Type 2 diabetes in East Asians: Similarities and differences with populations in Europe and the United States

Annals of the New York Academy of Sciences

Volumn 1281, Issue 1, 2013, Pages 64-91

  Ma, Ronald C W ^a   Chan, Juliana C N ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chinese; Diabetic complications; East Asians; Genetics; Gestational diabetes; Japanese; Koreans; Pathophysiology; Type 2 diabetes; Visceral adiposity; cell function

Indexed keywords

AMYLIN; AMYLOID; ANTIDIABETIC AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLITAZONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LOSARTAN; METFORMIN; PIOGLITAZONE; SULFONYLUREA DERIVATIVE;

ABDOMINAL OBESITY; ARTICLE; ASIA; ASIAN; AUTOIMMUNITY; BODY MASS; CELL FUNCTION; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; COST OF ILLNESS; CROSS-SECTIONAL STUDY; DIABETIC PATIENT; ENVIRONMENTAL FACTOR; FOOD INTAKE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GEOGRAPHIC DISTRIBUTION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEALTH CARE SYSTEM; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PATIENT EDUCATION; PREGNANCY DIABETES MELLITUS; PREVALENCE; SEX DIFFERENCE; SLEEP DEPRIVATION; SLEEP DISORDERED BREATHING; URBAN AREA;

EID: 84875641584     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12098     Document Type: Article

References (231)

1. International Diabetes Federation. 2011. Diabetes Atlas. 5th ed. Belgium: IDF.
2. Yoon, K.H., J.H. Lee, J.W. Kim, et al. 2006. Epidemic obesity and type 2 diabetes in Asia. Lancet 368: 1681-1688.
3. Chan, J.C., V. Malik, W. Jia, et al. 2009. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 301: 2129-2140.
4. Ramachandran, A., R.C. Ma & C. Snehalatha. 2010. Diabetes in Asia. Lancet 375: 408-418.
5. Ma, R.C. & P.C. Tong. 2010. "Epidemiology of type 2 diabetes." In: Textbook of Diabetes 4th ed. R. Holt, B. Goldstein, A. Flyvbjerg, C.S. Cockram, Eds.: 45-68. New York: Wiley-Blackwell.
6. Yang, W., J. Lu, J. Weng, et al. 2010. Prevalence of diabetes among men and women in China. N. Engl. J. Med. 362: 1090-1101.
7. Li, H., B. Oldenburg, C. Chamberlain, et al. 2012. Diabetes prevalence and determinants in adults in China mainland from 2000 to 2010: a systematic review. Diabetes Res. Clin. Pract. 98: 226-235.
8. Wong, K.C. & Z. Wang. 2006. Prevalence of type 2 diabetes mellitus of Chinese populations in Mainland China, Hong Kong, and Taiwan. Diabetes Res. Clin. Pract. 73: 126-134.
9. Centers for Disease Control and Prevention. 2011. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes in the United States, 2011. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention.
10. Dowse, G.K., P.Z. Zimmet & H. King. 1991. Relationship between prevalence of impaired glucose tolerance and NIDDM in a population. Diabetes Care 14: 968-974.
11. Chen, L., D.J. Magliano & P.Z. Zimmet. 2012. The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives. Nat. Rev. Endocrinol. 8: 228-236.
12. The DECODA Study Group. 2003. Age and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care 26: 1770-1780.
13. 2003. Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts. Diabetes Care 26: 61-69.
14. Jiang, Y.D., C.H. Chang, T.Y. Tai, et al. 2012. Incidence and prevalence rates of diabetes mellitus in Taiwan: analysis of the 2000-2009 Nationwide Health Insurance database. J. Formos. Med. Assoc. 111: 599-604.
15. 2012. Diagnosis and classification of diabetes mellitus. Diabetes Care 35(Suppl. 1): S64-S71.
16. World Health Organization, International Diabetes Federation. 2006. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia. Geneva, Switzerland: World Health Organization International Diabetes Federation.
17. Ko, G.T.C., J.C.N. Chan, J. Woo & C.S. Cockram. 1998. The use of the 1997 American Diabetes Association Diagnostic criteria in a Hong Kong Chinese population. Diabetes Care 21: 2094-2097.
18. Qiao, Q., T. Nakagami, J. Tuomilehto, et al. 2000. Comparison of the fasting and the 2-h glucose criteria for diabetes in different Asian cohorts. Diabetologia 43: 1470-1475.
19. World Health Organization. 2011. Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus. In: WHO, ed.: 25. Geneva, Switzerland: World Health Organization.
20. Dagogo-Jack, S. 2010. Pitfalls in the use of HbA(1)(c) as a diagnostic test: the ethnic conundrum. Nat. Rev. Endocrinol. 6: 589-593.
21. Bennett, C.M., M. Guo & S.C. Dharmage. 2007. HbA(1c) as a screening tool for detection of Type 2 diabetes: a systematic review. Diabet. Med. 24: 333-343.
22. Anand, S.S., F. Razak, V. Vuksan, et al. 2003. Diagnostic strategies to detect glucose intolerance in a multiethnic population. Diabetes Care 26: 290-296.
23. Herman, W.H., Y. Ma, G. Uwaifo, et al. Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program. Diabetes Care 2007; 30: 2453-2457.
24. Bao, Y., X. Ma, H. Li, et al. 2010. Glycated haemoglobin A1c for diagnosing diabetes in Chinese population: cross sectional epidemiological survey. Br. Med. J. 340: c2249.
