Vasopressors for the management of hypotension after spinal anesthesia for elective caesarean section. Systematic review and cumulative meta-analysis

Acta Anaesthesiologica Scandinavica

Volumn 56, Issue 7, 2012, Pages 810-816

  Veeser, M ^a   Hofmann, T ^a   Roth, R ^a   Klohr S ^a   Rossaint, R ^b   Heesen, M ^a  

^a Abteilung Angiologie Phlebologie   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPHEDRINE; PHENYLEPHRINE;

ACIDOSIS; ALKALOSIS; APGAR SCORE; ARTERIAL CARBON DIOXIDE TENSION; BRADYCARDIA; CESAREAN SECTION; CONFIDENCE INTERVAL; DATA EXTRACTION; DOUBLE BLIND PROCEDURE; EMBASE; FEMALE; FETUS; FETUS DISEASE; HUMAN; HYPOTENSION; INFORMATION RETRIEVAL; MATERNAL HYPERTENSION; MEDLINE; META ANALYSIS; NEWBORN; PH; PREGNANCY OUTCOME; PRIORITY JOURNAL; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGIONAL ANESTHESIA; REVIEW; RISK; SPINAL ANESTHESIA; SYSTEMATIC REVIEW; UMBILICAL ARTERY;

ACIDOSIS; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ANESTHETICS, LOCAL; BRADYCARDIA; CESAREAN SECTION; CLINICAL TRIALS AS TOPIC; DOUBLE-BLIND METHOD; EPHEDRINE; FEMALE; FETAL DISEASES; HEMODYNAMICS; HUMANS; HYPERTENSION; HYPOTENSION; INFANT, NEWBORN; MULTICENTER STUDIES AS TOPIC; PHENYLEPHRINE; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; SURGICAL PROCEDURES, ELECTIVE; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 84863698609     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2011.02646.x     Document Type: Review

References (35)

