nature 371, 652-653 (1994).
    • (1994) Nature , vol.371 , pp. 652-653
    • Collingridge, G.L.1
  • 49
    • 0027511788 scopus 로고
    • Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity
    • Lisman, J. E. & Harris, K. M. Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity. Trends Neurosci. 16, 141-147 (1993).
    • (1993) Trends Neurosci , vol.16 , pp. 141-147
    • Lisman, J.E.1    Harris, K.M.2
  • 50
    • 0030575870 scopus 로고    scopus 로고
    • Maturation of a central glutamatergic synapse
    • Wu, G., Malinow, R. & Cline, H. T. Maturation of a central glutamatergic synapse. Science 274, 972-976 (1996).
    • (1996) Science , vol.274 , pp. 972-976
    • Wu, G.1    Malinow, R.2    Cline, H.T.3
  • 51
    • 0028880861 scopus 로고
    • Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism
    • Lledo, P. M. et al. Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc. Natl Acad. Sci. USA 92, 11175-11179 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11175-11179
    • Lledo, P.M.1
  • 52
    • 0031919845 scopus 로고    scopus 로고
    • Development of excitatory circuitry in the hippocampus
    • Hsia, A. Y., Malenka, R. C. & Nicoll, R. A. Development of excitatory circuitry in the hippocampus. J. Neurophysiol. 79, 2013-2024 (1998).
    • (1998) J. Neurophysiol , vol.79 , pp. 2013-2024
    • Hsia, A.Y.1    Malenka, R.C.2    Nicoll, R.A.3
  • 53
    • 0029859597 scopus 로고    scopus 로고
    • Deficiency in induction but not expression of LTP in hippocampal slices from young rats
    • Liao, D. & Malinow, R. Deficiency in induction but not expression of LTP in hippocampal slices from young rats. Learn. Mem. 3, 138-149 (1996).
    • (1996) Learn. Mem , vol.3 , pp. 138-149
    • Liao, D.1    Malinow, R.2
  • 54
    • 0029921194 scopus 로고    scopus 로고
    • Durand, G. M., Kovalchuk, Y. & Konnerth, A. Longterm potentiation and functional synapse induction in developing hippocampus. Nature 381, 71-75 (1996). Another early demonstration of silent CA1 synapses (see also references 2 and 3), this paper was the first to provide an explicit analysis of the developmental time course of their expression.
    • Durand, G. M., Kovalchuk, Y. & Konnerth, A. Longterm potentiation and functional synapse induction in developing hippocampus. Nature 381, 71-75 (1996). Another early demonstration of silent CA1 synapses (see also references 2 and 3), this paper was the first to provide an explicit analysis of the developmental time course of their expression.
  • 55
    • 0842327834 scopus 로고    scopus 로고
    • Silent synapses in the immature visual cortex: Layer-specific developmental regulation
    • Rumpel, S., Kattenstroth, G. & Gottmann, K. Silent synapses in the immature visual cortex: layer-specific developmental regulation. J. Neurophysiol. 91, 1097-1101 (2004).
    • (2004) J. Neurophysiol , vol.91 , pp. 1097-1101
    • Rumpel, S.1    Kattenstroth, G.2    Gottmann, K.3
  • 57
    • 39149093971 scopus 로고    scopus 로고
    • Regulation of AMPA receptor recruitment at developing synapses
    • Hall, B. J. & Ghosh, A. Regulation of AMPA receptor recruitment at developing synapses. Trends Neurosci. 31, 82-89 (2008).
    • (2008) Trends Neurosci , vol.31 , pp. 82-89
    • Hall, B.J.1    Ghosh, A.2
  • 58
    • 37149027010 scopus 로고    scopus 로고
    • Hall, B. J., Ripley, B. & Ghosh, A. NR2B signaling regulates the development of synaptic AMPA receptor current. J. Neurosci. 27, 13446-13456 (2007).
    • Hall, B. J., Ripley, B. & Ghosh, A. NR2B signaling regulates the development of synaptic AMPA receptor current. J. Neurosci. 27, 13446-13456 (2007).
  • 59
    • 0035707110 scopus 로고    scopus 로고
    • NMDA receptor activation limits the number of synaptic connections during hippocampal development
    • Luthi, A., Schwyzer, L., Mateos, J. M., Gahwiler, B. H. & McKinney, R. A. NMDA receptor activation limits the number of synaptic connections during hippocampal development. Nature Neurosci. 4, 1102-1107 (2001).
