Comparison of metaraminol, phenylephrine and ephedrine in prophylaxis and treatment of hypotension in cesarean section under spinal anesthesia;Avaliação comparativa entre metaraminol, fenilefrina e efedrina na profilaxia e no tratamento da hipotensão em cesarianas sob raquianestesia

Revista Brasileira de Anestesiologia

Volumn 64, Issue 5, 2014, Pages 299-306

  de Aragão, Fábio Farias ^a,b   de Aragão, Pedro Wanderley ^b   de Souza Martins, Carlos Alberto ^a,b   Salgado Filho, Natalino ^b   de Souza Barcelos Barroqueiro, Elizabeth ^b  

^a Sociedade Brasileira de Anestesiologia   (Brazil)

^b FEDERAL UNIVERSITY OF MARANHÃO   (Brazil)

Author keywords

Anesthesia; Cesarean section; Hypotension; Spinal anesthesia; Vasoconstrictor agents

Indexed keywords

EPHEDRINE; METARAMINOL; PHENYLEPHRINE;

APGAR SCORE; ARTERIAL BLOOD; ARTICLE; BRADYCARDIA; CESAREAN SECTION; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; FETUS OUTCOME; HUMAN; HYPERTENSION; HYPOTENSION; INCIDENCE; MAJOR CLINICAL STUDY; MATERNAL DISEASE; NAUSEA; PREGNANT WOMAN; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; VOMITING;

EID: 84940219873     PISSN: 00347094     EISSN: 1806907X     Source Type: Journal    
DOI: 10.1016/j.bjan.2013.07.014     Document Type: Article

References (41)

