Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein

Journal of Biological Chemistry

Volumn 289, Issue 45, 2014, Pages 30990-31000

  Maloney, Janice A ^a   Bainbridge, Travis ^a   Gustafson, Amy ^a   Zhang, Shuo ^a   Kyauk, Roxanne ^a   Steiner, Pascal ^a   Van Der Brug, Marcel ^a   Liu, Yichin ^a   Ernst, James A ^a   Watts, Ryan J ^a   Atwal, Jasvinder K ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENES; GLYCOPROTEINS; NEURODEGENERATIVE DISEASES; STEM CELLS;

AGGREGATION KINETICS; AMYLOID PRECURSOR PROTEINS; CATALYTIC TURNOVER; HUMAN-INDUCED PLURIPOTENT STEM CELLS; MOLECULAR MECHANISM; PATHOGENIC MUTATION; PEPTIDE CLEAVAGES; RECOGNITION SEQUENCE;

PEPTIDES;

ALANINE; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; THREONINE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; COMPLEMENTARY DNA; PEPTIDE FRAGMENT; PROTEIN BINDING; SECRETASE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOTINYLATION; CATALYSIS; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME KINETICS; GENE FREQUENCY; HUMAN; HUMAN CELL; IMMUNOASSAY; MOLECULAR DYNAMICS; MORPHOLOGY; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ANIMAL; C57BL MOUSE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; HEK293 CELL LINE; HETEROZYGOTE; IC50; KINETICS; METABOLISM; MICROGLIA; MUTATION; NERVE CELL;

ALLELES; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CATALYSIS; DNA, COMPLEMENTARY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELLS; HETEROZYGOTE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MICE, INBRED C57BL; MICROGLIA; MUTATION; NEURONS; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 84909583532     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.589069     Document Type: Article

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