메뉴 건너뛰기




Volumn 16, Issue 7, 2014, Pages

Pharmacotherapy in the Aftermath of Trauma; Opportunities in the ‘Golden Hours’

Author keywords

Animal model; Cortisol; Post traumatic stress disorder; Prevention; Propranolol; Reconsolidation; Synapses

Indexed keywords


EID: 84939891938     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-014-0455-y     Document Type: Review
Times cited : (26)

References (109)
  • 1
    • 36849064255 scopus 로고    scopus 로고
    • Administration of corticosterone after memory reactivation disrupts subsequent retrieval of a contextual conditioned fear memory: dependence upon training intensity
    • COI: 1:CAS:528:DC%2BD2sXhsVelsb7J, PID: 17702613
    • Abrari K, Rashidy-Pour A, Semnanian S, Fathollahi Y. Administration of corticosterone after memory reactivation disrupts subsequent retrieval of a contextual conditioned fear memory: dependence upon training intensity. Neurobiol Learn Mem. 2008;89:178–84.
    • (2008) Neurobiol Learn Mem , vol.89 , pp. 178-184
    • Abrari, K.1    Rashidy-Pour, A.2    Semnanian, S.3    Fathollahi, Y.4
  • 2
    • 11144257694 scopus 로고    scopus 로고
    • Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes?
    • COI: 1:CAS:528:DC%2BD2MXktVyl, PID: 15626497
    • Alberini CM. Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci. 2005;28:51–6.
    • (2005) Trends Neurosci , vol.28 , pp. 51-56
    • Alberini, C.M.1
  • 3
    • 34247156174 scopus 로고    scopus 로고
    • Pharmacologic reduction of CNS noradrenergic activity in PTSD: the case for clonidine and prazosin
    • PID: 17414682
    • Boehnlein JK, Kinzie JD. Pharmacologic reduction of CNS noradrenergic activity in PTSD: the case for clonidine and prazosin. J Psychiatr Pract. 2007;13:72–8.
    • (2007) J Psychiatr Pract , vol.13 , pp. 72-78
    • Boehnlein, J.K.1    Kinzie, J.D.2
  • 4
    • 39049108307 scopus 로고    scopus 로고
    • Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder
    • PID: 17588604
    • Brunet A, Orr SP, Tremblay J, Robertson K, Nader K, Pitman RK. Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res. 2008;42:503–6.
    • (2008) J Psychiatr Res , vol.42 , pp. 503-506
    • Brunet, A.1    Orr, S.P.2    Tremblay, J.3    Robertson, K.4    Nader, K.5    Pitman, R.K.6
  • 5
    • 79960568421 scopus 로고    scopus 로고
    • Trauma reactivation under the influence of propranolol decreases posttraumatic stress symptoms and disorder: 3 open-label trials
    • PID: 21720237
    • Brunet A, Poundja J, Tremblay J, Bui E, Thomas E, Orr SP, et al. Trauma reactivation under the influence of propranolol decreases posttraumatic stress symptoms and disorder: 3 open-label trials. J Clin Psychopharmacol. 2011;31:547–50.
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 547-550
    • Brunet, A.1    Poundja, J.2    Tremblay, J.3    Bui, E.4    Thomas, E.5    Orr, S.P.6
  • 6
    • 0037374205 scopus 로고    scopus 로고
    • Epinephrine enhancement of human memory consolidation: Interaction with arousal at encoding
    • COI: 1:CAS:528:DC%2BD3sXht1Gisro%3D, PID: 12591227
    • Cahill L, Alkire MT. Epinephrine enhancement of human memory consolidation: Interaction with arousal at encoding. Neurobiol Learn Mem. 2003;79:194–8.
    • (2003) Neurobiol Learn Mem , vol.79 , pp. 194-198
    • Cahill, L.1    Alkire, M.T.2
  • 7
    • 0028172570 scopus 로고
    • Beta-adrenergic activation and memory for emotional events
    • COI: 1:CAS:528:DyaK2cXmslakt78%3D, PID: 7935815
    • Cahill L, Prins B, Weber M, McGaugh JL. Beta-adrenergic activation and memory for emotional events. Nature. 1994;371:702–4.
    • (1994) Nature , vol.371 , pp. 702-704
    • Cahill, L.1    Prins, B.2    Weber, M.3    McGaugh, J.L.4
  • 8
    • 33748678305 scopus 로고    scopus 로고
    • Postreactivation glucocorticoids impair recall of established fear memory
    • COI: 1:CAS:528:DC%2BD28XhtVSlu7zP, PID: 16971540
    • Cai WH, Blundell J, Han J, Greene RW, Powell CM. Postreactivation glucocorticoids impair recall of established fear memory. J Neurosci. 2006;26:9560–6.
    • (2006) J Neurosci , vol.26 , pp. 9560-9566
    • Cai, W.H.1    Blundell, J.2    Han, J.3    Greene, R.W.4    Powell, C.M.5
  • 9
    • 63849228542 scopus 로고    scopus 로고
    • Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory
    • COI: 1:CAS:528:DC%2BD1MXktFOjtbw%3D, PID: 19255436
    • Campolongo P, Roozendaal B, Trezza V, Hauer D, Schelling G, McGaugh JL, et al. Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory. Proc Natl Acad Sci U S A. 2009;106:4888–93.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4888-4893
    • Campolongo, P.1    Roozendaal, B.2    Trezza, V.3    Hauer, D.4    Schelling, G.5    McGaugh, J.L.6
  • 10
    • 44949262153 scopus 로고    scopus 로고
    • Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    • COI: 1:CAS:528:DC%2BD1cXntFantbc%3D, PID: 18524909
    • Champagne DL, Bagot RC, van Hasselt F, Ramakers G, Meaney MJ, de Kloet ER, et al. Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. J Neurosci. 2008;28:6037–45.
    • (2008) J Neurosci , vol.28 , pp. 6037-6045
    • Champagne, D.L.1    Bagot, R.C.2    van Hasselt, F.3    Ramakers, G.4    Meaney, M.J.5    de Kloet, E.R.6
  • 11
    • 0023205889 scopus 로고
    • Neurobiological mechanisms of panic-anxiety: biochemical and behavioural correlates of yohimbine-induced panic attacks
    • Charney DS, Woods SW, Goodman WK, Heninger GR. Neurobiological mechanisms of panic-anxiety: biochemical and behavioural correlates of yohimbine-induced panic attacks. Am J Psychiatry. 1987;44:1030–6.
    • (1987) Am J Psychiatry , vol.44 , pp. 1030-1036
    • Charney, D.S.1    Woods, S.W.2    Goodman, W.K.3    Heninger, G.R.4
  • 12
    • 78449285958 scopus 로고    scopus 로고
    • Calcium-permeable AMPA receptor dynamics mediate fear memory erasure
    • COI: 1:CAS:528:DC%2BC3cXhsVahurjP, PID: 21030604
    • Clem RL, Huganir RL. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science. 2010;330:1108–12.
    • (2010) Science , vol.330 , pp. 1108-1112
    • Clem, R.L.1    Huganir, R.L.2
  • 13
    • 0028686650 scopus 로고
    • Corticosterone potentiation of conditioned fear in rats
    • COI: 1:CAS:528:DyaK28XjvVSlt7c%3D, PID: 7825895
    • Corodimas KP, LeDoux JE, Gold PW, Schulkin J. Corticosterone potentiation of conditioned fear in rats. Ann N Y Acad Sci. 1994;746:392–3.
