-
1
-
-
34548609993
-
Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus
-
Bolen,S. et al. (2007) Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann. Intern. Med., 147, 386-399.
-
(2007)
Ann. Intern. Med.
, vol.147
, pp. 386-399
-
-
Bolen, S.1
-
2
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou,G. et al. (2001) Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest., 108, 1167-1174.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
-
3
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Diabetes Prevention Program Research Group
-
Knowler,W.C. et al.; Diabetes Prevention Program Research Group. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med., 346, 393-403.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 393-403
-
-
Knowler, W.C.1
-
4
-
-
34247185346
-
Methyl succinate antagonises biguanideinduced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer
-
Hinke,S.A. et al. (2007) Methyl succinate antagonises biguanideinduced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer. Br. J. Pharmacol., 150, 1031-1043.
-
(2007)
Br. J. Pharmacol.
, vol.150
, pp. 1031-1043
-
-
Hinke, S.A.1
-
5
-
-
77954933558
-
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
-
Foretz,M. et al. (2010) Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J. Clin. Invest., 120, 2355-2369.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2355-2369
-
-
Foretz, M.1
-
6
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta,S. et al. (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell, 40, 310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
-
7
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Düvel,K. et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell, 39, 171-183.
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
-
8
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw,R.J. et al. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science, 310, 1642-1646.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
-
9
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans,J.M. et al. (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ, 330, 1304-1305.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
-
10
-
-
69549097703
-
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
-
Libby,G. et al. (2009) New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care, 32, 1620-1625.
-
(2009)
Diabetes Care
, vol.32
, pp. 1620-1625
-
-
Libby, G.1
-
11
-
-
53749089278
-
Antidiabetic medication and prostate cancer risk: a population-based case-control study
-
Murtola,T.J. et al. (2008) Antidiabetic medication and prostate cancer risk: a population-based case-control study. Am. J. Epidemiol., 168, 925-931.
-
(2008)
Am. J. Epidemiol.
, vol.168
, pp. 925-931
-
-
Murtola, T.J.1
-
12
-
-
70350583054
-
Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study
-
Wright,J.L. et al. (2009) Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study. Canc. Causes Contr., 20, 1617-1622.
-
(2009)
Canc. Causes Contr.
, vol.20
, pp. 1617-1622
-
-
Wright, J.L.1
-
13
-
-
67749144226
-
Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
-
Jiralerspong,S. et al. (2009) Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J. Clin. Oncol., 27, 3297-3302.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3297-3302
-
-
Jiralerspong, S.1
-
14
-
-
67650945180
-
Antidiabetic therapies affect risk of pancreatic cancer
-
Li,D. et al. (2009) Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology, 137, 482-488.
-
(2009)
Gastroenterology
, vol.137
, pp. 482-488
-
-
Li, D.1
-
15
-
-
77953846828
-
Diabetes and cancer: a consensus report
-
Giovannucci,E. et al. (2010) Diabetes and cancer: a consensus report. CA. Cancer J. Clin., 60, 207-221.
-
(2010)
CA. Cancer J. Clin.
, vol.60
, pp. 207-221
-
-
Giovannucci, E.1
-
16
-
-
77956414137
-
Chemoprevention meets glucose control
-
Engelman,J.A. et al. (2010) Chemoprevention meets glucose control. Cancer Prev. Res. (Phila)., 3, 1049-1052.
-
(2010)
Cancer Prev. Res. (Phila).
, vol.3
, pp. 1049-1052
-
-
Engelman, J.A.1
-
17
-
-
77956401999
-
Metformin and other biguanides in oncology: advancing the research agenda
-
Pollak,M. (2010) Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev. Res. (Phila)., 3, 1060-1065.
-
(2010)
Cancer Prev. Res. (Phila).
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
18
-
-
77952116629
-
Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
-
Ben Sahra,I. et al. (2010) Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol. Cancer Ther., 9, 1092-1099.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 1092-1099
-
-
Ben Sahra, I.1
-
19
-
-
44849099894
-
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
-
Ben Sahra,I. et al. (2008) The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene, 27, 3576-3586.
-
(2008)
Oncogene
, vol.27
, pp. 3576-3586
-
-
Ben Sahra, I.1
-
20
-
-
79957438835
-
Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins
-
Yasmeen,A. et al. (2011) Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins. Gynecol. Oncol., 121, 492-498.
-
(2011)
Gynecol. Oncol.
, vol.121
, pp. 492-498
-
-
Yasmeen, A.1
-
21
-
-
79955980904
-
Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells
-
Zhuang,Y. et al. (2011) Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells. Mol. Cancer Res., 9, 603-615.
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 603-615
-
-
Zhuang, Y.1
-
22
-
-
47249088612
-
In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
-
Gotlieb,W.H. et al. (2008) In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. Gynecol. Oncol., 110, 246-250.
-
(2008)
Gynecol. Oncol.
, vol.110
, pp. 246-250
-
-
Gotlieb, W.H.1
-
23
-
-
79551489371
-
Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
-
Kim,H.G. et al. (2011) Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation. Br. J. Pharmacol., 162, 1096-1108.
-
(2011)
Br. J. Pharmacol.
