Characterization of thrombin-bound dabigatran effects on protease-activated receptor-1 expression and signaling in vitro

Molecular Pharmacology

Volumn 88, Issue 1, 2015, Pages 95-105

  Chen, Buxin ^a   Soto, Antonio G ^a   Coronel, Luisa J ^a   Goss, Ashley ^b   Van Ryn, Joanne ^c   Trejo, JoAnn ^a  

^a University of California San Diego   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; DABIGATRAN; FIBRINOGEN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; UBIQUITIN; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; PROTEIN BINDING; RETINA S ANTIGEN;

ARTICLE; CATALYSIS; CELL SURFACE; CLEARANCE; CONTROLLED STUDY; DRUG PROTEIN BINDING; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; INTERNALIZATION; LONG TERM EXPOSURE; PERMEABILITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENE EXPRESSION REGULATION; HELA CELL LINE; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTITHROMBINS; ARRESTINS; BENZIMIDAZOLES; BETA-ALANINE; DABIGATRAN; GENE EXPRESSION REGULATION; HELA CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IN VITRO TECHNIQUES; PROTEIN BINDING; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN;

EID: 84940189510     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.096446     Document Type: Article

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