Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: Insights from intact cell phosphorylation and recruitment assays

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25262-25275

  Beautrait, Alexandre ^a   Michalski, Kevin R ^b   Lopez, Thomas S ^c   Mannix, Katelynn M ^c   McDonald, Devin J ^c   Cutter, Amber R ^c   Medina, Christopher B ^c   Hebert, Aaron M ^c   Francis, Charnelle J ^c   Bouvier, Michel ^a,b   Tesmer, John J G ^d   Sterne Marr, Rachel ^c  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c SIENA COLLEGE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCKING SITES; G-PROTEIN COUPLED RECEPTORS; INTACT CELLS;

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; NORADRENALIN; ADRBK1 PROTEIN, HUMAN; ALPHA 2 ADRENERGIC RECEPTOR; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CHLOROCEBUS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; IN VITRO STUDY; MOLECULAR DOCKING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; HEK293 CELL LINE; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROCEDURES; PROTEIN ANALYSIS; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; COS CELLS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEK293 CELLS; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84906979513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.593178     Document Type: Article

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