    • (2001) Nature Neurosci , vol.4 , pp. 1102-1107
    • Luthi, A.1    Schwyzer, L.2    Mateos, J.M.3    Gahwiler, B.H.4    McKinney, R.A.5
  • 60
    • 1442348909 scopus 로고    scopus 로고
    • Creation of AMPA-silent synapses in the neonatal hippocampus
    • Xiao, M. Y., Wasling, P., Hanse, E. & Gustafsson, B. Creation of AMPA-silent synapses in the neonatal hippocampus. Nature Neurosci. 7, 236-243 (2004).
    • (2004) Nature Neurosci , vol.7 , pp. 236-243
    • Xiao, M.Y.1    Wasling, P.2    Hanse, E.3    Gustafsson, B.4
  • 61
    • 36248968160 scopus 로고    scopus 로고
    • Reversible synaptic depression in developing rat CA3-CA1 synapses explained by a novel cycle of AMPA silencing-unsilencing
    • Abrahamsson, T., Gustafsson, B. & Hanse, E. Reversible synaptic depression in developing rat CA3-CA1 synapses explained by a novel cycle of AMPA silencing-unsilencing. J. Neurophysiol. 98, 2604-2611 (2007).
    • (2007) J. Neurophysiol , vol.98 , pp. 2604-2611
    • Abrahamsson, T.1    Gustafsson, B.2    Hanse, E.3
  • 62
    • 0037186140 scopus 로고    scopus 로고
    • State-dependent heterogeneity in synaptic depression between pyramidal cell pairs
    • Montgomery, J. M. & Madison, D. V. State-dependent heterogeneity in synaptic depression between pyramidal cell pairs. Neuron 33, 765-777 (2002).
    • (2002) Neuron , vol.33 , pp. 765-777
    • Montgomery, J.M.1    Madison, D.V.2
  • 63
    • 0034662879 scopus 로고    scopus 로고
    • Silent synapses in the developing hippocampus: Lack of functional AMPA receptors or low probability of glutamate release?
    • Gasparini, S., Saviane, C., Voronin, L. L. & Cherubini, E. Silent synapses in the developing hippocampus: lack of functional AMPA receptors or low probability of glutamate release? Proc. Natl Acad. Sci. USA 97, 9741-9746 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 9741-9746
    • Gasparini, S.1    Saviane, C.2    Voronin, L.L.3    Cherubini, E.4
  • 64
    • 0037452670 scopus 로고    scopus 로고
    • Nicotine activates immature "silent" connections in the developing hippocampus
    • Maggi, L., Le Magueresse, C., Changeux, J. P. & Cherubini, E. Nicotine activates immature "silent" connections in the developing hippocampus. Proc. Natl Acad. Sci. USA 100, 2059-2064 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 2059-2064
    • Maggi, L.1    Le Magueresse, C.2    Changeux, J.P.3    Cherubini, E.4
  • 65
    • 0035046162 scopus 로고    scopus 로고
    • Montgomery, J. M., Pavlidis, P. & Madison, D. V. Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation. Neuron 29, 691-701 (2001). By simultaneously patch-clamping both the preand the postsynaptic neurons during recordings of silent synapses, these authors achieved a level of experimental control superior to contemporary methods of minimal extracellular stimulation and refuted many of the arguments for a presynaptic mechanism for synaptic silence.
    • Montgomery, J. M., Pavlidis, P. & Madison, D. V. Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation. Neuron 29, 691-701 (2001). By simultaneously patch-clamping both the preand the postsynaptic neurons during recordings of silent synapses, these authors achieved a level of experimental control superior to contemporary methods of minimal extracellular stimulation and refuted many of the arguments for a presynaptic mechanism for synaptic silence.
  • 66
    • 0037830240 scopus 로고    scopus 로고
    • Extrasynaptic glutamate spillover in the hippocampus: Evidence and implications
    • Kullmann, D. M. & Asztely, F. Extrasynaptic glutamate spillover in the hippocampus: evidence and implications. Trends Neurosci. 21, 8-14 (1998).
    • (1998) Trends Neurosci , vol.21 , pp. 8-14
    • Kullmann, D.M.1    Asztely, F.2
  • 67
    • 0029151067 scopus 로고
    • Independent mechanisms for long-term depression of AMPA and NMDA responses
    • Selig, D. K., Hjelmstad, G. O., Herron, C., Nicoll, R. A. & Malenka, R. C. Independent mechanisms for long-term depression of AMPA and NMDA responses. Neuron 15, 417-426 (1995).