    • (1994) Ann N Y Acad Sci , vol.746 , pp. 392-393
    • Corodimas, K.P.1    LeDoux, J.E.2    Gold, P.W.3    Schulkin, J.4
  • 14
    • 84872693120 scopus 로고    scopus 로고
    • The effects of N-methyl D-aspartate and B-adrenergic receptor antagonists on the reconsolidation of reward memory: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXktlGgsrY%3D, PID: 23261501, This paper reviews two of the most promising classes of drug that interfere with reconsolidation and have translational potential for human use are N-methyl-D-aspartate receptor (NMDAR) and B-Adrenergic receptor (B-AR) antagonists. An analysis of 52 independent effect sizes (NMDAR=30, B-AR=22) found robust effects of both classes of drug on memory reconsolidation, but a far greater overall effect of NMDAR antagonism than B-AR antagonism
    • Das RK, Freeman TP, Kamboj SK. The effects of N-methyl D-aspartate and B-adrenergic receptor antagonists on the reconsolidation of reward memory: a meta-analysis. Neurosci Biobehav Rev. 2013;37:240–55. This paper reviews two of the most promising classes of drug that interfere with reconsolidation and have translational potential for human use are N-methyl-D-aspartate receptor (NMDAR) and B-Adrenergic receptor (B-AR) antagonists. An analysis of 52 independent effect sizes (NMDAR=30, B-AR=22) found robust effects of both classes of drug on memory reconsolidation, but a far greater overall effect of NMDAR antagonism than B-AR antagonism.
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 240-255
    • Das, R.K.1    Freeman, T.P.2    Kamboj, S.K.3
  • 15
    • 33747083749 scopus 로고    scopus 로고
    • Effects of D-cycloserine on extinction: translation from preclinical to clinical work
    • COI: 1:CAS:528:DC%2BD28XotlKnu7w%3D, PID: 16919524
    • Davis M, Ressler K, Rothbaum BO, Richardson R. Effects of D-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry. 2006;60:369–75.
    • (2006) Biol Psychiatry , vol.60 , pp. 369-375
    • Davis, M.1    Ressler, K.2    Rothbaum, B.O.3    Richardson, R.4
  • 16
    • 0037168120 scopus 로고    scopus 로고
    • Cellular and systems reconsolidation in the hippocampus
    • COI: 1:CAS:528:DC%2BD38XosV2htb4%3D, PID: 12408854
    • Debiec J, LeDoux JE, Nader K. Cellular and systems reconsolidation in the hippocampus. Neuron. 2002;36:527–38.
    • (2002) Neuron , vol.36 , pp. 527-538
    • Debiec, J.1    LeDoux, J.E.2    Nader, K.3
  • 17
    • 33746453214 scopus 로고    scopus 로고
    • Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD
    • COI: 1:CAS:528:DC%2BD28XpvVehs7k%3D, PID: 16891611
    • Debiec J, LeDoux JE. Noradrenergic signaling in the amygdala contributes to the reconsolidation of fear memory: treatment implications for PTSD. Ann NY Acad Sci. 2006;1071:521–4.
    • (2006) Ann NY Acad Sci , vol.1071 , pp. 521-524
    • Debiec, J.1    LeDoux, J.E.2
  • 18
    • 0033215376 scopus 로고    scopus 로고
    • Stress and Cognition: are corticosteroids good or bad guys?
    • PID: 10481183
    • de Kloet ER, Oitzl MS, Joels M. Stress and Cognition: are corticosteroids good or bad guys? Trends Neurosci. 1999;22:422–6.
    • (1999) Trends Neurosci , vol.22 , pp. 422-426
    • de Kloet, E.R.1    Oitzl, M.S.2    Joels, M.3
  • 19
    • 20044395965 scopus 로고    scopus 로고
    • Stress and the brain: from adaptation to disease
    • PID: 15891777
    • de Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005;6:463–75.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 463-475
    • de Kloet, E.R.1    Joëls, M.2    Holsboer, F.3
  • 20
    • 0032552049 scopus 로고    scopus 로고
    • Stress and glucocorticoids impair retrieval of long-term spatial memory
    • PID: 9723618
    • de Quervain DJ, Roozendaal B, McGaugh JL. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature. 1998;394:787–90.
    • (1998) Nature , vol.394 , pp. 787-790
    • de Quervain, D.J.1    Roozendaal, B.2    McGaugh, J.L.3
  • 22
    • 0038755185 scopus 로고    scopus 로고
    • Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    • COI: 1:CAS:528:DC%2BD3sXltlensb4%3D, PID: 12832507
    • Di S, Malcher-Lopes R, Halmos KC, Tasker JG. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci. 2003;23:4850–7.
    • (2003) J Neurosci , vol.23 , pp. 4850-4857
    • Di, S.1    Malcher-Lopes, R.2    Halmos, K.C.3    Tasker, J.G.4
  • 23
    • 43049105394 scopus 로고    scopus 로고
    • Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories
    • COI: 1:CAS:528:DC%2BD1cXls1SntLg%3D, PID: 18410917
    • Diergaarde L, Schoffelmeer AN, De Vries TJ. Pharmacological manipulation of memory reconsolidation: towards a novel treatment of pathogenic memories. Eur J Pharmacol. 2008;585:453–7.
    • (2008) Eur J Pharmacol , vol.585 , pp. 453-457
    • Diergaarde, L.1    Schoffelmeer, A.N.2    De Vries, T.J.3
  • 24
    • 84896388390 scopus 로고    scopus 로고
    • D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial
    • PID: 24217129
    • Difede J, Cukor J, Wyka K, Olden M, Hoffman H, Lee FS, et al. D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial. Neuropsychopharmacology. 2013. doi:10.1038/npp.2013.317.
    • (2013) Neuropsychopharmacology
    • Difede, J.1    Cukor, J.2    Wyka, K.3    Olden, M.4    Hoffman, H.5    Lee, F.S.6
  • 25
    • 1842590400 scopus 로고    scopus 로고
    • The neurobiology of consolidations, or, how stable is the engram?
    • PID: 14744210
    • Dudai Y. The neurobiology of consolidations, or, how stable is the engram? Annu Rev Psychol. 2004;55:51–86.
    • (2004) Annu Rev Psychol , vol.55 , pp. 51-86
    • Dudai, Y.1
  • 26
    • 33645758285 scopus 로고    scopus 로고
    • Reconsolidation: the advantage of being refocused
    • COI: 1:CAS:528:DC%2BD28Xjs1Gkurw%3D, PID: 16563730
    • Dudai. Reconsolidation: the advantage of being refocused. Curr Opin Neurobiol. 2006;16:174–8.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 174-178
    • Dudai1
  • 27
    • 4043102043 scopus 로고    scopus 로고
    • Intrusive re-experiencing in post-traumatic stress disorder: phenomenology, theory, and therapy
    • PID: 15487537
    • Ehlers A, Hackmann A, Michael T. Intrusive re-experiencing in post-traumatic stress disorder: phenomenology, theory, and therapy. Memory. 2004;12:403–15.
