Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice

Journal of Neuroscience

Volumn 33, Issue 6, 2013, Pages 2457-2464

  Walker, John R ^a   Pacoma, Reynand ^a   Watson, James ^a   Ou, Weijia ^a   Alves, Juliano ^a   Mason, Daniel E ^a   Peters, Eric C ^a   Urbina, Hugo D ^a   Welzel, Gus ^a   Althage, Alana ^a   Liu, Bo ^a   Tuntland, Tove ^a   Jacobson, Laura H ^b   Harris, Jennifer L ^a   Schumacher, Andrew M ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN [1-40]; HYBRID PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG HALF LIFE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HISTOLOGY; LIQUID CHROMATOGRAPHY; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEPRILYSIN; PROTEOLYSIS;

EID: 84873314921     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3407-12.2013     Document Type: Article

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