    • (1995) Neuron , vol.15 , pp. 417-426
    • Selig, D.K.1    Hjelmstad, G.O.2    Herron, C.3    Nicoll, R.A.4    Malenka, R.C.5
  • 68
    • 0028072394 scopus 로고
    • Long-term potentiation: Evidence against an increase in transmitter release probability in the CA1 region of the hippocampus
    • Manabe, T. & Nicoll, R. A. Long-term potentiation: evidence against an increase in transmitter release probability in the CA1 region of the hippocampus. Science 265, 1888-1892 (1994).
    • (1994) Science , vol.265 , pp. 1888-1892
    • Manabe, T.1    Nicoll, R.A.2
  • 69
    • 0035503349 scopus 로고    scopus 로고
    • Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells
    • Diamond, J. S. Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells. J. Neurosci. 21, 8328-8338 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 8328-8338
    • Diamond, J.S.1
  • 70
    • 0036209793 scopus 로고    scopus 로고
    • A broad view of glutamate spillover
    • Diamond, J. S. A broad view of glutamate spillover. Nature Neurosci. 5, 291-292 (2002).
    • (2002) Nature Neurosci , vol.5 , pp. 291-292
    • Diamond, J.S.1
  • 71
    • 0036209924 scopus 로고    scopus 로고
    • Cooperation between independent hippocampal synapses is controlled by glutamate uptake
    • Arnth-Jensen, N., Jabaudon, D. & Scanziani, M. Cooperation between independent hippocampal synapses is controlled by glutamate uptake. Nature Neurosci. 5, 325-331 (2002).
    • (2002) Nature Neurosci , vol.5 , pp. 325-331
    • Arnth-Jensen, N.1    Jabaudon, D.2    Scanziani, M.3
  • 72
    • 0032945450 scopus 로고    scopus 로고
    • Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus
    • Lozovaya, N. A., Kopanitsa, M. V., Boychuk, Y. A. & Krishtal, O. A. Enhancement of glutamate release uncovers spillover-mediated transmission by N-methyl-D-aspartate receptors in the rat hippocampus. Neuroscience 91, 1321-1330 (1999).
    • (1999) Neuroscience , vol.91 , pp. 1321-1330
    • Lozovaya, N.A.1    Kopanitsa, M.V.2    Boychuk, Y.A.3    Krishtal, O.A.4
  • 73
    • 0032143280 scopus 로고    scopus 로고
    • Diamond, J. S., Bergles, D. E. & Jahr, C. E. Glutamate release monitored with astrocyte transporter currents during LTP. Neuron 21, 425-433 (1998). This paper, together with reference 74 (published back-to-back in the same issue), established that the magnitude of a glutamate-transporter current in CA1 astrocytes is a reliable surrogate for synaptic glutamate concentration, and that this concentration does not change after LTP.
    • Diamond, J. S., Bergles, D. E. & Jahr, C. E. Glutamate release monitored with astrocyte transporter currents during LTP. Neuron 21, 425-433 (1998). This paper, together with reference 74 (published back-to-back in the same issue), established that the magnitude of a glutamate-transporter current in CA1 astrocytes is a reliable surrogate for synaptic glutamate concentration, and that this concentration does not change after LTP.
  • 74
    • 0032142896 scopus 로고    scopus 로고
    • Monitoring glutamate release during LTP with glial transporter currents
    • Lüscher, C., Malenka, R. C. & Nicoll, R. A. Monitoring glutamate release during LTP with glial transporter currents. Neuron 21, 435-441 (1998).
    • (1998) Neuron , vol.21 , pp. 435-441
    • Lüscher, C.1    Malenka, R.C.2    Nicoll, R.A.3
  • 75
    • 0035102504 scopus 로고    scopus 로고
    • A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation
    • Renger, J. J., Egles, C. & Liu, G. A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation. Neuron 29, 469-484 (2001).
    • (2001) Neuron , vol.29 , pp. 469-484
    • Renger, J.J.1    Egles, C.2    Liu, G.3
  • 76
    • 0030582674 scopus 로고    scopus 로고
    • Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons
    • Arancio, O. et al. Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell 87, 1025-1035 (1996).
