Phenylephrine infusion versus bolus regimens during cesarean delivery under spinal anesthesia: A double-blind randomized clinical trial to assess hemodynamic changes

Anesthesia and Analgesia

Volumn 115, Issue 6, 2012, Pages 1343-1350

  Doherty, Anne ^a   Ohashi, Yayoi ^a   Downey, Kristi ^a   Carvalho, Jose C A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; FENTANYL; MORPHINE; PHENYLEPHRINE; RINGER LACTATE SOLUTION;

ADULT; ANESTHESIA INDUCTION; APGAR SCORE; ARTICLE; BIOREACTOR DESIGN; BLOOD GAS; BLOOD PRESSURE MEASUREMENT; BRADYCARDIA; CESAREAN SECTION; CLINICAL ASSESSMENT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG INFUSION; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HEART OUTPUT; HEART OUTPUT MEASUREMENT; HEART RATE; HEMODYNAMICS; HUMAN; HYPERTENSION; HYPOTENSION; MAJOR CLINICAL STUDY; MATERNAL BLOOD; NAUSEA; NON INVASIVE PROCEDURE; OUTCOME ASSESSMENT; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; SYSTOLIC BLOOD PRESSURE; UMBILICAL CORD BLOOD FLOW; VOMITING;

ADULT; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; BLOOD PRESSURE; CARDIAC OUTPUT; CESAREAN SECTION; DATA INTERPRETATION, STATISTICAL; DOUBLE-BLIND METHOD; FEMALE; HEART RATE; HEMODYNAMICS; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; NERVE BLOCK; PHENYLEPHRINE; PREGNANCY; STROKE VOLUME; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 84870244609     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31826ac3db     Document Type: Article

References (26)

1. Clark RB, Thompson DS, Thompson CH. Prevention of spinal hypotension associated with cesarean section. Anesthesiology 1976;45:670-4
2. Macarthur A, Riley ET. Obstetric anesthesia controversies: vasopressor choice for postspinal hypotension during cesarean delivery. Int Anesthesiol Clin 2007;45:115-32
3. Ngan Kee WD, Khaw KS, Ng FF. Prevention of hypotension during spinal anesthesia for cesarean delivery: an effective technique using combination phenylephrine infusion and crystalloid cohydration. Anesthesiology 2005;103:744-50
4. Roofthooft E, Van d, V. Low-dose spinal anaesthesia for caesarean section to prevent spinal-induced hypotension. Curr Opin Anaesthesiol 2008;21:259-62
5. Thomas DG, Robson SC, Redfern N, Hughes D, Boys RJ. Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for caesarean section. Br J Anaesth 1996;76:61-5
6. Cyna AM, Andrew M, Emmett RS, Middleton P, Simmons SW. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev 2006;CD002251
7. Dyer RA, Reed AR, van Dyk D, Arcache MJ, Hodges O, Lombard CJ, Greenwood J, James MF. Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery. Anesthesiology 2009;111:753-65
8. Stewart A, Fernando R, McDonald S, Hignett R, Jones T, Columb M. The dose-dependent effects of phenylephrine for elective cesarean delivery under spinal anesthesia. Anesth Analg 2010;111:1230-7
9. Doherty A, Ohashi Y, Downey K, Carvalho JC. Non-invasive monitoring based on bioreactance reveals significant hemodynamic instability during elective cesarean delivery under spinal anesthesia. Rev Bras Anestesiol 2011;61:320-5
10. Lee A, Ngan Kee WD, Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 2002;94:920-6
11. Wang SC, Borison HL. An analysis of the carotid sinus cardiovascular reflex mechanism. Am J Physiol 1947;150:712-21
12. Ferguson DW, Abboud FM, Mark AL. Relative contribution of aortic and carotid baroreflexes to heart rate control in man during steady state and dynamic increases in arterial pressure. J Clin Invest 1985;76:2265-74
13. Sullebarger JT, Liang CS, Woolf PD, Willick AE, Richeson JF. Comparison of phenylephrine bolus and infusion methods in baroreflex measurements. J Appl Physiol 1990;69:962-7
14. Tabachnick BG, Fidell LS. Using Multivariate Statistics. 5th ed. Boston: Allyn and Bacon, 2007
15. Ueland K, Gills RE, Hansen JM. Maternal cardiovascular dynamics: I. Cesarean section under subarachnoid block anesthesia Am J Obstet Gynecol 1968;100:42-54
16. Dyer RA, Reed AR. Spinal hypotension during elective cesarean delivery: closer to a solution. Anesth Analg 2010;111:1093-5
17. Von Anrep G. On the part played by the supra renals in the normal vascular reactions of the body. J Physiol 1912;45:307-7
18. Allen TK, George RB, White WD, Muir HA, Habib AS. A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. Anesth Analg 2010;111:1221-9
19. Langesaeter E, Rosseland LA, Stubhaug A. Continuous invasive blood pressure and cardiac output monitoring during cesarean delivery: a randomized, double-blind comparison of low-dose versus high-dose spinal anesthesia with intravenous phenylephrine or placebo infusion. Anesthesiology 2008;109:856-63
20. Tanaka M, Balki M, Parkes RK, Carvalho JC. ED95 of phenylephrine to prevent spinal-induced hypotension and/or nausea at elective cesarean delivery. Int J Obstet Anesth 2009;18:125-30
21. Ngan Kee WD, Khaw KS, Ng FF. Comparison of phenylephrine infusion regimens for maintaining maternal blood pressure during spinal anaesthesia for caesarean section. Br J Anaesth 2004;92:469-74
22. Petersson M. Cardiovascular effects of oxytocin. Prog Brain Res 2002;139:281-8
23. Keren H, Burkhoff D, Squara P. Evaluation of a noninvasive continuous cardiac output monitoring system based on thoracic bioreactance. Am J Physiol Heart Circ Physiol 2007;293:H583-9
24. Squara P, Denjean D, Estagnasie P, Brusset A, Dib JC, Dubois C. Noninvasive cardiac output monitoring (NICOM): a clinical validation. Intensive Care Med 2007;33:1191-4
25. Squara P, Rotcajg D, Denjean D, Estagnasie P, Brusset A. Comparison of monitoring performance of bioreactance vs. pulse contour during lung recruitment maneuvers. Crit Care 2009;13:R125
26. Ohashi Y, Ibrahim H, Furtado L, Kingdom J, Carvalho JCA. Non-invasive hemodynamic assessment of non-pregnant, healthy pregnant and preeclamptic women using bio-reactance. Rev Bras Anestesiol 2010;60:603-13