1. James FM 3rd, Greiss FC Jr, Kemp RA,. Continuous invasive blood pressure and cardiac output monitoring during cesarean delivery: a randomized, double-blind comparison of low-dose versus high-dose spinal anesthesia with intravenous phenylephrine or placebo infusion. Anesthesiology 1970; 33: 25-34.
2. Ralston DH, Shnider SM, DeLorimier AA,. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe. Anesthesiology 1974; 40: 354-370.
3. Langeseter E, Rosseland LA, Stubhaug A,. Continuous invasive blood pressure and cardiac output monitoring during cesarean delivery: a randomized, double-blind comparison of low-dose versus high-dose spinal anesthesia with intravenous phenylephrine or placebo infusion. Anesthesiology 2008; 109: 856-863.
4. Dyer RA, Reed AR, Van Dyk D, Arcache MJ, Hodges O, Lombard CJ, Greenwood J, James MF,. Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery. Anesthesiology 2009; 111: 753-765.
5. Ngan Kee WD, Khaw KS, Tan PE, Ng FF, Karmakar MK,. Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2009; 111: 506-512.
6. Ngan Kee WD,. Prevention of maternal hypotension after regional anaesthesia for caesarean section. Curr Opin Anaesthesiol 2010; 23: 304-309.
7. BDAktuell/DGAInfo. Durchführung von Analgesie- und Anästhesieverfahren in der Geburtshilfe. Anästh Intensivmed 2009; 50: 502-507.
8. Lee A, Ngan Kee WD, Gin T,. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 2002; 94: 920-926. (Pubitemid 34263741)
9. Saravanan S, Kocarev M, Wilson RC, Watkins E, Columb MO, Lyons G,. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in caesarean section. Br J Anaesth 2006; 96: 95-99. (Pubitemid 43124538)
10. Ngan Kee WD, Khaw KS, Lau TK, Ng FF, Chui K, Ng KL,. Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective caesarean section. Anaesthesia 2008; 63: 1319-1326.
11. Bender JS, Halpern SH, Thangaroopan M, Jadad AR, Ohlsson A,. Quality and retrieval of obstetrical anaesthesia randomized controlled trials. Can J Anaesth 1997; 44: 14-18. (Pubitemid 27158003)
12. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ,. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1-12. (Pubitemid 26120810)
13. Hall PA, Bennett A, Wilkes MP, Lewis M,. Spinal anaesthesia for caesarean section: comparison of infusions of phenylephrine and ephedrine. Br J Anaesth 1994; 73: 471-474. (Pubitemid 24307336)
14. Ayorinde BT, Buczkowski P, Brown J, Shah J, Buggy DJ,. Evaluation of pre-emptive intramuscular phenylephrine and ephedrine for reduction of spinal anaesthesia-induced hypotension during caesarean section. Br J Anaesth 2001; 86: 372-376. (Pubitemid 32219950)
15. Moran DH, Perillo M, LaPorta RF, Bader AM, Datta S,. Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. J Clin Anesth 1991; 3: 301-305.
16. Thomas DG, Robson SC, Redfern N, Hughes D, Boys RJ,. Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for caesarean section. Br J Anaesth 1996; 76: 61-65. (Pubitemid 26030218)
17. Alahuhta S, Räsänen J, Jouppila R, Hollmén AI,. Ephedrine and phenylephrine for avoiding maternal hypotension due to spinal anaesthesia for caesarean section. Int J Obstet Anesth 1992; 1: 129-134.
18. Magalhaes E, Govêia CS, De Araújo Ladeira LC, Nascimento BG, Cavalcante Kluthcouski SM,. Ephedrine versus phenylephrine: prevention of hypotension during spinal block for cesarean section and effects on the fetus. Rev Bras Anestesiol 2009; 59: 11-20.
19. Ngan Kee WD, Lee A, Khaw KS, Ng FF, Karmakar MK, Gin T,. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: the effects on fetal acid-base status and hemodynamic control. Anesth Analg 2008; 107: 1295-1302.
20. Adigun TA, Amanor-Boadu SD, Soyannwo OA,. Comparison of intravenous ephedrine with phenylephrine for the maintenance of arterial blood pressure during elective caesarean section under spinal anaesthesia. Afr J Med Med Sci 2010; 39: 13-20.
21. Loughrey JPR, Yao N, Datta S, Segal S, Pian-Smith M, Tsen LC,. Hemodynamic effects of spinal anesthesia and simultaneous intraveneous bolus of combined phenylephrine and ephedrine versus ephedrine for cesarean delivery. Int J Obstet Anesth 2005; 14: 43-47. (Pubitemid 41201406)
22. Cooper DW, Carpenter M, Mowbray P, Desira WR, Ryall DM, Kokri MS,. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2002; 97: 1582-1590. (Pubitemid 35417460)
23. Guillon A, Leyre S, Remérand F, Taihlan B, Perrotin F, Fusciardi J, Laffon M,. Modification of Tp-e and QTc intervals during caesarean section under spinal anaesthesia. Anaesthesia 2010; 65: 337-342.
24. Prakash S, Pramanik V, Chellani H, Salhan S, Gogia AR,. Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine during spinal anaesthesia for caesarean delivery: a randomised study. Int J Obstet Anesth 2010; 19: 24-30.
25. Mercier FJ, Riley ET, Frederickson WL, Roger-Christoph S, Benhamou D, Cohen SE,. Phenylephrine added to prophylactic ephedrine infusion during spinal anesthesia for elective cesarean section. Anesthesiology 2001; 95: 668-674.
26. Hennebry MC, Stocks GM, Belavadi P, Wray S, Columb MO, Lyons G,. Effect of i.v. phenylephrine or ephedrine on the ED50 of intrathecal bupivacaine with fentanyl for caesarean section. Br J Anaesth 2009; 102: 806-811.
27. LaPorta RF, Arthur GR, Datta S,. Phenylephrine in treating maternal hypotension due to spinal anaesthesia for caesarean delivery: effects on neonatal catecholamine concentrations, acid base status and Apgar scores. Acta Anaesthesiol Scand 1995; 39: 901-905.
28. Pierce ET, Carr DB, Datta S,. Effects of ephedrine and phenylephrine on maternal and fetal atrial natriuretic peptide levels during elective cesarean section. Acta Anaesthesiol Scand 1994; 38: 48-51. (Pubitemid 24035581)
29. Malin GL, Morris RK, Khan KS,. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ 2010; 340: c1471.
30. Ngan Kee W, Khaw K, Ng K, Chui K, Lau T,. Randomized double-blinded comparison of phenylephrine versus ephedrine for treating hypotension during spinal anaesthesia for emergency caesarean section. Eur J Anaesthesiol 2007; 24: 143.
31. Beilin Y,. The treatment should not be worse than the disease. Anesthesiology 2006; 103: 744-750.
32. Klöhr S, Roth R, Hofmann T, Rossaint R, Heesen M,. Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturients. Acta Anaesthesiol Scand 2010; 54: 909-921.
33. Allen TK, Muir HA, George RB, Habib AS,. A survey of the management of spinal-induced hypotension for scheduled caesarean delivery. Int J Obstet Anesth 2009; 18: 356-361.
34. Burns SM, Cowan CM, Wilkes RG,. Prevention and management of hypotension during spinal anaesthesia for elective caesarean section: a survey of practice. Anaesthesia 2001; 56: 794-798. (Pubitemid 32755151)
35. Cooper DW, Sharma S, Orakkan P, Gurung S,. Retrospective study of association between choice of vasopressor given during spinal anaesthesia for high-risk caesarean delivery and fetal pH. Int J Obstet Anesth 2010; 19: 44-49.