A review of the impact of phenylephrine administration on maternal hemodynamics and maternal and neonatal outcomes in women undergoing cesarean delivery under spinal anesthesia

Anesthesia and Analgesia

Volumn 114, Issue 2, 2012, Pages 377-390

  Habib, Ashraf S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; EPHEDRINE; FENTANYL; LEVOBUPIVACAINE; LOCAL ANESTHETIC AGENT; MORPHINE; PHENYLEPHRINE; SUFENTANIL CITRATE;

APGAR SCORE; ARTERIAL PRESSURE; BLOOD PRESSURE MEASUREMENT; CESAREAN SECTION; CHEMOPROPHYLAXIS; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; FETUS ACID BASE BALANCE; FETUS OUTCOME; HEART HEMODYNAMICS; HEART OUTPUT; HEART RATE; HEART RATE VARIABILITY; HUMAN; HYPOTENSION; PLACENTA CIRCULATION; POSTOPERATIVE NAUSEA AND VOMITING; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW; SPINAL ANESTHESIA; UMBILICAL CORD BLOOD;

ACID-BASE EQUILIBRIUM; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; APGAR SCORE; CESAREAN SECTION; EPHEDRINE; FEMALE; FETAL BLOOD; HEMODYNAMICS; HUMANS; HYPOTENSION; INFANT, NEWBORN; PHENYLEPHRINE; PLACENTAL CIRCULATION; PREGNANCY; PREGNANCY OUTCOME; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 84856213035     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182373a3e     Document Type: Review

References (53)