    • (2004) Memory , vol.12 , pp. 403-415
    • Ehlers, A.1    Hackmann, A.2    Michael, T.3
  • 28
    • 84869092559 scopus 로고    scopus 로고
    • Preclinical evaluation of reconsolidation blockade by clonidine as a potential novel treatment for posttraumatic stress disorder
    • 2-adrenoreceptor agonist to block reconsolidation as a novel treatment for PTSD symptoms
    • 2-adrenoreceptor agonist to block reconsolidation as a novel treatment for PTSD symptoms.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 2789-2796
    • Gamache, K.1    Pitman, R.K.2    Nader, K.3
  • 29
    • 0036669380 scopus 로고    scopus 로고
    • Role of adrenoceptor subtypes in memory consolidation
    • COI: 1:CAS:528:DC%2BD38XntVWnsbs%3D, PID: 12234500
    • Gibbs ME, Summers RJ. Role of adrenoceptor subtypes in memory consolidation. Prog Neurobiol. 2002;67:345–91.
    • (2002) Prog Neurobiol , vol.67 , pp. 345-391
    • Gibbs, M.E.1    Summers, R.J.2
  • 30
    • 84885138615 scopus 로고    scopus 로고
    • The roles of protein kinases in learning and memory
    • COI: 1:CAS:528:DC%2BC3sXhvFeis77I, PID: 24042850, A review paper on the role of the learning and memory-related kinases in short-term memory formation, memory consolidation, memory storage, retrieval, reconsolidation, and extinction
    • Giese KP, Mizuno K. The roles of protein kinases in learning and memory. Learn Mem. 2013;20:540–52. A review paper on the role of the learning and memory-related kinases in short-term memory formation, memory consolidation, memory storage, retrieval, reconsolidation, and extinction.
    • (2013) Learn Mem , vol.20 , pp. 540-552
    • Giese, K.P.1    Mizuno, K.2
  • 32
    • 84855979157 scopus 로고    scopus 로고
    • Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy
    • COI: 1:CAS:528:DC%2BC38XhtFCkt7Y%3D, PID: 22122881, This highly interesting paper reviews key genetic diatheses and molecular targets especially signaling pathways that mediate responses to trauma and severe stress and their potential contribution to the etiology of PTSD. The perspective is from sensitization of glucocorticoid receptor (GR) signaling and dysregulation of GR modulators FKBP5, STAT5B, Bcl-2, and Bax; all implicated in PTSD pathophysiology
    • Hauger RL, Olivares-Reyes JA, Dautzenberg FM, Lohr JB, Braun S, Oakley RH. Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy. Neuropharmacology. 2012;62:705–14. This highly interesting paper reviews key genetic diatheses and molecular targets especially signaling pathways that mediate responses to trauma and severe stress and their potential contribution to the etiology of PTSD. The perspective is from sensitization of glucocorticoid receptor (GR) signaling and dysregulation of GR modulators FKBP5, STAT5B, Bcl-2, and Bax; all implicated in PTSD pathophysiology.
    • (2012) Neuropharmacology , vol.62 , pp. 705-714
    • Hauger, R.L.1    Olivares-Reyes, J.A.2    Dautzenberg, F.M.3    Lohr, J.B.4    Braun, S.5    Oakley, R.H.6
  • 33
    • 84888122326 scopus 로고    scopus 로고
    • Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence
    • COI: 1:CAS:528:DC%2BC3sXhvFCisL7I, PID: 24191026
    • Herringa RJ, Birn RM, Ruttle PL, Burghy CA, Stodola DE, Davidson RJ, et al. Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence. Proc Natl Acad Sci U S A. 2013;110:19119–24.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 19119-19124
    • Herringa, R.J.1    Birn, R.M.2    Ruttle, P.L.3    Burghy, C.A.4    Stodola, D.E.5    Davidson, R.J.6
  • 34
    • 20144362430 scopus 로고    scopus 로고
    • A meta-analytic review of the effects of acute cortisol administration on human memory
    • COI: 1:CAS:528:DC%2BD2MXks1aktL4%3D, PID: 15919583
    • Het S, Ramlow G, Wolf OT. A meta-analytic review of the effects of acute cortisol administration on human memory. Psychoneuroendocrinology. 2005;30:771–84.
    • (2005) Psychoneuroendocrinology , vol.30 , pp. 771-784
    • Het, S.1    Ramlow, G.2    Wolf, O.T.3
  • 35
    • 84863049769 scopus 로고    scopus 로고
    • Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery
    • COI: 1:CAS:528:DC%2BC38Xjt1WqsLc%3D, PID: 22070357
    • Hoge EA, Worthington JJ, Nagurney JT, Chang Y, Kay EB, Feterowski CM, et al. Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery. CNS Neurosci Ther. 2012;18:21–7.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 21-27
    • Hoge, E.A.1    Worthington, J.J.2    Nagurney, J.T.3    Chang, Y.4    Kay, E.B.5    Feterowski, C.M.6
  • 36
    • 84877849388 scopus 로고    scopus 로고
    • AMPA receptor exchange underlies transient memory destabilization on retrieval
    • COI: 1:CAS:528:DC%2BC3sXhtV2ksLrO, PID: 23630279, This paper shows that at lateral amygdala synapses, fear memory consolidation correlates with increased surface expression of calcium-impermeable AMPA receptors (CI-AMPARs), known to be more stable at the synapse, whereas memory retrieval induces an abrupt exchange of CI-AMPARs to calcium-permeable AMPARs (CP-AMPARs), known to be less stable at the synapse. These are unexpected physiological roles of CI-AMPARs and CP-AMPARs in transforming a consolidated memory into an unstable memory and subsequently guiding reconsolidation
    • Hong I, Kim J, Kim J, Lee S, Ko HG, Nader K, et al. AMPA receptor exchange underlies transient memory destabilization on retrieval. Proc Natl Acad Sci U S A. 2013;110:8218–23. This paper shows that at lateral amygdala synapses, fear memory consolidation correlates with increased surface expression of calcium-impermeable AMPA receptors (CI-AMPARs), known to be more stable at the synapse, whereas memory retrieval induces an abrupt exchange of CI-AMPARs to calcium-permeable AMPARs (CP-AMPARs), known to be less stable at the synapse. These are unexpected physiological roles of CI-AMPARs and CP-AMPARs in transforming a consolidated memory into an unstable memory and subsequently guiding reconsolidation.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 8218-8223
    • Hong, I.1    Kim, J.2    Kim, J.3    Lee, S.4    Ko, H.G.5    Nader, K.6
  • 37
    • 34848875687 scopus 로고    scopus 로고
    • Emotion enhances learning via norepinephrine regulation of AMPA-Receptor trafficking
    • COI: 1:CAS:528:DC%2BD2sXht1CntLnF, PID: 17923095
    • Hu H, Real E, Takamiya K, Kang M, Ledoux JE, Huganir RL, et al. Emotion enhances learning via norepinephrine regulation of AMPA-Receptor trafficking. Cell. 2007;131:160–73.
    • (2007) Cell , vol.131 , pp. 160-173
    • Hu, H.1    Real, E.2    Takamiya, K.3    Kang, M.4    Ledoux, J.E.5    Huganir, R.L.6
  • 38
    • 0345549650 scopus 로고    scopus 로고
    • Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats
    • COI: 1:CAS:528:DC%2BD3sXps1equr8%3D, PID: 14670360
    • Hui GK, Figueroa IR, Poytress BS, Roozendaal B, McGaugh JL, Weinberger NM. Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats. Neurobiol Learn Mem. 2004;81:67–74.
