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Volumn 5, Issue , 2015, Pages

Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: An implication of synergy

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; MESSENGER RNA; METFORMIN;

EID: 84939825859     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13390     Document Type: Article
Times cited : (36)

References (59)
  • 2
    • 84898853705 scopus 로고    scopus 로고
    • Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment
    • Yue, W., Yang, C. S., DiPaola, R. S. & Tan, X. L. Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment. Cancer Prev Res (Phila) 7, 388-97 (2014).
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 388-397
    • Yue, W.1    Yang, C.S.2    DiPaola, R.S.3    Tan, X.L.4
  • 3
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108, 1167-74 (2001).
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1
  • 4
    • 77955287742 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
    • Kalender, A. et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 11, 390-401 (2010).
    • (2010) Cell Metab , vol.11 , pp. 390-401
    • Kalender, A.1
  • 5
    • 84884211823 scopus 로고    scopus 로고
    • Targeting metabolism for cancer treatment and prevention: Metformin, an old drug with multi-faceted effects
    • Pierotti, M. A. et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene 32, 1475-87 (2013).
    • (2013) Oncogene , vol.32 , pp. 1475-1487
    • Pierotti, M.A.1
  • 6
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • Hirsch, H. A., Iliopoulos, D. & Struhl, K. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc Natl Acad Sci USA 110, 972-7 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 972-977
    • Hirsch, H.A.1    Iliopoulos, D.2    Struhl, K.3
  • 7
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N. & Struhl, K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 69, 7507-11 (2009).
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 8
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley, S. A. et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336, 918-22 (2012).
    • (2012) Science , vol.336 , pp. 918-922
    • Hawley, S.A.1
  • 9
    • 84861648941 scopus 로고    scopus 로고
    • Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
    • e3
    • Din, F. V. et al. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 142, 1504-15 e3 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1504-15
    • Din, F.V.1
  • 10
    • 84904111180 scopus 로고    scopus 로고
    • Molecular targets of aspirin and cancer prevention
    • Alfonso, L., Ai, G., Spitale, R. C. & Bhat, G. J. Molecular targets of aspirin and cancer prevention. Br J Cancer 111, 61-7 (2014).
    • (2014) Br J Cancer , vol.111 , pp. 61-67
    • Alfonso, L.1    Ai, G.2    Spitale, R.C.3    Bhat, G.J.4
  • 11
    • 67949089533 scopus 로고    scopus 로고
    • Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells
    • Kim, S. R. et al. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun 387, 342-7 (2009).
    • (2009) Biochem Biophys Res Commun , vol.387 , pp. 342-347
    • Kim, S.R.1
  • 12
    • 84862908866 scopus 로고    scopus 로고
    • Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers
    • Deng, X. S. et al. Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers. Cell Cycle 11, 367-76 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 367-376
    • Deng, X.S.1
  • 13
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang, Z., Gerstein, M. & Snyder, M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10, 57-63 (2009).
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 14
    • 84939860188 scopus 로고    scopus 로고
    • Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
    • [Epub ahead of print]
    • Yue, W. et al. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget (2015) [Epub ahead of print].
    • (2015) Oncotarget
    • Yue, W.1
  • 16
    • 79955615667 scopus 로고    scopus 로고
    • Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situations
    • Lalau, J. D., Lemaire-Hurtel, A. S. & Lacroix, C. Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situations. Clin Drug Investig 31, 435-8 (2011).
    • (2011) Clin Drug Investig , vol.31 , pp. 435-438
    • Lalau, J.D.1    Lemaire-Hurtel, A.S.2    Lacroix, C.3
  • 17
    • 0028158709 scopus 로고
    • Accumulation of metformin by tissues of the normal and diabetic mouse
    • Wilcock, C. & Bailey, C. J. Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 24, 49-57 (1994).
    • (1994) Xenobiotica , vol.24 , pp. 49-57
    • Wilcock, C.1    Bailey, C.J.2
  • 18
    • 33746888993 scopus 로고    scopus 로고
    • Mitochondriotoxic compounds for cancer therapy
    • Fantin, V. R. & Leder, P. Mitochondriotoxic compounds for cancer therapy. Oncogene 25, 4787-97 (2006).
    • (2006) Oncogene , vol.25 , pp. 4787-4797
    • Fantin, V.R.1    Leder, P.2
  • 19
    • 84899620988 scopus 로고    scopus 로고
    • ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis
    • Okochi-Takada, E. et al. ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis. Oncogene 33, 2273-8 (2014).
    • (2014) Oncogene , vol.33 , pp. 2273-2278
    • Okochi-Takada, E.1
  • 20
    • 84906836551 scopus 로고    scopus 로고
    • Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma
    • Ng, K. T. et al. Clinical relevance and therapeutic potential of angiopoietin-like protein 4 in hepatocellular carcinoma. Mol Cancer 13, 196 (2014).