    • (1996) Cell , vol.87 , pp. 1025-1035
    • Arancio, O.1
  • 77
    • 0026326187 scopus 로고
    • A requirement for the intercellular messenger nitric oxide in long-term potentiation
    • Schuman, E. M. & Madison, D. V. A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 254, 1503-1506 (1991).
    • (1991) Science , vol.254 , pp. 1503-1506
    • Schuman, E.M.1    Madison, D.V.2
  • 78
    • 0030582764 scopus 로고    scopus 로고
    • Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase
    • Son, H. et al. Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase. Cell 87, 1015-1023 (1996).
    • (1996) Cell , vol.87 , pp. 1015-1023
    • Son, H.1
  • 79
    • 0027931569 scopus 로고
    • Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor
    • Cummings, J. A., Nicola, S. M. & Malenka, R. C. Induction in the rat hippocampus of long-term potentiation (LTP) and long-term depression (LTD) in the presence of a nitric oxide synthase inhibitor. Neurosci. Lett. 176, 110-114 (1994).
    • (1994) Neurosci. Lett , vol.176 , pp. 110-114
    • Cummings, J.A.1    Nicola, S.M.2    Malenka, R.C.3
  • 80
    • 0029788599 scopus 로고    scopus 로고
    • Examination of the role of cGMP in long-term potentiation in the CA1 region of the hippocampus
    • Selig, D. K. et al. Examination of the role of cGMP in long-term potentiation in the CA1 region of the hippocampus. Learn. Mem. 3, 42-48 (1996).
    • (1996) Learn. Mem , vol.3 , pp. 42-48
    • Selig, D.K.1
  • 81
    • 36049035307 scopus 로고    scopus 로고
    • A GluR1-cGKII interaction regulates AMPA receptor trafficking
    • Serulle, Y. et al. A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron 56, 670-688 (2007).
    • (2007) Neuron , vol.56 , pp. 670-688
    • Serulle, Y.1
  • 82
    • 27644593831 scopus 로고    scopus 로고
    • Synaptic plasticity at hippocampal mossy fibre synapses
    • Nicoll, R. A. & Schmitz, D. Synaptic plasticity at hippocampal mossy fibre synapses. Nature Rev. Neurosci. 6, 863-876 (2005).
    • (2005) Nature Rev. Neurosci , vol.6 , pp. 863-876
    • Nicoll, R.A.1    Schmitz, D.2
  • 83
    • 0025352966 scopus 로고
    • Comparison of two forms of long-term potentiation in single hippocampal neurons
    • Zalutsky, R. A. & Nicoll, R. A. Comparison of two forms of long-term potentiation in single hippocampal neurons. Science 248, 1619-1624 (1990).
    • (1990) Science , vol.248 , pp. 1619-1624
    • Zalutsky, R.A.1    Nicoll, R.A.2
  • 84
    • 0030175898 scopus 로고    scopus 로고
    • Long-term potentiation in cultures of single hippocampal granule cells: A presynaptic form of plasticity
    • Tong, G., Malenka, R. C. & Nicoll, R. A. Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity. Neuron 16, 1147-1157 (1996).
    • (1996) Neuron , vol.16 , pp. 1147-1157
    • Tong, G.1    Malenka, R.C.2    Nicoll, R.A.3
  • 85
    • 2642677679 scopus 로고    scopus 로고
    • Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures
    • Debanne, D., Gahwiler, B. H. & Thompson, S. M. Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures. J. Physiol. 507, 237-247 (1998).
    • (1998) J. Physiol , vol.507 , pp. 237-247
    • Debanne, D.1    Gahwiler, B.H.2    Thompson, S.M.3
  • 86
    • 0032408313 scopus 로고    scopus 로고
    • Postsynaptically silent synapses in single neuron cultures
    • Gomperts, S. N., Rao, A., Craig, A. M., Malenka, R. C. & Nicoll, R. A. Postsynaptically silent synapses in single neuron cultures. Neuron 21, 1443-1451 (1998).
    • (1998) Neuron , vol.21 , pp. 1443-1451
    • Gomperts, S.N.1    Rao, A.2    Craig, A.M.3    Malenka, R.C.4    Nicoll, R.A.5
  • 87
    • 33751007005 scopus 로고    scopus 로고
    • State-dependent mechanisms of LTP expression revealed by optical quantal analysis
    • Ward, B. et al. State-dependent mechanisms of LTP expression revealed by optical quantal analysis. Neuron 52, 649-661 (2006).