    • (2004) Neurobiol Learn Mem , vol.81 , pp. 67-74
    • Hui, G.K.1    Figueroa, I.R.2    Poytress, B.S.3    Roozendaal, B.4    McGaugh, J.L.5    Weinberger, N.M.6
  • 40
    • 84868373502 scopus 로고    scopus 로고
    • Pharmacotherapy for posttraumatic stress disorder: review with clinical applications
    • PID: 23015581
    • Jeffreys M, Capehart B, Friedman MJ. Pharmacotherapy for posttraumatic stress disorder: review with clinical applications. J Rehabil Res Dev. 2012;49:703–15.
    • (2012) J Rehabil Res Dev , vol.49 , pp. 703-715
    • Jeffreys, M.1    Capehart, B.2    Friedman, M.J.3
  • 41
    • 0038054210 scopus 로고    scopus 로고
    • Deficit in long-term contextual fear memory induced by blockade of beta-adrenoceptors in hippocampal CA1 region
    • PID: 12752794
    • Ji JZ, Wang XM, Li BM. Deficit in long-term contextual fear memory induced by blockade of beta-adrenoceptors in hippocampal CA1 region. Eur J Neurosci. 2003;17:1947–52.
    • (2003) Eur J Neurosci , vol.17 , pp. 1947-1952
    • Ji, J.Z.1    Wang, X.M.2    Li, B.M.3
  • 43
    • 67349151166 scopus 로고    scopus 로고
    • The neuro-symphony of stress
    • PID: 19339973
    • Joëls M, Baram TZ. The neuro-symphony of stress. Nat Rev Neurosci. 2009;10:459–66.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 459-466
    • Joëls, M.1    Baram, T.Z.2
  • 44
    • 79957853186 scopus 로고    scopus 로고
    • Stress and emotional memory: a matter of timing
    • PID: 21571575, This paper shows the importance of a dynamic interaction in the adaptive and potentially protective capacity of corticosteroids regarding traumatic memories
    • Joëls M, Fernandez G, Roozendaal B. Stress and emotional memory: a matter of timing. Trends Cogn Sci. 2011;15:280–8. This paper shows the importance of a dynamic interaction in the adaptive and potentially protective capacity of corticosteroids regarding traumatic memories.
    • (2011) Trends Cogn Sci , vol.15 , pp. 280-288
    • Joëls, M.1    Fernandez, G.2    Roozendaal, B.3
  • 45
    • 84860806555 scopus 로고    scopus 로고
    • The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
    • COI: 1:CAS:528:DC%2BC3sXhsFyisLw%3D, PID: 22583753
    • Kandel ER. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain. 2012;5:14.
    • (2012) Mol Brain , vol.5 , pp. 14
    • Kandel, E.R.1
  • 46
    • 30044444607 scopus 로고    scopus 로고
    • Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone
    • COI: 1:CAS:528:DC%2BD28XivV2nug%3D%3D, PID: 16361444
    • Karst H, Berger S, Turiault M, Tronche F, Schütz G, Joëls M. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci U S A. 2005;102:19204–7.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 19204-19207
    • Karst, H.1    Berger, S.2    Turiault, M.3    Tronche, F.4    Schütz, G.5    Joëls, M.6
  • 47
    • 77956284651 scopus 로고    scopus 로고
    • Metaplasticity of amygdalar responses to the stress hormone corticosterone
    • COI: 1:CAS:528:DC%2BC3cXhtVCls7nN, PID: 20663957
    • Karst H, Berger S, Erdmann G, Schütz G, Joëls M. Metaplasticity of amygdalar responses to the stress hormone corticosterone. Proc Natl Acad Sci U S A. 2010;107:14449–54.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 14449-14454
    • Karst, H.1    Berger, S.2    Erdmann, G.3    Schütz, G.4    Joëls, M.5
  • 48
    • 59649114125 scopus 로고    scopus 로고
    • Synaptic AMPA receptor plasticity and behaviour
    • COI: 1:CAS:528:DC%2BD1MXltFSntLw%3D, PID: 19217372
    • Kessels HW, Malinow R. Synaptic AMPA receptor plasticity and behaviour. Neuron. 2009;61:340–50.
    • (2009) Neuron , vol.61 , pp. 340-350
    • Kessels, H.W.1    Malinow, R.2
  • 49
    • 60749084639 scopus 로고    scopus 로고
    • Beyond extinction: erasing human fear responses and preventing the return of fear
    • COI: 1:CAS:528:DC%2BD1MXhvFKisL4%3D, PID: 19219038
    • Kindt M, Soeter M, Vervliet B. Beyond extinction: erasing human fear responses and preventing the return of fear. Nat Neurosci. 2009;12:256–8.
    • (2009) Nat Neurosci , vol.12 , pp. 256-258
    • Kindt, M.1    Soeter, M.2    Vervliet, B.3
  • 50
    • 84871720130 scopus 로고    scopus 로고
    • Reconsolidation in a human fear conditioning study: a test of extinction as updating mechanism
    • PID: 21986472
    • Kindt M, Soeter M. Reconsolidation in a human fear conditioning study: a test of extinction as updating mechanism. Biol Psychol. 2013;92:43–50.
    • (2013) Biol Psychol , vol.92 , pp. 43-50
    • Kindt, M.1    Soeter, M.2
  • 51
    • 84887430648 scopus 로고    scopus 로고
    • Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood
    • COI: 1:CAS:528:DC%2BC3sXhvVygsLjE, PID: 24145409
    • Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, et al. Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proc Natl Acad Sci U S A. 2013;110:18442–7.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 18442-18447
    • Kim, P.1    Evans, G.W.2    Angstadt, M.3    Ho, S.S.4    Sripada, C.S.5    Swain, J.E.6
  • 52
    • 84888434839 scopus 로고    scopus 로고
    • Prescriptive variables for d-cycloserine augmentation of exposure therapy for posttraumatic stress disorder
    • PID: 24183818
    • de Kleine RA, Hendriks GJ, Smits JA, Broekman TG, van Minnen A. Prescriptive variables for d-cycloserine augmentation of exposure therapy for posttraumatic stress disorder. J Psychiatr Res. 2014;48:40–6.
    • (2014) J Psychiatr Res , vol.48 , pp. 40-46
    • de Kleine, R.A.1    Hendriks, G.J.2    Smits, J.A.3    Broekman, T.G.4    van Minnen, A.5
  • 53
    • 84898679837 scopus 로고    scopus 로고
    • de Kleine RA, Rothbaum BO, van Minnen A. Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review. Eur J Psychotraumatol. 2013;4 The paper provides an overview of clinical studies on pharmacological enhancement of exposure-based treatment for PTSD
    • de Kleine RA, Rothbaum BO, van Minnen A. Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review. Eur J Psychotraumatol. 2013;4 The paper provides an overview of clinical studies on pharmacological enhancement of exposure-based treatment for PTSD.
  • 54
    • 84861096785 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder
    • PID: 22480663
    • de Kleine RA, Hendriks GJ, Kusters WJ, Broekman TG, van Minnen A. A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry. 2012;71:962–8.
    • (2012) Biol Psychiatry , vol.71 , pp. 962-968
    • de Kleine, R.A.1    Hendriks, G.J.2    Kusters, W.J.3    Broekman, T.G.4    van Minnen, A.5
  • 55
    • 84893785243 scopus 로고    scopus 로고
    • An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans
    • PID: 24362759, This paper reports evidence for reconsolidation of emotional episodic memories in humans. Single application of electroconvulsive therapy following memory reactivation in patients with depression disrupted reactivated, but not non-reactivated, memories for an emotional episode
    • Kroes MC, Tendolkar I, van Wingen GA, van Waarde JA, Strange BA, Fernández G. An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans. Nat Neurosci. 2013. doi:10.1038/nn.3609. This paper reports evidence for reconsolidation of emotional episodic memories in humans. Single application of electroconvulsive therapy following memory reactivation in patients with depression disrupted reactivated, but not non-reactivated, memories for an emotional episode.