25. Ko, G.T.C., J.C.N. Chan, V.T.F. Yeung, et al. 1998. The combined use of a fasting plasma glucose concentration and glycated hemoglobin or fructosamine predicts the likelihood of having diabetes mellitus in high risk subjects. Diabetes Care 21: 1221-1225.
26. Jia, W.P., C. Pang, L. Chen, et al. Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities. Diabetologia 2007; 50: 286-292.
27. Ko, G.T.C., J.C.N. Chan, J. Woo & C.S. Cockram. 1999. Prediction of hypertension, diabetes, dyslipidaemia or albuminuria using simple arthropometric indexes in Hong Kong Chinese. Int. J. Obes. 23: 1136-1142.
28. McKeigue, P.M., B. Shah & M.G. Marmot. 1991. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337: 382-386.
29. Deurenberg, P., M. Yap & W.A. van Staveren. 1998. Body mass index and percent body fat: a meta analysis among different ethnic groups. Int. J. Obes. Relat. Metab. Disord. 22: 1164-1171.
30. He, M., K.C. Tan, E.T. Li & A.W. Kung. 2001. Body fat determination by dual energy X-ray absorptiometry and its relation to body mass index and waist circumference in Hong Kong Chinese. Int. J. Obes. Related Metab. Dis. 25: 748-752.
31. WHO/IASO/IOTF. 2000. The Asia-Pacific Perspective: Redefining Obesity and Its Treatment. Western Pacific Region, Hong Kong: World Health Organsiation.
32. WHO Expert Consultation. 2004. Appropriate body mass index for Asian populations and its implications for policy and intervention strategies. Lancet 363: 157-163.
33. Boffetta, P., D. McLerran, Y. Chen, et al. 2011. Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900, 000 individuals in the Asia cohort consortium. PLoS One 6: e19930.
34. Koh-Banerjee, P., Y. Wang, F.B. Hu, et al. 2004. Changes in body weight and body fat distribution as risk factors for clinical diabetes in US men. Am. J. Epidemiol. 159: 1150-1159.
35. Wang, Y., E.B. Rimm, M.J. Stampfer, et al. 2005. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am. J. Clin. Nutr. 81: 555-563.
36. Huxley, R., W.P. James, F. Barzi, et al. 2008. Ethnic comparisons of the cross-sectional relationships between measures of body size with diabetes and hypertension. Obes. Rev. 9(Suppl. 1): 53-61.
37. Nyamdorj, R., J. Pitkaniemi, J. Tuomilehto, et al. 2010. Ethnic comparison of the association of undiagnosed diabetes with obesity. Int. J. Obes. 34: 332-339.
38. Stevens, J., K.P. Truesdale, E.G. Katz & J. Cai. 2008. Impact of body mass index on incident hypertension and diabetes in Chinese Asians, American Whites, and American Blacks: the People's Republic of China Study and the Atherosclerosis Risk in Communities Study. Am. J. Epidemiol. 167: 1365-1374.
39. Chiu, M., P.C. Austin, D.G. Manuel, et al. 2011. Deriving ethnic-specific BMI cutoff points for assessing diabetes risk. Diabetes Care 34: 1741-1748.
40. Ma, Y., J.R. Hebert, J.E. Manson, et al. 2012. Determinants of racial/ethnic disparities in incidence of diabetes in postmenopausal women in the U.S.: the Women's Health Initiative 1993-2009. Diabetes Care 35: 2226-2234.
41. Deurenberg, P., M. Deurenbery-Yap & S. Guricci. 2002. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes. Rev. 3: 141-146.
42. Fujimoto, W.Y., E.J. Boyko, T. Hayashi, et al. 2012. Risk factors for type 2 diabetes: lessons learned from Japanese Americans in Seattle. J. Diabet. Investig. 3: 212-224.
43. Fox, K.A., J.P. Despres, A.J. Richard, et al. 2009. Does abdominal obesity have a similar impact on cardiovascular disease and diabetes? A study of 91, 246 ambulant patients in 27 European countries. Eur. Heart J. 30: 3055-3063.
44. Bergstrom, R.W., L.L. Newell-Morris, D.L. Leonetti, et al. 1990. Association of elevated C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men. Diabetes 39: 104-111.
45. Boyko, E.J., W.Y. Fujimoto, D.L. Leonetti & L. Newell-Morris. 2000. Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care 23: 465-471.
46. Hayashi, T., E.J. Boyko, D.L. Leonetti, et al. 2003. Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans. Diabetes Care 26: 650-655.
47. Lear, S.A., K.H. Humphries, S. Kohli, et al. 2007. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT). Am. J. Clin. Nutr. 86: 353-359.
48. Unger, R.H. 1996. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes 44: 863-870.
49. Fraser, A., R. Harris, N. Sattar, et al. 2009. Alanine aminotransferase, gamma-glutamyltransferase, and incident diabetes: the British Women's Heart and Health Study and meta-analysis. Diabetes Care 32: 741-750.
50. Wong, V.W. 2012. Gestational diabetes mellitus in five ethnic groups: a comparison of their clinical characteristics. Diabet. Med. 29: 366-371.
51. Taylor, R. 2008. Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 51: 1781-1789.
52. Kahn, S.E. 2003. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46: 3-19.
53. Abdul-Ghani, M.A., D. Tripathy & R.A. DeFronzo. 2006. Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care 29: 1130-1139.
54. Chiu, K.C., P. Cohan, N.P. Lee & L.M. Chuang. 2000. Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function. Diabetes Care 23: 1353-1358.