    • (2006) Neuron , vol.52 , pp. 649-661
    • Ward, B.1
  • 88
    • 0034955245 scopus 로고    scopus 로고
    • Visualization of changes in presynaptic function during long-term synaptic plasticity
    • Zakharenko, S. S., Zablow, L. & Siegelbaum, S. A. Visualization of changes in presynaptic function during long-term synaptic plasticity. Nature Neurosci. 4, 711-717 (2001).
    • (2001) Nature Neurosci , vol.4 , pp. 711-717
    • Zakharenko, S.S.1    Zablow, L.2    Siegelbaum, S.A.3
  • 89
    • 0033360169 scopus 로고    scopus 로고
    • Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
    • Liao, D., Zhang, X., O'Brien, R., Ehlers, M. D. & Huganir, R. L. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nature Neurosci. 2, 37-43 (1999).
    • (1999) Nature Neurosci , vol.2 , pp. 37-43
    • Liao, D.1    Zhang, X.2    O'Brien, R.3    Ehlers, M.D.4    Huganir, R.L.5
  • 90
    • 0030572753 scopus 로고    scopus 로고
    • Localization of the glutamate receptor subunit GluR1 on the surface of living and within cultured hippocampal neurons
    • Richmond, S. A. et al. Localization of the glutamate receptor subunit GluR1 on the surface of living and within cultured hippocampal neurons. Neuroscience 75, 69-82 (1996).
    • (1996) Neuroscience , vol.75 , pp. 69-82
    • Richmond, S.A.1
  • 91
    • 0034332164 scopus 로고    scopus 로고
    • Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons
    • Pickard, L., Noel, J., Henley, J. M., Collingridge, G. L. & Molnar, E. Developmental changes in synaptic AMPA and NMDA receptor distribution and AMPA receptor subunit composition in living hippocampal neurons. J. Neurosci. 20, 7922-7931 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 7922-7931
    • Pickard, L.1    Noel, J.2    Henley, J.M.3    Collingridge, G.L.4    Molnar, E.5
  • 92
    • 0035882289 scopus 로고    scopus 로고
    • Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors
    • Liao, D., Scannevin, R. H. & Huganir, R. Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors. J. Neurosci. 21, 6008-6017 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 6008-6017
    • Liao, D.1    Scannevin, R.H.2    Huganir, R.3
  • 93
    • 0035132869 scopus 로고    scopus 로고
    • Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons
    • Lu, W.-Y. et al. Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29, 243-254 (2001).
    • (2001) Neuron , vol.29 , pp. 243-254
    • Lu, W.-Y.1
  • 94
    • 0034788303 scopus 로고    scopus 로고
    • Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes
    • Pickard, L. et al. Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes. Neuropharmacology 41, 700-713 (2001).
    • (2001) Neuropharmacology , vol.41 , pp. 700-713
    • Pickard, L.1
  • 95
    • 0032167980 scopus 로고    scopus 로고
    • Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
    • Nusser, Z. et al. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21, 545-559 (1998).
    • (1998) Neuron , vol.21 , pp. 545-559
    • Nusser, Z.1
  • 96
    • 0033363480 scopus 로고    scopus 로고
    • Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
    • Petralia, R. S. et al. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nature Neurosci. 2, 31-36 (1999).
    • (1999) Nature Neurosci , vol.2 , pp. 31-36
    • Petralia, R.S.1
  • 97
    • 0034175501 scopus 로고    scopus 로고
    • NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area
    • Racca, C., Stephenson, F. A., Streit, P., Roberts, J. D. B. & Somogyi, P. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. J. Neurosci. 20, 2512-2522 (2000).
    • (2000) J. Neurosci , vol.20 , pp. 2512-2522
    • Racca, C.1    Stephenson, F.A.2    Streit, P.3    Roberts, J.D.B.4    Somogyi, P.5
  • 98
    • 0342375000 scopus 로고    scopus 로고
    • Different modes of expression of AMPA and NMDA receptors in hippocampal synapses
    • Takumi, Y., Ramirez-Leon, V., Laake, P., Rinvik, E. & Ottersen, O. P. Different modes of expression of AMPA and NMDA receptors in hippocampal synapses. Nature Neurosci. 2, 618-624 (1999).