    • (2013) Nat Neurosci
    • Kroes, M.C.1    Tendolkar, I.2    van Wingen, G.A.3    van Waarde, J.A.4    Strange, B.A.5    Fernández, G.6
  • 56
    • 77956907522 scopus 로고    scopus 로고
    • Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
    • COI: 1:CAS:528:DC%2BC3cXhtFWksrbN, PID: 20820185
    • Krugers HJ, Hoogenraad CC, Groc L. Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory. Nat Rev Neurosci. 2010;11:675–81.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 675-681
    • Krugers, H.J.1    Hoogenraad, C.C.2    Groc, L.3
  • 57
    • 84879634149 scopus 로고    scopus 로고
    • Propranolol’s effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis
    • PID: 23182304
    • Lonergan MH, Olivera-Figueroa LA, Pitman RK, Brunet A. Propranolol’s effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis. J Psychiatry Neurosci. 2013;38:222–31.
    • (2013) J Psychiatry Neurosci , vol.38 , pp. 222-231
    • Lonergan, M.H.1    Olivera-Figueroa, L.A.2    Pitman, R.K.3    Brunet, A.4
  • 58
    • 70350752569 scopus 로고    scopus 로고
    • AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis
    • COI: 1:CAS:528:DC%2BD1MXhsFylsbrK, PID: 19914186
    • Makino H, Malinow R. AMPA receptor incorporation into synapses during LTP: the role of lateral movement and exocytosis. Neuron. 2009;64:381–90.
    • (2009) Neuron , vol.64 , pp. 381-390
    • Makino, H.1    Malinow, R.2
  • 59
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • COI: 1:CAS:528:DC%2BD38XmtF2hsLw%3D, PID: 12052905
    • Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci. 2002;25:103–26.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 60
    • 79961233798 scopus 로고    scopus 로고
    • Metyrapone administration reduces the strength of an emotional memory trace in a long-lasting manner
    • This paper demonstrated that decreasing GC levels via metyrapone administration is an efficient way to reduce the strength of an emotional memory in a long-lasting manner
    • Marin MF, Hupbach A, Maheu FS, Nader K, Lupien SJ. Metyrapone administration reduces the strength of an emotional memory trace in a long-lasting manner. J Clin Endocrinol Metab. 2011;96:1221–7. This paper demonstrated that decreasing GC levels via metyrapone administration is an efficient way to reduce the strength of an emotional memory in a long-lasting manner.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1221-1227
    • Marin, M.F.1    Hupbach, A.2    Maheu, F.S.3    Nader, K.4    Lupien, S.J.5
  • 61
    • 0033969570 scopus 로고    scopus 로고
    • Memory–a century of consolidation
    • COI: 1:CAS:528:DC%2BD3cXlvVSnsQ%3D%3D, PID: 10634773
    • McGaugh JL. Memory–a century of consolidation. Science. 2000;287:248–51.
    • (2000) Science , vol.287 , pp. 248-251
    • McGaugh, J.L.1
  • 62
    • 79961094858 scopus 로고    scopus 로고
    • Contextual learning requires synaptic AMPA receptor delivery in the hippocampus
    • COI: 1:CAS:528:DC%2BC3MXpvV2qsb8%3D, PID: 21746893
    • Mitsushima D, Ishihara K, Sano A, Kessels HW, Takahashi T. Contextual learning requires synaptic AMPA receptor delivery in the hippocampus. Proc Natl Acad Sci U S A. 2011;108:12503–8.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12503-12508
    • Mitsushima, D.1    Ishihara, K.2    Sano, A.3    Kessels, H.W.4    Takahashi, T.5
  • 63
    • 66149153122 scopus 로고    scopus 로고
    • Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories
    • COI: 1:CAS:528:DC%2BD1MXlslWnu7o%3D, PID: 19342552
    • Monfils MH, Cowansage KK, Klann E, LeDoux JE. Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories. Science. 2009;324:951–5.
    • (2009) Science , vol.324 , pp. 951-955
    • Monfils, M.H.1    Cowansage, K.K.2    Klann, E.3    LeDoux, J.E.4
  • 64
    • 0034680134 scopus 로고    scopus 로고
    • Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
    • COI: 1:CAS:528:DC%2BD3cXmt1Cgt7Y%3D, PID: 10963596
    • Nader K, Schafe GE, Le Doux JE. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature. 2000;406:722–6.
    • (2000) Nature , vol.406 , pp. 722-726
    • Nader, K.1    Schafe, G.E.2    Le Doux, J.E.3
  • 65
    • 0034571503 scopus 로고    scopus 로고
    • The labile nature of consolidation theory
    • COI: 1:CAS:528:DC%2BD3MXivVSjsLs%3D, PID: 11257912
    • Nader K, Schafe GE, LeDoux JE. The labile nature of consolidation theory. Nat Rev Neurosci. 2000;1:216–9.
    • (2000) Nat Rev Neurosci , vol.1 , pp. 216-219
    • Nader, K.1    Schafe, G.E.2    LeDoux, J.E.3
  • 66
    • 77950246539 scopus 로고    scopus 로고
    • Memory reconsolidation: an update
    • PID: 20392274
    • Nader K, Einarsson EO. Memory reconsolidation: an update. Ann NY Acad Sci. 2010;1191:27–41.
    • (2010) Ann NY Acad Sci , vol.1191 , pp. 27-41
    • Nader, K.1    Einarsson, E.O.2
  • 67
    • 37349016848 scopus 로고    scopus 로고
    • Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
    • COI: 1:CAS:528:DC%2BD2sXhsVGjsbbI, PID: 18094707
    • Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci. 2008;9:65–75.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 65-75
    • Neves, G.1    Cooke, S.F.2    Bliss, T.V.3
  • 68
    • 0026532055 scopus 로고
    • Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning
    • COI: 1:STN:280:DyaK383gslCjug%3D%3D, PID: 1313244
    • Oitzl MS, de Kloet ER. Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning. Behav Neurosci. 1992;106:62–71.
    • (1992) Behav Neurosci , vol.106 , pp. 62-71
    • Oitzl, M.S.1    de Kloet, E.R.2
  • 69
    • 77952341577 scopus 로고    scopus 로고
    • Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood
    • COI: 1:CAS:528:DC%2BC3cXhtVaiurbL, PID: 20463226
    • Oomen CA, Soeters H, Audureau N, Vermunt L, van Hasselt FN, Manders EM, et al. Severe early life stress hampers spatial learning and neurogenesis, but improves hippocampal synaptic plasticity and emotional learning under high-stress conditions in adulthood. J Neurosci. 2010;30:6635–45.
    • (2010) J Neurosci , vol.30 , pp. 6635-6645
    • Oomen, C.A.1    Soeters, H.2    Audureau, N.3    Vermunt, L.4    van Hasselt, F.N.5    Manders, E.M.6
  • 70
    • 0025735847 scopus 로고
    • A corticosteroid receptor in neuronal membranes
    • COI: 1:CAS:528:DyaK3MXks1Gjtrw%3D, PID: 2063198
    • Orchinik M, Murray TF, Moore FL. A corticosteroid receptor in neuronal membranes. Science. 1991;252:1848–51.
