Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner

Molecular Biology of the Cell

Volumn 22, Issue 11, 2011, Pages 1943-1954

  He, Kunyan ^a   Jang, Sung Wuk ^a   Joshi, Jayashree ^a   Yoo, Min Heui ^a   Ye, Keqiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GUANOSINE TRIPHOSPHATASE; NETRIN 1; PHOSPHATIDYLINOSITOL 3 KINASE ENHACER A; PROTEIN KINASE B; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNC5B PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN HEK293; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; GLIOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; MICE; NERVE GROWTH FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 79957612244     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-11-0923     Document Type: Article

References (29)

1. Ahn JY, Hu Y, Kroll TG, Allard P, Ye K (2004a). PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci USA 101, 6993-6998. (Pubitemid 38596431)
2. Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K (2004b). PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem 279, 16441-16451. (Pubitemid 38509342)
3. Arakawa H (2004). Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 4, 978-987.
4. Bernet A, Mazelin L, Coissieux MM, Gadot N, Ackerman SL, Scoazec JY, Mehlen P (2007). Inactivation of the UNC5C netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 133, 1840-1848. (Pubitemid 350186160)
5. Brooks CL, Li M, Gu W (2007). Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation. J Biol Chem 282, 22804-22815. (Pubitemid 47267318)
6. Cai Y, Wang J, Li R, Ayala G, Ittmann M, Liu M (2009). GGAP2/PIKE-A directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression. Cancer Res 69, 819-827.
7. Chan CB, Ye K (2007). PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. J Cell Mol Med 11, 39-53. (Pubitemid 46439624)
8. Grady WM (2007). Making the case for DCC and UNC5C as tumor-suppressor genes in the colon. Gastroenterology 133, 2045-2049.
9. Liu X, Hu Y, Hao C, Rempel SA, Ye K (2007). PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. Oncogene 26, 4918-4927. (Pubitemid 47172641)
10. Liu X, Yue P, Khuri FR, Sun SY (2004). p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res 64, 5078-5083. (Pubitemid 39006522)
11. Llambi F, Causeret F, Bloch-Gallego E, Mehlen P (2001). Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20, 2715-2722. (Pubitemid 32938556)
12. Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P (2005). The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J 24, 1192-1201. (Pubitemid 40516602)
13. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P (2004). Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431, 80-84. (Pubitemid 39215111)
14. Muller M, Schleithoff ES, Stremmel W, Melino G, Krammer PH, Schilling T (2006). One, two, three-p53, p63, p73 and chemosensitivity. Drug Resist Updat 9, 288-306.
15. Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y (2002). Akt enhances MDM2-mediated ubiquitination and degradation of p53. J Biol Chem 277, 21843-21850. (Pubitemid 34952337)
16. Rong R, Ahn JY, Huang H, Nagata E, Kalman D, Kapp JA, Tu J, Worley PF, Snyder SH, Ye K (2003). PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci 6, 1153-1161. (Pubitemid 37346035)
17. Roperch JP, El Ouadrani K, Hendrix A, Emami S, De Wever O, Melino G, Gespach C (2008). Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. Cancer Res 68, 8231-8239.
18. Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M (1996). Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014. (Pubitemid 26427984)
19. Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M (1994). The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424. (Pubitemid 24250806)
20. Tang X et al. (2008). Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B. Nat Cell Biol 10, 698-706. (Pubitemid 351772935)
21. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (2003). p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 5, 216-223. (Pubitemid 36322248)
22. Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P (2003). The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 100, 4173-4178. (Pubitemid 36418176)
23. Vogelstein B, Lane D, Levine AJ (2000). Surfing the p53 network. Nature 408, 307-310.
24. Vousden KH, Woude GF (2000). The ins and outs of p53. Nat Cell Biol 2, E178-180.
25. Wee KB, Aguda BD (2006). Akt versus p53 in a network of oncogenes and tumor suppressor genes regulating cell survival and death. Biophys J 91, 857-865.
26. Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SH (2002). Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415, 541-544. (Pubitemid 34130610)
27. Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH (2000). PIKE. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103, 919-930.
28. Yin Y, Stephen CW, Luciani MG, Fahraeus R (2002). p53 stability and activity is regulated by MDM2-mediated induction of alternative p53 translation products. Nat Cell Biol 4, 462-467. (Pubitemid 34746166)
29. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC (2001). HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3, 973-982. (Pubitemid 34428742)