    • (1999) Nature Neurosci , vol.2 , pp. 618-624
    • Takumi, Y.1    Ramirez-Leon, V.2    Laake, P.3    Rinvik, E.4    Ottersen, O.P.5
  • 99
    • 26444501014 scopus 로고    scopus 로고
    • Long-term potentiation of exogenous glutamate responses at single dendritic spines
    • Bagal, A. A., Kao, J. P., Tang, C. M. & Thompson, S. M. Long-term potentiation of exogenous glutamate responses at single dendritic spines. Proc. Natl Acad. Sci. USA 102, 14434-14439 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14434-14439
    • Bagal, A.A.1    Kao, J.P.2    Tang, C.M.3    Thompson, S.M.4
  • 100
    • 40949110901 scopus 로고    scopus 로고
    • Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons
    • By using glutamate uncaging to trigger uEPSCs and thus to bypass the presynaptic terminal, this paper was the first to demonstrate unequivocally that silent synapses express no functional AMPARs in the postsynaptic membrane
    • Busetto, G., Higley, M. J. & Sabatini, B. L. Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons. J. Physiol. 586, 1519-1527 (2008). By using glutamate uncaging to trigger uEPSCs and thus to bypass the presynaptic terminal, this paper was the first to demonstrate unequivocally that silent synapses express no functional AMPARs in the postsynaptic membrane.
    • (2008) J. Physiol , vol.586 , pp. 1519-1527
    • Busetto, G.1    Higley, M.J.2    Sabatini, B.L.3
  • 101
    • 37549053317 scopus 로고    scopus 로고
    • Locally dynamic synaptic learning rules in pyramidal neuron dendrites
    • Harvey, C. D. & Svoboda, K. Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature 450, 1195-1200 (2007).
    • (2007) Nature , vol.450 , pp. 1195-1200
    • Harvey, C.D.1    Svoboda, K.2
  • 102
    • 0035708355 scopus 로고    scopus 로고
    • Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
    • Matsuzaki, M. et al. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nature Neurosci. 4, 1086-1092 (2001).
    • (2001) Nature Neurosci , vol.4 , pp. 1086-1092
    • Matsuzaki, M.1
  • 103
    • 3042554012 scopus 로고    scopus 로고
    • Structural basis of long-term potentiation in single dendritic spines
    • This paper was the first to induce LTP at single spines through repetitive glutamate uncaging. It demonstrated conclusively that LTP could occur by a purely postsynaptic mechanism
    • Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R. & Kasai, H. Structural basis of long-term potentiation in single dendritic spines. Nature 429, 761-766 (2004). This paper was the first to induce LTP at single spines through repetitive glutamate uncaging. It demonstrated conclusively that LTP could occur by a purely postsynaptic mechanism.
    • (2004) Nature , vol.429 , pp. 761-766
    • Matsuzaki, M.1    Honkura, N.2    Ellis-Davies, G.C.R.3    Kasai, H.4
  • 104
    • 50149095303 scopus 로고    scopus 로고
    • Optical induction of plasticity at single synapses reveals input-specific accumulation of αCaMKII
    • Zhang, Y.-P., Holbro, N. & Oertner, T. G. Optical induction of plasticity at single synapses reveals input-specific accumulation of αCaMKII. Proc. Natl Acad. Sci. USA 105, 12039-12044 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 12039-12044
    • Zhang, Y.-P.1    Holbro, N.2    Oertner, T.G.3
  • 105
    • 0034708587 scopus 로고    scopus 로고
    • Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction
    • Hayashi, Y. et al. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science 287, 2262-2267 (2000).
    • (2000) Science , vol.287 , pp. 2262-2267
    • Hayashi, Y.1
  • 106
    • 0033546052 scopus 로고    scopus 로고
    • Shi, S.-H. et al. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811-1816 (1999). In hippocampal neurons that expressed a recombinant GluR1 AMPAR subunit tagged with GFP, these authors observed rapid delivery of tagged receptors to the postsynaptic membrane from intracellular stores following LTP induction, providing evidence that LTP occurs by trafficking AMPARs to synapses.
    • Shi, S.-H. et al. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284, 1811-1816 (1999). In hippocampal neurons that expressed a recombinant GluR1 AMPAR subunit tagged with GFP, these authors observed rapid delivery of tagged receptors to the postsynaptic membrane from intracellular stores following LTP induction, providing evidence that LTP occurs by trafficking AMPARs to synapses.