    • (1991) Science , vol.252 , pp. 1848-1851
    • Orchinik, M.1    Murray, T.F.2    Moore, F.L.3
  • 71
    • 0029074855 scopus 로고
    • Effects of Alzheimer’s disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine
    • COI: 1:CAS:528:DyaK2MXoslSms7s%3D, PID: 7654129
    • Peskind ER, Wingerson D, Murray S, Pascualy M, Dobie DJ, Le Corre P, et al. Effects of Alzheimer’s disease and normal aging on cerebrospinal fluid norepinephrine responses to yohimbine and clonidine. Arch Gen Psychiatry. 1995;52:774–82.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 774-782
    • Peskind, E.R.1    Wingerson, D.2    Murray, S.3    Pascualy, M.4    Dobie, D.J.5    Le Corre, P.6
  • 72
    • 0037081437 scopus 로고    scopus 로고
    • Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
    • COI: 1:CAS:528:DC%2BD38Xos1Ciug%3D%3D, PID: 11822998
    • Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry. 2002;51:189–92.
    • (2002) Biol Psychiatry , vol.51 , pp. 189-192
    • Pitman, R.K.1    Sanders, K.M.2    Zusman, R.M.3    Healy, A.R.4    Cheema, F.5    Lasko, N.B.6
  • 73
    • 79960955704 scopus 로고    scopus 로고
    • Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect
    • PID: 21688892, Highly interesting paper that evaluated the ability of postreactivation mifepristone (RU38486, a glucocorticoid antagonist), alone and in combination with propranolol (a beta-adrenergic blocker), both given systemically, to reduce cue-conditioned fear in rats. It was shown that postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol
    • Pitman RK, Milad MR, Igoe SA, Vangel MG, Orr SP, Tsareva A, et al. Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect. Behav Neurosci. 2011;125:632–8. Highly interesting paper that evaluated the ability of postreactivation mifepristone (RU38486, a glucocorticoid antagonist), alone and in combination with propranolol (a beta-adrenergic blocker), both given systemically, to reduce cue-conditioned fear in rats. It was shown that postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol.
    • (2011) Behav Neurosci , vol.125 , pp. 632-638
    • Pitman, R.K.1    Milad, M.R.2    Igoe, S.A.3    Vangel, M.G.4    Orr, S.P.5    Tsareva, A.6
  • 74
    • 0030815148 scopus 로고    scopus 로고
    • Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats
    • COI: 1:CAS:528:DyaK2sXhtVyis74%3D, PID: 9013504
    • Pugh CR, Fleshner M, Rudy JW. Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats. Neurobiol Learn Mem. 1997;67:75–9.
    • (1997) Neurobiol Learn Mem , vol.67 , pp. 75-79
    • Pugh, C.R.1    Fleshner, M.2    Rudy, J.W.3
  • 75
    • 0030947184 scopus 로고    scopus 로고
    • A selective role for corticosterone in contextual-fear conditioning
    • COI: 1:CAS:528:DyaK2sXmvVKjsrg%3D, PID: 9189265
    • Pugh CR, Tremblay D, Fleshner M, Rudy JW. A selective role for corticosterone in contextual-fear conditioning. Behav Neurosci. 1997;111:503–11.
    • (1997) Behav Neurosci , vol.111 , pp. 503-511
    • Pugh, C.R.1    Tremblay, D.2    Fleshner, M.3    Rudy, J.W.4
  • 76
    • 80053225616 scopus 로고    scopus 로고
    • Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear
    • COI: 1:CAS:528:DC%2BC3MXhtFGnurvP, PID: 21909089
    • Rao-Ruiz P, Rotaru DC, van der Loo RJ, Mansvelder HD, Stiedl O, Smit AB, et al. Retrieval-specific endocytosis of GluA2-AMPARs underlies adaptive reconsolidation of contextual fear. Nat Neurosci. 2011;14:1302–8.
    • (2011) Nat Neurosci , vol.14 , pp. 1302-1308
    • Rao-Ruiz, P.1    Rotaru, D.C.2    van der Loo, R.J.3    Mansvelder, H.D.4    Stiedl, O.5    Smit, A.B.6
  • 77
    • 48549094903 scopus 로고    scopus 로고
    • Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation
    • COI: 1:CAS:528:DC%2BD1cXotF2htbg%3D, PID: 18579737
    • Roozendaal B, Schelling G, McGaugh JL. Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation. J Neurosci. 2008;28:6642–51.
    • (2008) J Neurosci , vol.28 , pp. 6642-6651
    • Roozendaal, B.1    Schelling, G.2    McGaugh, J.L.3
  • 78
    • 33646227453 scopus 로고    scopus 로고
    • Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala
    • COI: 1:CAS:528:DC%2BD28XksVKrtbY%3D, PID: 16611726
    • Roozendaal B, Okuda S, Van der Zee EA, McGaugh JL. Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala. Proc Natl Acad Sci U S A. 2006;103:6741–676.
    • (2006) Proc Natl Acad Sci U S A , vol.103
    • Roozendaal, B.1    Okuda, S.2    Van der Zee, E.A.3    McGaugh, J.L.4
  • 79
    • 67349174522 scopus 로고    scopus 로고
    • Stress, memory and the amygdala
    • COI: 1:CAS:528:DC%2BD1MXlslGlsbg%3D, PID: 19469026
    • Roozendaal B, McEwen BS, Chattarji S. Stress, memory and the amygdala. Nat Rev Neurosci. 2009;10:423–33.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 423-433
    • Roozendaal, B.1    McEwen, B.S.2    Chattarji, S.3
  • 80
    • 15944411690 scopus 로고    scopus 로고
    • Postsynaptic receptor trafficking underlying a form of associative learning
    • COI: 1:CAS:528:DC%2BD2MXivVaqs78%3D, PID: 15746389
    • Rumpel S, LeDoux J, Zador A, Malinow R. Postsynaptic receptor trafficking underlying a form of associative learning. Science. 2005;308:83–8.
    • (2005) Science , vol.308 , pp. 83-88
    • Rumpel, S.1    LeDoux, J.2    Zador, A.3    Malinow, R.4
  • 81
    • 0028338250 scopus 로고
    • Corticosterone enhances long-term retention in one-day-old chicks trained in a weak passive avoidance learning paradigm
    • COI: 1:CAS:528:DyaK2cXksFCgtro%3D, PID: 8069692
    • Sandi C, Rose SP. Corticosterone enhances long-term retention in one-day-old chicks trained in a weak passive avoidance learning paradigm. Brain Res. 1994;647:106–12.
    • (1994) Brain Res , vol.647 , pp. 106-112
    • Sandi, C.1    Rose, S.P.2
  • 82
    • 73849133254 scopus 로고    scopus 로고
    • Preventing the return of fear in humans using reconsolidation update mechanisms
    • COI: 1:CAS:528:DC%2BD1MXhsFemtrzL, PID: 20010606
    • Schiller D, Monfils MH, Raio CM, Johnson DC, Ledoux JE, Phelps EA. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature. 2010;463:49–53.