55. Hayashi, T., E.J. Boyko, M.J. McNeely, et al. 2008. Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans. Diabetes 57: 1269-1275.
56. Tanaka, Y., Y. Atsumi, K. Matsuoka, et al. 2000. Interesting insulin response to oral glucose load in young Japanese subjects with impaired glucose tolerance. Diabetes Care 23: 710-712.
57. Kawamori, R. 2002. Diabetes trends in Japan. Diabetes Metab. Res. Rev. 18(Suppl. 3): S9-S13.
58. Goodpaster, B.H., S. Krishnaswami, H. Resnick, et al. 2003. Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. Diabetes Care 26: 372-379.
59. Chiu, K.C., L.M. Chuang & C. Yoon. 2001. Comparison of measured and estimated indices of insulin sensitivity and beta cell function: impact of ethnicity on insulin sensitivity and beta cell function in glucose-tolerant and normotensive subjects. J. Clin. Endocrinol. Metab. 86: 1620-1625.
60. Ahima, R.S. & S.F. Jeffery. 2000. Adipose tissue as an endocrine organ. Trends Endocrinol. Metab. 11: 327-332.
61. Hsu, W.C., E. Okeke, S. Cheung, et al. 2011. A cross-sectional characterization of insulin resistance by phenotype and insulin clamp in East Asian Americans with type 1 and type 2 diabetes. PLoS One 6: e28311.
62. Tso, A.W., A. Xu, P.C. Sham, et al. 2007. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 30: 2667-2672.
63. Cheung, B.M., N.M. Wat, Y.B. Man, et al. 2007. Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study. Diabetes Care 30: 1430-1436.
64. Wallace, D.C. 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39: 359-407.
65. Abdul-Ghani, M.A. & R.A. DeFronzo. 2008. Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus. Curr. Diab. Rep. 8: 173-178.
66. Ng, M.C.Y., S.C. Lee, G.T.C. Ko, et al. 2001. Familial early onset type 2 diabetes in Chinese: the more significant roles of obesity and genetics than autoimmunity. Diabetes Care 24: 667-671.
67. Park, K.S., J.C. Chan, L.M. Chuang, et al. 2008. A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia 51: 602-608.
68. Wallace, D.C. 2010. Bioenergetics and the epigenome: interface between the environment and genes in common diseases. Dev. Disabil. Res. Rev. 16: 114-119.
69. Chan, J.C., W. So, R.C. Ma, et al. 2011. The complexity of vascular and non-vascular complications of diabetes: the Hong Kong Diabetes Registry. Curr. Cardiovasc. Risk Rep. 5: 230-239.
70. Urakami, T., S. Kubota, Y. Nitadori, et al. 2005. Annual incidence and clinical characteristics of type 2 diabetes in children as detected by urine glucose screening in the Tokyo metropolitan area. Diabetes Care 28: 1876-1881.
71. Wei, J.N., F.C. Sung, C.C. Lin, et al. 2003. National surveillance for type 2 diabetes mellitus in Taiwanese children. JAMA 290: 1345-1350.
72. Huen, K.F., L.C.K. Low, P.T. Cheung, et al. 2009. An update on the epidemiology of childhood diabetes in Hong Kong. HK J. Paediatr. 14: 252-259.
73. Dabelea, D., R.A. Bell, R.B. D'Agostino, Jr., et al. 2007. Incidence of diabetes in youth in the United States. JAMA 297: 2716-2724.
74. Chuang, L.M., S. Soegondo, P. Soewondo, et al. 2006. Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia. Diabetes Res. Clin. Pract. 71: 146-155.
75. Gu, D., K. Reynolds, X. Duan, et al. 2003. Prevalence of diabetes and impaired fasting glucose in the Chinese adult population: International Collaborative Study of Cardiovascular Disease in Asia (InterASIA). Diabetologia 46: 1190-1198.
76. Thai, A.C., V. Mohan, B.A. Khalid, et al. 2008. Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): association with clinical characteristics, beta cell function and cardio-metabolic risk factors. Diabetes Res. Clin. Pract. 80: 224-230.
77. Ko, G.T.C., J.C.N. Chan, V.T.F. Yeung, et al. 1998. Antibodies to glutamic acid decarboxylase in young Chinese diabetic patients. Ann. Clin. Biochem. 35: 761-767.
78. Annis, A.M., M.S. Caulder, M.L. Cook & D. Duquette. 2005. Family history, diabetes, and other demographic and risk factors among participants of the National Health and Nutrition Examination Survey 1999-2002. Prev. Chronic. Dis. 2: A19.
79. Yang, Q., T. Liu, R. Valdez, et al. 2010. Improvements in ability to detect undiagnosed diabetes by using information on family history among adults in the United States. Am. J. Epidemiol. 171: 1079-1089.
80. Ng, M.C., S.C. Lee, G.T. Ko, et al. 2001. Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity. Diabetes Care 24: 663-671.
81. Chung, J.O., D.H. Cho, D.J. Chung & M.Y. Chung. 2010. Plasma C-peptide level is inversely associated with family history of type 2 diabetes in Korean type 2 diabetic patients. Endocr. J. 57: 931-938.
82. Yoon, K.H., S.H. Ko, J.H. Cho, et al. 2003. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J. Clin. Endocrinol. Metab. 88: 2300-2308.
83. Chan, W.B., P.C.Y. Tong, C.C. Chow, et al. 2004. The associations of body mass index, C peptide and metabolic status in Chinese type 2 diabetic patients. Diabet. Med. 21: 349-353.