1. Reynolds F, Seed PT. Anaesthesia for Caesarean section and neonatal acid-base status: A meta-analysis. Anaesthesia 2005; 60:636-53 (Pubitemid 40908988)
2. Laudenbach V, Mercier FJ, Roze JC, Larroque B, Ancel PY, Kaminski M, Breart G, Diemunsch P, Subtil D, Lejus C, Fresson J, Arnaud C, Rachet B, Burguet A, Cambonie G. Anaesthesia mode for caesarean section and mortality in very preterm infants: An epidemiologic study in the EPIPAGE cohort. Int J Obstet Anesth 2009;18:142-9
3. Ralston DH, Shnider SM, DeLorimier AA. Effects of equipotent ephedrine, metaraminol, mephentermine, and methoxamine on uterine blood flow in the pregnant ewe. Anesthesiology 1974;40:354-70
4. James FM 3rd, Greiss FC Jr., Kemp RA. An evaluation of vasopressor therapy for maternal hypotension during spinal anesthesia. Anesthesiology 1970;33:25-34
5. Lee A, Ngan Kee WD, Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 2002;94:920-6 (Pubitemid 34263741)
6. Burns SM, Cowan CM, Wilkes RG. Prevention and management of hypotension during spinal anaesthesia for elective Caesarean section: A survey of practice. Anaesthesia 2001; 56:794-8 (Pubitemid 32755151)
7. Allen TK, Muir HA, George RB, Habib AS. A survey of the management of spinal-induced hypotension for scheduled cesarean delivery. Int J Obstet Anesth 2009;18:356-61
8. Borgeat A, Ekatodramis G, Schenker CA. Postoperative nausea and vomiting in regional anesthesia: A review. Anesthesiology 2003;98:530-47 (Pubitemid 36592823)
9. Datta S, Alper MH, Ostheimer GW, Weiss JB. Method of ephedrine administration and nausea and hypotension during spinal anesthesia for cesarean section. Anesthesiology 1982; 56:68-70 (Pubitemid 12204775)
10. Racke K, Schworer H. Regulation of serotonin release from the intestinal mucosa. Pharmacol Res 1991;23:13-25
11. Ngan Kee WD, Khaw KS, Ng FF, Lee BB. Prophylactic phenylephrine infusion for preventing hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 2004;98:815-21 (Pubitemid 38252682)
12. Ngan Kee WD, Lee A, Khaw KS, Ng FF, Karmakar MK, Gin T. A randomized double-blinded comparison of phenylephrine and ephedrine infusion combinations to maintain blood pressure during spinal anesthesia for cesarean delivery: The effects on fetal acid-base status and hemodynamic control. Anesth Analg 2008;107:1295-302
13. Saravanan S, Kocarev M, Wilson RC, Watkins E, Columb MO, Lyons G. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section. Br J Anaesth 2006;96:95-9 (Pubitemid 43124538)
14. Ngan Kee WD, Khaw KS, Lau TK, Ng FF, Chui K, Ng KL. Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section. Anaesthesia 2008;63: 1319-26
15. Prakash S, Pramanik V, Chellani H, Salhan S, Gogia AR. Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine during spinal anaesthesia for caesarean delivery: A randomised study. Int J Obstet Anesth 2010;19:24-30
16. Dyer RA, Reed AR, van Dyk D, Arcache MJ, Hodges O, Lombard CJ, Greenwood J, James MF. Hemodynamic effects of ephedrine, phenylephrine, and the coadministration of phenylephrine with oxytocin during spinal anesthesia for elective cesarean delivery. Anesthesiology 2009;111:753-65
17. Moran DH, Perillo M, LaPorta RF, Bader AM, Datta S. Phenylephrine in the prevention of hypotension following spinal anesthesia for cesarean delivery. J Clin Anesth 1991;3:301-5
18. Magalhaes E, Goveia CS, de Araujo Ladeira LC, Nascimento BG, Kluthcouski SM. Ephedrine versus phenylephrine: prevention of hypotension during spinal block for cesarean section and effects on the fetus. Rev Bras Anestesiol 2009;59:11-20
19. Loughrey JP, Yao N, Datta S, Segal S, Pian-Smith M, Tsen LC. Hemodynamic effects of spinal anesthesia and simultaneous intravenous bolus of combined phenylephrine and ephedrine versus ephedrine for cesarean delivery. Int J Obstet Anesth 2005;14:43-7 (Pubitemid 41201406)
20. Ngan Kee WD, Khaw KS, Tan PE, Ng FF, Karmakar MK. Placental transfer and fetal metabolic effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2009;111:506-12
21. Cooper DW, Carpenter M, Mowbray P, Desira WR, Ryall DM, Kokri MS. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for cesarean delivery. Anesthesiology 2002;97:1582-90 (Pubitemid 35417460)
22. Hall PA, Bennett A, Wilkes MP, Lewis M. Spinal anaesthesia for caesarean section: Comparison of infusions of phenylephrine and ephedrine. Br J Anaesth 1994;73:471-4 (Pubitemid 24307336)
23. Ngan Kee WD, Khaw KS, Ng FF. Prevention of hypotension during spinal anesthesia for cesarean delivery: An effective technique using combination phenylephrine infusion and crystalloid cohydration. Anesthesiology 2005;103:744-50 (Pubitemid 41415522)
24. Ngan Kee WD, Khaw KS, Ng FF. Comparison of phenylephrine infusion regimens for maintaining maternal blood pressure during spinal anaesthesia for Caesarean section. Br J Anaesth 2004;92:469-74 (Pubitemid 38443846)
25. Mercier FJ, Riley ET, Frederickson WL, Roger-Christoph S, Benhamou D, Cohen SE. Phenylephrine added to prophylactic ephedrine infusion during spinal anesthesia for elective cesarean section. Anesthesiology 2001;95:668-74
26. Allen TK, George RB, White WD, Muir HA, Habib AS. A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery. Anesth Analg 2010;111:1221-9
27. das Neves JF, Monteiro GA, de Almeida JR, Sant'Anna RS, Bonin HB, Macedo CF. Phenylephrine for blood pressure control in elective cesarean section: Therapeutic versus prophylactic doses. Rev Bras Anestesiol 2010;60:391-8