    • (2010) Nature , vol.463 , pp. 49-53
    • Schiller, D.1    Monfils, M.H.2    Raio, C.M.3    Johnson, D.C.4    Ledoux, J.E.5    Phelps, E.A.6
  • 83
    • 84857202935 scopus 로고    scopus 로고
    • Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial
    • PID: 21908494, One of the first studies that combined treatment in PTSD: treatment with paroxetine plus prolonged exposure was more efficacious than prolonged exposure plus placebo for PTSD. It was part of a call to looking into combined treatment of medication and prolonged exposure therapy
    • Schneier FR, Neria Y, Pavlicova M, Hembree E, Suh EJ, Amsel L, et al. Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial. Am J Psychiatry. 2012;169:80–8. One of the first studies that combined treatment in PTSD: treatment with paroxetine plus prolonged exposure was more efficacious than prolonged exposure plus placebo for PTSD. It was part of a call to looking into combined treatment of medication and prolonged exposure therapy.
    • (2012) Am J Psychiatry , vol.169 , pp. 80-88
    • Schneier, F.R.1    Neria, Y.2    Pavlicova, M.3    Hembree, E.4    Suh, E.J.5    Amsel, L.6
  • 85
    • 84877580950 scopus 로고    scopus 로고
    • D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: evidence from the treatment of height phobia
    • COI: 1:CAS:528:DC%2BC3sXht1GmtLk%3D, PID: 23332511, This paper presents important results demonstrating the efficacy of DCS for augmenting exposure-based CBT depends on the success of exposure sessions (as indexed by end fear)
    • Smits JA, Rosenfield D, Otto MW, Powers MB, Hofmann SG, Telch MJ, et al. D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: evidence from the treatment of height phobia. Biol Psychiatry. 2013;73:1054–8. This paper presents important results demonstrating the efficacy of DCS for augmenting exposure-based CBT depends on the success of exposure sessions (as indexed by end fear).
    • (2013) Biol Psychiatry , vol.73 , pp. 1054-1058
    • Smits, J.A.1    Rosenfield, D.2    Otto, M.W.3    Powers, M.B.4    Hofmann, S.G.5    Telch, M.J.6
  • 86
    • 77953541504 scopus 로고    scopus 로고
    • Dissociating response systems: erasing fear from memory
    • PID: 20381628
    • Soeter M, Kindt M. Dissociating response systems: erasing fear from memory. Neurobiol Learn Mem. 2010;94:30–41.
    • (2010) Neurobiol Learn Mem , vol.94 , pp. 30-41
    • Soeter, M.1    Kindt, M.2
  • 87
    • 79957612249 scopus 로고    scopus 로고
    • Disrupting reconsolidation: pharmacological and behavioral manipulations
    • COI: 1:CAS:528:DC%2BC3MXnvFemsrs%3D, PID: 21576515
    • Soeter M, Kindt M. Disrupting reconsolidation: pharmacological and behavioral manipulations. Learn Mem. 2011;18:357–66.
    • (2011) Learn Mem , vol.18 , pp. 357-366
    • Soeter, M.1    Kindt, M.2
  • 89
    • 0036331601 scopus 로고    scopus 로고
    • Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humans
    • PID: 12153837
    • Southwick SM, Davis M, Horner B, Cahill L, Morgan CA, Gold PE, et al. Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humans. Am J Psychiatry. 2002;159:1420–2.
    • (2002) Am J Psychiatry , vol.159 , pp. 1420-1422
    • Southwick, S.M.1    Davis, M.2    Horner, B.3    Cahill, L.4    Morgan, C.A.5    Gold, P.E.6
  • 90
    • 0034565065 scopus 로고    scopus 로고
    • Pharmacotherapy for posttraumatic stress disorder (PTSD). The Cochrane database of systematic reviews
    • Stein, D.J., Ipser, J.C., Seedat, S., 2006. Pharmacotherapy for posttraumatic stress disorder (PTSD). The Cochrane database of systematic reviews, CD002795.
    • (2006) CD002795
    • Stein, D.J.1    Ipser, J.C.2    Seedat, S.3
  • 91
    • 84878740503 scopus 로고    scopus 로고
    • Interfering with the reconsolidation of traumatic memory: sirolimus as a novel agent for treating veterans with posttraumatic stress disorder
    • This interesting paper studied pairing of sirolimus with traumatic memory reactivation. In Vietnam-era veterans who had recent combat trauma, PTSD symptom scores fell significantly
    • Suris A, Smith J, Powell C, North CS. Interfering with the reconsolidation of traumatic memory: sirolimus as a novel agent for treating veterans with posttraumatic stress disorder. Ann Clin Psychiatry Off J Am Acad Clin Psychiatr. 2013;25:33–40. This interesting paper studied pairing of sirolimus with traumatic memory reactivation. In Vietnam-era veterans who had recent combat trauma, PTSD symptom scores fell significantly.
    • (2013) Ann Clin Psychiatry Off J Am Acad Clin Psychiatr , vol.25 , pp. 33-40
    • Suris, A.1    Smith, J.2    Powell, C.3    North, C.S.4
  • 92
    • 78649574898 scopus 로고    scopus 로고
    • ‘Silent’ priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors
    • Tenorio G, Connor SA, Guévremont D, Abraham WC, Williams J, O’Dell TJ, et al. ‘Silent’ priming of translation-dependent LTP by ß-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors. Learn Mem. 2010;23:627–38.
    • (2010) Learn Mem , vol.23 , pp. 627-638
    • Tenorio, G.1    Connor, S.A.2    Guévremont, D.3    Abraham, W.C.4    Williams, J.5    O’Dell, T.J.6
  • 93
    • 0030248096 scopus 로고    scopus 로고
    • Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region
    • COI: 1:CAS:528:DyaK28XlvFansrs%3D, PID: 8816710
    • Thomas MJ, Moody TD, Makhinson M, O’Dell TJ. Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region. Neuron. 1996;17:475–82.
    • (1996) Neuron , vol.17 , pp. 475-482
    • Thomas, M.J.1    Moody, T.D.2    Makhinson, M.3    O’Dell, T.J.4
  • 94
    • 84881376045 scopus 로고    scopus 로고
    • Stress and excitatory synapses: from health to disease
    • COI: 1:CAS:528:DC%2BC3sXhtFSlsLbI, PID: 23727506, This paper addresses how stress regulates brain function and what determines the threshold between adaptive and maladaptive responses
    • Timmermans W, Xiong H, Hoogenraad CC, Krugers HJ. Stress and excitatory synapses: from health to disease. Neuroscience. 2013;248:626–36. This paper addresses how stress regulates brain function and what determines the threshold between adaptive and maladaptive responses.
    • (2013) Neuroscience , vol.248 , pp. 626-636
    • Timmermans, W.1    Xiong, H.2    Hoogenraad, C.C.3    Krugers, H.J.4
  • 95
    • 33947402766 scopus 로고    scopus 로고
    • Molecular mechanisms of memory reconsolidation
    • COI: 1:CAS:528:DC%2BD2sXjt1Sktbw%3D
    • Tronson NC, Taylor JR. Molecular mechanisms of memory reconsolidation. Nat Neurosci Rev. 2007;8:262–75.
    • (2007) Nat Neurosci Rev , vol.8 , pp. 262-275
    • Tronson, N.C.1    Taylor, J.R.2
  • 96
    • 0030446363 scopus 로고    scopus 로고
    • The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    • COI: 1:CAS:528:DyaK2sXitlSjuw%3D%3D, PID: 8980238
    • Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell. 1996;87:1327–38.