84. Fujimoto, W.Y., R.W. Bergstrom, E.J. Boyko, et al. 2000. Type 2 diabetes and the metabolic syndrome in Japanese Americans. Diabetes Res. Clin. Pract. 50(Suppl. 2): S73-S76.
85. McCarthy, M.I. 2010. Genomics, type 2 diabetes, and obesity. N. Engl. J. Med. 363: 2339-2350.
86. Voight, B.F., L.J. Scott, V. Steinthorsdottir, et al. 2010. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42: 579-589.
87. Cho, Y.S., C.H. Chen, C. Hu, et al. 2011. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians. Nat. Genet. 44: 67-72.
88. Morris, A.P., B.F. Voight, T.M. Teslovich, et al. 2012. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44: 981-990.
89. Li, J.K., M.C. Ng, W.Y. So, et al. 2006. Phenotypic and genetic clustering of diabetes and metabolic syndrome in Chinese families with type 2 diabetes mellitus. Diabetes Metab. Res. Rev. 22: 46-52.
90. Kuroe, A., M. Fukushima, M. Usami, et al. 2003. Impaired beta-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance. Diabetes Res. Clin. Pract. 59: 71-77.
91. Nishi, Y., M. Fukushima, H. Suzuki, et al. 2005. Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia. Diabetes Res. Clin. Pract. 70: 46-52.
92. Takeuchi, M., K. Okamoto, T. Takagi & H. Ishii. 2008. Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: a systematic review and meta-analysis focusing on fasting serum insulin. Diabetes Res. Clin. Pract. 81: 370-376.
93. Taniguchi, A., M. Fukushima, M. Sakai, et al. 2000. Insulin secretion, insulin sensitivity, and glucose effectiveness in nonobese individuals with varying degrees of glucose tolerance. Diabetes Care 23: 127-128.
94. Fukushima, M., M. Usami, M. Ikeda, et al. 2004. Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes. Metabolism 53: 831-835.
95. Utzschneider, K.M., R.L. Prigeon, M.V. Faulenbach, et al. 2009. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 32: 335-341.
96. Abdul-Ghani, M.A., K. Williams, R.A. DeFronzo & M. Stern. 2007. What is the best predictor of future type 2 diabetes? Diabetes Care 30: 1544-1548.
97. Kim, S.K., J.H. Kim, J.Y. Park, et al. 2011. Indexes of beta-cell function from the oral glucose tolerance test can modestly predict pancreatic beta-cell area in Korean. Diabetes Res. Clin. Pract. 93: 220-227.
98. Torrens, J.I., J. Skurnick, A.L. Davidow, et al. 2004. Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN). Diabetes Care 27: 354-361.
99. Kahn, S.E., C.B. Verchere, S. Andrikopoulos, et al. 1998. Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans. Diabetes 47: 640-645.
100. Haataja, L., T. Gurlo, C.J. Huang & P.C. Butler. 2008. Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocr. Rev. 29: 303-316.
101. Butler, A.E., J. Janson, S. Bonner-Weir, et al. 2003. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52: 102-110.
102. Zhao, H.L., F.M.M. Lai, P.C.Y. Tong, et al. 2003. Prevalence and clinicopathological characteristics of islet amyloid in Chinese patients with type 2 diabetes. Diabetes 52: 2759-2766.
103. Turner, R.C., I. Stratton, V. Horton, et al. 1997. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 350: 1288-1293.
104. Park, Y., H. Lee, C.S. Koh, et al. 1996. The low prevalence of immunogenetic markers in Korean adult-onset IDDM patients. Diabetes Care 19: 241-245.
105. Tsuruoka, A., I. Matsuba, T. Toyota, et al. 1995. Antibodies to GAD in Japanese diabetic patients: a multicenter study. Diabetes Res. Clin. Pract. 28: 191-199.
106. Zinman, B., S.E. Kahn, S.M. Haffner, et al. 2004. Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe. Diabetes 53: 3193-3200.
107. Roh, M.O., C.H. Jung, B.Y. Kim, et al. 2010. The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. Acta Diabetol. Oct. 16; PMID: 20953640.
108. Ng, M.C., K.S. Park, B. Oh, et al. 2008. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6, 719 Asians. Diabetes 57: 2226-2233.
109. Yokoi, N., M. Kanamori, Y. Horikawa, et al. 2006. Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects. Diabetes 55: 2379-2386.
110. Yasuda, K., K. Miyake, Y. Horikawa, et al. 2008. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat. Genet. 40: 1092-1097.
111. Tsai, F.J., C.F. Yang, C.C. Chen, et al. 2010. A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet. 6: e1000847.
112. Barker, D.J., P.D. Gluckman, K.M. Godfrey, et al. 1993. Fetal nutrition and cardiovascular disease in adult life. Lancet 341: 938-941.
113. Gluckman, P.D., M.A. Hanson, C. Cooper & K.L. Thornburg. 2008. Effect of in utero and early-life conditions on adult health and disease. N. Engl. J. Med. 359: 61-73.
114. Gluckman, P.D., M.A. Hanson, T. Buklijas, et al. 2009. Epigenetic mechanisms that underpin metabolic and cardiovascular diseases. Nat. Rev. Endocrinol. 5: 401-408.
115. Godfrey, K.M., K.A. Lillycrop, G.C. Burdge, et al. 2007. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr. Res. 61: 5R-10R.
