An Early Folding Contact between Phe19 and Leu34 is Critical for Amyloid-β Oligomer Toxicity

ACS Chemical Neuroscience

Volumn 6, Issue 8, 2015, Pages 1290-1295

  Das, Anand K ^a   Rawat, Anoop ^a   Bhowmik, Debanjan ^a   Pandit, Rucha ^a   Huster, Daniel ^b   Maiti, Sudipta ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alzheimer therapeutics; folding landscape; membrane affinity; neurodegeneration; Protein aggregation; small oligomers

Indexed keywords

AMYLOID BETA PROTEIN; LEUCINE; OLIGOMER; PHENYLALANINE; 1-PALMITOYL-2-OLEOYLGLYCERO-3-PHOSPHOGLYCEROL; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; AMYLOID BETA PROTEIN[1-40]; ARTIFICIAL MEMBRANE; LIPOSOME; PEPTIDE FRAGMENT; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CELL; CELL VIABILITY; CONTROLLED STUDY; GENE MUTATION; HYDROGEN BOND; HYDROPHOBICITY; LIPID MEMBRANE; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; RAT; TOXICITY; ANIMAL; ARTIFICIAL MEMBRANE; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; GENETICS; MUTATION; NERVE CELL; PHYSIOLOGY; WISTAR RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; MEMBRANES, ARTIFICIAL; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PROTEIN FOLDING; RATS, WISTAR; UNILAMELLAR LIPOSOMES;

EID: 84939824933     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00074     Document Type: Article

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