  • 107
    • 29144486135 scopus 로고    scopus 로고
    • Photoinactivation of native AMPA receptors reveals their real-time trafficking
    • Adesnik, H., Nicoll, R. A. & England, P. M. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron 48, 977-985 (2005).
    • (2005) Neuron , vol.48 , pp. 977-985
    • Adesnik, H.1    Nicoll, R.A.2    England, P.M.3
  • 108
    • 0021262466 scopus 로고
    • The biochemistry of memory: A new and specific hypothesis
    • Lynch, G. & Baudry, M. The biochemistry of memory: a new and specific hypothesis. Science 224, 1057-1063 (1984).
    • (1984) Science , vol.224 , pp. 1057-1063
    • Lynch, G.1    Baudry, M.2
  • 109
    • 54249116986 scopus 로고    scopus 로고
    • TARP proteins have fundamental roles in the gating of glutamate receptors and the tuning of synaptic function
    • in the press
    • Wang, R. et al. TARP proteins have fundamental roles in the gating of glutamate receptors and the tuning of synaptic function. Neuron (in the press).
    • Neuron
    • Wang, R.1
  • 110
    • 33746096995 scopus 로고    scopus 로고
    • Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins
    • Walker, C. S. et al. Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. Proc. Natl Acad. Sci. USA 103, 10781-10786 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10781-10786
    • Walker, C.S.1
  • 111
    • 33644674232 scopus 로고    scopus 로고
    • Auxiliary subunits assist AMPA-type glutamate receptors
    • Nicoll, R. A., Tomita, S. & Bredt, D. S. Auxiliary subunits assist AMPA-type glutamate receptors. Science 311, 1253-1256 (2006).
    • (2006) Science , vol.311 , pp. 1253-1256
    • Nicoll, R.A.1    Tomita, S.2    Bredt, D.S.3
  • 112
    • 0026571255 scopus 로고
    • Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents
    • Manabe, T., Renner, P. & Nicoll, R. A. Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents. Nature 355, 50-55 (1992).
    • (1992) Nature , vol.355 , pp. 50-55
    • Manabe, T.1    Renner, P.2    Nicoll, R.A.3
  • 113
    • 0029739999 scopus 로고    scopus 로고
    • Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells
    • Isaac, J. T., Hjelmstad, G. O., Nicoll, R. A. & Malenka, R. C. Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells. Proc. Natl Acad. Sci. USA 93, 8710-8715 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 8710-8715
    • Isaac, J.T.1    Hjelmstad, G.O.2    Nicoll, R.A.3    Malenka, R.C.4
  • 114
    • 0029879243 scopus 로고    scopus 로고
    • Bidirectional control of quantal size by synaptic activity in the hippocampus
    • Oliet, S. H., Malenka, R. C. & Nicoll, R. A. Bidirectional control of quantal size by synaptic activity in the hippocampus. Science 271, 1294-1297 (1996).
    • (1996) Science , vol.271 , pp. 1294-1297
    • Oliet, S.H.1    Malenka, R.C.2    Nicoll, R.A.3
  • 115
    • 0032565873 scopus 로고    scopus 로고
    • Modulation of AMPA receptor unitary conductance by synaptic activity
    • Benke, T. A., Luthi, A., Isaac, J. T. R. & Collingridge, G. L. Modulation of AMPA receptor unitary conductance by synaptic activity. Nature 393, 793-797 (1998).
    • (1998) Nature , vol.393 , pp. 793-797
    • Benke, T.A.1    Luthi, A.2    Isaac, J.T.R.3    Collingridge, G.L.4
  • 116
    • 4644370333 scopus 로고    scopus 로고
    • Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurons
    • Andrásfalvy, B. K. & Magee, J. C. Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurons. J. Physiol. 559, 543-554 (2004).
    • (2004) J. Physiol , vol.559 , pp. 543-554
    • Andrásfalvy, B.K.1    Magee, J.C.2
  • 117
    • 0141918783 scopus 로고    scopus 로고
    • AMPA receptor trafficking at excitatory synapses
    • Bredt, D. S. & Nicoll, R. A. AMPA receptor trafficking at excitatory synapses. Neuron 40, 361-379 (2003).
    • (2003) Neuron , vol.40 , pp. 361-379
    • Bredt, D.S.1    Nicoll, R.A.2
  • 118
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow, R. & Malenka, R. C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103-126 (2002).