116. Li, Y., Y. He, L. Qi, et al. 2010. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 59: 2400-2406.
117. Ma, R.C. & J.C. Chan. 2009. Pregnancy and diabetes scenario around the world: China. Int. J. Gynaecol. Obstet. 104(Suppl. 1): S42-S45.
118. Lawrence, J.M., R. Contreras, W. Chen & D.A. Sacks. 2008. Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999-2005. Diabetes Care 31: 899-904.
119. Pettitt, D.J., K.A. Aleck, H.R. Baird, et al. 1988. Congenital susceptibility to NIDDM. Role of intrauterine environment. Diabetes 37: 622-628.
120. Dabelea, D., R.L. Hanson, R.S. Lindsay, et al. 2000. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 49: 2208-2211.
121. Sobngwi, E., P. Boudou, F. Mauvais-Jarvis, et al. 2003. Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet 361: 1861-1865.
122. Dabelea, D. & T. Crume. 2011. Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes 60: 1849-1855.
123. Pettitt, D.J., J.M. Lawrence, J. Beyer, et al. 2008. Association between maternal diabetes in utero and age at offspring's diagnosis of type 2 diabetes. Diabetes Care 31: 2126-2130.
124. Pavkov, M.E., R.L. Hanson, W.C. Knowler, et al. 2010. Effect of intrauterine diabetes exposure on the incidence of end-stage renal disease in young adults with type 2 diabetes. Diabetes Care 33: 2396-2398.
125. Ferrara, A. 2007. Increasing prevalence of gestational diabetes mellitus: a public health perspective. Diabetes Care 30(Suppl. 2): S141-S146.
126. Zhang, F., L. Dong, C.P. Zhang, et al. 2011. Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008. Diabet. Med. 28: 652-657.
127. Hedderson, M., S. Ehrlich, S. Sridhar, et al. 2012. Racial/ethnic disparities in the prevalence of gestational diabetes mellitus by BMI. Diabetes Care 35: 1492-1498.
128. Kim, C., K.M. Newton & R.H. Knopp. 2002. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care 25: 1862-1868.
129. HAPO Study Cooperative Research Group. 2009. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. Diabetes 58: 453-459.
130. Boney, C.M., A. Verma, R. Tucker & B.R. Vohr. 2005. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115: e290-e296.
131. Tam, W.H., R.C. Ma, X. Yang, et al. 2008. Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero. Pediatrics 122: 1229-1234.
132. Tam, W.H., R.C. Ma, X. Yang, et al. 2010. Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study. Diabetes Care 33: 1382-1384.
133. Asia Pacific Cohort Studies Collaboration. 2007. The burden of overweight and obesity in the Asia-Pacific region. Obes. Rev. 8: 191-196.
134. Gu, D., K. Reynolds, X. Wu, et al. 2005. Prevalence of the metabolic syndrome and overweight among adults in China. Lancet 365: 1398-1405.
135. Gu, D., A. Gupta, P. Muntner, et al. 2005. Prevalence of cardiovascular disease risk factor clustering among the adult population of China: results from the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia). Circulation 112: 658-665.
136. He, J., D. Gu, X. Wu, et al. 2005. Major causes of death among men and women in China. N. Engl. J. Med. 353: 1124-1134.
137. Popkin, B.M., S. Horton, S. Kim, et al. 2001. Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutr. Rev. 59: 379-390.
138. Du, S., B. Lu, F. Zhai & B.M. Popkin. 2002. A new stage of the nutrition transition in China. Public Health Nutr. 5: 169-174.
139. Foster-Powell, K., S.H. Holt & J.C. Brand-Miller. 2002. International table of glycemic index and glycemic load values: 2002. Am. J. Clin. Nutr. 76: 5-56.
140. Villegas, R., S. Liu, Y.T. Gao, et al. 2007. Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women. Arch. Intern. Med. 167: 2310-2316.
141. Nanri, A., T. Mizoue, M. Noda, et al. 2010. Rice intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study. Am. J. Clin. Nutr. 92: 1468-1477.
142. Hu, E.A., A. Pan, V. Malik & Q. Sun. 2012. White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review. Br. Med. J. 344: e1454.
143. Henry, C.J., H.J. Lightowler, K. Newens, et al. 2008. Glycaemic index of common foods tested in the UK and India. Br. J. Nutr. 99:840-845.
144. Nakanishi, N., K. Nakamura, Y. Matsuo, et al. 2000. Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men. Ann. Intern. Med. 133: 183-191.
145. Chen, Z., Y.S. Shin & R. Beaglehole. 2012. Tobacco control in China: small steps towards a giant leap. Lancet 379: 779-780.
146. Lim, S., Y.M. Cho, K.S. Park & H.K. Lee 2010. Persistent organic pollutants, mitochondrial dysfunction, and metabolic syndrome. Ann. N.Y. Acad. Sci. 1201: 166-176.
147. Spiegel, K., E. Tasali, R. Leproult & Van E. Cauter. 2009. Effects of poor and short sleep on glucose metabolism and obesity risk. Nat. Rev. Endocrinol. 5: 253-261.
148. Olds, T., S. Blunden, J. Petkov & F. Forchino. 2010. The relationships between sex, age, geography and time in bed in adolescents: a meta-analysis of data from 23 countries. Sleep. Med. Rev. 14: 371-378.
149. Shaw, J.E., N.M. Punjabi, J.P. Wilding, et al. 2008. Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention. Diabetes Res. Clin. Pract. 81: 2-12.