    • (2014) Mol Cancer , vol.13 , pp. 196
    • Ng, K.T.1
  • 21
    • 84858161646 scopus 로고    scopus 로고
    • Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice
    • Mizutani, N. et al. Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. Exp Clin Endocrinol Diabetes 120, 139-44 (2012).
    • (2012) Exp Clin Endocrinol Diabetes , vol.120 , pp. 139-144
    • Mizutani, N.1
  • 22
    • 84894574242 scopus 로고    scopus 로고
    • RET revisited: Expanding the oncogenic portfolio
    • Mulligan, L. M. RET revisited: expanding the oncogenic portfolio. Nat Rev Cancer 14, 173-86 (2014).
    • (2014) Nat Rev Cancer , vol.14 , pp. 173-186
    • Mulligan, L.M.1
  • 23
    • 84889011636 scopus 로고    scopus 로고
    • Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
    • Nair, V. et al. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis 34, 2870-9 (2013).
    • (2013) Carcinogenesis , vol.34 , pp. 2870-2879
    • Nair, V.1
  • 24
    • 84907495391 scopus 로고    scopus 로고
    • Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: Role of specificity protein (Sp) transcription factors
    • Nair, V. et al. Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. J Biol Chem 289, 27692-701 (2014).
    • (2014) J Biol Chem , vol.289 , pp. 27692-27701
    • Nair, V.1
  • 25
    • 0035974877 scopus 로고    scopus 로고
    • MEN2A-RET-induced cellular transformation by activation of STAT3
    • Schuringa, J. J. et al. MEN2A-RET-induced cellular transformation by activation of STAT3. Oncogene 20, 5350-8 (2001).
    • (2001) Oncogene , vol.20 , pp. 5350-5358
    • Schuringa, J.J.1
  • 26
    • 84908021084 scopus 로고    scopus 로고
    • Inflammatory chemokines and metastasis-tracing the accessory
    • Borsig, L., Wolf, M. J., Roblek, M., Lorentzen, A. & Heikenwalder, M. Inflammatory chemokines and metastasis-tracing the accessory. Oncogene 33, 3217-24 (2014).
    • (2014) Oncogene , vol.33 , pp. 3217-3224
    • Borsig, L.1    Wolf, M.J.2    Roblek, M.3    Lorentzen, A.4    Heikenwalder, M.5
  • 27
    • 84879850236 scopus 로고    scopus 로고
    • Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: A role for targeting the CCL2/CCR2 axis
    • Sanford, D. E. et al. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis. Clin Cancer Res 19, 3404-15 (2013).
    • (2013) Clin Cancer Res , vol.19 , pp. 3404-3415
    • Sanford, D.E.1
  • 28
    • 84855568783 scopus 로고    scopus 로고
    • Tumor cells and tumor-associated macrophages: Secreted proteins as potential targets for therapy
    • Baay, M., Brouwer, A., Pauwels, P., Peeters, M. & Lardon, F. Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy. Clin Dev Immunol 2011, 565187 (2011).
    • (2011) Clin Dev Immunol , vol.2011 , pp. 565187
    • Baay, M.1    Brouwer, A.2    Pauwels, P.3    Peeters, M.4    Lardon, F.5
  • 29
    • 84872369042 scopus 로고    scopus 로고
    • Recruitment of monocytes/macrophages in different tumor microenvironments
    • Lee, H. W., Choi, H. J., Ha, S. J., Lee, K. T. & Kwon, Y. G. Recruitment of monocytes/macrophages in different tumor microenvironments. Biochim Biophys Acta 1835, 170-9 (2013).
    • (2013) Biochim Biophys Acta , vol.1835 , pp. 170-179
    • Lee, H.W.1    Choi, H.J.2    Ha, S.J.3    Lee, K.T.4    Kwon, Y.G.5
  • 30
    • 77955464738 scopus 로고    scopus 로고
    • Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
    • Baldwin, A. et al. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3. Proc Natl Acad Sci USA 107, 12463-8 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12463-12468
    • Baldwin, A.1
  • 31
    • 33645735705 scopus 로고    scopus 로고
    • Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis
    • Tanaka, S. et al. Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis. J Natl Cancer Inst 98, 491-8 (2006).
    • (2006) J Natl Cancer Inst , vol.98 , pp. 491-498
    • Tanaka, S.1
  • 32
    • 84897987462 scopus 로고    scopus 로고
    • Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
    • Oliveras-Ferraros, C. et al. Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile. Cell Cycle 13, 1132-44 (2014).