1. Macarthur A., Riley E.T. Obstetric anesthesia controversies: vasopressor choice for postspinal hypotension during cesarean delivery. Int Anesthesiol Clin. 2007, 45:115-132.
2. Lee A., Ngan Kee W.D., Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg. 2002, 94:920-926.
3. Cyna AM, Andrew M, Emmett RS, et al. Techniques for preventing hypotension during spinal anaesthesia for caesarean section (Review). Disponível em http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD002251/pdf_fs.html.(acessado em 7/11/2010).
4. Jackson R., Reid J.A., Thorburn J. Volume preloading is not essential to prevent spinal-induced hypotension at cesarean section. Br J Anaesth. 1995, 75:262-265.
5. Cooper D.W. Cesarean delivery vasopressor management. Curr Opin Anesthesiol. 2012, 25:300-308.
6. Ralston D.H., Shnider S.M., Delorimier A.A. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe. Anesthesiology. 1974, 40:354-370.
7. Clyburn P. Spinal anaesthesia for caesarean section: time for re-appraisal?. Anaesthesia. 2005, 60:633-635.
8. Cooper D.W., Carpenter M., Mowbray P., et al. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia form cesarean delivery. Anesthesiology. 2002, 97:1589-1590.
9. Montan S. Increased risk in the elderly parturient. Curr Opin Obstet Gynecol. 2007, 19:110-112.
10. Ezra Y., McParland P., Farine D. High delivery intervention rates in nulliparous women over age 35. Eur J Obstet Gynecol Reprod Biol. 1995, 62:203-207.
11. Vienne C.M., Creveuil C., Dreyfus M. Does young maternal age increase the risk of adverse obstetric, fetal and neonatal outcomes: a cohort study. Eur J Obstet Gynecol Reprod Biol. 2009, 147:151-156.
12. Neves J.F.N.P., Monteiro G.A., Almeida J.R., et al. Utilização da fenilefrina para controle da pressão arterial em cesarianas eletivas: dose terapêutica versus profilática. Rev Bras Anestesiol. 2010, 60:391-398.
13. Cardoso M.S.C., Santos M.M., Yamaguchi E.T., et al. Expansão volêmica em raquianestesia para cesariana: como realizá-la?. Rev Bras Anestesiol. 2004, 54:13-19.
14. Allen T.K., George R.B., White W.D., et al. A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. Anesth Analg. 2010, 111:1221-1229.
15. Ngan Kee W.D., Lau T.K., Khaw K.S. Comparison of metaraminol and ephedrine infusions for maintaining arterial pressure during spinal anesthesia for elective cesarean section. Anesthesiology. 2001, 95:307-313.
16. Saravanan S., Kocarev M., Wilson R.C., et al. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in caesarean section. Br J Anaesth. 2006, 96:95-99.
17. Habbib A.S. A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia. Anesth Analg. 2012, 114:337-390.
18. Magalhães E., Govêia C.S., Ladeira L.C.A., et al. Efedrina versus fenilefrina: prevenção de hipotensão arterial durante anestesia raquídea para cesariana e efeitos sobre o feto. Rev Bras Anestesiol. 2009, 59:11-20.
19. Veeser M., Hofmann T., Roth R., et al. Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis. Acta Anaesthesiol Scand. 2012, 56:810-816.
20. Carvalho J.C.A., Cardoso M.M.S.C., Capelli E.L., et al. Efedrina profilática durante raquianestesia para cesariana: estudo dose-resposta da administração em bólus e em infusão contínua. Rev Bras Anestesiol. 1999, 49:309-314.
21. Bhardwaj N., Kajal J., Arora S., et al. A comparison of three vasopressor for tight control of maternal blood pressure during cesarean section under spinal anesthesia: effect on maternal and fetal outcome. J Anaesthesiol Clin Pharmacol. 2013, 29:26-31.
22. Banerjee M.D., Stocche R.M., Angle P., et al. Preload or coload for spinal anesthesia for elective cesarean delivery: a meta-analysis. Can J Anesth. 2010, 57:24-31.
23. Mercier F.J. Cesarean delivery fluid management. Curr Opin Anesthesiol. 2012, 25:286-291.
24. a ed. M. Siaulys (Ed.).
25. Critchley L.A., Stuart J.C., Conway F., et al. Hypotension during subarachnoid anaesthesia: haemodynamic effects of ephedrine. Br J Anaesth. 1995, 74:373-378.
26. Ngan Kee W.D., Lee A., Khaw K.S., et al. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control. Anesth Analg. 2008, 107:1295-1302.
27. Balki M., Carvalho J.C.A. Intraoperative nausea and vomiting during cesarean section under regional anaesthesia. Int J Obstet Anaesthe. 2005, 14:230-241.
28. Sia A.T.H., Tan H.S., Sng B.L. Closed-loop double-vasopressor automated system to treat hypotension during spinal anaesthesia for caesarean section: a preliminary study. Anaesthesia. 2012, 67:1348-1355.
29. Doherty A., Ohashi Y., Downey K., et al. Phenylephrine infusion versus bolus regimens during cesarean delivery under spinal anesthesia: a double-blind randomized clinical trial to assess hemodynamic changes. Anesth Analg. 2012, 115:1343-1350.
30. Gupta S. Vasopressors and tight control of maternal blood pressure during cesarean delivery: a rocky alliance. J Anaesthesiol Clin Pharmacol. 2013, 29:1-3.
31. Dyer R.A., Reed A.R., Van Dyk D., et al. Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery. Anesthesiology. 2009, 111:753-765.
32. Auler Júnior J.O.C., Torres M.L.A., Cardoso M.M., et al. Clinical evaluation of the flotrac/vigileoTM system for continuous cardiac output monitoring in patients undergoing regional anesthesia for elective cesarean section: a pilot study. Clinics. 2010, 65:793-798.
33. Cooper D.W., Schofield L., Hynd R., et al. Prospective evaluation of systolic arterial pressure control with a phenylephrine infusion regimen during spinal anaesthesia for caesarean section. Int J Obstet Anaesth. 2012, 21:245-252.
34. Malin G.L., Morris R.K., Khan K.S. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ 2014, 340:c1471.
35. Reynolds F., Seed T. Anaesthesia for caesarean section and neonatal acid-base status: a meta-analysis. Anaesthesia. 2005, 60:636-653.
36. Lin F., Qiu M., Ding X., et al. Ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean section: an updated meta-analysis. CNS Neuroscience & Therapeutics. 2012, 18:591-597.
37. Dyer R.A., Biccard B.M. Ephedrine for spinal hypotension during elective caesarean section: the final nail in the coffin?. Acta Anaesthesiol Scand. 2012, 56:807-809.
38. Ngan Kee D.W., Khaw K.S., Tan P.E., et al. Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology. 2009, 111:506-512.
39. Landau R., Liu S., Blouin J., et al. The effect of maternal and fetal (2-adrenoceptor and nitric oxide synthase genotype on vasopressor requirement and fetal acid-base status during spinal anesthesia for cesarean delivery. Anesth Analg. 2011, 112:1432-1437.
40. Ngan Kee D.W., Lee A. Multivariate analysis of factors associated with umbilical arterial pH and standard base excess after caesarean section under spinal anaesthesia. Anaesthesia. 2003, 58:125-130.
41. Maayn-Metzger A., Schuhan-Eisen I., Tordis L., et al. The effect of time intervals on neonatal outcome in elective cesarean delivery at term under regional anaesthesia. Int J Gynecol Obstet. 2010, 111:224-228.