150. Kim, J., H.M. Kim, K.M. Kim & D.J. Kim. 2009. The association of sleep duration and type 2 diabetes in Korean male adults with abdominal obesity: the Korean National Health and Nutrition Examination Survey. 2005. Diabetes Res. Clin. Pract. 86: e34-e36.
151. Kachi, Y., K. Ohwaki & E. Yano. 2012. Association of sleep duration with untreated diabetes in Japanese men. Sleep. Med. 13: 307-309.
152. Ko, G.T., J.C. Chan, A.W. Chan, et al. 2007. Association between sleeping hours, working hours and obesity in Hong Kong Chinese: the 'better health for better Hong Kong' health promotion campaign. Int. J. Obes. 31: 254-260.
153. Kong, A.P., Y.K. Wing, K.C. Choi, et al. 2011. Associations of sleep duration with obesity and serum lipid profile in children and adolescents. Sleep. Med. 12: 659-665.
154. Jeon, C.Y., M.N. Haan, C. Cheng, et al. 2012. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care 35: 520-525.
155. Ojetti, V., R. Pellicano, S. Fagoonee, et al. 2010. Helicobacter pylori infection and diabetes. Minerva. Med. 101: 115-119.
156. Tian, T., L.Q. Zhang, X.H. Ma, et al. 2012. Diabetes mellitus and incidence and mortality of gastric cancer: a meta-analysis. Exp. Clin. Endocrinol. Diabetes 120: 217-223.
157. So, W.Y., P.C. Tong, G.T. Ko, et al. 2009. Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic beta-cell function. Diabetes Res. Clin. Pract. 86: 89-95.
158. Lao, T.T., K.Y. Tse, L.Y. Chan, et al. 2003. HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women. Diabetes Care 26: 3011-3016.
159. Cheng, A.Y., A.P. Kong, V.W. Wong, et al. 2006. Chronic hepatitis B viral infection independently predicts renal outcome in type 2 diabetic patients. Diabetologia 49: 1777-1784.
160. Cockram, C.S. & N. Lee. 2010. "Diabetes and Infection." In: Textbook of Diabetes. 4th Edition ed. R.I. Holt, C.S. Cockram, A. Flyvberg, B.J. Goldstein, Eds.: 835-858. Chichester, West Sussex: John Wiley & Sons, Ltd.
161. Lee, E.T., M. Lu, P.H. Bennett & H. Keen. 2001. Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 44(Suppl. 2): S78-S81.
162. Lee, E.T., H. Keen, P.H. Bennett, et al. 2001. Follow-up of the WHO Multinational Study of Vascular Disease in Diabetes: general description and morbidity. Diabetologia 44(Suppl. 2): S3-S13.
163. Chi, Z.S., E.T. Lee, M. Lu, H. Keen & P.H. Bennett. 2001. Vascular disease prevalence in diabetic patients in China: standardised comparison with the 14 centres in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 44(Suppl. 2): S82-S86.
164. McGill, M.J., R. Donnelly, L. Molyneaux & D.K. Yue. 1996. Ethnic differences in the prevalence of hypertension and proteinuria in NIDDM. Diabetes Res. Clin. Pract. 33: 173-179.
165. Wu, A.Y., N.C. Kong, F.A. de Leon, et al. 2005. An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study. Diabetologia 48: 17-26.
166. Parving, H.H., R. Osterby & E. Ritz. 2000. "Diabetic Nephropathy." In: The Kidney. B.M. Brenner, Ed.: 1731-1773. Philadelphia: WB Saunders.
167. Adler, A.I., R.J. Stevens, S.E. Manley, et al. 2003. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64). Kidney Int. 63: 225-232.
168. Parving, H.H., J.B. Lewis, M. Ravid, et al. 2006. Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective. Kidney Int. 69: 2057-2063.
169. Kenealy, T., C.R. Elley, J.F. Collins, et al. 2012. Increased prevalence of albuminuria among non-European peoples with type 2 diabetes. Nephrol. Dial. Transplant. 27: 1840-1846.
170. Young, B.A., W.J. Katon, M. Von Korff, et al. 2005. Racial and ethnic differences in microalbuminuria prevalence in a diabetes population: the pathways study. J. Am. Soc. Nephrol. 16: 219-228.
171. Luk, A.O., W.Y. So, R.C. Ma, et al. 2008. Metabolic syndrome predicts new onset of chronic kidney disease in 5, 829 patients with type 2 diabetes: a 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care 31: 2357-2361.
172. Luk, A. & J.C. Chan. 2008. Diabetic nephropathy-what are the unmet needs Diabetes Res. Clin. Pract. 82(Suppl. 1): S15-S20.
173. Karter, A.J., A. Ferrara, J.Y. Liu, et al. 2002. Ethnic disparities in diabetic complications in an insured population. JAMA 287: 2519-2527.
174. Clarke, P.M., P. Glasziou, A. Patel, et al. 2010. Event rates, hospital utilization, and costs associated with major complications of diabetes: a multicountry comparative analysis. PLoS Med. 7: e1000236.
175. Liu, J., Y. Hong, RB D'Agostino, Sr., et al. 2004. Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study. JAMA 291: 2591-2599.
176. Woodward, M., X. Zhang, F. Barzi, et al. 2003. The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia-Pacific region. Diabetes Care 26: 360-366.
177. Turner, R.C., H. Millns, H.A. Neil, et al. 1998. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). Br. Med. J. 316: 823-828.