    • (2014) Cell Cycle , vol.13 , pp. 1132-1144
    • Oliveras-Ferraros, C.1
  • 33
    • 34447297824 scopus 로고    scopus 로고
    • Loss of WISP-2/CCN5 signaling in human pancreatic cancer: A potential mechanism for epithelial-mesenchymaltransition
    • Dhar, G. et al. Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymaltransition. Cancer Lett 254, 63-70 (2007).
    • (2007) Cancer Lett , vol.254 , pp. 63-70
    • Dhar, G.1
  • 34
    • 84921775573 scopus 로고    scopus 로고
    • Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer
    • Yang, Z. et al. Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer. Mol Cancer Res 13, 107-19 (2015).
    • (2015) Mol Cancer Res , vol.13 , pp. 107-119
    • Yang, Z.1
  • 35
    • 57049086869 scopus 로고    scopus 로고
    • Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer
    • Ma, J., Jiang, Y., Jiang, Y., Sun, Y. & Zhao, X. Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer. J Gastroenterol Hepatol 23, 1852-9 (2008).
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1852-1859
    • Ma, J.1    Jiang, Y.2    Jiang, Y.3    Sun, Y.4    Zhao, X.5
  • 36
    • 67549142835 scopus 로고    scopus 로고
    • Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours
    • Wang, W. et al. Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours. Eur J Surg Oncol 35, 826-32 (2009).
    • (2009) Eur J Surg Oncol , vol.35 , pp. 826-832
    • Wang, W.1
  • 37
    • 4644284196 scopus 로고    scopus 로고
    • Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
    • Hagihara, A. et al. Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers. Oncogene 23, 8705-10 (2004).
    • (2004) Oncogene , vol.23 , pp. 8705-8710
    • Hagihara, A.1
  • 38
    • 80052174886 scopus 로고    scopus 로고
    • Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    • Mori, Y. et al. Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning. Endocr Relat Cancer 18, 465-78 (2011).
    • (2011) Endocr Relat Cancer , vol.18 , pp. 465-478
    • Mori, Y.1
  • 39
    • 79957612244 scopus 로고    scopus 로고
    • Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner
    • He, K., Jang, S. W., Joshi, J., Yoo, M. H. & Ye, K. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. Mol Biol Cell 22, 1943-54 (2011).
    • (2011) Mol Biol Cell , vol.22 , pp. 1943-1954
    • He, K.1    Jang, S.W.2    Joshi, J.3    Yoo, M.H.4    Ye, K.5
  • 40
    • 84881475232 scopus 로고    scopus 로고
    • Clinical significance of UNC5B expression in bladder cancer
    • Liu, J., Zhang, Z., Li, Z. H. & Kong, C. Z. Clinical significance of UNC5B expression in bladder cancer. Tumour Biol 34, 2099-108 (2013).
    • (2013) Tumour Biol , vol.34 , pp. 2099-2108
    • Liu, J.1    Zhang, Z.2    Li, Z.H.3    Kong, C.Z.4
  • 41
    • 84455163052 scopus 로고    scopus 로고
    • Clinical significance of UNC5B expression in colorectal cancer
    • Okazaki, S. et al. Clinical significance of UNC5B expression in colorectal cancer. Int J Oncol 40, 209-16 (2012).
    • (2012) Int J Oncol , vol.40 , pp. 209-216
    • Okazaki, S.1
  • 42
    • 0020529342 scopus 로고
    • Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase
    • Roth, G. J., Machuga, E. T. & Ozols, J. Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase. Biochemistry 22, 4672-5 (1983).
    • (1983) Biochemistry , vol.22 , pp. 4672-4675
    • Roth, G.J.1    Machuga, E.T.2    Ozols, J.3
  • 43
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Vane, J. R. & Botting, R. M. The mechanism of action of aspirin. Thromb Res 110, 255-8 (2003).
    • (2003) Thromb Res , vol.110 , pp. 255-258
    • Vane, J.R.1    Botting, R.M.2
  • 44
    • 64549161198 scopus 로고    scopus 로고
    • Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells
    • Alfonso, L. F. et al. Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells. Int J Oncol 34, 597-608 (2009).
    • (2009) Int J Oncol , vol.34 , pp. 597-608
    • Alfonso, L.F.1
  • 45
    • 80053205123 scopus 로고    scopus 로고
    • Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets
    • Marimuthu, S. et al. Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets. Int J Oncol 39, 1273-83 (2011).
    • (2011) Int J Oncol , vol.39 , pp. 1273-1283
    • Marimuthu, S.1
  • 46
    • 84871862076 scopus 로고    scopus 로고
    • Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1alpha genes
    • Kamble, P., Selvarajan, K., Aluganti Narasimhulu, C., Nandave, M. & Parthasarathy, S. Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1alpha genes. Eur J Pharmacol 699, 55-61 (2013).
