Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms

Frontiers in Genetics

Volumn 6, Issue APR, 2015, Pages

  Qian, Yufeng ^a,b   Ziehr, Jessica L ^a   Johnson, Kenneth A ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b PACIFIC BIOSCIENCES   (United States)

Author keywords

Alpers; Human mitochondria; Kinetics; Pol mutations; Replisome; Yeast

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; DNA DIRECTED DNA POLYMERASE GAMMA A; DNA DIRECTED DNA POLYMERASE GAMMA B; UNCLASSIFIED DRUG;

ALPERS DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME PURIFICATION; ESCHERICHIA COLI; FUNGUS MUTANT; GENE FREQUENCY; GENE MUTATION; HUMAN; MITOCHONDRIAL DNA REPLICATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REPLISOME;

EID: 84940032113     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2015.00135     Document Type: Article

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