178. Yang, X., W.Y. So, A.P. Kong, et al. 2008. Development and validation of a total coronary heart disease risk score in type 2 diabetes mellitus. Am. J. Cardiol. 101: 596-601.
179. Matsushita, K., M. van der Velde, B.C. Astor, et al. 2010. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 375: 2073-2081.
180. So, W.Y., A.P. Kong, R.C. Ma, et al. 2006. Glomerular filtration rate, cardiorenal end points, and all-cause mortality in type 2 diabetic patients. Diabetes Care 29: 2046-2052.
181. Ma, R.C., W.Y. So, X. Yang, et al. 2008. Erectile dysfunction predicts coronary heart disease in type 2 diabetes. J. Am. Coll. Cardiol. 51: 2045-2050.
182. Gazzaruso, C., S.B. Solerte, A. Pujia, et al. 2008. Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors. J. Am. Coll. Cardiol. 51: 2040-2044.
183. Sone, H., S. Tanaka, S. Iimuro, et al. 2012. Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study. Diabetes Care 35: 1150-1157.
184. Seshasai, S.R., S. Kaptoge, A. Thompson, et al. 2011. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N. Engl. J. Med. 364: 829-841.
185. Noto, H., T. Tsujimoto & M. Noda. 2012. Significantly increased risk of cancer in diabetes mellitus patients: a meta-analysis of epidemiological evidence in Asians and non-Asians. J. Diabetes Investig. 3: 24-33.
186. Leung, C.C., T.H. Lam, W.M. Chan, et al. 2008. Diabetic control and risk of tuberculosis: a cohort study. Am. J. Epidemiol. 167:1486-1494.
187. Harries, A.D., M.B. Murray, C.Y. Jeon, et al. 2010. Defining the research agenda to reduce the joint burden of disease from diabetes mellitus and tuberculosis. Trop. Med. Int. Health 15: 659-663.
188. Hu, D., P. Fu, J. Xie, et al. 2008. Increasing prevalence and low awareness, treatment and control of diabetes mellitus among Chinese adults: the InterASIA study. Diabetes Res. Clin. Pract. 81: 250-257.
189. Chan, J.C., J.J. Gagliardino, S.H. Baik, et al. 2009. Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS). Diabetes Care 32: 227-233.
190. Fisher, E.B., J.C. Chan, H. Nan, et al. 2012. Co-occurrence of diabetes and depression: conceptual considerations for an emerging global health challenge. J. Affect. Disord. 142(Suppl.): S56-S66.
191. Inzucchi, S.E., R.M. Bergenstal, J.B. Buse, et al. 2012. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35: 1364-1379.
192. Rodbard, H.W., P.S. Jellinger, J.A. Davidson, et al. 2009. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr. Pract. 15: 540-559.
193. IDF Clinical Guidelines Task Force. 2005. Global guideline for Type 2 Diabetes. Brussels: International Diabetes Federation.
194. Pan, C.Y. & H. Landen. 2007. Post-marketing surveillance of acarbose treatment in patients with type 2 diabetes mellitus and subjects with impaired glucose tolerance in China. Clin. Drug Investig. 27: 397-405.
195. Kobayashi, M., K. Yamazaki, K. Hirao, et al. 2006. The status of diabetes control and antidiabetic drug therapy in Japan-a cross-sectional survey of 17, 000 patients with diabetes mellitus (JDDM 1). Diabetes Res. Clin. Pract. 73: 198-204.
196. Tong, P.C., G.T. Ko, W.Y. So, et al. 2008. Use of anti-diabetic drugs and glycaemic control in type 2 diabetes-tThe Hong Kong Diabetes Registry. Diabetes Res. Clin. Pract. 82: 346-352.
197. Yurgin, N., K. Secnik & M.J. Lage. 2007. Antidiabetic prescriptions and glycemic control in German patients with type 2 diabetes mellitus: a retrospective database study. Clin. Ther. 29: 316-325.
198. Li, Y., W. Xu, Z. Liao, et al. 2004. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 27: 2597-2602.
199. Weng, J., Y. Li, W. Xu, et al. 2008. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 371: 1753-1760.
200. Mohan, V., W. Yang, H.Y. Son, et al. 2009. Efficacy and safety of sitagliptin in the treatment of patients with type 2 diabetes in China, India, and Korea. Diabetes Res. Clin. Pract. 83: 106-116.
201. Kikuchi, M., N. Abe, M. Kato, et al. 2009. Vildagliptin dose-dependently improves glycemic control in Japanese patients with type 2 diabetes mellitus. Diabetes Res. Clin. Pract. 83: 233-240.
202. Pan, C., W. Yang, J.P. Barona, et al. 2008. Comparison of vildagliptin and acarbose monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial. Diabet. Med. 25: 435-441.
203. Seino, Y., M.F. Rasmussen, T. Nishida & K. Kaku. 2010. Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes. Curr. Med. Res. Opin. 26: 1013-1022.
204. Mu, Y.M., A. Misra, J.M. Adam, et al. 2012. Managing diabetes in Asia: overcoming obstacles and the role of DPP-IV inhibitors. Diabetes Res. Clin. Pract. 95: 179-188.
205. Chan, J.C.N., N.M.S. Wat, W.Y. So, et al. 2004. RAAS blockade and renal disease in type 2 diabetic patients: an Asian perspective from the RENAAL Study. Diabetes Care 27: 874-879.
206. Wang, W., C.W. Fu, C.Y. Pan, et al. 2009. How do type 2 diabetes mellitus-related chronic complications impact direct medical cost in four major cities of urban China Value Health 12: 923-929.