28. Stewart A, Fernando R, McDonald S, Hignett R, Jones T, Columb M. The dose-dependent effects of phenylephrine for elective cesarean delivery under spinal anesthesia. Anesth Analg 2010;111:1230-7
29. Santha E, Lendvai B, Gerevich Z. Low temperature prevents potentiation of norepinephrine release by phenylephrine. Neurochem Int 2001;38:237-42
30. Thomas DG, Robson SC, Redfern N, Hughes D, Boys RJ. Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for Caesarean section. Br J Anaesth 1996;76:61-5 (Pubitemid 26030218)
31. Langesaeter E, Rosseland LA, Stubhaug A. Continuous invasive blood pressure and cardiac output monitoring during cesarean delivery: A randomized, double-blind comparison of low-dose versus high-dose spinal anesthesia with intravenous phenylephrine or placebo infusion. Anesthesiology 2008;109: 856-63
32. Mohta M, Janani SS, Sethi AK, Agarwal D, Tyagi A. Comparison of phenylephrine hydrochloride and mephentermine sulphate for prevention of post spinal hypotension. Anaesthesia 2010;65:1200-5
33. Robson SC, Boys RJ, Rodeck C, Morgan B. Maternal and fetal haemodynamic effects of spinal and extradural anaesthesia for elective caesarean section. Br J Anaesth 1992;68:54-9
34. Tihtonen K, Koobi T, Yli-Hankala A, Huhtala H, Uotila J. Maternal haemodynamics in pre-eclampsia compared with normal pregnancy during caesarean delivery. BJOG 2006;113:657-63 (Pubitemid 43781696)
35. Dyer RA, Piercy JL, Reed AR, Lombard CJ, Schoeman LK, James MF. Hemodynamic changes associated with spinal anesthesia for cesarean delivery in severe preeclampsia. Anesthesiology 2008;108:802-11 (Pubitemid 351589475)
36. Alahuhta S, Rasanen J, Jouppila P, Jouppila R, Hollmen AI. Ephedrine and phenylephrine for avoiding maternal hypotension due to spinal anaesthesia for caesarean section. Effects on uteroplacental and fetal haemodynamics. Int J Obstet Anesth 1992;1:129-34
37. Ngan Kee WD, Lau TK, Khaw KS, Lee BB. Comparison of metaraminol and ephedrine infusions for maintaining arterial pressure during spinal anesthesia for elective cesarean section. Anesthesiology 2001;95:307-13 (Pubitemid 32720717)
38. ACOG committee opinion. Use and abuse of the Apgar score. Number 174-July 1996 (replaces No. 49, November 1986). Committee on Obstetric Practice and American Academy of Pediatrics: Committee on Fetus and Newborn. American College of Obstetricians and Gynecologists. Int J Gynaecol Obstet 1996;54:303-5
39. Sykes GS, Molloy PM, Johnson P, Gu W, Ashworth F, Stirrat GM, Turnbull AC. Do Apgar scores indicate asphyxia? Lancet 1982;1:494-6
40. Malin GL, Morris RK, Khan KS. Strength of association between umbilical cord pH and perinatal and long term outcomes: Systematic review and meta-analysis. BMJ 2010; 340:c1471
41. Miller JM Jr., Bernard M, Brown HL, St Pierre JJ, Gabert HA. Umbilical cord blood gases for term healthy newborns. Am J Perinatol 1990;7:157-9 (Pubitemid 20138165)
42. Thorp JA, Dildy GA, Yeomans ER, Meyer BA, Parisi VM. Umbilical cord blood gas analysis at delivery. Am J Obstet Gynecol 1996;175:517-22
43. Armstrong L, Stenson BJ. Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Child Fetal Neonatal Ed 2007;92:F430-4 (Pubitemid 350043997)
44. Ngan Kee WD, Lee A. Multivariate analysis of factors associated with umbilical arterial pH and standard base excess after Caesarean section under spinal anaesthesia. Anaesthesia 2003;58:125-30 (Pubitemid 36284739)
45. LaPorta RF, Arthur GR, Datta S. Phenylephrine in treating maternal hypotension due to spinal anaesthesia for caesarean delivery: Effects on neonatal catecholamine concentrations, acid base status and Apgar scores. Acta Anaesthesiol Scand 1995;39:901-5
46. Wilkening RB, Meschia G. Fetal oxygen uptake, oxygenation, and acid-base balance as a function of uterine blood flow. Am J Physiol 1983;244:H749-55 (Pubitemid 13066958)
47. Cooper DW, Sharma S, Orakkan P, Gurung S. Retrospective study of association between choice of vasopressor given during spinal anaesthesia for high-risk caesarean delivery and fetal pH. Int J Obstet Anesth 2010;19:44-9
48. Tanaka M, Balki M, Parkes RK, Carvalho JC. ED95 of phenylephrine to prevent spinal-induced hypotension and/or nausea at elective cesarean delivery. Int J Obstet Anesth 2009;18: 25-30
49. George RB, McKeen D, Columb MO, Habib AS. Up-down determination of the 90% effective dose of phenylephrine for the treatment of spinal anesthesia-induced hypotension in parturients undergoing cesarean delivery. Anesth Analg 2010;110:154-8
50. Stewart A, Fernando R, McDonald S, Hignett R, Jones T, Columb M. Can phenylephrine infusions cause reactive hypertension during elective caesarean section? Int J Obstet Anesth 2011;20:S7
51. Ngan Kee WD, Khaw KS, Tam YH, Ng FF. Comparison of closed-loop feedback computer-controlled and manualcontrolled phenylephrine infusions during spinal anesthesia for cesarean section. Int J Obstet Anesth 2011;20:S17
52. Pierce ET, Carr DB, Datta S. Effects of ephedrine and phenylephrine on maternal and fetal atrial natriuretic peptide levels during elective cesarean section. Acta Anaesthesiol Scand 1994;38:48-51 (Pubitemid 24035581)
53. Cooper DW, Gibb SC, Meek T, Owen S, Kokri MS, Malik AT, Koneti KK. Effect of intravenous vasopressor on spread of spinal anaesthesia and fetal acid-base equilibrium. Br J Anaesth 2007;98:649-56 (Pubitemid 47072619)