    • (2002) Annu. Rev. Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 119
    • 0036829584 scopus 로고    scopus 로고
    • Regulation of AMPA receptors during synaptic plasticity
    • Song, I. & Huganir, R. L. Regulation of AMPA receptors during synaptic plasticity. Trends Neurosci. 25, 578-588 (2002).
    • (2002) Trends Neurosci , vol.25 , pp. 578-588
    • Song, I.1    Huganir, R.L.2
  • 120
    • 0037844849 scopus 로고    scopus 로고
    • Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapses
    • Emptage, N. J., Reid, C. A., Fine, A. & Bliss, T. V. P. Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapses. Neuron 38, 797-804 (2003).
    • (2003) Neuron , vol.38 , pp. 797-804
    • Emptage, N.J.1    Reid, C.A.2    Fine, A.3    Bliss, T.V.P.4
  • 121
    • 54249159801 scopus 로고    scopus 로고
    • Ramón y Cajal, S. Histologie du Système Nerveux de l'Homme et des vertébrés (Maloine, Paris, 1909).
    • Ramón y Cajal, S. Histologie du Système Nerveux de l'Homme et des vertébrés (Maloine, Paris, 1909).
  • 122
    • 0031039544 scopus 로고    scopus 로고
    • Silent synapses during development of thalamocortical inputs
    • Isaac, J. T., Crair, M. C., Nicoll, R. A. & Malenka, R. C. Silent synapses during development of thalamocortical inputs. Neuron 18, 269-280 (1997).
    • (1997) Neuron , vol.18 , pp. 269-280
    • Isaac, J.T.1    Crair, M.C.2    Nicoll, R.A.3    Malenka, R.C.4
  • 123
    • 0017624955 scopus 로고
    • An attempt to assess the effects of monocular deprivation and strabismus on synaptic efficiency in the kitten's visual cortex
    • Blakemore, C. & Hillman, P. An attempt to assess the effects of monocular deprivation and strabismus on synaptic efficiency in the kitten's visual cortex. Exp. Brain Res. 30, 187-202 (1977).
    • (1977) Exp. Brain Res , vol.30 , pp. 187-202
    • Blakemore, C.1    Hillman, P.2
  • 124
    • 0032212201 scopus 로고    scopus 로고
    • Silent synapses in the developing rat visual cortex: Evidence for postsynaptic expression of synaptic plasticity
    • Rumpel, S., Hatt, H. & Gottmann, K. Silent synapses in the developing rat visual cortex: evidence for postsynaptic expression of synaptic plasticity. J. Neurosci. 18, 8863-8874 (1998).
    • (1998) J. Neurosci , vol.18 , pp. 8863-8874
    • Rumpel, S.1    Hatt, H.2    Gottmann, K.3
  • 125
    • 38149132453 scopus 로고    scopus 로고
    • Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves
    • Shah, R. D. & Crair, M. C. Retinocollicular synapse maturation and plasticity are regulated by correlated retinal waves. J. Neurosci. 28, 292-303 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 292-303
    • Shah, R.D.1    Crair, M.C.2
  • 126
    • 0036095402 scopus 로고    scopus 로고
    • Silent synapses in developing cerebellar granule neurons
    • Losi, G., prybylowski, K., Fu, Z., Luo, J. H. & Vicini, S. Silent synapses in developing cerebellar granule neurons. J. Neurophysiol. 87, 1263-1270 (2002).
    • (2002) J. Neurophysiol , vol.87 , pp. 1263-1270
    • Losi, G.1    prybylowski, K.2    Fu, Z.3    Luo, J.H.4    Vicini, S.5
  • 127
    • 44649196647 scopus 로고    scopus 로고
    • Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors
    • Balland, B., lachamp, P., Kessler, J.-P. & Tell, F. Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors. J. Neurosci. 28, 4624-4634 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 4624-4634
    • Balland, B.1    lachamp, P.2    Kessler, J.-P.3    Tell, F.4
  • 128
    • 34247899166 scopus 로고    scopus 로고
    • Conversion of functional synapses into silent synapses in the trigeminal brainstem after neonatal peripheral nerve transection
    • Lo, F.-S. & Erzurumlu, R. S. Conversion of functional synapses into silent synapses in the trigeminal brainstem after neonatal peripheral nerve transection. J. Neurosci. 27, 4929-4934 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 4929-4934
    • Lo, F.-S.1    Erzurumlu, R.S.2
  • 129


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.