207. Cho, J.H., S.A. Chang, H.S. Kwon, et al. 2006. Long-term effect of the Internet-based glucose monitoring system on HbA1c reduction and glucose stability: a 30-month follow-up study for diabetes management with a ubiquitous medical care system. Diabetes Care 29: 2625-2631.
208. Cho, J.H., H.C. Lee, D.J. Lim, et al. 2009. Mobile communication using a mobile phone with a glucometer for glucose control in Type 2 patients with diabetes: as effective as an Internet-based glucose monitoring system. J. Telemed. Telecare 15: 77-82.
209. Cho, J.H., H.S. Kwon, H.S. Kim, et al. 2011. Effects on diabetes management of a health-care provider mediated, remote coaching system via a PDA-type glucometer and the Internet. J. Telemed. Telecare 17: 365-370.
210. Tricco, A.C., N.M. Ivers, J.M. Grimshaw, et al. 2012. Effectiveness of quality improvement strategies on the management of diabetes: a systematic review and meta-analysis. Lancet 379: 2252-2261.
211. Chan, J.C., W.Y. So, C.Y. Yeung, et al. 2009. Effects of structured versus usual care on renal endpoint in type 2 diabetes: the SURE study: a randomized multicenter translational study. Diabetes Care 32: 977-982.
212. Chan, J., W. So, G. Ko, et al. 2009. The Joint Asia Diabetes Evaluation (JADE) Program: a web-based program to translate evidence to clinical practice in type 2 diabetes. Diabet. Med. 26: 693-699.
213. Hanson, M.A., P.D. Gluckman, R.C. Ma, et al. 2012. Early life opportunities for prevention of diabetes in low and middle income countries. BMC Public Health 12: 1025.
214. Imamura, M., S. Maeda, T. Yamauchi, et al. 2012. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum. Mol. Genet. 21: 3042-3049.
215. Kong, A., V. Steinthorsdottir, G. Masson, et al. 2009. Parental origin of sequence variants associated with complex diseases. Nature 462: 868-874.
216. Whiting, D., N. Unwin & G. Roglic. 2010. "Diabetes: equity and social determinants." In: Equity, social determinants and public health programmes. E. Blas, A. Kurup, Eds.: 77-94. Geneva, Switzerland: World Health Organization.
217. Wang, W.Q., T.P. Ip & K.S. Lam. 1998. Changing prevalence or retinopathy in newly diagnosed NIDDM patients in Hong Kong. Diabetes Res. Clin. Pract. 39: 185-191.
218. Chang, C., F. Lu, Y.C. Yang, et al. 2000. Epidemiologic study of type 2 diabetes in Taiwan. Diabetes Res. Clin. Pract. 50(Suppl. 2): S49-S59.
219. Liu, D.P., L. Molyneaux, E. Chua, et al. 2002. Retinopathy in a Chinese population with type 2 diabetes: factors affecting the presence of this complication at diagnosis of diabetes. Diabetes Res. Clin. Pract. 56: 125-131.
220. Wong, T.Y., N. Cheung, W.T. Tay, et al. 2008. Prevalence and risk factors for diabetic retinopathy: the Singapore Malay Eye Study. Ophthalmology 115: 1869-1875.
221. Wang, F.H., Y.B. Liang, F. Zhang, et al. 2009. Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology 116: 461-467.
222. Kim, J.H., H.S. Kwon, Y.M. Park, et al. 2011. Prevalence and associated factors of diabetic retinopathy in rural Korea: the Chungju metabolic disease cohort study. J. Korean Med. Sci. 26: 1068-1073.
223. So, W.Y., J. Raboca, L. Sobrepena, et al. 2011. Comprehensive risk assessments of diabetic patients from seven Asian countries: The Joint Asia Diabetes Evaluation (JADE) program. J. Diabetes 3: 109-118.
224. Zhang, X., J.B. Saaddine, C.F. Chou, et al. 2010. Prevalence of diabetic retinopathy in the United States, 2005-2008. JAMA 304: 649-656.
225. Wong, T.Y., F.M. Islam, R. Klein, et al. 2006. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest. Ophthalmol. Vis. Sci. 47: 2341-2350.
226. Kanaya, A.M., N. Adler, H.H. Moffet, et al. 2011. Heterogeneity of diabetes outcomes among asians and pacific islanders in the US: the diabetes study of northern california (DISTANCE). Diabetes Care 34: 930-937.
227. Tao, M., M.A. McDowell, S.H. Saydah & M.S. Eberhardt. 2008. Relationship of polyunsaturated fatty acid intake to peripheral neuropathy among adults with diabetes in the National Health and Nutrition Examination Survey (NHANES) 1999 2004. Diabetes Care 31: 93-95.
228. Liu, Z., Fu C. Wang W. & Xu B. 2010. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients-a cross-sectional hospital based survey in urban China. Health Qual. Life Outcomes 8: 62.
229. Yang, X., W. So, G.T. Ko, et al. 2008. Independent associations between low-density lipoprotein cholesterol and cancer among patients with type 2 diabetes mellitus. CMAJ 179: 427-437.
230. Yang, X., W.Y. So, R.C. Ma, et al. 2008. Predicting values of lipids and white blood cell count for all-site cancer in type 2 diabetes. Endocr. Relat. Cancer 15: 597-607.
231. Jee, S.H., H. Ohrr, J.W. Sull, et al. 2005. Fasting serum glucose level and cancer risk in Korean men and women. JAMA 293: 194-202.