    • (2013) Eur J Pharmacol , vol.699 , pp. 55-61
    • Kamble, P.1    Selvarajan, K.2    Aluganti Narasimhulu, C.3    Nandave, M.4    Parthasarathy, S.5
  • 47
    • 84933044342 scopus 로고    scopus 로고
    • Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration
    • Passacquale, G. et al. Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration. Br J Pharmacol 172, 3548-64 (2015).
    • (2015) Br J Pharmacol , vol.172 , pp. 3548-3564
    • Passacquale, G.1
  • 48
    • 84939802864 scopus 로고    scopus 로고
    • Effects of acetylsalicylic acid and salicylic acid on the growth of HT. 3 cervical cancer cell line
    • Ibrahim Mohammed, A. M. T. Rilwanu Isah Tsamiya. Effects of acetylsalicylic acid and salicylic acid on the growth of HT3 cervical cancer cell line. American Journal of Pharmacy and Pharmacology 1, 32-44 (2014).
    • (2014) American Journal of Pharmacy and Pharmacology , vol.1 , pp. 32-44
    • Mohammed, I.1    Rilwanu Isah Tsamiya, A.M.T.2
  • 50
    • 84892170909 scopus 로고    scopus 로고
    • Molecular pathways: Sterols and receptor signaling in cancer
    • Gabitova, L., Gorin, A. & Astsaturov, I. Molecular pathways: sterols and receptor signaling in cancer. Clin Cancer Res 20, 28-34 (2014).
    • (2014) Clin Cancer Res , vol.20 , pp. 28-34
    • Gabitova, L.1    Gorin, A.2    Astsaturov, I.3
  • 52
    • 77953589054 scopus 로고    scopus 로고
    • Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
    • Algire, C., Amrein, L., Zakikhani, M., Panasci, L. & Pollak, M. Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocr Relat Cancer 17, 351-60 (2010).
    • (2010) Endocr Relat Cancer , vol.17 , pp. 351-360
    • Algire, C.1    Amrein, L.2    Zakikhani, M.3    Panasci, L.4    Pollak, M.5
  • 53
    • 84864072013 scopus 로고    scopus 로고
    • Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis
    • Bhalla, K. et al. Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis. Cancer Prev Res (Phila) 5, 544-52 (2012).
    • (2012) Cancer Prev Res (Phila) , vol.5 , pp. 544-552
    • Bhalla, K.1
  • 54
    • 84884596941 scopus 로고    scopus 로고
    • Metformin inhibits macrophage cholesterol biosynthesis rate: Possible role for metformin-induced oxidative stress
    • Koren-Gluzer, M., Aviram, M. & Hayek, T. Metformin inhibits macrophage cholesterol biosynthesis rate: possible role for metformin-induced oxidative stress. Biochem Biophys Res Commun 439, 396-400 (2013).
    • (2013) Biochem Biophys Res Commun , vol.439 , pp. 396-400
    • Koren-Gluzer, M.1    Aviram, M.2    Hayek, T.3
  • 56
    • 79952027445 scopus 로고    scopus 로고
    • Novel roles for Slits and netrins: Axon guidance cues as anticancer targets?
    • Mehlen, P., Delloye-Bourgeois, C. & Chedotal, A. Novel roles for Slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer 11, 188-97 (2011).
    • (2011) Nat Rev Cancer , vol.11 , pp. 188-197
    • Mehlen, P.1    Delloye-Bourgeois, C.2    Chedotal, A.3
  • 57
    • 84875626156 scopus 로고    scopus 로고
    • Semaphorins in cancer: Biological mechanisms and therapeutic approaches
    • Rehman, M. & Tamagnone, L. Semaphorins in cancer: biological mechanisms and therapeutic approaches. Semin Cell Dev Biol 24, 179-89 (2013).
    • (2013) Semin Cell Dev Biol , vol.24 , pp. 179-189
    • Rehman, M.1    Tamagnone, L.2
  • 58
    • 84877138671 scopus 로고    scopus 로고
    • The role of semaphorins and their receptors in vascular development and cancer
    • Gu, C. & Giraudo, E. The role of semaphorins and their receptors in vascular development and cancer. Exp Cell Res 319, 1306-16 (2013).
    • (2013) Exp Cell Res , vol.319 , pp. 1306-1316
    • Gu, C.1    Giraudo, E.2
  • 59
    • 68449101067 scopus 로고    scopus 로고
    • Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
    • Durinck, S., Spellman, P. T., Birney, E. & Huber, W. Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt. Nat Protoc 4, 1184-91 (2009).
    • (2009) Nat Protoc , vol.4 , pp. 1184-1191
    • Durinck, S.1    Spellman, P.T.2    Birney, E.3    Huber, W.4


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