, vol.162
, pp. 1096-1108
-
-
Kim, H.G.1
-
24
-
-
79952290187
-
Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells
-
Tan,B.K. et al. (2011) Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells. J. Clin. Endocrinol. Metab., 96, 808-816.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, pp. 808-816
-
-
Tan, B.K.1
-
25
-
-
33745226490
-
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation
-
Abdelrahim,M. et al. (2006) Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. J. Natl Cancer Inst., 98, 855-868.
-
(2006)
J. Natl Cancer Inst.
, vol.98
, pp. 855-868
-
-
Abdelrahim, M.1
-
26
-
-
34047261665
-
Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
-
Chintharlapalli,S. et al. (2007) Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res., 67, 2816-2823.
-
(2007)
Cancer Res.
, vol.67
, pp. 2816-2823
-
-
Chintharlapalli, S.1
-
27
-
-
79951831653
-
GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway
-
Pathi,S.S. et al. (2011) GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Mol. Cancer Res., 9, 195-202.
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 195-202
-
-
Pathi, S.S.1
-
28
-
-
84857355139
-
Identification of oncogenic microRNA-17-92/ZBTB4/ specificity protein axis in breast cancer
-
Kim,K. et al. (2012) Identification of oncogenic microRNA-17-92/ZBTB4/ specificity protein axis in breast cancer. Oncogene, 31, 1034-1044.
-
(2012)
Oncogene
, vol.31
, pp. 1034-1044
-
-
Kim, K.1
-
29
-
-
36349001297
-
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells
-
Mertens-Talcott,S.U. et al. (2007) The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res., 67, 11001-11011.
-
(2007)
Cancer Res.
, vol.67
, pp. 11001-11011
-
-
Mertens-Talcott, S.U.1
-
30
-
-
77953812438
-
Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth
-
Jutooru I.,et al. (2010) Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp. Cell Res., 316, 2174-2188.
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 2174-2188
-
-
Jutooru, I.1
-
31
-
-
48549085442
-
Curcumin decreases specificity protein expression in bladder cancer cells
-
Chadalapaka,G. et al. (2008) Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res., 68, 5345-5354.
-
(2008)
Cancer Res.
, vol.68
, pp. 5345-5354
-
-
Chadalapaka, G.1
-
32
-
-
77955506109
-
Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation
-
Jutooru,I. et al. (2010) Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation. J. Biol. Chem., 285, 25332-25344.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 25332-25344
-
-
Jutooru, I.1
-
33
-
-
77954934314
-
Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a
-
Jutooru,I. et al. (2010) Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Mol. Pharmacol., 78, 226-236.
-
(2010)
Mol. Pharmacol.
, vol.78
, pp. 226-236
-
-
Jutooru, I.1
-
34
-
-
4644274880
-
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells
-
Abdelrahim,M. et al. (2004) Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Res., 64, 6740-6749.
-
(2004)
Cancer Res.
, vol.64
, pp. 6740-6749
-
-
Abdelrahim, M.1
-
35
-
-
34248160592
-
Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells
-
Abdelrahim,M. et al. (2007) Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res., 67, 3286-3294.
-
(2007)
Cancer Res.
, vol.67
, pp. 3286-3294
-
-
Abdelrahim, M.1
-
36
-
-
23044452436
-
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins
-
Abdelrahim,M. et al. (2005) Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Mol. Pharmacol., 68, 317-329.
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 317-329
-
-
Abdelrahim, M.1
-
37
-
-
73549120404
-
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
-
Lu,S. et al. (2010) Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. Int. J. Cancer, 126, 416-425.
-
(2010)
Int. J. Cancer
, vol.126
, pp. 416-425
-
-
Lu, S.1
-
38
-
-
45849120181
-
Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process
-
Wang,Y.T. et al. (2008) Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process. J. Mol. Biol., 380, 869-885.
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 869-885
-
-
Wang, Y.T.1
-
39
-
-
67649866042
-
Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeatcontaining protein
-
Wei,S. et al. (2009) Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeatcontaining protein. Mol. Pharmacol., 76, 47-57.
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 47-57
-
-
Wei, S.1
-
40
-
-
34447330714
-
Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
-
Nonn,L. et al. (2007) Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis, 28, 1188-1196.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1188-1196
-
-
Nonn, L.1
-
41
-
-
62849099510
-
Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells
-
Jan,H.J. et al. (2009) Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells. Cancer Lett., 277, 141-148.
-
(2009)
Cancer Lett.
, vol.277
, pp. 141-148
-
-
Jan, H.J.1
-
42
-
-
83355169738
-
Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/ DUSP1)
-
Chen,C.C. et al. (2011) Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1/ DUSP1). J. Biol. Chem., 286, 43091-43102.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43091-43102
-
-
Chen, C.C.1
-
43
-
-
69249162223
-
Metformin disrupts crosstalk between G proteincoupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
-
Kisfalvi,K. et al. (2009) Metformin disrupts crosstalk between G proteincoupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth. Cancer Res., 69, 6539-6545.
-
(2009)
Cancer Res.
, vol.69
, pp. 6539-6545
-
-
Kisfalvi, K.1
-
44
-
-
84855792427
-
Cancer statistics, 2012
-
Siegel,R. et al. (2012) Cancer statistics, 2012. CA. Cancer J. Clin., 62, 10-29.
-
(2012)
CA. Cancer J. Clin.
, vol.62
, pp. 10-29
-
-
Siegel, R.1
|