    • (1996) Cell , vol.87 , pp. 1327-1338
    • Tsien, J.Z.1    Huerta, P.T.2    Tonegawa, S.3
  • 97
    • 0031927530 scopus 로고    scopus 로고
    • Memory for emotional events: differential effects of centrally versus peripherally acting β-blocking agents
    • PID: 9725752
    • Van Stegeren AH, Everaerd W, Cahill L, McGaugh JL, Gooren LJG. Memory for emotional events: differential effects of centrally versus peripherally acting β-blocking agents. Psychopharmacology. 1998;138:305–10.
    • (1998) Psychopharmacology , vol.138 , pp. 305-310
    • Van Stegeren, A.H.1    Everaerd, W.2    Cahill, L.3    McGaugh, J.L.4    Gooren, L.J.G.5
  • 98
    • 40649103412 scopus 로고    scopus 로고
    • The role of the noradrenergic system in emotional memory
    • Van Stegeren AH. The role of the noradrenergic system in emotional memory. Acta Psychol. 2008;127:532–41.
    • (2008) Acta Psychol , vol.127 , pp. 532-541
    • Van Stegeren, A.H.1
  • 99
    • 0032969434 scopus 로고    scopus 로고
    • Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats
    • COI: 1:STN:280:DyaK1MzhsFerug%3D%3D, PID: 10383636
    • Venero C, Borrell J. Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats. Eur J Neurosci. 1999;11:2465–73.
    • (1999) Eur J Neurosci , vol.11 , pp. 2465-2473
    • Venero, C.1    Borrell, J.2
  • 100
    • 84861174168 scopus 로고    scopus 로고
    • Biological and clinical framework for posttraumatic stress disorder
    • PID: 22608629, This paper provides a comprehensive overview of the biological and clinical studies in PTSD of the time since its inclusion in DMSIII in 1980
    • Vermetten E, Lanius RA. Biological and clinical framework for posttraumatic stress disorder. Handb Clin Neurol. 2012;106:291–342. This paper provides a comprehensive overview of the biological and clinical studies in PTSD of the time since its inclusion in DMSIII in 1980.
    • (2012) Handb Clin Neurol , vol.106 , pp. 291-342
    • Vermetten, E.1    Lanius, R.A.2
  • 101
    • 84891073959 scopus 로고    scopus 로고
    • Reactivating fear memory under propranolol resets pre-trauma levels of dendritic spines in basolateral amygdala but not dorsal hippocampus neurons
    • PID: 24391566
    • Vetere G, Piserchia V, Borreca A, Novembre G, Aceti M, Ammassari-Teule M. Reactivating fear memory under propranolol resets pre-trauma levels of dendritic spines in basolateral amygdala but not dorsal hippocampus neurons. Front Behav Neurosci. 2013;7:211.
    • (2013) Front Behav Neurosci , vol.7 , pp. 211
    • Vetere, G.1    Piserchia, V.2    Borreca, A.3    Novembre, G.4    Aceti, M.5    Ammassari-Teule, M.6
  • 102
    • 0037088911 scopus 로고    scopus 로고
    • Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats
    • COI: 1:CAS:528:DC%2BD38XisVGit7g%3D, PID: 11896173
    • Walker DL, Ressler KJ, Lu KT, Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002;22:2343–23.
    • (2002) J Neurosci , vol.22
    • Walker, D.L.1    Ressler, K.J.2    Lu, K.T.3    Davis, M.4
  • 103
    • 0142136741 scopus 로고    scopus 로고
    • Dissociable stages of human memory consolidation and reconsolidation
    • COI: 1:CAS:528:DC%2BD3sXnvV2hs7w%3D, PID: 14534587
    • Walker MP, Brakefield T, Hobson JA, Stickgold R. Dissociable stages of human memory consolidation and reconsolidation. Nature. 2003;425:616–20.
    • (2003) Nature , vol.425 , pp. 616-620
    • Walker, M.P.1    Brakefield, T.2    Hobson, J.A.3    Stickgold, R.4
  • 104
    • 33644763991 scopus 로고    scopus 로고
    • Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
    • COI: 1:CAS:528:DC%2BD28XksF2ku7c%3D, PID: 16484373
    • Weaver IC, Meaney MJ, Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A. 2006;103:3480–5.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3480-3485
    • Weaver, I.C.1    Meaney, M.J.2    Szyf, M.3
  • 105
    • 70149109794 scopus 로고    scopus 로고
    • Stress and memory in humans: twelve years of progress?
    • COI: 1:CAS:528:DC%2BD1MXhtFGlsrjI, PID: 19376098
    • Wolf OT. Stress and memory in humans: twelve years of progress? Brain Res. 2009;1293:142–54.
    • (2009) Brain Res , vol.1293 , pp. 142-154
    • Wolf, O.T.1
  • 106
    • 70449413781 scopus 로고    scopus 로고
    • Status of glucocorticoid alterations in post-traumatic stress disorder
    • COI: 1:CAS:528:DC%2BD1MXhsFChtL3O, PID: 19906232
    • Yehuda R. Status of glucocorticoid alterations in post-traumatic stress disorder. Ann NY Acad Sci. 2009;1179:56–69.
    • (2009) Ann NY Acad Sci , vol.1179 , pp. 56-69
    • Yehuda, R.1
  • 107
    • 78149412794 scopus 로고    scopus 로고
    • Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice
    • COI: 1:CAS:528:DC%2BC3cXhtl2itL3O, PID: 20849967
    • Zhou M, Bakker EH, Velzing EH, Berger S, Oitzl M, Joëls M, et al. Both mineralocorticoid and glucocorticoid receptors regulate emotional memory in mice. Neurobiol Learn Mem. 2010;94:530–7.
    • (2010) Neurobiol Learn Mem , vol.94 , pp. 530-537
    • Zhou, M.1    Bakker, E.H.2    Velzing, E.H.3    Berger, S.4    Oitzl, M.5    Joëls, M.6
  • 108
    • 62449276450 scopus 로고    scopus 로고
    • Can posttraumatic stress disorder be prevented?
    • PID: 19169193
    • Zohar J, Sonnino R, Juven-Wetzler A, Cohen H. Can posttraumatic stress disorder be prevented? CNS Spectr. 2009;14:44–51.
    • (2009) CNS Spectr , vol.14 , pp. 44-51
    • Zohar, J.1    Sonnino, R.2    Juven-Wetzler, A.3    Cohen, H.4
  • 109
    • 80053386486 scopus 로고    scopus 로고
    • High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies
    • This paper called for a “window of opportunity” in the early aftermath of trauma to help those who are vulnerable to the development of chronic PTSD. Early single high-dose hydrocortisone intervention attenuated the core symptoms of both the acute stress and of subsequent PTSD in patients. High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma
    • Zohar J, Yahalom H, Kozlovsky N, Cwikel-Hamzany S, Matar MA, Kaplan Z, et al. High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: interplay between clinical and animal studies. Eur Neuropsychopharmacol. 2011;11:796–809. This paper called for a “window of opportunity” in the early aftermath of trauma to help those who are vulnerable to the development of chronic PTSD. Early single high-dose hydrocortisone intervention attenuated the core symptoms of both the acute stress and of subsequent PTSD in patients. High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.
    • (2011) Eur Neuropsychopharmacol , vol.11 , pp. 796-809
    • Zohar, J.1    Yahalom, H.2    Kozlovsky, N.3    Cwikel-Hamzany, S.4    Matar, M.A.5    Kaplan, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.