Structure and function of the hypertension variant A486V of G protein-coupled receptor kinase 4

Journal of Biological Chemistry

Volumn 290, Issue 33, 2015, Pages 20360-20373

  Allen, Samantha J ^a   Parthasarathy, Gopal ^a   Darke, Paul L ^a   Diehl, Ronald E ^a   Ford, Rachael E ^a   Hall, Dawn L ^a   Johnson, Scott A ^a   Reid, John C ^a   Rickert, Keith W ^a   Shipman, Jennifer M ^a   Soisson, Stephen M ^a   Zuck, Paul ^a   Munshi, Sanjeev K ^a   Lumb, Kevin J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD PRESSURE; MASS SPECTROMETRY; PROTEINS;

ACIDIC SURFACE; AUTOPHOSPHORYLATION; G PROTEIN-COUPLED RECEPTOR KINASE; G-PROTEIN COUPLED RECEPTORS; KINASE ACTIVITY; PHOSPHOPEPTIDES; PRE-INCUBATION; SUBSTRATE-BINDING SITES;

ENZYMES;

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; DOPAMINE 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 4; G PROTEIN COUPLED RECEPTOR KINASE 4ALPHA; G PROTEIN COUPLED RECEPTOR KINASE 6; PROTEIN KINASE C; PROTEIN VARIANT; RGS PROTEIN; SERINE; UNCLASSIFIED DRUG; GRK4 PROTEIN, HUMAN;

ACIDITY; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYPERTENSION; MASS SPECTROMETRY; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; WILD TYPE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; G-PROTEIN-COUPLED RECEPTOR KINASE 4; HUMANS; HYPERTENSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84939628351     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.648907     Document Type: Article

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